| Mood Disorders |
NCT06183580: Neurofeedback and Neural Plasticity of Self-Processing and Affect Regulation Circuits in Suicide Attempting Adolescents |
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| Completed | 1 | 90 | US | neurofeedback training involving dACC, neurofeedback training involving amygdala | University of Minnesota | Suicide, Attempted, Suicide, Ideation, Depression | 11/23 | 11/23 | | |
| Terminated | 1 | 3 | US | C-STRESS | Benten Technologies, Inc., University of California, Irvine, National Institute of Mental Health (NIMH) | Depression, Anxiety, Stress, Psychological, Mobile Phone Use | 05/22 | 05/22 | | |
ACTRN12621000160831: A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of GRX-917 in Healthy Subjects |
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| Completed | 1 | 76 | | | Gaba Therapeutics Australia Pty Ltd a subsidiary of Gaba Therapeutics, Inc, Gaba Therapeutics Australia Pty Ltd a subsidiary of Gaba Therapeutics, Inc | Anxiety | | | | |
ChiCTR2200058175: The effectiveness of mindful Tai Chi training on physical and mental health of college students |
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| Not yet recruiting | 1 | 119 | | Mindfull Tai chi ;Traditonal Tai chi | Sun Yat-Sen University; Sun Yat-Sen University, Sun Yat-Sen University | Anxiety | | | | |
| Completed | 1 | 19 | US | MBCT | Massachusetts General Hospital, National Institute on Aging (NIA) | Acute Coronary Syndrome, Coronary Artery Disease, Anxiety, Sleep | 06/22 | 06/22 | | |
ChiCTR2300074371: MBCT reduces interference of negative stimuli to working memory in subthreshold depressed individuals |
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| Completed | 1 | 42 | | MBCT+LKM ;see in study plan file | Dong Yang; Faculty of psychology, Southwest University, Fundamental Research Funds for the Central Universities | subclinical depression | | | | |
ChiCTR2100051542: To explore the effect of decompressing steamed stuffed bun on alleviating the anxiety of pregnant women during perioperative cesarean section |
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| Not yet recruiting | 1 | 120 | | Maternal pinching and decompressing steamed stuffed bun before and during operation ;No intervention | The First Affiliated Hospital of Shihezi University Medical College; The First Affiliated Hospital of Shihezi University Medical College, Institute level project | gestation | | | | |
NCT04861311: Testing the Efficacy of a Mindfulness- and Acceptance-Based Smartphone App for PTSD: A Randomized Controlled Trial |
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| Not yet recruiting | 1 | 64 | NA | Mindfulness/Acceptance-Based Smartphone App (MABSA) Intervention | University of Nevada, Las Vegas | Posttraumatic Stress Disorder | 06/22 | 06/22 | | |
ChiCTR2200061351: Effects of auricular acupressure on depression and anxiety in isolated COVID-19 patients: A single-blind randomized controlled trial |
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| Not yet recruiting | 1 | 68 | | Auricular acupressure on Shenmen, Subcortex, Liver and Endocrine ;Auricular acupressure on Knee, Wrist, Elbow, Shoulder | Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China, Shanghai University of Traditional Chinese Medicine | depression and anxiety of isolated COVID-19 patients | | | | |
ChiCTR2200061218: Internet-based psychoeducation intervention for depressive symptoms of adolescents: a randomized controlled trial |
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| Not yet recruiting | 1 | 60 | | watching video ;waiting | Peking University; Peking University, Peking University | depression | | | | |
NCT03367533: Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response |
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| Completed | 1 | 13 | US | Ketamine, Perampanel, Placebo | Yale University, National Institute of Mental Health (NIMH) | Depressive Disorder, Major, Bipolar Disorder, Post Traumatic Stress Disorder | 07/22 | 07/22 | | |
NCT03848715: Sleep and Healthy Aging Research on Depression for Younger Women |
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| Active, not recruiting | 1 | 40 | US | Endotoxin, Placebo | University of California, Los Angeles | Anhedonia, Depression | 07/22 | 05/24 | | |
