Mood Disorders |
NCT04711915: Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humans |
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| Active, not recruiting | 1 | 30 | US | 0.1 mg/kg Dimethyltryptamine (DMT), Low Dose DMT, 0.3 mg/kg Dimethyltryptamine (DMT), Moderate Dose DMT | Yale University | Major Depressive Disorder, Depression | 12/24 | 12/24 | | |
| Recruiting | 1 | 40 | US | Cannabidiol, CBD, Placebo | Johns Hopkins University, Canopy Growth Corporation | Autism Spectrum Disorder | 11/24 | 12/24 | | |
| Not yet recruiting | 1 | 50 | | For the intervention, choose Nintendo Switch's Fitness Ring Adventure series of sports games ;Maintain daily lifestyle and join waiting list | School of Nursing, Jilin University; Jilin University, 1. Fundamental Research Funds for the Central Universities; 2.Jilin Scientific and Technological Development Program; 3. Educational Commission of Jilin Province of China | Subthreshold depression (StD) | | | | |
| Not yet recruiting | 1 | 384 | | Brief CBT based on mobile apps ;Wait for access Bali Sujati programme if they wish to use it after collecting follow up data | Universitas Pendidikan Ganesha, Indonesia; Direktorat Riset, Teknologi, dan Pengabdian kepada Masyarakat, Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi, Ministry of Education, Culture, Research and Technologies in Indonesia, DIPA Direktorat Riset, Teknologi, dan Pengabdian kepada Masyarakat, Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi (Ministry of Education, Culture, Research and Technologies in Indonesia) un | Mental health | | | | |
ChiCTR2300070341: The efficacy of esketamine for postoperative pain and depression in women undergoing second cesarean section |
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| Recruiting | 1 | 120 | | Esketamine + sufentanil ;Butorphanol + sufentanil ;NS + sufentanil | Lishui People's Hospital; 丽水市人民医院, The talent training project of key discipline in Lishui city | Postpartum pain and depression | | | | |
ChiCTR2300071438: Clinical study on the treatment of insomnia with anxiety and depression disorder (liver-depression and spleen-deficiency type) in middle-aged and young adults by pacifying the liver and strengthening the spleen formula |
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| Not yet recruiting | 1 | 72 | | Calming the Liver and Strengthening the Spleen Soup ;Relieving Liver Depression Capsules | The Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine; The Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai Pudong New Area Famous Traditional Chinese Medicine Training Program | Insomnia with anxiety and depression | | | | |
ChiCTR2100053376: Study on analgesic effect and depression state of esketamine combined with sufentanil after cesarean section |
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| Recruiting | 1 | 90 | | Sufentanil 3.0 μg / kg + Tropisetron Hydrochloride 10 mg ;Sufentanil 2.5μg / kg + Esketamine 0.5mg / kg + Tropisetron Hydrochloride 10mg ;Sufentanil 2.0μg / kg + Esketamine 1.0mg / kg + Tropisetron Hydrochloride 10mg | Affiliated Hospital of Jining Medical University; Affiliated Hospital of Jining Medical University, Shandong Medical Association | cesarean section patients | | | | |
ChiCTR2200057420: The effect of acupoint application combined with five-element music therapy on alleviating preoperative anxiety and improve prognosis in patients with elective coronary intervention |
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| Not yet recruiting | 1 | 126 | | Routine care: routine preoperative examination, antiplatelet drugs, ALLEN test. Preoperative health guidance includes: illustrated and textual introduction of surgical knowledge (operation time, catheter room environment, local anesthesia, postoperative complications, preoperative and postoperative precautions, etc.), defecation on the training b ;Patients in the intervention group were added to the control group on the basis of the conventional care of the control group with acupuncture point patches combined with five elements of music therapy, (1) acupuncture points: taking the middle and bilateral internal guan, three yin intercourse and foot thr | The Fifth Affiliated Hospital of Sun Yat-sen University; The Fifth Affiliated Hospital of Sun Yat-sen University, Nursing Department of The Fifth Affiliated Hospital of Sun Yat-sen University | Cardiovascular diseases | | | | |
ChiCTR2200058667: Time-varying characteristics and influencing factors of cognitive function in elderly patients with depression and mild cognitive impairment |
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| Not yet recruiting | 1 | 300 | | No | Fujian Provincial Hospital; Fujian Provincial Hospital, National Natural Science Foundation of China (72104050) | Late-life depression and mild cognitive impairment | | | | |
ChiCTR2200060313: Effects of a single dose of esketamine on the prevention and treatment of perinatal depression in cesarean delivery women after delivery of the fetus |
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| Not yet recruiting | 1 | 320 | | After the fetus is delivered and the umbilical cord is clipped, intravenous injection of normal saline 0.1 mg/kg ;After the fetus was delivered and the umbilical cord was clipped, intravenous esketamine 0.5 mg/kg was administered | The First Affiliated Hospital of USTC Anhui Provincial Hospital; The First Affiliated Hospital of USTC Anhui Provincial Hospital, Chen Xiaoping Foundation | perinatal depression | | | | |
