Mood Disorders |
ATTUNE, NCT04951076: A Phase 2b Study of BNC210 Tablet Formulation in Adults With Post-Traumatic Stress Disorder (PTSD) |
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| Completed | 2b | 212 | Europe, US | BNC210, Placebo | Bionomics Limited | Post-Traumatic Stress Disorder | 07/23 | 08/23 | | |
| Not yet recruiting | 2 | 15 | | | The University of Sydney, Lambert Initiative for Cannabinoid Therapeutics | Anxiety | | | | |
ACTRN12624000871549: Pilot investigation of psychedelic-assisted psychotherapy for treatment of post-traumatic stress disorder (PTSD) in people diagnosed with co-occurring borderline personality disorder – a controlled before-and-after study |
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| Not yet recruiting | 2 | 20 | | | Spectrum Personality Disorder Service for Victoria, Spectrum Personality Disorder Service for Victoria | borderline personality disorder (BPD), post-traumatic stress disorder (PTSD) | | | | |
| Not yet recruiting | 2 | 20 | | | University of New South Wales, National Cannabis Prevention and Information Centre | Mood disorders; Cannabis use | | | | |
| Not yet recruiting | 2 | 24 | | | University of Otago, University of Otago | anorexia nervosa; depressive disorder; anxiety disorder; obessional disorder | | | | |
ACTRN12619001334190p: The Effect of 3, 4-Methylenedioxymethamphetamine (MDMA)-assisted therapy on Mood and Anxiety symptoms in advanced-stage Cancer Study |
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| Not yet recruiting | 2 | 24 | | | University of Otago, University of Otago | Depression symptoms; Anxiety symptoms; Advanced-stage cancer | | | | |
| Not yet recruiting | 2 | 24 | | | University of Otago, University of Otago | anorexia nervosa, depressive disorder, anxiety disorder, obessional disorder | | | | |
| Not yet recruiting | 2 | 30 | | | Concord Hospital, Department of Psychiatry, Concord Hospital, Department of Psychiatry | Borderline Personality Disorder (BPD) | | | | |
ACTRN12624000816550: Feasibility study testing the protocol of single dose of psilocybin given to people who have had little improvements with brief psychological intervention |
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| Not yet recruiting | 2 | 30 | | | University of Otago, University of Otago, Ashburn Clinic: James Humes Bequest Fund | Anxiety, Depression | | | | |
| Not yet recruiting | 2 | 40 | | | The Alfred, Transport Accident Commission | Multi-system trauma with femoral shaft fracture | | | | |
ACTRN12616001113448: KARVIAH Sub-study: Examining the use of curcumin on cognition and mood in an older population |
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| Not yet recruiting | 2 | 40 | | | Macquarie University, Anglicare Community Services | Alzheimer's disease, depression | | | | |
ACTRN12611000610932: Therapeutic effect of saffron on cognitive function in multiple sclerosis patients |
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| Not yet recruiting | 2 | 60 | | | Tehran University of medical science, green plants of life | Multiple sclerosis, Cognitive dysfunction, Depression | | | | |
ACTRN12609000384257: Heads Up: A Phase II trial of a radiotherapy-based intervention for depression and malnutrition in Head and Neck cancer patients. |
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| Not yet recruiting | 2 | 70 | | | Calvary Mater Newcastle, Cancer Institute NSW | Malnutrition and depression in Head and Neck Cancer during radiotherapy | | | | |
| Not yet recruiting | 2 | 72 | | | Monash University, Incannex Healthcare Ltd | Generalised Anxiety Disorder | | | | |
ACTRN12615000522516: A study comparing resuscitation outcomes following administration of an intravenous oxygen carrier (HBOC-201) to Normal Saline in urban adult trauma patients. |
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| Not yet recruiting | 2 | 110 | | | Alfred Health, Alfred Health, HbO2 Therapeutics LLC | Haemorrhagic shock, Major Trauma | | | | |
ACTRN12623001004651: Evaluating the management of treatment resistant depression with psychedelic (psilocybin) assisted psychotherapy (EMPACT) |
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| Not yet recruiting | 2 | 140 | | | The Australian National University, Australian Department of Health and Aged Care -Medical Research Future Fund, The Australian National University, Mynd Life Sciences | Treatment Resistant Depression | | | | |
ACTRN12613001276741: Effect of supplementary oral L-tyrosin plus 5-hydroxytriptophan on severity of Parkinson's Disease; a clinical trial |
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| Not yet recruiting | 2 | 153 | | | Daniel F Fouladi, Tabriz University of Medical Sciences, Drug Applied Research Center | Parkinson's Disease | | | | |
ACTRN12622000474752p: TIDE (Trimetazidine in bipolar depression): A double-blind, randomised, placebo-controlled trial |
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| Not yet recruiting | 2 | 180 | | | Deakin University, Stanley Medical Research Institute | Bipolar depression | | | | |