NCT05321602: Study to Evaluate the PK Profiles of LY03010 in Patients With Schizophrenia or Schizoaffective Disorder |
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| Completed | 1 | 89 | US | LY03010 156 mg treatment group, deltoid, paliperidone palmitate, LY03010 156 mg treatment group, gluteal, LY03010 351 mg treatment group, deltoid, LY03010 351 mg treatment group, gluteal | Luye Pharma Group Ltd. | Schizophrenia, Psychotic Disorders, Mood Disorders, Schizophrenia Spectrum and Other Psychotic Disorders, Mental Disorders, Antipsychotic Agents, Tranquilizing Agents, Central Nervous System Depression, Physiological Effects of Drugs, Psychotropic Drugs, Neurotransmitter Agents, Molecular Mechanisms of Pharmacological Action | 09/22 | 10/22 | | |
NCT04777110: The Effectiveness and Safety of Esketamine in Modified Electroconvulsive Therapy |
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| Not yet recruiting | 1 | 396 | NA | Esketamine, Saline | First Affiliated Hospital of Chongqing Medical University | Esketamine, ECT, Depression | 08/22 | 12/22 | | |
ChiCTR2200057637: Personalized functional connectivity guided rTMS treatment for adolescent patients with major depressive disorder |
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| Not yet recruiting | 1 | 60 | | pgACC FC-guided iTBS ;classical coordinate guided iTBS | The Affiliated Hospital of Hangzhou Normal University; The Affiliated Hospital of Hangzhou Normal University, Key Medical Discipline of Hangzhou | MDD | | | | |
ChiCTR2200057947: Administration of S(+)-ketamine during induction on anxiety, depression and immunology function in patients undergoing radical mastectomy |
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| Not yet recruiting | 1 | 80 | | 0.3 mg/kg s-esketamine ;0.3 ug/kg sufentanil | The Third Affiliated Hospital of Sun Yat-sen University; The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Pharmaceutical Association | Breast cancer | | | | |
IMPACT, NCT02415387: Typhoid Vaccine in Testing Response to Immune Stress in Patients With Stage I-IIIA Breast Cancer |
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| Active, not recruiting | 1 | 209 | US | typhoid vaccine, Placebo, PLCB | Ohio State University Comprehensive Cancer Center | Cognitive Side Effects of Cancer Therapy, Depression, Recurrent Breast Carcinoma, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage IIA Breast Cancer, Stage IIB Breast Cancer, Stage IIIA Breast Cancer | 09/22 | 09/22 | | |
NCT05417087: Single Dose Oral Bioequivalence Study of Vortioxetine Hemihydrobromide Orally Disintegrating Tablets |
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| Completed | 1 | 48 | RoW | Vortioxetine Hemihydrobromide Orally Disintegrating Tablets, SF001 ODT, Vortioxetine Hydrobromide Tablets, Trintellix | Seasons Biotechnology (Taizhou) Co., Ltd. | Major Depressive Disorder (MDD) | 09/22 | 09/22 | | |
NCT05157035: Testing a Mindfulness/Acceptance-Based Smartphone App for Nurses Impacted by the COVID-19 Pandemic |
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| Not yet recruiting | 1 | 60 | NA | Mindfulness/Acceptance-Based Smartphone App (MABSA) | University of Nevada, Las Vegas | Posttraumatic Stress Disorder | 10/22 | 10/22 | | |
NCT05416957: Food Effect Bioavailability Study of Vortioxetine Hemihydrobromide Orally Disintegrating Tablets |
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| Completed | 1 | 24 | RoW | Vortioxetine Hemihydrobromide Orally Disintegrating Tablets, SF001 ODT | Seasons Biotechnology (Taizhou) Co., Ltd. | Major Depressive Disorder (MDD) | 10/22 | 10/22 | | |
NCT06258031: PsilOCD: A Pharmacological-Challenge Feasibility Study |
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| Recruiting | 1 | 20 | Europe | Psilocybin (COMP360), O-phosphoryl-4-hydroxy-N,N-dimethyltryptamine | Imperial College London | Obsessive-Compulsive Disorder | 06/24 | 07/24 | | |
ChiCTR2200062320: Influence of epidural labor analgesia combined with intravenous administration of esketamine on postpartum depression: a randomized controlled trial |
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| Not yet recruiting | 1 | 334 | | infusion of s-ketamine | Affiliated Hospital of Southwest Medical University; Affiliated Hospital of Southwest Medical University, self-payinbg | postpartum depression | | | | |