ChiCTR2200058981: Based on the cohort of middle-aged and elderly people with chronic pain in Beijing community, the clinical information and neuroimaging prediction model of comorbidity of pain and depression in middle-aged and elderly people were established |
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| Not yet recruiting | 1 | 204 | | None | Beijing Friendship Hospital Affiliated to Capital Medical University; Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing Municipal Medical Administration ''Cultivation Program'', PX2020005 | Pain | | | | |
ChiCTR2200061575: The effect of continuous use of S(+)-ketamine in the perioperative period on postoperative depression in breast cancer patients: a randomized controlled, double-blind study |
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| Not yet recruiting | 1 | 80 | | During the induction of intoxication, S(+)-ketamine 0.5 mg/kg (diluted to 5 ml with normal saline) was given after the patient lost consciousness, and S(+)-ketamine 0.25 mg/kg/h (diluted with normal saline to 1 mg) during the anesthesia maintenance phase /ml). ;During anesthesia induction, 5ml of normal saline was given after the patient's consciousness disappeared, and 0.25ml/kg/h of normal saline was given during the anesthesia maintenance phase. | Ethics Committee of Hangzhou First People's Hospital; Hangzhou First People's Hospital, Self-funded | Depression | | | | |
| Recruiting | 1 | 80 | US | Virtual Reality-Reward Training (VR-RT), Virtual Reality-Memory Training (VR-MT) | University of California, Los Angeles | Positive Affect, Depression | 12/24 | 12/24 | | |
ChiCTR2200063641: A randomized, double-blind, placebo-controlled cross-over study of scopolamine intravenous injection on refractory depression |
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| Not yet recruiting | 1 | 40 | | scopolamine/placebo intravenous injection ;placebo/scopolamine intravenous injection | Huzhou Third People's Hospital; psychosomatic department, self-funding | major depressive disorder | | | | |
ChiCTR2300069342: Construction and validation of a peri-induction remote management APP for women with fetal anomalies |
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| Not yet recruiting | 1 | 90 | | Remote management APP ;Peri-abortion depression intervention program ;Routine nursing | Xiangya School of Nursing, Central South University; Central South University, National Natural Science Foundation of China (General Project) | depression | | | | |
NCT04152993: Responsive Neurostimulation for Post-Traumatic Stress Disorder |
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| Recruiting | 1 | 6 | US | NeuroPace® RNS® System | VA Greater Los Angeles Healthcare System, University of California, Los Angeles | Post-Traumatic Stress Disorder | 07/26 | 07/26 | | |
NCT05217706: Low-Dose Intravenous Ketamine for Adolescents With Depression and Suicidal Ideation in the Emergency Department |
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| Recruiting | 1 | 30 | US | Ketamine, normal Saline | Rady Children's Hospital, San Diego, University of California, San Diego | Depression, Suicidal Ideation | 01/24 | 01/24 | | |
NCT05610917: Community-based Rehabilitation Management for Patients With Remitted Geriatric Depression |
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| Not yet recruiting | 1 | 120 | RoW | CBRM (community-based rehabilitation management), TAR(treatment as routine) | Duan Li | Geriatric Depression | 01/24 | 01/26 | | |
| Recruiting | 1 | 24 | US | Psilocybin, Mindfulness-Based Stress Reduction (MBSR) | University of Utah, Heffter Research Institute, Usona Institute | Depression, Burnout, Professional | 01/24 | 01/24 | | |
NCT06480201: Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression |
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| Recruiting | 1 | 100 | US | Ketamine, Saline | Baylor College of Medicine, National Institute of Mental Health (NIMH) | Healthy, Major Depressive Disorder, Treatment Resistant Depression | 12/25 | 12/25 | | |
NCT06274034: MUSE-S Headband System for Improving Anxiety and Insomnia Among Breast Cancer Survivors |
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| Recruiting | 1 | 40 | US | Electronic Health Record Review, Medical Device Usage and Evaluation, Meditation Therapy, Meditation, Survey Administration | Mayo Clinic | Breast Carcinoma | 01/25 | 01/25 | | |
NCT06065735: Concentration-QT Study of Paroxetine in Healthy Adults |
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| Completed | 1 | 38 | Europe | Paroxetine | GlaxoSmithKline | Anxiety Disorders | 01/24 | 01/24 | | |
| Suspended | 1 | 10 | US | [11C]UCB-J radiotracer, C11-UCB-J, PET-MR | Davidzon, Guido, M.D., Stanford University | Major Depressive Disorder | 02/25 | 02/25 | | |
| Completed | 1 | 34 | US | Cannabigerol, Placebo | Washington State University | Focus: To Examine Acute Effects of CBG on Anxiety, Stress, and Cognition | 11/23 | 11/23 | | |
NCT06135090: Testing a Peer-led Trauma-focused Intervention for Significant Others of Those With BPD |