ACTRN12624000236594: Treating anxiety in young people (12-25 years) using Cannabidiol (CBD) when conventional anxiety treatments have proven ineffective. |
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| Not yet recruiting | 2 | 180 | | | Orygen Centre for Youth Mental Health, The Medical Research Future Fund (MRFF) Department of Health and Aged Care | Anxiety, Treatment-Resistant Anxiety | | | | |
ACTRN12623000544673: Online Cognitive Behavioural Therapy for Death Anxiety: A Randomised Controlled Trial |
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| Not yet recruiting | 2 | 184 | | | The University of Sydney, National Health and Medical Research Council | Death Anxiety | | | | |
| Not yet recruiting | 2 | 220 | | | Professor Doug Sellman, Ministry of Health, University of Otago | Alcoholism, Depression | | | | |
ACTRN12613001275752: Effect of supplementary oral 5-hydroxytryptophan on severity of depression in patients on chronic selective serotonin reuptake inhibitors; a clinical trial |
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| Not yet recruiting | 2 | 240 | | | Daniel F Fouladi, Tabriz University of Medical Sciences, Drug Applied Research Center | Major depression | | | | |
ACTRN12622000474752: TIDE (Trimetazidine in bipolar depression): A double-blind, randomised, placebo-controlled trial |
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| Not yet recruiting | 2 | 260 | | | Deakin University, Stanley Medical Research Institute | Bipolar depression | | | | |
| Not yet recruiting | 2 | 1032 | | | Flinders University of South Australia, Flinders University | Major depressive disorder (MDD), Schizophrenia, , schizoaffective disorder, bipolar disorder | | | | |
ACTRN12613000274774: The effects of minocycline on breathing during sleep in patients prescribed opioid drugs for chronic pain. |
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| Recruiting | 2 | 15 | | | Repatriation General Hospital, The Repat Foundation | Central sleep apnoea, chronic pain | | | | |
| Recruiting | 2 | 24 | | | University of Otago, University of Otago | Depression | | | | |
| Recruiting | 2 | 30 | | | University of Technology, Sydney | Anxiety | | | | |
| Recruiting | 2 | 44 | | | Swinburne University of Technology, Milken Institute | Bipolar disorder, neurocognition | | | | |
| Recruiting | 2 | 50 | | | University of Otago, University of Otago | Major depressive disorder, Cancer | | | | |
| Recruiting | 2 | 70 | | | Dr Allison Waters, Griffith University | Pediatric Specific Phobia Disorder | | | | |
ACTRN12622001359729: D-Cycloserine Augmentation of Intermittent Theta Burst Stimulation (iTBS) in Depression
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| Recruiting | 2 | 180 | | | Alfred Health, Monash Alfred Psychiatry Research Centre | Major Depressive Disorder | | | | |
ACTRN12608000042347: From rehabilitation to recovery: A model to optimise consumer and carer involvement in the first year post stroke |
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| Active, not recruiting | 2 | 120 | | | St.Vincent's Health Melbourne, Auatralian Research Council (ARC) | Stroke, Depression, Quality of Life, Carer burden | | | | |
ACTRN12614000411640: The Post Anaesthesia N-Acetycysteine Cognitive Evaluation trial, investigating the potential for N-Acetylcysteine to reduce cognitive dysfunction following major elective non-cardiac surgery |
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| Recruiting | 2 | 370 | | | The Geelong Hospital, The Geelong Hospital, CRC for Mental Health, Sydney Parker Smith Scholarship | Post Operative Cognitive Dysfunction
, Surgical Stress Response, Post Operative Mood Disorder, Post surgical pain | | | | |
ACTRN12616000473460: Efficacy of D-Cycloserine in combination with intensive exposure therapy in the treatment of obsessive compulsive disorder (OCD) in children |
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| Recruiting | 2 | 80 | | | Dr Lara Farrell, National Health and Medical Research Council | Pediatric Obsessive Compulsive Disorder | | | | |
ACTRN12620001015932: Double-Blind Randomised Investigation of Bazedoxifene and Conjugated Estrogen for Depression in Menopausal Women |
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| Recruiting | 2 | 90 | | | Monash University, Monash University | Depression, Menopause | | | | |
ACTRN12621000429853: Oral Ketamine Trial on people aged 16 years and older with Treatment-Resistant Depression |
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| Recruiting | 2 | 25 | | | Thompson Institute, University of the Sunshine Coast, Thompson Institute, University of the Sunshine Coast | Treatment-Resistant Depression | | | | |
| Recruiting | 2 | 30 | | | St Vincent's Hospital Melbourne, St Vincent's Hospital Melbourne | Mood disorders, Cannabis use | | | | |
ACTRN12621001097831: A study of psilocybin-assisted psychotherapy for treatment-resistant depression (TRD) |