| Recruiting | 1 | 80 | US | Estradiol, Estrace, Placebo | NYU Langone Health | Stress Disorders, Post-Traumatic, Healthy | 11/22 | 11/22 | | |
NCT04876066: Use of Transmucosal Ketamine in Post Stroke Depression |
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| Recruiting | 1 | 21 | US | Ketamine | West Virginia University | Post-stroke Depression | 11/22 | 11/22 | | |
NCT05121831: A First in Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of DGX-001 |
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| Completed | 1 | 68 | RoW | DGX-001Dose 1, DGX-001, DGX-001 Dose 2, DGX-001 Dose 3, DGX-001 Dose 4, MAD dose panel of DGX-001 | Digestome Therapeutics | Depressive Disorder | 11/22 | 11/22 | | |
NCT05429788: Safety, Tolerability, and Efficacy of RLS103 in Subjects With Acute Anxiety Within Social Anxiety Disorder (SAD) |
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| Withdrawn | 1 | 40 | US | Low dose RLS103, High dose RLS103, placebo inhaled dry powder | Receptor Life Sciences | Social Anxiety Disorder | 11/22 | 11/22 | | |
| Completed | 1 | 8 | US | Psilocybin and Midazolam, Psilocybine, Psilocibin, benzodiazepine | University of Wisconsin, Madison | Psychedelic Experiences, Amnesia | 11/22 | 11/22 | | |
NCT05416762: Single Dose Study to Evaluate Dose-proportionality of Vortioxetine Hemihydrobromide Orally Disintegrating Tablets |
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| Completed | 1 | 30 | RoW | Vortioxetine Hemihydrobromide Orally Disintegrating Tablets 5mg, SF001 ODT 5mg, Vortioxetine Hemihydrobromide Orally Disintegrating Tablets 10mg, SF001 ODT 10mg, Vortioxetine Hemihydrobromide Orally Disintegrating Tablets 20mg, SF001 ODT 20mg | Seasons Biotechnology (Taizhou) Co., Ltd. | Major Depressive Disorder (MDD | 11/22 | 11/22 | | |
| Completed | 1 | 11 | US | Transcranial Electrical Stimulation (tES), Transcranial Direct Current Stimulation (tDCS) | Northwestern University, Brain & Behavior Research Foundation | Depression | 11/22 | 11/22 | | |
NCT05251779: A Clinical Study on the Effects of Inhalation of Volatile Oil of Cang-Ai Via the Nose on Patients With Depression |
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| Not yet recruiting | 1 | 60 | NA | Volatile Oil of Cang-Ai, CAVO, Bergamot essential oils, Citrus bergamia | Jieqiong Cui | Depressive Disorder, Mental Disorder in Adolescence | 12/22 | 12/22 | | |
| Not yet recruiting | 1 | 160 | NA | Cannabidiol Oral Product, Placebo | University of Connecticut | Anxiety and Fear | 12/24 | 02/25 | | |
NCT04525222: mHealth Mood Management Tool (Actify) to Improve Population-Level Smoking Cessation |
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| Completed | 1 | 242 | US | Health Promotion and Education, Smoking Cessation Intervention (Actify app), Smoking and Tobacco Use Cessation Interventions, Smoking Cessation Intervention (Current Standard Care app), Survey Administration | Fred Hutchinson Cancer Center, National Institute on Drug Abuse (NIDA) | Cigarette Smoking-Related Carcinoma | 12/22 | 04/23 | | |
| Active, not recruiting | 1 | 12 | RoW | [18F] PI-2620 Tau Ligand | Macquarie University, Australia, Omniscient Neurotechnology, Life Molecular Imaging GmbH | Chronic Traumatic Encephalopathy, Traumatic Encephalopathy, Head Injury Trauma, Cognitive Impairment, Neurodegenerative Diseases | 05/23 | 12/24 | | |
NCT05189977: A Trial to Assess the Effects of Prazosin or Propranolol on Blood Pressure in the Presence of Brexpiprazole/Sertraline |
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| Terminated | 1 | 34 | US | Propranolol, Prazosin | Otsuka Pharmaceutical Development & Commercialization, Inc., Iqvia Pty Ltd | Post-traumatic Stress Disorder (PTSD) | 08/23 | 08/23 | | |
ChiCTR2200057820: The effect of virtual reality-based cognitive training system and eye movement desensitization and reprocessing system in depressed patients |
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| Recruiting | 1 | 400 | | VR-based cognitive training ;VR-based EMDR ;VR-based cognitive training ;VR-based cognitive training+VR-based EMDR ;Treatment as usal ;Treatment as usal ;VR-based EMDR ;CCRT intervention | First Affiliated Hospital of Jinan University; First Affiliated Hospital of Jinan University, National Natural Science Foundation of China (No:81801347), Science And Technology Planning Project of Guangdong Province, China (No:2017B020227011) | Depression | | | | |
