Not yet recruiting

2

24

 

Dr Paul O'Halloran from La Trobe University , La Trobe University Faculty of Health Sciences Physical Activity and Rehabilitation group

hip fracture rehabilitation - increasing activity, hip fracture rehabilitation - quality of life , hip fracture rehabilitation - mental health

 

 

Not yet recruiting

2

40

 

Monash University, Monash University Department of Epidemiology and Preventive Medicine

Tibial shaft fracture, Femoral shaft fracture

 

 

Not yet recruiting

2

60

 

Queensland Health, Queensland Health

Subacromial Impingement Syndrome

 

 

Not yet recruiting

2

72

 

Westmead Hospital, Westmead Research Foundation

osteoarthritis

 

 

Not yet recruiting

2

114

 

Levin Health Ltd, Levin Health Ltd

chronic non-cancer pain, musculoskeletal injury

 

 

Ongoing

2

60

Europe

XEOMIN, Powder for solution for injection, XEOMIN 100 units powder for solution for injection

, ASSISTANCE PUBLIQUE – HÔPITAUX DE PARIS - Direction de la Recherche Clinique et de l’Innovation

Degenerative tendinopathies of the rotator cuff Tendinopathies dégénératives de la coiffe des rotateurs, Diseases of the tendons of the patella of the shoulder Maladies des tendons de la rotule de l'épaule, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Recruiting

2

250

 

Nepean Hospital (Nepean Blue Mountain Local Health District), Orthopaedic Department, Nepean Hospital

Intra capsular neck of femur fractures

 

 

Recruiting

2

92

 

The University of Sydney, Arthropharm Pty Ltd

Musculoskeletal Knee Osteoarthritis

 

 

Ongoing

2

200

Europe

Rose Hip, NA, Coated tablet, Tablet, ALGIX

ISTITUTO ORTOPEDICO RIZZOLI

PATIENTS TO BE IMPLANTED WITH HIP PROSTHESIS SOGGETTI CANDIDATI ALLA PROTESI D'ANCA, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

2

50

Europe

botulinum toxin, Powder for solution for injection, Dysport

Handkirurgiska kliniken, Universitetssjukhuset Örebro, Handkirurgiska kliniken, Universitetssjukhuset Örebro

Chronic lateral humerus epiconcylitis Kronisk lateral humerusepikondylit., Tennis elbow Tennisarmbåge., Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

2

34

Europe

Mesenchymal stromal cells, Mesenchymal stromal cells, Injection

Orthopaedic Research Laboratory, Ã…rhus University Hospital, Orthopaedic Research Laboratory, Ã…rhus University Hospital

Moderate intervertebral disc degeneration without radiculopathy Moderat intervertebral diskus degeneration uden udstrålende smerter, Moderate arthrosis/low back pain Moderat lænderygssmerter uden smerter i benene., Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

2

64

Europe

PRP (OBTENIDO POR PRGF-ENDORET), Solution for injection

Unidad de Cirugia Artroscópica, OSAKIDETZA

Acute Muscle Injury Type 3A-3B (Munich classification) or type II (Classification of Otto Chan), confirmed by radiological diagnosis and clinical agreement. Lesión muscular aguda tipo 3A-3B (clasificación de Munich) o tipo II (Clasificación de Otto Chan), confirmada mediante diagnóstico radiológico, y concordancia clínica., Acute Muscle Injury Lesion muscular aguda, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

2

20

Europe

Solution for injection in pre-filled syringe, Kineret

Institut de Recerca HSCSP, Swedish Orphan Biovitrum

Inflammation in periarticular structures in patients refractory to NSAIDs and / or corticosteroids. Problemas de inflamación localizados en estructuras periarticulares en pacientes refractarios a AINEs y/o corticoides., Inflammation in periarticular structures in patients refractory to NSAIDs and / or corticosteroids. Problemas de inflamación localizados en estructuras periarticulares en pacientes refractarios a AINEs y/o corticoides., Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

2

40

Europe

Trental (Pentoxifylline), Tokoferol (Vitamin E), Bonefos (klodronat), NDC:0039-0078-10, NPU26649, PL 00010/0522, Tablet, Capsule, Trental, Tokoferol, Bonefos

Västra Götalandsregionen/NÄL, Västra Götalandsregionen

Osteoradionecrosis Osteoradionekros, Osteoradionecrosis Benvävnadsdöd efter strålbehandling, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

2

80

Europe

Trental (pentoxyfylline), Tokoferol (Vitamin E), NDC: 0039-0078-10, NPU26649, Tablet, Capsule, Trental, Tokoferol

Västra Götalandsregionen/NÄL, Västra Götalandsregionen

Osteoradionecrosis Osteoradionekros, Osteonecrosis after radiation Benvävnadsdöd efter strålbehandling, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