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| Recruiting | 2 | 15 | | | Swinburne University of Technology , Swinburne University of Technology , St Vincent's Hospital Melbourne, The Barbara dicker Brain Sciences Foundation, Usona Institute | Treatment Resistant Depression (TRD) | | | | |
| Recruiting | 2 | 72 | | | Alfred Hospital, Monash Alfred Psychiatry Research Centre | Borderline Personality Disorder | | | | |
ACTRN12623000838617: A study to investigate the safety and feasibility of delivering MDMA-assisted psychotherapy to patients with posttraumatic stress disorder |
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| Recruiting | 2 | 5 | | | Emyria Ltd, Emyria Ltd | Posttraumatic Stress Disorder | | | | |
ACTRN12619001334190: Effect of 3, 4-Methylenedioxymethamphetamine (MDMA)-assisted therapy on Mood and Anxiety symptoms in patients with advanced-stage Cancer Study (EMMAC Study) |
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| Recruiting | 2 | 32 | | | University of Otago, University of Otago, Individual donor, Multidisciplinary Association for Psychedelic Studies (MAPS), Individual donor, Multidisciplinary Association for Psychedelic Studies (MAPS) | Depression symptoms, Anxiety symptoms, Advanced-stage cancer | | | | |
ACTRN12623000872639: The effects of cannabidiol (CBD) on psychosocial stress, situational anxiety and nausea experienced in a virtual reality environment |
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| Recruiting | 2 | 74 | | | University of Sydney, Lambert Initiative for Cannabinoid Therapeutics | Psychosocial stress
, Situational anxiety , Motion sickness, Cybersickness | | | | |
ACTRN12623000971639: MDMA-assisted therapy for Post-Traumatic Stress Disorder in Military Veterans and First Responders |
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| Recruiting | 2 | 24 | | | Monash University, Monash University, Philanthropic - private, Multidisciplinary Association for Psychedelic Studies | Post-Traumatic Stress Disorder | | | | |
ACTRN12623001080617: An Open Label Safety and Efficacy Study of XW10508 Modified Release (MR) in Patients with Major Depressive Disorder |
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| Recruiting | 2 | 24 | | | XW Laboratories (Australia) Pty Ltd, XW Laboratories (Australia) Pty Ltd | Major Depressive Disorder | | | | |
ACTRN12623000812695: Efficacy and safety of prehospital fibrinogen early in severe trauma study: A feasibility phase II study (PRE-FEISTY II) (Stage 1). |
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| Recruiting | 2 | 23 | | | New South Wales Ambulance, NSW Ambulance | Acute traumatic haemorrhage
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| Recruiting | 2 | 293 | | | Macquarie University, Woke Pharmaceuticals | Major Depressive Disorder of moderate severity | | | | |
ACTRN12622001525774: Developing Optimal Psychedelic Assisted Psychotherapy for Obsessive-Compulsive Disorder |
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| Recruiting | 2 | 40 | | | Australian National University, Monarch Mental Health Group | Treatment Resistant Obsessive-Compulsive Disorder | | | | |
ACTRN12624000128594: Assessing the effects of Lysergic acid diethylamide (LSD) microdosing in people experiencing depression (LSDDEP2) |
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| Recruiting | 2 | 90 | | | The University of Auckland, Health Reseach Council of New Zealand, MindBio Therapeutics Ltd | Major Depressive Disorder (MDD) | | | | |
2004-000502-40: A thematic analysis of semi-structured interviews using a phenomenological approach into palliative care patients experiences of change in "fatigue" following treatment with methylphenidate– an exploratory study |
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| Ongoing | 2 | 15 | Europe | Methylphenidate hydrochloride, Tablet, Ritalin | Southampton University Hospitals Trust | Patients with cancer in palliative stage of their illness. Suffering from fatigue with or without decreased concentration, depression or drowsiness, who feel their fatigue is severe enough to decrease their quality of life. | | | | |
2005-003409-98: Enhancement by tacrolimus of nerve regeneration after peripheral nerve repair. |
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| Ongoing | 2 | 10 | Europe | Prograf, FK506, Capsule, hard, Prograf 0.5 mg Capsules, Prograf 1 mg Capsules, Prograf 5 mg Capsules | Hôpital Erasme, Cliniques Universitaires de Bruxelles | Patients presenting a total section of a major nerve at the arm, forearm, or leg, and treated by conventional nerve suture under microscope within ten days of the trauma. Patients with nerve autografts performed in good conditions (well-vascularized bed, absence of tension, operation performed within 4 months after the nerve section) can be included in the study. | | | | |
ChiCTR-TRC-12002614: A phase II clinical research on Renzhu Jianwei granule in treating chronic atrophic gastritis (qi deficiency, blood stasis and hot depression syndrome) |