NCT03623711: A Prediction Study of Multiple Indexes of the Effect of Different Mechanisms of Antidepressants Treatment on Depression |
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| Recruiting | 1 | 200 | RoW | Escitalopram, Lexapro, Duloxetine, cymbalta, Bupropion, bupropion hydrochloride tablets, Healthy control, placebo tablets | Yuqi Cheng | Major Depressive Disorder, Depression, Unipolar | 12/22 | 12/22 | | |
ChiCTR2100046542: Clinical trial of Topia Stress-Free Capsule in improving depressive state |
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| Recruiting | 1 | 240 | | Topia Stress-freeCapsule 1 capsule, orally taken twice daily for two months ;Delexin 1 capsule, orally taken twice daily for two months ;Topia Stress-freeCapsule 1 capsule and Delexin 1 capsule, orally taken twice daily for two months | The 960th Hospital of PLA (Zibo Hospital); The 960th Hospital of PLA (Zibo Hospital), Qilu Medical University | Depression | | | | |
ChiCTR2100050345: Risk investigation and intervention study of metabolic syndrome in patients with bipolar disorder |
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| Not yet recruiting | 1 | 60 | | Tai Ji Chuan, Wuqinxi, healthy and balanced diet ;Metformin and statins as lipid regulators | Suzhou Second People's Hospital; Suzhou Second People's Hospital, Provincial government funding | Bipolar Disorder | | | | |
| Completed | 1 | 73 | US | Drug: CVL-354, Drug: Placebo | Cerevel Therapeutics, LLC | Major Depressive Disorder | 01/23 | 01/23 | | |
ChiCTR2200064585: Effects of positive psychology of writing and expression on optimism and coping style of newly diagnosed HIV/AIDS patients |
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| Not yet recruiting | 1 | 84 | | Positive psychology of writing expression ;Routine health education | The Public Health Clinical Center of Chengdu; The Public Health Clinical Center of Chengdu, Project of Sichuan Provincial Health Commission in 2020 | HIV/AIDS | | | | |
ChiCTR2200057864: A clinical research based on multi-fMRI of acupuncture combined with SSRIs treating major depressive disorder |
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| Recruiting | 1 | 90 | | Acupuncture ;sham acupuncture | Shuguang Hospital Attached with Shanghai Chinese Medicine University; Shuguang Hospital Attached with Shanghai Chinese Medicine University, Shanghai Health Care Commission | Major Depression Disorder | | | | |
ChiCTR2200064523: The effect of mindfulness training on competition anxiety of athletes |
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| Not yet recruiting | 1 | 60 | | mindfulness training ;No intervention | Beijing Sport University; Beijing Sport University, the Fundamental Research Funds for the Central Universities of China | other | | | | |
NCT04597450: Lu AG06466 in Participants With Post Traumatic Stress Disorder (PTSD) |
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| Completed | 1 | 35 | US | Lu AG06466, Placebo | H. Lundbeck A/S | PTSD | 02/23 | 02/23 | | |
| Completed | 1 | 27 | Europe | Naltrexone, Placebo, Ketamine | King's College London | Depressive Disorder, Treatment-Resistant | 02/23 | 02/23 | | |
NCT03279393: PPG Project 3 - PET/MRI of the Brain-hematopoiesis-atherosclerosis Axis in PTSD Patients |
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| Completed | 1 | 190 | US | fluorodeoxyglucose (FDG)-PET/MRI | Zahi Fayad, Massachusetts General Hospital, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH) | PTSD, Trauma, Healthy | 02/23 | 02/23 | | |
ChiCTR2200063681: Application of ultrasound-guided anterior nerve block in hospital emergency treatment under the background of trauma center interaction |
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| Not yet recruiting | 1 | 120 | | Ultrasound guided anterior nerve block at the trauma center ;After complete examination and preparation, ultrasound-guided nerve block was performed in the operating room ;Ultrasound guided nerve block group requiring moving position | The Second Affiliated Hospital of Jiaxing University; The Second Affiliated Hospital of Jiaxing University, Zhejiang medical and health science and technology plan | Traumatic pain | | | | |