2

1000

Europe

Zoledronic acid fresenius kabi, Concentrate and solvent for solution for injection/infusion, zoledronic acid fresenius kabi

Region Östergötland, Swedish Research Council

Prosthetic loosening of hip and knee arthroplasty, Joint replacements of the hip and knee becoming loose, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Therapeutic techniques [E02]

 

 

Not yet recruiting

2

10

Europe

PLASMASAFE, Solution for infusion, PLASMASAFE - SOLUZIONE PER INFUSIONE 1 SACCA DA 200 ML

AZIENDA OSPEDALIERA UNIVERSITARIA INTEGRATA VERONA, AOUI Verona

type VI Osteogenesis Imperfecta OSTEOGENESI IMPERFETTA TIPO VI, Osteogenesis Imperfecta Osteogenesi Imperfetta, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

2

50

Europe

Prolia, Prolia

Håkan Ledin (investigator initiated trial), Motala Specialist Care Proxima AB

Patients with idiopathic osteoarthritis of the knee, scheduled for a cemented total knee prosthesis

 

 

Ongoing

2

186

Europe

ORENCIA 125 mg solution for injection, ORENCIA 125 mg solution for injection

King’s College London, Guy\'s and St. Thomas\' NHS Foundation Trust, Bristol-Myers Squibb

The target population for therapeutic intervention will be subjects who carry serum autoantibodies (antibodies to citrullinated protein antigens – ACPA; rheumatoid factor – RF) and who have joint pains (arthralgia) but no joint swelling. These subjects are deemed to be at highest risk of developing rheumatoid arthritis.

 

 

Ongoing

2

24

Europe

Tizanidine Extended Release Tablets 12 mg, Zanaflex Tablets 4 mg, GALPHARM ONE A NIGHT NIGHTCALM 50MG TABLETS (Diphenhydramine Hydrochloride), Zanaflex Tablets, GALPHARM ONE A NIGHT NIGHTCALM 50MG TABLETS, Zanaflex Tablets, GALPHARM ONE A NIGHT NIGHTCALM 50MG TABLETS

Sun Pharma Advanced Research Company, Sun Pharma Advanced Research Company

healthy volunteers (acute musculoskeletal pain)

 

 

Ongoing

2

36

Europe

Capsule, Canemes 1 mg Kapseln

OA Dr. Philipp Becker c/o Abteilung für Wirbelsäulenchirurgie, Orthopädisches Spital Speising GmbH, Orthopädisches Spital Speising GmbH, AOP Orphan Pharmaceuticals AG

Spine disease Wirbelsäulenerkrankung, Spine disease Wirbelsäulenerkrankung, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

2

94

Europe

Bone marrow-derived mononuclear cells (BMC), Implantation suspension

Dekan der medizinischen Fakultät, Universitätsklinikum Frankfurt, Goethe-Universität, Hessisches Ministerium für Wissenschaft und Kunst

Investigation of cell based therapy by implanted bone marrow-derived mononuclear cells for bone augmentation on osteosynthesis of proximal humeral fractures Untersuchung der zellbasierten Therapie von bone marrow-derived mononuclear cells zur Knochenaugmentation bei der Osteosynthese proximaler Humerusfrakturen, Subcapatical humeral fractures Subkapitale Humerusfrakturen, Body processes [G] - Bones and nerves physological processes [G11]

 

 

Ongoing

2

80

Europe

zoledronate, zol, Concentrate for solution for injection/infusion, Zoledronsyre ”Fresenius Kabi”

Randers Regional Hospital, The Research Foundation of The Central Denmark Region, Randers Regional Hospital, Aarhus University, Dagmar Marshalls Foundation, Riisfort Foundation, Linex Foundation

cerebral palsy, osteopenia, fracture cerebral parese, osteopeni, fraktur, physical impairment, low bone density, broken bone spastisk lammelse, lav knogletæthed, knoglebrud, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

2

50

Europe

Oral drops, solution, Detremin

Breastcentre, Capio St Gorans Hospital, ALF Funding

Breast cancer survivors on adjuvant treatment with an aromatase inhibitor having joint pain, Breast cancer survivors with joint pain on treatment with an aromatase inhibitor to reduce their risk for breast cancer relapse, Diseases [C] - Cancer [C04]

 

 

Ongoing

2

72

Europe

Prednisolone 5mg Gastro-resistant Tablets, Capsule, Prednisolone 5mg Gastro-resistant Tablets

Research Governance and Integrity, University of Manchester, Arthritis Research UK, NIHR CRN: Greater Manchester

Early diffuse cutaneous systemic sclerosis, Early (within 3 years of onset) diffuse cutaneous scleroderma, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

2

40

Europe

M2R. Terapia sérica autóloga con células de la serie blanca, PRP. Plasma Rico en Plaquetas, Blood fraction modifier