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| Not yet recruiting | 1 | 60 | Canada | Trauma Recovery Program (official title TBD) | York University, The Sashbear Foundation | Posttraumatic Stress Disorder, Family Members, Spouses | 01/26 | 01/26 | | |
Tetrasol, NCT06425094: Effects of a Microalgae Extract Dietary Supplement on Gut Health, Anxiety, and Immune Function |
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| Recruiting | 1 | 60 | US | Microalgae Extract Capsules, Placebo | Colorado State University | Gastrointestinal Problem, Anxiety, Stress, Gastrointestinal Symptoms | 05/24 | 12/24 | | |
NCT05738850: Study to Assess Adverse Events and How ABBV-932 Oral Capsules Moves Through the Body of Healthy Adult Participants |
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| Completed | 1 | 104 | US | ABBV-932, Placebo | AbbVie, Gedeon Richter Plc. | Generalized Anxiety Disorder (GAD), Healthy Participants | 05/24 | 05/24 | | |
NCT03554174: Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder |
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| Active, not recruiting | 1 | 18 | US | Low Dose Psilocybin, Placebo, Medium Dose Psilocybin | Yale University, Heffter Research Institute | Major Depressive Disorder | 07/21 | 04/25 | | |
NCT04231643: Effects of Cannabis on Cognition and Endocannabinoid Levels in Bipolar Disorder Patients and Healthy Volunteers |
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| Terminated | 1 | 19 | US | Dronabinol, Epidiolex, Placebos | University of California, San Diego, National Institute on Drug Abuse (NIDA) | Bipolar Disorder | 11/23 | 11/23 | | |
NCT05655507: Zuranolone Pharmacokinetics (PK) and Safety Study Adolescent Participants With Major Depressive Disorder (MDD) |
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| Recruiting | 1 | 18 | US | Zuranolone, SAGE-217, BIIB125 | Sage Therapeutics, Biogen | Major Depressive Disorder | 09/24 | 10/24 | | |
| Withdrawn | 1 | 15 | NA | Ketamine 100 MG/ML | Northwell Health | Cancer-related Problem/Condition, Depressive Symptoms, Anxiety Disorders | 03/24 | 03/24 | | |
ChiCTR2300073124: Clinical efficacy and safety of acupuncture in improving anxiety and depression after interventional intervention of qi stasis and blood stasis coronary heart disease |
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| Not yet recruiting | 1 | 102 | | Acupuncture ;Sham acupuncture ;Basic medicine treatment | Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine; Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai Science and Technology Program: Exploring the Improvement of Coronary Slow Blood Flow by Inhibition of Integrina5b1/YAP357 Phosphorylation by Acupuncture Based on Hemodynamic Mathematical Model (Project No.: 21JC1405300) | Qi stasis coronary heart disease interventional postoperative anxiety and depression state | | | | |
NCT06303648: A Single, Ascending Dose Evaluation of the Safety, Pharmacokinetics of Methylone in Healthy Subjects |
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| Recruiting | 1 | 24 | RoW | Methylone | Transcend Therapeutics | Post Traumatic Stress Disorder | 05/24 | 05/24 | | |
ChiCTR2300069440: Study on the depression of hydrogen inhalation on nocturnal hypertension in the elderly |
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| Not yet recruiting | 1 | 100 | | Oxygen inhalation ;Hydrogen and oxygen mixture inhalation | Central Hospital of Tai'an; Central Hospital of Tai'an, Scientific research funds | hypertension | | | | |
ChiCTR2300073211: Study on the relationship between short-term post-traumatic blood glucose variability and post-traumatic stress disorder in non-diabetic patients |
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| Not yet recruiting | 1 | 200 | | Nil ;Nil | The First Aid Center of Affiliated Hospital of Xuzhou Medical University, Jiangsu; Affiliated Hospital of Xuzhou Medical University, Jiangsu Province ordinary university postgraduate research and practice innovation program project (Approval number: SJCX22_1269) | Post-traumatic Stress Disorder | | | | |
NCT04032301: Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans |
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| Recruiting | 1 | 108 | US | Ketamine, Ketamine Hydrochloride, Normal Saline, Sodium Chloride in Water | University of Minnesota, Minneapolis Veterans Affairs Medical Center | Post-Traumatic Stress Disorders, Major Depressive Disorder | 04/24 | 04/25 | | |
| Recruiting | 1 | 240 | US | Estradiol patch, Placebo patch | Emory University, National Institute of Mental Health (NIMH) | PTSD, Trauma | 08/24 | 08/24 | | |
| Not yet recruiting | 1 | 10 | NA | transcranial magnetic stimulation, TMS, accelerated intermittent theta burst stimulation, aiTBS | Brigham and Women's Hospital | Major Depressive Disorder, Depression, Psychiatric Disorder, Mood Disorders, Mental Disorder, Anxiety Disorders, OCD, PTSD | 04/25 | 04/26 | | |
PAP-OCD, NCT06299319: Feasibility, Clinical Effects, and Safety of Psilocybin-assisted Psychotherapy for Treatment-resistant OCD |
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| Not yet recruiting | 1 | 10 | NA | Psilocybin, PEX010 | Centre for Addiction and Mental Health | Obsessive-Compulsive Disorder | 06/24 | 09/24 | | |
NCT06355414: Psilocybin in Chronic Low Back Pain and Depression |