| Not yet recruiting | 1 | 40 | NA | Orgasmic Meditation | Institute of OM Foundation | PTSD | 03/23 | 03/23 | | |
| Completed | 1 | 96 | RoW | HS-10353, HS-10353 capsules, Placebo, HS-10353 placebo | Jiangsu Hansoh Pharmaceutical Co., Ltd. | Major Depressive Disorder | 03/23 | 03/23 | | |
NCT04451187: A Study of Oral Seltorexant as an add-on Medication to an Antidepressant on On-road Driving Performance in Participants With Major Depressive Disorder |
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| Completed | 1 | 63 | Europe | Seltorexant Dose 1, JNJ-42847922, Seltorexant Dose 2, Placebo, Zopiclone | Janssen Research & Development, LLC | Depressive Disorder, Major | 03/23 | 03/23 | | |
ACTRN12622000713796: A Double-Blind, Randomized, Placebo-Controlled Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Single, Ascending, Subcutaneous Doses of FT-104 HCl In Healthy Volunteers
Safety, Tolerability, and Pharmacokinetics of Subcutaneous FT-104 HCl (SAIL-101)
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| Completed | 1 | 48 | | | Field Trip Psychedelics Inc, Field Trip Psychedelics Inc | Post Partum Depression
, Treatment Resistant Depression | | | | |
NCT04950868: The Safety, Tolerability, and Effectiveness of Quetiapine in Postpartum Depression |
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| Recruiting | 1 | 30 | Canada | Quetiapine | Verinder Sharma | Postpartum Depression | 03/23 | 12/24 | | |
ChiCTR2300071340: Study on Individual and Group Intervention Models of Yishu Psychodrama Technology in the Treatment and Rehabilitation of Outpatient Depression |
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| Completed | 1 | 50 | | Yi Shu psychodrama treatment ;first-line antidepressant (escitalopram oxalate) treatment | The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, Chongqing Technology Innovation and Application Demonstration Project | Depression | | | | |
NCT05597241: Multiple Ascending Dose and Electroencephalography Trial of GATE-202 in Healthy Volunteers |
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| Completed | 1 | 40 | US | apimostinel, GATE-202, Placebo | Gate Neurosciences, Inc | Major Depressive Disorder | 04/23 | 04/23 | | |
NCT05644093: IM and IV SPL026 Drug Product in Healthy Participants |
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| Completed | 1 | 14 | Europe | SPL026 IV, DMT, SPL026 IM | Small Pharma Ltd | Major Depressive Disorder | 04/23 | 04/23 | | |
ChiCTR2200059232: A study based on the influence of head-mounted personalized immersion experience on perioperative anxiety and resuscitation of children |
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| Not yet recruiting | 1 | 120 | | Language to placate ;Personalized immersion experience ;animated video | The Second Affiliated Hospital of Anhui Medical University; The Second Affiliated Hospital of Anhui Medical University, self-financing | Children delirium | | | | |
NCT04711005: Phase 1 Evaluation of (2R,6R)-Hydroxynorketamine |
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| Completed | 1 | 74 | US | (2R,6R)-Hydroxynorketamine hydrochloride, Placebo | National Institute of Mental Health (NIMH) | Major Depressive Disorder | 04/23 | 05/23 | | |
NCT05680584: Comparison Between Oral Melatonin and Hydroxyzine in Pediatric Patients Undergoing Adenotonsillectomy |
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| Recruiting | 1 | 78 | RoW | Melatonin 3 MG, Melatonin, Hydroxyzine Pill, Atarax 10mg, Placebo | Minia University | Effect of Drug, Anxiety | 01/24 | 01/24 | | |
NCT04827056: Effect of Sublingual Formulation of Dexmedetomidine HCl (BXCL501) - Alcohol Interaction Study |
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| Completed | 1 | 10 | US | Placebo, Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg, BXCL501 40µg, Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 80µg, BXCL501 80µg, Ethanol Infusion, PTSD Reactivity Condition, Alcohol Cue Reactivity | Pharmacotherapies for Alcohol and Substance Use Disorders Alliance, United States Department of Defense, Congressionally Directed Medical Research Programs, RTI International, VA Connecticut Healthcare System, BioXcel Therapeutics Inc, Yale University | Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD) | 05/23 | 06/23 | | |
