| Mood Disorders |
NCT03065335: Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder |
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| Recruiting | 1 | 150 | US | Ketamine, Placebo, Cobot TS MV robotic arm for TMS, NeurOptics PLRTM-30000 Pupillometer | National Institute of Mental Health (NIMH) | Healthy Volunteer, Major Depressive Disorder, Depression | 01/25 | 01/28 | | |
ChiCTR2100052655: Clinical Study of Yiqi Huayu Lishui Recipe in Treating Post Ankle Joint Trauma (Bone Marrow Edema) |
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| Not yet recruiting | 1 | 100 | | Yiqi Huayu Lishui Recipe ;Diclofenac Sodium Sustained Release Tablets | Huadong Hospital; Huadong Hospital, School-level project funding | Post-traumatic ankle joint disease | | | | |
ICONE, NCT05699005: Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO |
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| Recruiting | 1 | 238 | Europe | Packed Red Blood Cells (PRBCs), ScVO2 assesment to guide transfusion | University Hospital, Lille, Amiens University Hospital, University Hospital, Caen, University Hospital, Rouen, Centre Hospitalier Universitaire Dijon, Centre hospitalier de Dunkerque, Centre Hospitalier de Lens | Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Transfusion Related Complication, Anemia, Oxygen Delivery | 09/25 | 12/25 | | |
NCT04887116: Piloting Virtual Reality Environments to Treat PTSD in Healthcare Workers and Patients Consequent to the COVID-19 Pandemic |
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| Recruiting | 1 | 20 | US | Virtual Reality Exposure Therapy | Weill Medical College of Cornell University, Cornell University | Posttraumatic Stress Disorder | 01/25 | 01/25 | | |
NCT05522673: [11C]-(R)-Rolipram to Measure cAMP Signaling Before and After Ketamine |
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| Terminated | 1 | 1 | US | 11(R)-rolipram | National Institute of Mental Health (NIMH) | Depression | 02/23 | 01/24 | | |
| Not yet recruiting | 1 | 55 | NA | Oxycodone Hydrochloride, oxynorm, Placebo | Leiden University Medical Center | Opioid Induced Respiratory Depression, Depressive Disorder, Anxiety Disorders | 01/25 | 04/25 | | |
NCT03973268: Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression |
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| Recruiting | 1 | 70 | US | Arm 1, 2, 3 device interventions, Arm 2 Interventions, Arm 1, 2, 3 drug Interventions, Arm 1 and 2 Interventions | National Institute of Mental Health (NIMH) | Depression, Major Depressive Disorder, Major Depression | 02/25 | 02/25 | | |
NCT04951609 / 2021-000567-77: A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adolescents With Major Depressive Disorder Who Have an Inadequate Response to Selective Serotonin Reuptake Inhibitor (SSRI) and Psychotherapy |
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| Terminated | 1 | 31 | Europe, US | Seltorexant, JNJ-42827922, Placebo | Janssen Research & Development, LLC, Janssen-Cilag International NV | Depressive Disorder, Major | 04/24 | 04/24 | | |
NCT05320107: The Effect of Ketamine on Aesthetics and Role for Antidepressant Effects |
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| Recruiting | 1 | 60 | Europe | Ketamine, Placebo | Medical University of Vienna | Major Depressive Disorder | 02/25 | 02/25 | | |
NCT06024239: A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of ABBV-932 in Healthy Adult Participants, Participants With Generalized Anxiety Disorder (GAD) and Participants With Bipolar Disorder (BPD) |
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| Recruiting | 1 | 64 | US | ABBV-932, Placebo for ABBV-932 | AbbVie | Healthy Volunteers, Generalized Anxiety Disorder (GAD), Bipolar Disorder (BPD) | 11/24 | 11/24 | | |