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| Recruiting | 1 | 40 | US | Psilocybin, Methylphenidate | Johns Hopkins University, National Center for Complementary and Integrative Health (NCCIH) | Chronic Low-back Pain, Depression | 07/26 | 08/26 | | |
NCT05223829: Utility of Brexanolone to Target Stress-induced Alcohol Use Among Men and Women With Posttraumatic Stress Disorder |
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| Recruiting | 1 | 25 | US | Brexanolone, Zulresso | Yale University, National Institute on Alcohol Abuse and Alcoholism (NIAAA), Sage Therapeutics | PTSD, Alcohol Use Disorder | 04/24 | 04/24 | | |
NCT05894902: Open-Label Dose-Ranging Study of Oral SM-001 in Healthy Adults |
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| Not yet recruiting | 1 | 12 | US | SM-001, Ayahuasca | Advanced Integrative Medical Science Institute | Major Depression, Post Traumatic Stress Disorder | 04/24 | 06/24 | | |
NCT04878627: Role of CBD in Regulating Meal Time Anxiety in Anorexia Nervosa |
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| Recruiting | 1 | 40 | US | Cannabidiol, Epidiolex, Placebo | University of California, San Diego | Anorexia Nervosa | 10/24 | 10/24 | | |
ROAR, NCT05338632: Reversal of Opioid-induced Respiratory Depression With Opioid Antagonists |
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| Recruiting | 1 | 24 | Europe | Narcan 40 MG/ML Nasal Spray, Intranasal naloxone, Naloxone Hydrochloride, Intramuscular naloxone | Leiden University Medical Center, U.S. Food and Drug Administration (FDA) | Opioid Induced Respiratory Depression, Chronic Opioid Use | 05/24 | 05/24 | | |
ChiCTR2300071344: The role of blood lipids and inflammatory factors in the occurrence of suicidal ideation in adolescents with depressive disorders |
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| Not yet recruiting | 1 | 224 | | no ;no | The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, Graduate research funding | depression | | | | |
NCT06361095: Confirmatory Efficacy Trial of Attention Bias Modification for Depression |
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| Not yet recruiting | 1 | 600 | US | Traditional Attention Bias Modification, Gamified Attention Bias Modification, Sham Attention Bias Modification | University of Texas at Austin, Arcade Therapeutics | Depression | 03/28 | 03/28 | | |
NCT03463239: Bioengineered Penile Tissue Constructs for Irreversibly Damaged Penile Corpora |
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| Not yet recruiting | 1 | 10 | US | Autologous tissue engineered corpora | Wake Forest University Health Sciences, United States Department of Defense | Urologic Diseases, Male Urogenital Diseases, Penile Diseases, Corpus Callosum Malformation, Corpora Cavernosa; Inflammation, Trauma Injury | 03/25 | 10/25 | | |
| Recruiting | 1 | 50 | Europe | Ebselen, SPI-1005, PZ-51, Ebselene, Ebselenum, Ebseleno, Harmokisane, Placebo, Dummy | University of Oxford, Medical Research Council, Sound Pharmaceuticals, Incorporated | Depressive Disorder, Treatment-Resistant | 05/24 | 05/24 | | |
| Enrolling by invitation | 1 | 50 | US | Nitrous Oxide, Laughing Gas, Placebo gas | Washington University School of Medicine, American Foundation for Suicide Prevention | Major Depressive Disorder, Depression, Mood Disorders, Suicidal Ideation | 06/24 | 07/24 | | |
| Recruiting | 1 | 10 | US | Brexanolone, Zulresso | University of North Carolina, Chapel Hill, Sage Therapeutics | Postpartum Psychosis | 06/24 | 06/24 | | |
NCT05873517: Trauma-Focused Intervention With Women Experiencing Homelessness |
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| Recruiting | 1 | 50 | US | Immediate Narrative Exposure Therapy (NET)+, Waitlist + NET+ | Rush University Medical Center, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) | Psychological Trauma, Trauma and Stress Related Disorders, Substance-Related Disorders, Substance Use, Substance Use Disorders | 12/24 | 03/25 | | |
NCT06213298: Effect of Kava on Anxiety and Stress in Cancer Survivors |
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| Not yet recruiting | 1 | 43 | NA | Kava, Placebo | Masonic Cancer Center, University of Minnesota | Kava, Anxiety, Stress, Cancer, Depression, Sleep | 07/24 | 08/25 | | |
| Recruiting | 1 | 20 | US | Psilocybin, Trauma-focused psychotherapy, Standard psychological support | Johns Hopkins University | Post Traumatic Stress Disorder | 05/26 | 05/27 | | |
NCT04850222: Fluoxetine Mitigation Mental Health Study for Patients With Musculoskeletal Trauma |
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| Recruiting | 1 | 150 | US | Fluoxetine, Calcium | University of Florida | Musculoskeletal Injury | 06/24 | 06/24 | | |
NCT05022524: Exploring Novel Uses of Microbiota Therapy for Managing the Side Effects of Psychiatric Pharmaceutical Interventions |
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| Recruiting | 1 | 10 | Canada | Acetate (Apple Cider Vinegar) | Lawson Health Research Institute | Depression, Anxiety | 06/24 | 08/24 | | |
ChiCTR2300075055: Effect of Esketamine on Preventing Depression After Resection of the Colorectal Cancer: A Randomized Clinical Trial |