NCT05426746: First-In-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALT-100 |
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| Completed | 1 | 32 | RoW | ALT-100, Normal Saline | Aqualung Therapeutics Corp. | ARDS, Human | 05/23 | 05/23 | | |
| Active, not recruiting | 1 | 80 | US | Lipopolysaccharide, LPS | Yale University, National Institute of Mental Health (NIMH) | Post Traumatic Stress Disorder | 05/23 | 09/24 | | |
| Completed | 1 | 160 | US | Endotoxin, Placebo | Michael Irwin, MD | Depression in Old Age | 04/24 | 04/24 | | |
ChiCTR2300072167: Effect of Esketamine on analgesic and anti-depression in patients after laparoscopic resection of gastric carcinoma |
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| Completed | 1 | 124 | | Normal saline was used for control during perioperative period ;Esketamine was used perioperatively | The First Affiliated Hospital of Wenzhou Medical University; The First Affiliated Hospital of Wenzhou Medical University, Zhejiang Health Office [2020] No. 18-9 [Talent Management] 2020 Zhejiang Medical Talent | Gastric cancer | | | | |
ChiCTR2200057944: Clinical effect of transcranial alternating-current stimulation on depression and anxiety in perimenopausal woman |
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| Recruiting | 1 | 150 | | real stimulus ;sham stimulus | The Second Xiangya Hospital of Central South University; The Second Xiangya Hospital of Central South University, National Natural Science Foundation of China | Depression and anxiety | | | | |
NCT03671746: Inflammatory Markers in Trauma Patient Outcomes |
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| Completed | 1 | 70 | US | Ketorolac, Toradol, Saline Solution, Normal Saline | Arun Aneja | Polytrauma | 06/23 | 06/23 | | |
| Completed | 1 | 12 | Canada | D-cycloserine, Seromycin, Transcranial Magnetic Stimulator | University of Calgary | Major Depressive Disorder | 06/23 | 06/23 | | |
ChiCTR2000040441: Tiao Shen Shu Gan acupuncture treatment for post stroke depression: A randomized, parallel and controlled trial |
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| Not yet recruiting | 1 | 114 | | Acupuncture treatment of Tiao Shen Shu Gan ;Common acupuncture treatment ;Sham acupuncture treatment | Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai Municipal Health Commission | post stroke depression | | | | |
ChiCTR2200060598: Effectiveness of the self-determination based intervention in the nursing home residents with depression: a randomized controlled trials |
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| Not yet recruiting | 1 | 60 | | Physical activity intervention based on the self-determination theory ;General physical activity intervention | Shenyang Medical College; The First Hospital of China Medical University, Natural Science Foundation of Liaoning Province | Depression disorder | | | | |
NCT05905120: Assessing Dopamine Transporter Occupancy in the Healthy Adult Brain With Toludivenlafaxine Hydrochloride Extended-Release Tablets Using 11C-CFT Positron Emission Tomography (PET) |
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| Completed | 1 | 6 | RoW | Toludivenlafaxine hydrochloride sustained-release tablets | Shanghai Mental Health Center, Yantai University | Major Depressive Disorder | 06/23 | 07/23 | | |
NCT05872087: Comparative Study Between Nebulised Dexmedetomidine and Nebulised Midazolam in Children Undergoing Lower Abdominal Surgeries |
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| Completed | 1 | 60 | RoW | Nebulised Dexmeditomidine, premedication by nebulised dexmeditomidine, Nebulised Midazolam, Premedication by nebulised midazolam | Ain Shams University | Emergence Delirium, Anxiety Preoperative | 09/23 | 02/24 | | |
| Not yet recruiting | 1 | 60 | | Liuzijue Qigong ;blank control | Beijing University of Traditional Chinese Medicine; Beijing University of Traditional Chinese Medicine, Fundamental Research Funds for Beijing University of Traditional Chinese Medicine | subthreshold depression | | | | |
| Recruiting | 1 | 40 | RoW | Electroconvulsive therapy | Charles University, Czech Republic | Major Depressive Disorder, Bipolar Depression | 07/23 | 01/24 | | |
ACTRN12622001335785: Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-Ascending Doses of EMP-01 in Healthy Adult Volunteers |