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| Completed | 2 | 240 | | Renzhujianwei granule ;Weifuchun tablet | General Hospital of Shenyang Military Region; General Hospital of Shenyang Miliary Region, Nanjing Zhongshan Pharmaceutical Factory | chronic atrophic gastritis | | | | |
| Ongoing | 2 | 20 | Europe | Xenon pro Anaesthesia, Inhalation gas, Xenon pro Anaesthesia | Klinik für Anästhesiologie Universitätsklinikum Aachen | Major depressive disorder and recurrent mayor depressive disorder (ICD 10 F32.2 and 33.3) | | | | |
2010-022673-33: The Dexametasone-CRH-test as a potential predictor of treatment effect in depression: a pilot study. |
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| Ongoing | 2 | 40 | Europe | Citalopram Cnspharma, Tablet, citalopram | Psykiatri Nordväst, Karolinska Universitetssjukhuset Solna, AFA and the Swedish Research Council | In total 40 subjects, aged 20-65 years, with depressive symptoms, considered by their physician to need antidepressant treatment, will be recruited from primary care clinics in the Stockholm area. | | | | |
| Completed | 2 | 720 | | Gratitude - participants write 2 diaries per week for 1 month, focusing on thankful events ;Hassles - participants write 2 diaries per week for 1 month, focusing on hassles ;Participants will be normal adults and health-care workers. In the control group, no intervention will be given. | Department of Psychological Studies, Hong Kong Institute of Education,; None, Self-finance | Depression (depressive symptoms) | | | | |
ChiCTR-TNRC-11001528: Efficacy of Umbilical cord Mesenchymal stem cells transplantation in the treatment of brain trauma sequela patients |
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| Completed | 2 | 40 | | rehabitation therapy ;stem cell transplantation | General Hospital of Chinese People's Armed Police Forces; General Hospital of Chinese People's Armed Police Forces, General Hospital of Chinese People's Armed Police Forces | brain trauma sequela | | | | |
| Ongoing | 2 | 16 | Europe | Film-coated tablet, Incivo, Paroxetine Sandoz | Radboud University Nijmegen Medical Centre, Janssen Cilag | chronic hepatitis C infection with depression, chronic hepatitis C infection with depression, Diseases [C] - Virus Diseases [C02] | | | | |
| | 2 | 24 | US | Glutamine, Glutamine Dipeptide, Placebo, Surgery | Ziegler, Thomas R., M.D. | Stress Hyperglycemia, Insulin Resistance, Trauma, Critical Illness | 07/13 | 02/14 | | |
2013-002545-10: An open safety study with the monoaminergic stabilizer (-)-OSU6162 in patients with mental fatigue and related vitality and wakefulness disturbances associated with neurologiacal disorders, e g Parkinson’s disease, Huntington’s disease, brain trauma, stroke, myalgic encephalomyelitis and narcolepsy. En öppen studie av säkerhet hos den monoaminerga stabiliseraren (-)-OSU6162 hos patienter med mental trötthet och därmed relaterad vitalitets- och vakenhetsstörning registrerade vid neuro-psykiatriska sjukdomar som Parkinsons sjukdom, Huntingtons sjukdom, traumatisk hjärnskada, stroke, Myalgisk encefalomyelit och narkolepsi. |
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| Ongoing | 2 | 240 | Europe | OSU6162 similar to (-)-OSU 6162, Coated tablet | A. Carlsson Research AB, A. Carlsson Research AB | Parkinsons disease Huntingtons disease Multiple scleros Brain trauma Stroke Myalgic encephalomyelitis Narcolepsy Parkinsons sjukdom Huntingtons sjukdom Multipel scleros Traumatisk hjärnskada Stroke Myalgisk encefalomyelit Narkolepsi, Parkinsons disease Huntingtons disease Multiple scleros Brain trauma Stroke Myalgic encephalomyelitis Narcolepsy Parkinsons sjukdom Huntingtons sjukdom Multipel scleros Traumatisk hjärnskada Stroke Myalgisk encefalomyelit Narkolepsi, Diseases [C] - Nervous System Diseases [C10] | | | | |
ACTRN12614000525684: FAB study: Fan, Activity and Breathlessness: assessing the fan’s capacity to increase physical activity in patients with breathlessness and reducing carer anxiety |
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| Active, not recruiting | 2 | 60 | | | The University of Notre Dame Australia, , Sacred Heart Clinical Trials Unit, The Cunningham Centre for Palliative Care | Breathlessness, Physical activity, Self management, Self-efficacy - care givers | | | | |
2013-003196-35: Assessing the subjective intensity of oral psilocybin in patients with treatment-resistant depression |
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| Ongoing | 2 | 12 | Europe | Psilocybin, Psilocybin, Capsule | Imperial College London | Major depressive disorder, Pervasive and persistent low mood that is accompanied by low self-esteem and by a loss of interest or pleasure in normally enjoyable activities., Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2014-004937-15: Effects of BNC210 on human brain activity in anxious subjects. |
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| Ongoing | 2 | 24 | Europe | BNC210 300mg, BNC210 2000mg, Powder for oral suspension | BIONOMICS LIMITED, BIONOMICS LIMITED | Generalized Anxiety Disorder, Generalized Anxiety Disorder, Psychiatry and Psychology [F] - Behaviours [F01] | | | | |