| Recruiting | 1 | 100 | US | BrainHQ Computerized Cognitive Training - Visual Perception Training Paradigm, BrainHQ Computerized Cognitive Training - Visual Cognitive Control Training Paradigm | University of Minnesota, National Institute of Mental Health (NIMH) | Psychosis, Schizophrenia, Schizo Affective Disorder, Schizoaffective Disorder, Schizophreniform Disorders, Psychotic Disorders, Psychotic Mood Disorders, Psychoses, Affective, Psychosis Nos/Other, Schizophrenia Spectrum and Other Psychotic Disorders | 03/25 | 03/25 | | |
| Recruiting | 1 | 40 | US | Affective Awareness | VA Office of Research and Development | Suicide, Schizophrenia, Bipolar Disorder, Post Traumatic Stress Disorder, Major Depressive Disorder | 03/25 | 05/25 | | |
| Not yet recruiting | 1 | 40 | | Cognitive training ;No intervention | Wenzhou Medical University; Wenzhou Medical University, Special fund of Wenzhou Medical College | Depression and anxiety | | | | |
NCT04582916: PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD) |
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| Recruiting | 1 | 64 | US | 11C-MCI, 11CPS13 | National Institute of Mental Health (NIMH) | Depression | 10/29 | 04/30 | | |
| Active, not recruiting | 1 | 20 | RoW | Lithium, Lithicarb | Melbourne Health | Depressive Disorder | 05/25 | 06/25 | | |
ChiCTR2200060333: Study on the effect mechanism of Yangyin Shugan formula combined with frontal (spinal) acupuncture in the treatment of climacteric depression based on brain intestinal axis pathway |
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| Not yet recruiting | 1 | 120 | | YYSG granule + Frontal Acupuncture ;YYSG granule + Sham Frontal Acupuncture ;Frontal Acupuncture + YYSG placebo granules ;YYSG placebo granule + Sham Frontal Acupuncture | Guangdong Provincial Hospital of Chinese Medicine; Guangdong Provincial Hospital of Chinese Medicine, Research Fund for Zhaoyang Talents of Guangdong Provincial Hospital of Chinese Medicine | Climacteric depression | | | | |
ChiCTR2200059863: Application of NIRS in the effect evaluation of metacognitive training in the adjuvant treatment of depression in children and adolescents |
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| Not yet recruiting | 1 | 120 | | Metacognitive Training program ;Routine antidepressant treatment | The Second Affiliated Hospital of Xinxiang Medical University; The Second Affiliated Hospital of Xinxiang Medical University, The Second Affiliated Hospital of Xinxiang Medical University | Depression | | | | |
ChiCTR2300071110: The impact of the thinking healthy programme-based perinatal depression Internet intervention model on pregnant women: a randomized controlled trial |
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| Not yet recruiting | 1 | 260 | | THP-based Internet intervention model ;enhanced usual care | Wuhan University School of Nursing; Wuhan University School of Nursing, No | Perinatal depression | | | | |
| Enrolling by invitation | 1 | 30 | US | Psilocybin | University of California, Los Angeles | Major Depressive Disorder | 06/25 | 12/25 | | |
ChiCTR2200061863: Effects of mindfulness-based cognitive therapy for adults with post-traumatic stress disorder symptoms in primary care: a randomised controlled trial |
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| Recruiting | 1 | 160 | | Mindfulness-based cognitive therapy ;Seeking Safety | The Chinese University of Hong Kong; Level of the institution：, General Research Fund | Post-traumatic stress disorder symptoms | | | | |
ChiCTR2300075213: An online self-help intervention for people with post-traumatic stress symptoms |
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| Not yet recruiting | 1 | 106 | | Self-help and psychoeducation focused on PTSD ;Self-help resources unrelated to PTSD | Hong Kong Baptist University; Research Grants Council (RGC), RGC Postdoctoral Fellowship Scheme (PDFS), Research Grants Council (RGC), University Grants Committee (UGC), Hong Kong, China | Post-traumatic stress disorder (PTSD) | | | | |
ChiCTR2300074390: A Randomized Controlled Clinical Study of Kuanxiong Aerosol on Coronary Heart Disease combined with Depression |