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| Not yet recruiting | 1 | 120 | | Eesketamine + Sufentanil PCIA group (Group E, n=60, esketamine 1.0 mg / kg and sufentanil 2.0 μ g / kg) ;Sufentanil PCIA group (Group C, n=60, sufentanil 2.0 μ g / kg) | Xiangya Hospital of Central South University; Xiangya Hospital of Central South University, Medical Scientific Research Foundation of Hunan Provincial Medical Association | Postoperative depression | | | | |
NCT05266560: Effects of Ciprofol Anesthesia on Learning and Memory Function and Antidepressant Effects of ECT in Depressive Patients |
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| Not yet recruiting | 1 | 390 | NA | ciprofol, 2-[(1R)-1-cyclopropylethyl]-6-isopropyl-phenol, Propofol, 2,6-Diisopropylphenol | First Affiliated Hospital of Chongqing Medical University | Depressive Disorder | 07/24 | 12/24 | | |
NCT03522545: Adjunctive Allogeneic Mesenchymal Stem Cells for Treatment-resistant Bipolar Depression |
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| Recruiting | 1 | 30 | US | Allogeneic Bone Marrow Derived Multipotent Mesenchymal Stromal Cells (MSCs), Placebo | The University of Texas Health Science Center, Houston | Treatment-resistant Bipolar Depression | 12/24 | 12/24 | | |
NCT05382897: Fasting-mimicking Diet in Treatment of Depressive Symptoms in IBD |
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| Recruiting | 1 | 120 | Canada | Plant-based fasting-mimicking diet | University of Alberta, W. Garfield Weston Foundation | Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis | 07/24 | 12/24 | | |
ChiCTR2200063472: Based on the theory of brain-gut axis to analyze the effect of the Wu Yin Tiao Shen therapy on post-stroke (mild to moderate) depression |
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| Recruiting | 1 | 102 | | wu yin tiao shen ;repetitive transcranial magnetic stimulation | The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine; The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Province Traditional Chinese Medicine Science and Technology Project | post-stroke depression | | | | |
NCT06476509: A Study to Assess Serotonin Transporter Occupancy of Healthy Adults Using 11C-DASB PET |
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| Not yet recruiting | 1 | 8 | NA | LV232 40mg, LV232, Escitalopram 20 mg, Escitalopram | Vigonvita Life Sciences | Major Depressive Disorder | 09/24 | 10/24 | | |
NCT06482762: Low-Intensity Focused Ultrasound of the Amygdala for Bipolar Disorder |
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| Not yet recruiting | 1 | 20 | US | BrainSonix Pulsar 1002 | Massachusetts General Hospital | Bipolar | 12/25 | 12/25 | | |
| Not yet recruiting | 1 | 50 | NA | Psilocybin | Yale University, Usona Institute | Safety, Feasibility, and Tolerability of Psilocybin Treatment in Individuals With Functional Impairment Due to Psychiatric Symptoms | 07/27 | 07/27 | | |
NCT06435949: Effect of Oxycodone on Anxiety State in Painless Abortion |
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| Not yet recruiting | 1 | 300 | NA | Fentanyl (as Citrate), Oxycodone | Ruijin Hospital | Abortion Complication | 06/26 | 06/26 | | |
ChiCTR2200060050: Predictive study of drug and cognitive behavioral therapy on the efficacy of obsessive-compulsive disorder based on image classification |
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| Not yet recruiting | 1 | 160 | | Medication + cognitive behavioral therapy ;None | The Second Affiliated Hospital of Xinxiang Medical University; The Second Affiliated Hospital of Xinxiang Medical University, Subproject of National 863 Program | obsession | | | | |
NCT05086250: Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients With Pancreatic Cancer |
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| Recruiting | 1 | 20 | US | Ketamine, Ketalar, Placebo | Cedars-Sinai Medical Center | Anxiety, Pancreatic Cancer | 07/25 | 12/25 | | |
NCT06224127: Treating Stress and Anxiety in Individuals With Alcohol Use Disorder (AUD) |
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| Not yet recruiting | 1 | 36 | US | active heat, Active c tactile fiber stimulation, sham heat, Sham c tactile fiber stimulation | Soovu Labs Inc. | Anxiety Disorders, Alcohol Use Disorder, Stress, Psychological | 12/24 | 03/25 | | |
PNMD, NCT06235177: Psychoneuromentalism Disorder: A Medical Condition That Affects People With Psychological Impairments From Health Issues |
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| Not yet recruiting | 1 | 30 | NA | Decompartmentalization Framework, Liquid Herbal TInctures, Herbal Tincture, Mental Imagery, Mindfulness, Clinical Yoga, Yoga, Mediation, Dietary Supplements, Vitamins, Applied Relaxation, Meditation, Breathing Exercises, Music Therapy, Pain Relaxation Techniques, Comprehensive Theocentric Psychological Assessment | The Essence of Integrative Health and Medicine Practice | Schizoaffective Disorder, Bipolar Type, Bipolar Disorder, ADHD - Combined Type, Dissociative Disorder, Stress Disorder, Dementia, Anxiety, Chronic Fatigue Syndrome | 04/25 | 09/25 | | |
NCT05025605: Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder |
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| Recruiting | 1 | 140 | US | BXCL501 80 Micrograms, Dexmedetomidine, Placebo Film, Placebo, BXCL501 120 Micrograms, BXCL501 60 Micrograms | BioXcel Therapeutics Inc, Cognitive Research Corporation | Schizophrenia, Schizo-Affective Disorder, Schizophreniform; Schizophrenic, Bipolar Disorder I, Bipolar Disorder II | 07/24 | 07/24 | | |