ChiCTR-IPR-14005341: The establishment and verification of traditional chinese medicine for depression using Combined Disease and Symdrome |
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| Recruiting | 2 | 120 | | traditional Chinese medicine ;zoloft | Guangdong Hospital of Chinese Medicine; Guangdong Hospital of Chinese Medicine, Science and Technology Department of Guangdong Province | Depression | | | | |
2015-001456-29: A Double-blind, Placebo-controlled, Randomized, Multicenter Proof-of-principle Trial of Adjunctive Minocycline for Patients With Treatment Resistant Unipolar Major Depressive Disorder (MDD) Eine doppelt-verblindete, placebo-kontrollierte, randomisierte, mulitzentrische Studie zur Überprüfung der Wirksamkeit einer Minocyclinaugmentation bei Patienten mit therapierefraktärer unipolarer depressiver Erkrankung |
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| Ongoing | 2 | 160 | Europe | Minocycline, Capsule, hard, Udima | Charité - Universitätsmedizin Berlin, Bundeministerium für Bildung und Forschung (BMBF) | Minocycline, a broad-spectrum and central nervous system entering tetracycline, reduces within an additional therapy the symptomatology of depressive patients. Minocyclin, ein pleiotropes, ZNS-gängiges Tetrazyklin, reduziert im Rahmen einer Begleittherapie die Symptomatik von depressiven Patienten. Ursächlich hierfür ist u.a. eine anti-inflammatorische sowie neuroprotektive Wirkung., Minocycline, a broad-spectrum and central nervous system entering tetracycline, reduces within an additional therapy the symptomatology of depressive patients. Minocyclin, ein Tetrazyklin, reduziert im Rahmen einer Begleittherapie die Symptomatik von depressiven Patienten durch u.a. seine anti-inflammatorische sowie neuroprotektive Wirkung., Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2004-002540-94: Effects of allopregnanolone in women with PMDD, depression, PCOS och oral contraceptives |
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| Ongoing | 2 | 50 | Europe | Allopregnanolone, UC1009, | Norrlands university hospital | PMDD (premenstrual dysphoric disorder) includes depressed mood and anxiety but occurs only during the late phase of the menstrual cycle. Major depression are more common in women and especially post partum and during the menopause. PCOS (polycystic ovary syndrome) include symptoms like hirsutism, amenorrhoea and obesity but depressive symptom also occur. Mental side effects from oral contraceptives are common. | | | | |
2004-002577-23: Efficacy and safety of Agomelatine (25 mg with potential adjustment at 50 mg) given orally once a day for 12 weeks in out-patients with Generalised Anxiety Disorder. A randomised flexible dose double-blind, placebo-controlled, parallel groups, international study. |
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| Ongoing | 2 | 80 | Europe | S20098-F55, | Institut de Recherches Internationales Servier | Generalised Anxiety Disorder | | | | |
| Ongoing | 2 | 12 | Europe | Genotropin, Testogel, Genotropin, Testogel, Genotropin, Testogel | VästraGötaland, Movember | Depression, Anxiety | | | | |
2006-001475-38: A DOUBLE BLIND, PLACEBO CONTROLLED, RANDOMIZED, SEQUENTIAL GROUP, MULTIPLE DOSE STUDY OF THE EFFICACY OF THE CRF1-RECEPTOR ANTAGONIST R317573 ON CCK-4 INDUCED ANXIETY IN HEALTHY MALE SUBJECTS. |
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| Ongoing | 2 | 72 | Europe | R317573 200 mg, R317573 10 mg, R317573 50 mg, F006, F008, F007, | Janssen Cliag Ltd. C/O Johnson & Johnson PRD | Anxiety and depression | | | | |
2006-003659-19: A Double Blind, Placebo- and Active-Controlled, Randomized, Sequential Group, Multiple Dose Study to Examine the Effect of the CRF1-Receptor Antagonist R317573 on 7.5% CO2-Inhalation Induced Anxiety in Healthy Subjects |
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| Ongoing | 2 | 32 | Europe | R317573 10mg, R317573 50mg, N/A, F008, F007, F320, Temesta 1mg, Temesta 1mg | Janssen-Cilag International N.V. | Anxiety disorders and depression | | | | |
2006-003912-23: A Phase IIa, double-blind, placebo-controlled, randomised, parallel-group study, to investigate the safety, tolerability and anxiolytic effect of the mGluR5 negative allosteric modulator ADX10059 in patients with dental anxiety undergoing dental treatment. |
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| Ongoing | 2 | 50 | Europe | ADX10059, ADX10059, | Addex Pharmaceuticals SA | Dental anxiety | | | | |
2006-003571-12: Breath Methionine and Other Indices of Oxidant Stress in the Critical Care Setting. The effect of two doses of Dipeptiven given independently of parenteral nutrition. |
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| Ongoing | 2 | 60 | Europe | Dipeptiven, Dipeptiven | Barts and the London NHS Trust | 60 consecutive critically ill patients will be recruited with illnesses such as severe infection, trauma and post-surgery. | | | | |