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| Recruiting | 1 | 120 | | Conventional Western Medicine+Shugan Jieyu capsules ;conventional Western medicine+Kuanxiong aerosol | The First Affiliated Hospital of Henan University of Chinese Medicine; The First Affiliated Hospital of Henan University of Chinese Medicine, Suke'an Pharmaceutical Co., Ltd. (self raised by the enterprise) | Coronary heart disease combined with depression | | | | |
ChiCTR2300074818: Acupuncture plus Chinese herbal formula for post-stroke depression: A protocol for randomized controlled trial |
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| Not yet recruiting | 1 | 64 | | Acupincture: Main points: Yintang, Baihui, Shuigou, Neiguan (bilateral), Sanyinjiao (affected side); matching points: Jiquan, Chize, Weizhong, Hegu, Qiuxu, Tiantu, based on the patient's accompanying symptoms of stroke. 30 mintues for one time, and once a day for four weeks. Chinese Herbal medicine: The decoction of Yu-Dian Tang will be administered orally at a dose of 150ml two times a day for four weeks. One is before breakfast and another one after dinner. The supply of the herbs will be by Heilongjiang Mental Health Hospital and no endangered species or restricted herbs will be used in the study. All the decoctions will be boiled by the TCM pharmacy in Heilongjiang Mental Health Hospital. ;Patients in the control group will receive orally administered Fluoxetine (FLX) for four weeks. The dose is initiated at 10mg per day and the different optimal dose will be escalated for every patient within one week based on his/her response. | the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine; the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Postdoctoral Scientific Research Developmental Fund of Heilongjiang Province (LBH-Q21180) | post-stroke depression | | | | |
| Not yet recruiting | 1 | 30 | US | Trauma, psilocybin | NWTraumatherapies, World Health Organization | Trauma, Nervous System | 08/25 | 10/25 | | |
NCT05962424: HNC: Human Neural Circuits Electrophysiology During Cognition |
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| Recruiting | 1 | 120 | US | Ketamine Hydrochloride, Ketalar | Stanford University | Psychiatric Disorder | 09/25 | 09/26 | | |
NCT05546658: Effects of Psilocybin in Obsessive Compulsive Disorder |
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| Recruiting | 1 | 30 | US | Psilocybin | Johns Hopkins University | Obsessive-Compulsive Disorder | 09/25 | 09/26 | | |
| Enrolling by invitation | 1 | 30 | US | Adderall-XR, Placebo | University of California, Los Angeles | Major Depressive Disorder | 09/25 | 09/25 | | |
NCT01327690: Mental Health in Veterans and Families After Group Therapies |
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| Recruiting | 1 | 100 | US | CBT (Cognitive Behavior Therapy), EFT (Emotional Freedom Techniques) | Soul Medicine Institute | Post-Traumatic Stress Disorders | 12/27 | 12/27 | | |
ChiCTR2300072060: Personalized functional connectivity guided rTMS treatment for adolescent patients with depression: a randomized controlled study |
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| Recruiting | 1 | 124 | | sgACC FC-guided iTBS ;pgACC FC-guided iTBS | The Affiliated Hospital of Hangzhou Normal University; The Affiliated Hospital of Hangzhou Normal University, Clinical Cognitive Psychology Key Discipline Funding: Hangzhou Medical Key Discipline Construction Project | depression | | | | |
ChiCTR2300074306: Efficacy of transcutaneous auricular vagus nerve stimulation in the treatment of AIDS with depression symptoms |
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| Not yet recruiting | 1 | 30 | | ART conventional treatment and transcutaneous auricular vagus nerve stimulation ;ART conventional treatment and transcutaneous non-vagus nerve stimulation | Institute of acupuncture and moxibustion, China Academy of Chinese Medical Sciences; Institute of acupuncture and moxibustion, China Academy of Chinese Medical Sciences, Institute of acupuncture and moxibustion, China Academy of Chinese Medical Sciences | AIDS with depressive symptoms | | | | |