XCELL Medical Solutions, XCELL Medical Solutions SL

Patients with Rotulian Tendinopathy Pacientes con tendinopatía Rotuliana, Patients with Rotulian Tendinopathy Pacientes con tendinopatía Rotuliana, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Not yet recruiting

2

30

Europe

autologous Microfat, Injection

Clinique Juge, Clinique Juge

knee osteoarthritis, knee osteoarthritis, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

2

24

Europe

Lopain, MTX-071, Concentrate for solution for injection

Mestex, Mestex AG

chronic osteoarthritic knee-joint pain, Pain due to degenerative lesions of the knee joint, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

2

160

Europe

Cannabidiol, CBD, Tablet

Aalborg university hospital dept. of rheumatology, Region Nordjyllands Sundhedsvidenskabelige Forskningsfond, Forskningenshus uddannelse og innovation, Aalborg University Hospital dept. of reumatology, Aalborg University

Psoriatic ArthritisHand Osteoarthritis Psoriasis gigtHånd artrose, Psoriatic arthritisHand osteoarthritis Psoriasis gigtSlidgigt i hænderne, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Not yet recruiting

2

16

Europe

RoActemra 162 mg soluzione iniettabile in siringa preriempita, NA, Solution for injection, RoActemra 162 mg soluzione iniettabile in siringa preriempita

Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, AIFA (Agenzia Italiana del Farmaco)

Myositis (dermatomyositis [DM] or polymyositis [PM]) Miositi: Dermatomiosite (DM) e Polimiosite (PM), Chronic inflammatory disorders of striated muscle with variable involvement of internal organs Patologie infiammatorie croniche del muscolo striato con variabile interessamento degli organi interni, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

2

7

Europe

Cultured mesenchymal stem cells from bone marrow isolation, BM-MSCs, Suspension for injection

Enrique Gomez-Barrena, Instituto Carlos III

Osteonecrosis of the Femoral Head Osteonecrosis de la cabeza femoral, Osteonecrosis of the Femoral Head Osteonecrosis de la cabeza femoral, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

2

180

Europe

Solution for injection, Cyklokapron 100 mg/ml Injektionslösung

Medical University Vienna, Medical University Vienna

Blood loss in patients undergoing elective total hip or knee arthroplasty., Blood loss in patients undergoing planned total hip or knee replacement surgery., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Surgical Procedures, Operative [E04]

 

 

Not yet recruiting

2

110

Europe

Pembrolizumab, [MK-3475], Solution for infusion

SARC, SARC, Merck Sharp & Dohme Corp.

This trial investigates whether neoadjuvant radiotherapy combined with pembrolizumab followed by surgical resection and adjuvant pembrolizumab improves disease-free survival for patients with high-risk soft tissue sarcoma of the extremity (undifferentiated pleomorphic sarcoma or dedifferentiated/pleomorphic liposarcoma, tumor size > 5 cm, grade 2 or 3 out of 3) compared to radiotherapy alone followed by surgical resection Lo studio indaga se la radioterapia neoadiuvante abbinata a pembrolizumab seguita da exeresi chirurgica e in seguito da pembrolizumab adiuvante migliori la sopravvivenza libera da malattia dei pazienti con sarcoma dei tessuti molli degli arti ad alto rischio (sarcoma pleomorfo indifferenziato o liposarcoma pleomorfo/dedifferenziato, dimensioni > 5 cm, grado 2 o 3 su 3) rispetto a sola radioterapia seguita da chirurgia., This trial investigates whether pre and post surgery pembrolizumab treatment improves disease-free survival for patients with high-risk soft tissue sarcoma of extremity vs RT alone followed by surgery Indaga se il trattamento con pembrolizumab pre e post chirurgia migliora sopravvivenza libera da malattia dei pazienti con sarcoma tessuti molli degli arti ad alto rischio rispetto a RT più chirurgia., Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Not yet recruiting

2

150

Europe

ACE-083, ACE-083, Lyophilisate for solution for injection

Acceleron Pharma Inc., Acceleron Pharma Inc.