2006-006443-30: A phase IIa open-label study using ICX-RHY to enhance the aesthetic appearance of facial skin imperfections. |
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| Ongoing | 2 | 10 | Europe | ICX-RHY-013, ICX-RHY-013, | Intercytex | Facial skin imperfections such as small scars, depressions, pock-marks and other localised contour deformities of healthy adults | | | | |
2007-000083-24: A survey of efficacy of zolpidem in patients with brain injury including SPECT brain scans in selected patients |
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| | 2 | 300 | Europe | Stilnoct®, Stilnoct® | Regen Therapeutics PLC | Brain damage of any original cause, such as strokes, trauma, birth injury, post-viral infection. | | | | |
2008-000453-35: Open-label phase IIa pilot study exploring safety and potential efficacy of recombinant human erythropoietin in early mild Alzheimer Dementia and therapy-refractory Major Depression (“EPO-AD”) |
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| Ongoing | 2 | 20 | Europe | Erypo, Erypo | Max-Planck-Institute of Experimental Medicine | Early, mild dementia of the Alzheimer’s Type and therapy-refractory Major Depression | | | | |
2007-005564-27: Effect of agomelatine (25 mg) given orally once a day for 7 days on cerebral activity measured by functional MRI during processing of emotional stimuli in patients with Major Depressive Disorder. A randomised, double-blind, placebo-controlled study with an open extension period of 6 months with agomelatine (25 mg).Comparison to functional MRI profiles of healthy volunteers. |
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| Ongoing | 2 | 60 | Europe | S20098, S20098, | Institut de Recherches Internationales Servier | Major Depressive Disorder | | | | |
2008-007110-29: An international randomised, double-blind, placebo-controlled study to assess the efficacy and safety of 2 dosing regimens of FIBRINOGENE T1 in the treatment of peri-operative bleeding associated with revision total hip arthroplasty |
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| Ongoing | 2 | 60 | Europe | Human fibrinogen, FGT1, | LFB BIOTECHNOLOGIES | Severe Acute Haemorrhage (SAH)The main clinical situations of SAH are trauma and surgery-related haemorrhages and obstretical haemorrheges. Othopedic procedures can induce SAH. One of the most haemorrhagic types of surgery is revision total hip arthroplasty (THA). For the purpose of the study patient with elective revision THA including major acetabular and/or femoral reconstruction. | | | | |
2009-011115-20: Nordic Longterm OCD treatment Study: A Nordic Multicenter treatment study evaluating a stepped care model based on the \"Expert Clinical Guidelines\". The study is performed with no sponsor from pharmaceutical firms. |
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| Ongoing | 2 | 11 | Europe | aripripazol, abilify, Abilify, Abilify | The Centre for Child and Adolescent Mental Health, Eastern and Southern Norway (R.BUP), The Centre for Child and Adolescent Mental Health, Eastern and Southern | Obsessive Compulsive Disorder | | | | |
| Ongoing | 2 | 90 | Europe | Circadin, Circadin, Circadin | University of Oxford | Bipolar Disorder (mania and hypomania) | | | | |
2009-014056-30: Reconnaissance des expressons faciales émotionnelles chez les patients présentant un épisode dépressif magnétique transcranienne répétée du cortex préfrontal dorsolatéral droit à basse fréquence et/ou venlafaxine |
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| Ongoing | 2 | 60 | Europe | Effexor, Effexor | CHU Clermont-Ferrand | depression | | | | |
2010-020906-14: Investigation on the efficacy of treatment of patients with functional abdominal pain and anxiety disorder with escitalopram, compared to placebo. |
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| Ongoing | 2 | 80 | Europe | Escitalopram, NL/H/0984/001, escitalopram, escitalopram | MUMC, MUMC | IBS and panic disorder | | | | |
2011-003654-40: A study to see if the medication Ketamine can relieve depression in people who have not responded to another class of medication called Selective Serotonin Re-uptake Inhibitors (SSRIs) |
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| Ongoing | 2 | 20 | Europe | ketalar, ketalar | Department of Psychiatry, Department of Psychaitry | Depression | | | | |
2015-004587-11: Is dexmedetomidine a safe medicine to calm elderly patients when they are waiting for an operation? |
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| Ongoing | 2 | 48 | Europe | Solution for infusion, Dexdor | University Medical Center Groningen, University Medical Center Groningen | Anxiety, preoperative, Fear and anxiety in the hours directly preceding a surgical procedure, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
2014-001541-24: Neuroenhancement of Interpersonal Psychotherapy in Major Depression Augmentation von Interpersoneller Psychotherapie durch D-Cycloserin |