NCT05907213: Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery |
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| Recruiting | 1 | 12 | US | Ketamine (Ketalar) Dose Level 1, 0.05 mg/kg/1hr loading dose Ketamine, Ketamine (Ketalar) Dose Level 2, 0.08 mg/kg/1hr loading dose Ketamine, Ketamine (Ketalar) Dose Level 3, 0.12 mg/kg/1hr loading dose Ketamine, Ketamine (Ketalar) Dose Level 4, 0.18 mg/kg/1hr loading dose Ketamine | Grace Lim, MD, MS, National Institute of Mental Health (NIMH) | Pain, Postoperative, Depression, Postpartum | 12/25 | 07/26 | | |
NCT05032105: The Impact of Focused Ultrasound Thalamotomy of the Anterior Nucleus for Focal-Onset Epilepsy on Anxiety |
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| Not yet recruiting | 1 | 10 | US | Magnetic Resonance Imaging-guided Focused Ultrasound Ablation (MRgFUSA) | Ohio State University | Anxiety, Medication-refractory Focal-onset Epilepsy | 12/25 | 12/25 | | |
ChiCTR2200067173: Mechanism of low frequency repetitive transcranial magnetic stimulation on cognitive function in patients with obsessive-compulsive disorder |
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| Recruiting | 1 | 80 | | Transcranial magnetic stimulation ;Transcranial magnetic stimulation ;Transcranial magnetic pseudostimulation | Ningbo Kangning Hospital; Ningbo Kangning Hospital, Ningbo Natural Science Foundation Project | obsession | | | | |
| Withdrawn | 1 | 200 | NA | Ketamine, Placebo | Sanford Health | Pain, Trauma | 12/25 | 01/26 | | |
ChiCTR2300070743: Stanford University neuromodulation therapy for major depressive disorder and its brain imaging mechanism |
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| Not yet recruiting | 1 | 40 | | SNT - sgACC FC-guided iTBS ;SNT - Classic coordinates | The Affiliated Hospital of Hangzhou Normal University; The Affiliated Hospital of Hangzhou Normal University, Key Medical Discipline of Hangzhou | depression | | | | |
NCT03895658: Title: Safety and Feasibility of Individualized Low Amplitude Seizure Therapy (iLAST) |
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| Recruiting | 1 | 20 | US | MRI, MagPro TMS stimulator and coil, MECTA paired with the 4X1 HD-ECT | National Institute of Mental Health (NIMH) | Unipolar Depression | 12/25 | 12/25 | | |
Efficacy, NCT06346431: of Digital Problem Solving Application in Reduction of Anxiety, Depression and Substance Use Disorder Symptoms |
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| Not yet recruiting | 1 | 100 | NA | DSPT - Digital Support for Problem-solving Therapy | 7 Generation Games | Anxiety, Depressive Symptoms, Substance Use Disorders | 11/26 | 12/26 | | |
| Recruiting | 1 | 80 | US | Endotoxin, Placebo | University of California, Los Angeles, National Institute on Aging (NIA) | Anhedonia, Inflammation, Anxiety, Aging, Depression | 03/26 | 03/26 | | |
NCT00737399: Anxiety and Depression Levels in Cancer Patients After Self-Application of EFT (Emotional Freedom Techniques) |
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| Active, not recruiting | 1 | 14 | US | Lifestyle Counseling with Emotional Freedom Techniques (EFT) | Soul Medicine Institute | Depression | 04/28 | 12/28 | | |
NCT04846829: Effects of Intravenous (IV) Citalopram Hydrochloride During Transcranial Magnetic Stimulation in Major Depressive Disorder (MDD) |
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| Active, not recruiting | 1 | 30 | US | Placebo, intermittent theta burst stimulation, intravenous citalopram hydrochloride (CIT), continuous theta burst stimulation | University of California, Los Angeles | Major Depressive Disorder | 04/26 | 04/26 | | |
ChiCTR2300071782: The relationship between parent-child brain synchronization and emotional regulation in adolescents with depression |
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| Recruiting | 1 | 200 | | Parent-child synchronous movement ;Waiting-list ;None | Beijing Huilongguan Hospital, Beijing, China; Beijing Huilongguan Hospital, research funding | depression | | | | |