ChiCTR2300073911: Effect of electroacupuncture on discomfort during DSA(Digital Subtraction Angiography): A randomized, controlled clinical trial |
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| Recruiting | 1 | 93 | | Before the whole brain angiography (DSA) examination, the following acupuncture points are: bilateral Hegu (LI4), Neiguan (PC6), Zusanli (ST36), Shenmen (HT7), Yintang (EX-HN3). Use disposable sterile stainless steel needles for treatment. After inserting the needle, the acupuncturist does the needle until the patient reaches a sense of breath. Two pairs of electrodes of the electroacupuncture instrument are connected to the acupuncture needles of LI4 and ST36 on both sides, providing continuous waves with low-frequency (2 Hz) and 2 mA current for 20-30 minutes of continuous treatment. ;The acupuncturist used non-acupoints for superficial acupuncture as a control. Use the same needle to insert the surface depth as the EA group. The needle is connected to the electrode for 30 minutes, but does not provide current. | Haikou People's Hospital; Haikou People's Hospital, Self-financing | Cerebrovascular disease | | | | |
NCT05355311: Enhancing the Effects of Adolescent Alcohol Treatment With Acetyl-L-Carnitine |
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| Not yet recruiting | 1 | 50 | US | Acetyl-l-carnitine, L-carnitine, Placebo, Sugar Pill | Brown University, Rhode Island Hospital, Colorado State University, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcohol Use Disorder | 08/24 | 08/24 | | |
NCT06378528: Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP) |
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| Not yet recruiting | 1 | 5 | US | Ketamine, Ketamine Assisted Psychotherapy, SmartSleep EEG recording headband | University of Wisconsin, Madison | Posttraumatic Stress Disorder | 08/25 | 08/25 | | |
CAPER, NCT06222268: Wayne State Warriors Marijuana Clinical Research Program: Cannabinoid Adjunct to Prolonged Exposure & Recovery |
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| Not yet recruiting | 1 | 350 | US | Cannabidiol (CBD) only, Cannabis, Placebo only, Sugar Pill, Delta-9-tetrahydrocannabinol (THC) only, THC:CBD 1:1, THC:CBD 1:10 | Wayne State University | PTSD, Post Traumatic Stress Disorder | 09/27 | 09/27 | | |
NCT06335407: Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study |
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| Not yet recruiting | 1 | 10 | US | Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg, BXCL501 40µg, Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 80µg, BXCL501 80µg | Pharmacotherapies for Alcohol and Substance Use Disorders Alliance, United States Department of Defense, Congressionally Directed Medical Research Programs, VA Connecticut Healthcare System, BioXcel Therapeutics Inc, Yale University, RTI International | Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD) | 09/25 | 10/25 | | |
NCT03356483: Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study. |
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| Active, not recruiting | 1 | 31 | US | Psilocybin (0.25mg/kg), "Magic Mushrooms", Niacin (250mg), Nicotinic acid | Yale University, Heffter Research Institute, National Institute of Mental Health (NIMH) | Obsessive-Compulsive Disorder | 08/24 | 12/24 | | |
NCT03748446: Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder |
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| Recruiting | 1 | 20 | US | Xenon, Nitrogen gas | Massachusetts General Hospital | Major Depressive Disorder, Bipolar Depression | 09/24 | 12/24 | | |
ChiCTR2300074828: The effects of music therapy combined with aromatherapy on anxiety, depression and sleep quality in tumor patient |
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| Recruiting | 1 | 200 | | Routine care ;Routine care + music therapy ;Routine care + aromatherapy ;Routine care + music therapy + aromatherapy | The First People's Hospital of Zunyi; The First People's Hospital of Zunyi, Project funding | Anxiety,depression and sleep problems in oncology patients | | | | |
NCT05921929: First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM) |
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| Withdrawn | 1 | 36 | Europe | Fluoroethylnormemantine (FENM) | ReST Therapeutics | PTSD, Alzheimer Disease, Brain Diseases, Neuro-Degenerative Disease, Major Depressive Disorder, Treatment Resistant Depression | 05/24 | 05/24 | | |
CBD, NCT04075435: Cannabidiol Solution for the Treatment of Behavioral Symptoms in Older Adults With Mild Cognitive Impairment or Alzheimer's Dementia |
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| Recruiting | 1 | 12 | US | high CBD/low THC sublingual solution | Mclean Hospital, Spier Family Foundation | Alzheimer Disease, Anxiety, Agitation,Psychomotor | 09/24 | 09/24 | | |
ChiCTR2200059786: Blocking effect of Danhun Ningshen Recipe on structural changes of brain dysfunction in anxiety disorder |