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| Ongoing | 2 | 28 | Europe | Cycloserin-Kapseln, Capsule, hard, Cycloserine | University Medical Center Freiburg, University Medical Center Freiburg | Major Depression (ICD-10; F32.2/F33.2) Depressive Störung (ICD-10; F32.2/F33.2), Disorder in which the fundamental disturbances are a change in affect or mood to depression and a usually accompanied change in the overall level of activity. Störung deren Hauptsymptome eine Veränderung der Stimmung oder der Affektivität zur Depression hin und eine Veränderung des allgemeinen Aktivitätsniveaus sind., Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
| Ongoing | 2 | 105 | Europe | Artesunate 10mg/ml, ST7570, Powder and solvent for solution for infusion | Queen Mary University of London, The Wellcome Trust Ltd | Organ Dysfunction and Failure in Traumatic Hemorrhage, Organ failure following severe injury-induced critical bleeding, Diseases [C] - Injuries, poisonings, and occupational diseases [C21] | | | | |
2010-018486-37: Treatment of exacerbations of post-traumatic stress disorder by short-term dexamethasone, a pilot study. |
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| Ongoing | 2 | 10 | Europe | Dexacortal, Dexacortal | Kris-och Traumacentrum | Posttraumatic stress syndrome F431 | | | | |
| Ongoing | 2 | 54 | Europe | Bocouture (Botulinumtoxin A), Powder for solution for injection, Bocouture | Medizinische Hochschule Hannover, Asklepios Klinik Nord, Medizinische Hochschule Hannover | Borderline personality disorder Borderline-Persönlichkeitsstörung, n.a., Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2015-003676-70: Preanesthetic medication in pediatric patients: A comparison of midazolam, clonidine and dexmedetomidine |
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| Ongoing | 2 | 300 | Europe | Klonidinhydroklorid APL, Concentrate and solvent for solution for infusion, Oral solution, Dexdor, Klonidin APL, Midazolam APL | Norrbottens läns landsting, Norrbottens läns landsting, Umeå university | Is there a difference in anxiety- and sedation-level, and in anesthesia induction compliance between the preanesthetics included in study, in pediatric patients? Can we prevent and reduce anxiety without causing negative cardiorespiratory effects by selected preanesthetic included in study, in TIVA in pediatric patients? Does the preanesthetic used in this study prevent and/or reduce pain, vomiting, shivering, events of emergence delirium and maladaptive behaviors, without prolonging recovery?, This study investigates the anxiety and sedation in children before and after anesthesia, comparing the effects of three different sedative medicines given to the child to facilitate the anesthesia., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
NCT01375114: The Effects of Ginseng on Cancer-Related Fatigue |
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| Active, not recruiting | 2 | 165 | US | Panax Ginseng, Placebo, Sugar Pill, Questionnaires, Surveys | M.D. Anderson Cancer Center, Indena S.p.A | Advanced Cancers, Solid Tumors | 05/16 | 10/25 | | |
2015-000465-31: An 8-week randomized, double-blind, placebo-controlled clinical trial of Cannabidiol as add-on therapy in bipolar depression Eine 8-wöchige, randomisierte, doppelblinde, placebo-kontrollierte klinische Studie mit Cannabidiol als Add-on-Therapie zur Behandlung der bipolaren Depression |
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| Ongoing | 2 | 126 | Europe | Cannabidiol, CBD, Capsule, hard | Charité - Universitätsmedizin Berlin, Charité - Universitätsmedizin Berlin | Bipolar disorder, current episode depressed Bipolare affektive Störung, gegenwärtig depressive Episode, Bipolar disorder, current episode depressed aktuelle depressive Episode bei einer Bipolaren Störung, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2015-002255-10: Can artificially made human erythropoietin improve recovery after major injuries? |
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| Ongoing | 2 | 10 | Europe | Eprex (rhEPO), NA, Solution for injection in pre-filled syringe, Eprex | Abertawe Bro Morgannwg University Health Board, Abertawe Bro Morgannwg University Health Board | Post-trauma multiple organ failure: a manifestation of the systemic inflammatory/immune response to major injuries., This study will see if artificially made human erythropoietin helps people recover from serious injury quicker by boosting immunity through bone marrow or improving the way the body creates energy., Body processes [G] - Immune system processes [G12] | | | | |
| Ongoing | 2 | 120 | Europe | Infusion, Ketamine (Ketalar by Pfizer) | UZ Leuven, IWT Agentschap voor Innovatie door Wetenschap en Technologie | Major depressive disorder and Bipolar Disorder I and II, depression, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2015-004527-32: Sitagliptin is an established diabetes drug medication that acts primarily by stimulating the body’s ability to release insulin, leading to a lowering of blood sugar levels. This clinical trial will examine whether treatment with Sitagliptin can improve both depression and type 2 diabetes together |