| Recruiting | 1 | 30 | US | Psilocybin | Yale University, Steven & Alexandra Cohen Foundation | Obsessive-Compulsive Disorder | 07/26 | 07/27 | | |
NCT05327699: Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine |
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| Recruiting | 1 | 250 | US | Ketamine, Ketalar, Placebo | Emory University, National Institute of Mental Health (NIMH) | Major Depressive Disorder | 11/26 | 12/26 | | |
NCT05023317: Strengths-based Linkage to Alcohol Care (SLAC) for Hazardous Drinkers in Primary Care |
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| Recruiting | 1 | 140 | US | Strengths-based linkage to alcohol care, SLAC, Usual care | VA Office of Research and Development | Alcohol-induced Disorders, Alcohol Drinking, Mental Health | 12/26 | 12/26 | | |
ChiCTR2300074664: Efficacy and safety of using fibrinogen concentration during prehospital transport in Trauma Patients at Risk for Hemorrhagic Shock |
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| Not yet recruiting | 1 | 100 | | Enrolled patients were given human fibrinogen according to their weight (3 g for patients weighing 30-60 kg, 4.5 g for patients weighing 60-90 kg, and 6 g for patients weighing > 90 kg). And Hemodynamics target-oriented use (maintaining systolic blood pressure ≥80 mmHg). The maximum amount of crystal fluid should not exceed 20 ml kg; after admission to the trauma center, follow the trauma resuscitation process for further treatment ;The maximum amount of crystal fluid should not exceed 20 ml kg; after admission to the trauma center, follow the trauma resuscitation process for further treatment | The Second Affiliated Hospital, Hengyang Medical School, University of South China; The Second Affiliated Hospital, Hengyang Medical School, University of South China, Shanghai RAAS Blood Products Co., Ltd.The Second Affiliated Hospital, Hengyang Medical School, University of South China | Trauma | | | | |
NCT03792360: Adipose Derived SVF for Aero-digestive & Enterocutaneous Fistulae |
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| Withdrawn | 1 | 10 | NA | SVF (Stromal Vascular Fraction) | Mayo Clinic | Tracheoesopharyngeal Fistula, Bronchoesophageal Fistula, Tracheoesophageal Fistula | 02/27 | 02/28 | | |
NCT00515372: Depression Treatment and Screening in Ovarian Cancer Patients |
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| Active, not recruiting | 1 | 409 | US | Telephone Counseling, Survey, Usual Care | M.D. Anderson Cancer Center, Lance Armstrong Foundation, National Cancer Institute (NCI) | Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer | 12/27 | 12/27 | | |
NCT03752918: The Effects of MDMA on Prefrontal and Amygdala Activation in PTSD. |
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| Withdrawn | 1 | 20 | US | MDMA, 3,4-Methylenedioxymethamphetamine, Niacin, Nicotinic acid | Yale University | Post Traumatic Stress Disorder | 01/28 | 01/28 | | |
NCT03705715: Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: A Dimensional Approach |
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| Recruiting | 1 | 200 | US | PET with radiotracer [11C]PBR-28 ( or [11C]ER176), [O-methyl-11C]N-acetyl-N-(2-methoxybenzyl)-2-phenoxy- 5-pyridinamine, Affective challenge, biobehavioral challenges | The University of Texas Health Science Center, Houston | Neuropsychiatric Syndromes | 08/28 | 08/28 | | |
| Completed | 1 | 6 | US | Sphenopalatine ganglion block | New York State Psychiatric Institute | Post Traumatic Stress Disorder | 06/23 | 06/23 | | |
NCT05915013: Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response |
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| Recruiting | 1 | 50 | US | Ketamine, Perampanel, Placebo | Yale University, National Institute of Mental Health (NIMH) | Depressive Disorder, Major, Bipolar Disorder, Post Traumatic Stress Disorder | 12/32 | 12/32 | | |
