| Reperfusion Injury |
2019-000171-16: Comparison of the differences in the outcomes of patients receiving two different types of anaesthetics during heart surgery. |
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| Not yet recruiting | 4 | 50 | Europe | Desflurane, Isoflurane, Sevoflurane, Propofol, Inhalation vapour, liquid, Emulsion for injection/infusion, Desflurane, Isoflurane, Sevoflurane, Diprivan | King's College Hospital NHS Foundation Trust, National Institute for Academic Anaesthesia | Cardiopulmonary bypass (CPB) and revascularisation-induced ischaemic reperfusion injury, Complications following Cardiopulmonary bypass (CPB) surgery, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
NCT06155110: A Randomized, Single-blind, Controlled Clinical Study of Cardiomyopeptidin on Improving Ischemia-reperfusion Injury in Patients With Acute ST-segment Elevation Myocardial Infarction After Primary PCI |
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| Active, not recruiting | 4 | 160 | RoW | cardiomyopeptidin | Chinese PLA General Hospital, Dalian Zhen-Ao Bio-Tech Co., Ltd. | Cardiovascular Diseases | 03/24 | 05/24 | | |
2017-002514-32: XePOHCAS is a prospective, randomized, multicenter, interventional trial in adult subjects with OHCA during which the standard-of-care for post–cardiac arrest intensive care including TTM) is compared to the same treatment with the addition of 50% xenon by inhalation. |
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| Ongoing | 3 | 1436 | Europe | XENEXâ„¢ (Xenon gas for inhalation), Medicinal gas, compressed | NeuroproteXeon, Inc., NeuroproteXeon, Inc. | Post-cardiac arrest syndrome, A syndrome including all clinical and biological manifestations related to the phenomenon of global ischemia-reperfusion triggered by cardiac arrest and return of spontaneous circulation., Diseases [C] - Nervous System Diseases [C10] | | | | |
| Recruiting | 3 | 496 | RoW | Neu2000KWL group, Placebo group | GNT Pharma | Ischemic Stroke | 06/24 | 01/25 | | |
2021-006767-14: Alkaline phosphatase as a treatment to protect a kidney from hypoxia during tranplantation Alkalische fosfatase als behandeling om een nier te beschermen tegen zuurstoftekort tijdens transplantatie |
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| Ongoing | 2 | 50 | Europe | bovine Rescue Alkaline Phosphatase, Infusion | Amsterdam UMC, Alloksys life sciences B.V., Health Holland B.V. | ischemia reperfusion injury in kidneys transplanted from donors after cardiac death ischemie reperfusieschade in getransplanteerde nieren van overleden donoren na hartdood, hypoxic damage in transplanted kidneys from deceased donors nierschade door zuurstoftekort tijdens transplantatie nadat donor overleden is, Body processes [G] - Immune system processes [G12] | | | | |
NCT05246618: FIH Phase I/IIa Trial Evaluating Safety of TUM012 to Minimize Ischemic Reperfusion Injury in Kidney Transplantation |
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| Completed | 1/2 | 18 | Europe | TUM012, Ex-vivo infusion, Placebo | iCoat Medical AB, CTC Clinical Trial Consultants AB, Region Skane | Ischemia-reperfusion Injury, Kidney Transplant; Complications | 07/23 | 05/24 | | |
NCT04005469: Safety and Efficacy of Treprostinil (Remodulin®) In Reducing Ischemia-Reperfusion Injury During Kidney Transplantation |
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| Recruiting | 1/2 | 20 | US | Treprostinil, Remodulin® | Rhode Island Hospital, University of Rhode Island, United Therapeutics | Ischemia Reperfusion Injury, Delayed Graft Function | 07/25 | 06/26 | | |
NCT06097702: A Study to Evaluate the Safety and Pharmacokinetics of BX-001N in Healthy Participants |
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| Recruiting | 1 | 64 | RoW | BX-001N Part 1, BX-001N Part 2, Placebo | Bilix Co.,Ltd. | Ischemia-reperfusion Injury | 04/24 | 06/24 | | |
| Completed | N/A | 11 | Europe | Perla® Cold Preservation solution | Advanced Life Solutions, Complexo Hospitalario Universitario de A Coruña | Organ Transplant, Ischemic Reperfusion Injury | 04/22 | 04/22 | | |
EURO-ICE, NCT03447834: EUROpean Intracoronary Cooling Evaluation in Patients With ST-elevation Myocardial Infarction. |
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| Active, not recruiting | N/A | 200 | Europe | Selective intracoronary hypothermia + PPCI, Selective intracoronary hypothermia, Standard PPCI | Catharina Ziekenhuis Eindhoven, Abbott, Golden Jubilee National Hospital, Onze Lieve Vrouwziekenhuis Aalst, Rigshospitalet, Denmark, Örebro University, Sweden, Skane University Hospital, University of Belgrade, Mid and South Essex NHS Foundation Trust | Acute Myocardial Infarction, Reperfusion Injury | 09/22 | 06/23 | | |
NCT03176823: Remote Ischemic Conditioning as a Treatment for Traumatic Brain Injury |
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| Completed | N/A | 44 | Canada | CellAegis Technologies autoRIC device, Remote Ischemic Conditioning, Best Practice Management of Traumatic Brain Injury | Unity Health Toronto, Defence Research and Development Canada | Traumatic Brain Injury, Trauma, Nervous System, Reperfusion Injury, Ischemia, Brain | 11/23 | 03/24 | | |