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| Ongoing | 2 | 60 | Europe | Januvia (Sitagliptin), Capsule, hard, Januvia (Sitagliptin) | King's College London, Kings College Hospital NHS Foundation Trust, KHP BRC Experimental Medicine Pilot Project Award | Depression in type 2 diabetes, Depression in type 2 diabetes, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
ChiCTR-IPR-14005672: The therapeutic effect of statins on patients with depression after acute coronary syndrome |
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| Recruiting | 2 | 180 | | Rosavastatin calcium 20mg/d p.o. ;sertraline 25-50 mg/d p.o. ;Rosavastatin calcium 5mg/d p.o. | Tongji Hospital Affiliated to Tongji University; Tongji hospital affiliated to Tongji University, Shanghai Municipal Health Bureau | depression secondary to coronary artery disease | | | | |
2016-002068-14: Investigation of antidepressant efficacy of oral ketamine treatment |
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| Ongoing | 2 | 60 | Europe | Solution for injection/infusion, Ketamin-hameln, Dormicum | Medical University of Vienna, Medical University of Vienna | Major depressive episode (Major depressive disorder, Biploar disorder), Depression, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
| Not yet recruiting | 2 | 60 | Europe | SPI-1005, Ebselen, NA, Capsule | University of Oxford, The Stanley Medical Research Institute | Patients with bipolar disorder meeting DSM-5 criteria for hypomania or mania, Bipolar disorder is characterised by periods of elevated mood and periods of depression. The elevated mood is known as hypomania or mania: an individual feels abnormally happy, energetic or irritable., Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
NCT02804022: Vital-signs-integrated Patient-assisted Intravenous Opioid Analgesia |
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| Active, not recruiting | 2 | 20 | RoW | VPIA analgesia, VPIA delivery system, Morphine, Morphine-VPIA | KK Women's and Children's Hospital | Respiratory Depression | 05/17 | 12/24 | | |
2017-002232-16: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TAK-653 in the Treatment of Subjects with Treatment-Resistant Depression |
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| Not yet recruiting | 2 | 90 | Europe | TAK-653, TAK-653, Tablet | Millennium Pharmaceuticals, Inc, a wholly owned subsidiary of Takeda Pharmaceutical Company, Ltd, Millennium Pharmaceuticals, Inc, a wholly owned subsidiary of Takeda Pharmaceutical Company, Ltd | Treatment Resistant Depression, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
| Ongoing | 2 | 66 | Europe | Solution for injection in pre-filled syringe, RoActemra | Linköping University, Region Östergötland | Major depressive disorder, Depression, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2018-002140-88: A study to evaluate the safety, tolerability and efficacy of ORY-2001 in aggressionin patients with Alzheimer's Disease, Lewy Body Dementia, Adult attention Deficit Hyperactivity Disorder, Borderline Personality Disorder, Autism Spectrum Disorder Estudio para evaluar la seguridad, tolerabilidad y eficacia de ORY-2001 en el tratamiento de la agresividad en pacientes con Enfermedad de Alzheimer, Demencia de Cuerpos de Lewy, Trastorno por Déficit de Atención e Hiperactividad, Trastorno LÃmite de la Personalidad y Trastorno del Espectro Autista. |
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| Ongoing | 2 | 30 | Europe | ORY-2001, Capsule | Oryzon Genomics S.A., Oryzon Genomics S.A. | Agression Agresividad, Agression Agresividad, Diseases [C] - Nervous System Diseases [C10] | | | | |
2018-001212-30: A trial to study effects of a single dose Citalopram on emotion processing in patients with Borderline Personality Disorder and the associated modulation of fMRI BOLD signals |
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| Ongoing | 2 | 30 | Europe | Film-coated tablet, Citalopram | Central Institute of Mental Health, represented by commercial and administrative Director, Boehringer Ingelheim Pharma GmbH & Co KG | Borderline Personality Disorder, Borderline Personality Disorder, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2016-004974-16: Trial treating brain injured patients with the anti-inflammatory drug Kineret: IL1ra-TBI |
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| Ongoing | 2 | 60 | Europe | Kineret, Injection, Kineret | Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge, Sobi (Swedish Orphan Biovitrum AB), Swedish Society of Medicie, National Institute of Health Research, Swedish Brain Foundation | We wish to study the drug Kineret in patients suffering from moderate-to-severe traumatic brain injury, Traumatic brain injury is defined as blunt trauma to the brain causing injuries and hemorrhages, which in turn lead to a harmful environment for surviving brain cells., Diseases [C] - Nervous System Diseases [C10] | | | | |