Facioscapulohumeral Muscular Dystrophy Distrofia muscular facioescapulohumeral, Muscle disease characterized by muscle weakness and wasting (atrophy). The most affected muscles are the face (facio-), around the shoulder blades (scapulo-), and in the upper arms (humeral). Enfermedad muscular caracterizada por debilidad y desgastemuscular(atrofia).Músculos más afectados: cara(facio-),alrededor de losomóplatos (escapulo-),y parte superior de los brazos (humeral)., Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Not yet recruiting

2

10

Europe

Mesenchymal stem cells and microporous Bi-phasic calcium phosphate (MBCP+), Behandling, Ortho, Granules

University of Bergen, University of Bergen, The research counsil of Norway, Biomatlante

Diaphyseal and/or metaphysodiaphyseal fractures (femur, tibia, humerus) status delayed union (after 3 months) treated by standard care procedures, Fractures in arm or leg that have not healed after 3 months with conventional treatment. Brudd i underarm eller legg som ikke vil gro normalt etter forventet tid., Diseases [C] - Injuries, poisonings, and occupational diseases [C21]

 

 

Not yet recruiting

2

58

Europe

Orencia, Solution for injection in pre-filled syringe, Orencia

The University of Leeds, Bristol Myers Squibb

Inflammatory arthritis, Inflammatory arthritis, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Not yet recruiting

2

45

Europe

LRX712, Suspension for injection

Novartis Pharma AG, Novartis Pharma AG

Cartilage injuries, Cartilage injuries, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Not yet recruiting

2

80

Europe

Film-coated tablet, Xeljanz 5 mg tablets

Charite University, Pfizer Pharma GmbH, unrestricted grant

Psoriatic Arthritis with axial (spinal) involvement, Psoriatic Arthritis with Inflammation at the spine or sacroiliacal joints, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Not yet recruiting

2

25

Europe

Olumiant, Tablet, Olumiant

University of Manchester, Eli Lilly and Company

Idiopathic Inflammatory Myopathy (IIM), Inflammation of muscle tissue which can lead to profound weakness, fatigue and disability, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

2

40

Europe

Solution for injection, NEFOPAM MEDISOL 20 mg/2 ml, solution injectable

Hospices Civils de Lyon, Hospices Civils de Lyon, APICIL

Major patients who have a surgery in the orthopedic surgery department of the Croix Rousse hospital for a total knee replacement. Patients majeurs devant être opérés d'une chirurgie de prothèse totale de genou dans le service d’orthopédie de l’hôpital de la Croix-Rousse ., Total knee replacement surgery. Chirurgie de prothèse totale de genou., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]

 

 

Not yet recruiting

2

43

Europe

Powder for solution for infusion, XYDALBA

CHU de Nice, CHU de Nice

Osteo-articular infections Infections ostéo-articulaires associées aux prothèses, Osteo-articular infections Infections ostéo-articulaires associées aux prothèses, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Recruiting

2

10

RoW

Mesenchymal Stem Cell + NaCl 0,9% 2ml

Ahmad Jabir Rahyussalim

Degenerative Disc Disease, Low Back Pain, Disc Degeneration

12/20

12/20

Completed

2

24

RoW

Hypertonic Dextrose Solution, Liquid Phase Concentrated Growth Factor (LPCGFs)

Nourhan M.Aly, Alexandria University

Temporomandibular Joint Disorders, Temporomandibular Disorder

04/21

06/21

Completed

2

170

 

Monash University, National Health and Medical Research Council

Low back pain with lumbar disc herniation

 

 

Not yet recruiting

2

256

Europe, RoW

CC-99677 60mg Capsule, CC-99677 30mg Capsule, Capsule

Celgene Corporation, Celgene Corporation

Ankylosing Spondylitis, Ankylosing spondylitis (AS) is a long-term condition in which the spine and other areas of the body become inflamed., Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Recruiting

2

30

Europe

Cannabidiol Oil, Nimesulide

Pomeranian Medical University Szczecin

Temporomandibular Joint Disorders, Temporomandibular Joint Dysfunction Syndrome, Temporomandibular Joint Pain

07/21

12/21

Active, not recruiting

2

240

RoW

Dimolegin 40 mg, DD217, Dimolegin 60 mg, Fragmin, Dalteparin sodium

PharmaDiall Ltd.

Venous Thromboembolism

08/21

12/22

Recruiting

2

24

RoW

Ru-Yih-Jin- Huang-Saan(RYJHS), Wan-Yin-Gao-Jia-Jean-Wey(WYGJJW), placebo ( topical agent without therapeutic effects)

YUAN-CHIEH YEH

Bone Fractures, Traditional Chinese Medicine, Chinese Herbal Medicine

09/21

09/22

Not yet recruiting

2

48

Europe

MAG 2 100mg, Tablet, MAG 2 100 mg

University Hospital of Clermont-Ferrand, Appel d'offre interne 2021 (institutional source)

postmenopausal osteoporosis, osteoporosis, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Not yet recruiting

2

150

Europe

Co-crystal of ketoprofen, lysine and gabapentin, Ketoprofen Lysine Salt, DFL24412, KLS, Capsule, hard

Dompè Farmaceutici S.p.A., DOMPé FARMACEUTICI S.P.A., Dompè Farmaceutici S.p.A.

Chronic Low Back Pain Lumbalgia crónica (LC), Chronic Low Back Pain Lumbalgia crónica, Diseases [C] - Musculoskeletal Diseases [C05]