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| Recruiting | 1 | 100 | | traditional Chinese medicine ;Oral buspirone tablets | Guang'anmen Hospital of Chinese Academy of Traditional Chinese Medicine ; Guang'anmen Hospital of Chinese Academy of Traditional Chinese Medicine, Fund for science and technology innovation project of Chinese Academy of traditional Chinese Medicine | Generalized anxiety disorder | | | | |
NCT06123702: Cannabidiol Effects on Fear Extinction in Social Phobia |
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| Not yet recruiting | 1 | 20 | US | Fear extinction, Cannabidiol Cap/Tab, CBD, Placebo | Hartford Hospital | Social Anxiety Disorder | 12/24 | 12/24 | | |
NCT05703685: [18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET |
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| Recruiting | 1 | 56 | US | 18F-PF-06445974 | National Institute of Mental Health (NIMH) | Depression | 10/28 | 04/29 | | |
ChiCTR2300072206: Effect of Jiedu Quyu Ziyin Formula on the Clinical Efficacy of Sjogren's Syndrome, Immune Inflammatory Indexes and Depression |
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| Not yet recruiting | 1 | 100 | | jie-du-qu-yu-zi-yin fang with HCQ ;HCQ ;Iguratimod | Huzhou Third People's Hospital; Huzhou Third People's Hospital, self-funded | Sjogren's Syndrome | | | | |
| Suspended | 1 | 20 | US | Medtronic SenSight Directional DBS lead | Northwell Health, Medtronic | Treatment Resistant Depression | 10/24 | 10/28 | | |
ChiCTR2200061391: Clinical study of Yijing tang combined with acupuncture on premature ovarian insufficiency of liver depression and kidney deficiency |
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| Recruiting | 1 | 60 | | Chinese medicine ;Acupuncture + Chinese medicine | Guang'anmen Hospital, China Academy of Chinese Medical Sciences; China Academy of Chinese Medical Sciences, China Academy of Chinese Medical Sciences | Premature Ovarian Insufficiency | | | | |
ChiCTR2200062222: Clinical Study and Mechanism of Jiakangtongzhi Formulation in the Treatment of Graves Disease(Yin Deficiency and Yang Excess, Liver Depression and Phlegm Obstruction) |
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| Not yet recruiting | 1 | 260 | | placebo + methimazole ;Jiakangtongzhi Formulation + methimazole | Guang'anmen Hospital, Chinese Academy of Traditional Chinese Medicine; Guang'anmen Hospital, Chinese Academy of Traditional Chinese Medicine, Science and Technology Innovation Project of China Academy of Chinese Medical Sciences (NO. CI2021A01610) | Graves Disease | | | | |
NCT05562973: Safety and Tolerability of Psilocybin in Post-Traumatic Stress Disorder |
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| Withdrawn | 1 | 30 | NA | Psilocybin | Johns Hopkins University | Post-Traumatic Stress Disorder | 12/25 | 12/25 | | |
TREK, NCT06001372: Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI Cancers |
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| Recruiting | 1 | 12 | US | Ketamine, Ketamine Assisted Psychotherapy | University of Utah | Gastrointestinal Cancer, Depression, Anxiety | 11/24 | 11/25 | | |
NCT04413799: PVB vs Ketamine/Lidocaine in Rib Fracture Patients |
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| Recruiting | 1 | 170 | US | lidocaine, ketamine intravenous infusion, paravertebral block with ropivicaine | George Washington University | Rib Fractures, Rib Trauma, Rib Fracture Multiple, Pain, Acute | 12/24 | 05/25 | | |
ChiCTR2300074325: Efficacy of propofol combined with different doses of esmketamine anesthesia and MECT in the treatment of severe depression |
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| Recruiting | 1 | 70 | | The electrocardiogram, peripheral blood oxygen saturation, blood pressure and anesthesia depth (BIS) were monitored. Atropine 0.5mg, propofol 0.5mg/kg and esketamine 0.5mg/kg were given intravenously, and succinylcholine 1mg/kg was given when BIS value was less than 60. ECT was started after the end of muscle fibrillation. Ect-related parameters were set by psychosomatic physicians specialized in ECT treatment. Blood pressure, ECG, EEG, pulse oxygen saturation, and respiratory rate were monitored during the treatment. Drug maintenance treatment regimens after ECT were developed and recorded according to guidelines for the treatment of major depression. The HAMDS, PHQ-9 and CSSRS were evaluated at 1 week, 2 weeks, 3 weeks, 1 month, 2 months and 3 months after ECT. The DSST was evaluated at the end of ECT and 1 month, 2 months and 3 months after ECT. Psychosomatic physicians and patients were unaware of the anesthesia assignments. ;he electrocardiogram, peripheral blood oxygen saturation, blood pressure and anesthesia depth (BIS) were monitored. Atropine 0.5mg was intravenously injected, and then propofol 1mg/kg was intravenously injected according to the group. When BIS value was less than 60, succinyl choline 1mg/kg was given. Ect-related parameters were set by psychosomatic physicians specialized in ECT treatment. Blood pressure, ECG, EEG, pulse oxygen saturation, and respiratory rate were monitored during the treatment. Drug maintenance treatment regimens after ECT were developed and recorded according to guidelines for the treatment of major depression. The HAMDS, PHQ-9 and CSSRS were evaluated at 1 week, 2 weeks, 3 weeks, 1 month, 2 months and 3 months after ECT. The DSST was evaluated at the end of ECT and 1 month, 2 months and 3 months after ECT. Psychosomatic physicians and patients were unaware of the anesthesia assignments. | Deyang People's Hospital; Deyang People's Hospital, The subject was from Sichuan Nursing Vocational and Technical College, the project number was 2023IRY18. Source of funds: Supporting units | Depression | | | | |
NCT06085937: Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department |
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| Recruiting | 1 | 50 | US | Ketamine | Lindsay Maguire, MD | Suicide, Suicidal Ideation, Depression | 04/25 | 04/25 | | |
SVF, NCT05515523: Stromal Vascular Fraction () for Knee Post-Trauma Osteoarthritis (PTOA) |
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| Not yet recruiting | 1 | 10 | US | Adipose Derived (AD) Stromal Vascular Fraction (SVF) | Wake Forest University Health Sciences | Osteoarthritis | 04/25 | 04/26 | | |
NCT06073015: Effect of Esketamine on Reducing Postoperative Anxiety and Depression in Adolescent Patients |
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| Not yet recruiting | 1 | 200 | NA | Esketamine | Henan Provincial People's Hospital | Anxiety-depression | 12/24 | 02/25 | | |
NCT04123314: Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease |
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| Recruiting | 1 | 20 | US | Psilocybin | Johns Hopkins University | Depressive Symptoms, Depression, Alzheimer Disease, Mild Cognitive Impairment | 12/24 | 12/24 | | |
NCT04080427: Effects of Delta9-tetrahydrocannabinol (THC) on Retention of Memory for Fear Extinction Learning in PTSD: R33 Study |
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| Recruiting | 1 | 100 | US | Placebo capsule, sugar pill, Dronabinol 7.5 milligram oral capsule, Marinol | Wayne State University, National Institute of Mental Health (NIMH) | Posttraumatic Stress Disorder | 12/24 | 12/25 | | |
ChiCTR2100054147: Correlation between dopamine receptor gene polymorphism and clinical effect of bipolar depressive episode |
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| Not yet recruiting | 1 | 180 | | Lamotrigine ;Quetiapine ;Bupropion ;None | Jiaxing Kangci Hospital; Jiaxing Kangci Hospital, Provincial Health Commission, Jiaxing Kangci Hospital, self-funded | Bipolar depression | | | | |
ChiCTR2200059591: Auricular electroacupuncture based on MRI brain imaging and intestinal flora in the treatment of depression and gut-brain axis mechanism and prediction of efficacy |
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| Not yet recruiting | 1 | 40 | | Electrical stimulation of auriculae ;Electrical stimulation of the auricular rim | Guang'anmen Hospital of China Academy of Chinese Medical Sciences; Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Major Key Projects of Science and Technology Innovation Project of China Academy of Chinese Medical Sciences | depression | | | | |
ChiCTR2200060409: Problem management plus (PM+) intervention for depression in adolescents: an efficacy and mechanism study |
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| Recruiting | 1 | 200 | | Enhanced conventioal therapy ;PM+ psychological therapy intervention | Shenzhen Kangning Hospital; Shenzhen Kangning Hospital, Shenzhen Sanmin Project | depression | | | | |
ChiCTR2200066916: Clinical observation and mechanism of different body surface stimulation in the treatment of mild to moderate anxiety disorder |
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| Not yet recruiting | 1 | 66 | | Electric pulse stimulation of routine acupuncture at Neiguan point ;Electric pulse stimulation by shallow needling at Neiguan point | AMHT Group Aerospace 731 Hospital; AMHT Group Aerospace 731 Hospital, Capital Medical Development Research Fund 2022-3-6111 | Generalized anxiety disorder (GAD) | | | | |
ChiCTR2300074472: The mechanism and effect of virtual reality intervention for death anxiety of cancer patients based on acceptance and commitment therapy |
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| Not yet recruiting | 1 | 74 | | The virtual reality platform was used to implement the death anxiety acceptance and commitment therapy virtual reality platform intervention for 8 weeks, once a week, with one theme module each time, about 35-45 minutes each time. The intervention was conducted in a separate room in the project support unit to ensure that the environment was quiet and undisturbed. The staff consisted of a researcher, a graduate student, a virtual reality engineer and a medical staff. ;The control group adopted the standard control group, and received routine psychological care for cancer patients, including: using language or non-language communication skills, active psychological counseling for patients; Talk to the patient about topics of interest to promote relationships and distract attention; To meet the information needs of patients and their families, pay attention to their psychological state, encourage family members to accompany patients more, and increase social support; Different psychological nursing methods were adopted for patients with different ages, personalities, educational levels, social experiences and course of disease. | The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital; Hunan Cancer Hospital, Supported by the National Natural Science Foundation of China in 2021 | Cancer | | | | |