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| Completed | 1 | 32 | | | EmpathBio Australia Pty. Ltd. , EmpathBio Australia Pty. Ltd. | Post-traumatic stress disorder (PTSD) | | | | |
NCT06242535: Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With Obesity |
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| Active, not recruiting | 1 | 40 | US | GLY-LOW, GLYLO | Hoskinson Health and Wellness Clinic, Buck Institute for Research on Aging, University of Wyoming | Insulin Resistance, Obesity, Cardiovascular Diseases, Cognitive Impairment, Physical Disability, Depression, Inflammation, Hormone Deficiency, Physical Inactivity, Hyperlipidemias, Hypertension, Overeating | 07/24 | 07/24 | | |
NCT05299398: Prevention of Postpartum Depression: A Pilot Placebo-controlled Trial of Trazodone |
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| Not yet recruiting | 1 | 28 | Canada | Trazodone, Placebo | Verinder Sharma | Postpartum Depression | 07/23 | 03/24 | | |
ChiCTR2300070984: Personalized functional connectivity guided rTMS treatment for adolescent patients with major depressive disorder |
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| Not yet recruiting | 1 | 10 | | A group of subjects received the "psychotherapy" intervention and the "anterior cingulate gyrus functional connectivity positioning" intervention, respectively, using an ABBA design to balance the sequential effects. | The Affiliated Hospital of Hangzhou Normal University; The Affiliated Hospital of Hangzhou Normal University, Key Medical Discipline of Hangzhou | MDD | | | | |
NCT05195125: Use of Direct Peritoneal Resuscitation in High-risk Liver Transplant Recipients |
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| Active, not recruiting | 1 | 15 | US | Direct Peritoneal Resuscitation | University of Colorado, Denver | End Stage Liver DIsease, Obesity, Acute Kidney Injury | 08/23 | 12/23 | | |
| Withdrawn | 1 | 20 | NA | Psilocybin, Melocin, Inonotus Obliquus Whole Extract, Chaga | Optimi Health Corporation, University of Calgary | Mood Disturbance, Mood Change, Sleep Disturbance, Drug Effect, Psychedelic Experiences, Health, Subjective, Psilocin Toxicity, Psilocybin Toxicity, Psilocybin Causing Adverse Effects in Therapeutic Use, Anxiety | 08/23 | 12/23 | | |
ChiCTR2300070335: Clinical application of EMAC comprehensive intervention for post-stroke depression |
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| Not yet recruiting | 1 | 48 | | EMAC comprehensive intervention ;usual care | the first affiliated Hospital of Zhejiang Chinese Medical University; the first affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Medical and Health Science and Technology Program | Post-stroke depression | | | | |
NCT05553691: SPL026 With or Without SSRIs in Participants With MDD |
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| Completed | 1 | 18 | Europe | SPL026, N,N-dimethyltryptamine, DMT | Small Pharma Ltd | Major Depressive Disorder | 08/23 | 08/23 | | |
ChiCTR2200062241: Safety and pharmacokinetic/pharmacodynamic studies of dexmedetomidine hydrochloride nasal spray in healthy adult volunteers |
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| Not yet recruiting | 1 | 48 | | 25μg, two cycles, two crosses ;50μg, 10 patients (5 men and 5 women) received the experimental drug, and 2 patients (1 man and 1 woman) received placebo ;75μg, 10 patients (5 men and 5 women) received the experimental drug, and 2 patients (1 man and 1 woman) received placebo ;100μg, 10 patients (5 men and 5 women) received the experimental drug, and 2 patients (1 man and 1 woman) received placebo | Xiangya Third Hospital, Central South University; Xiangya Third Hospital, Central South University, Yichang Renfu Pharmaceutical Co., Ltd. | preoperative anxiety | | | | |
NCT04937829: A Study to Test How Well Different Doses of BI 1569912 Are Tolerated and How Well They Work in People With Depression Who Take Anti-depressive Medication |
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| Completed | 1 | 59 | US | BI 1569912, Placebo | Boehringer Ingelheim | Depressive Disorder, Major | 11/23 | 11/23 | | |
ChiCTR2300068244: Different doses of intermittent theta-burst stimulation on mood disorders |
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| Not yet recruiting | 1 | 200 | | intermittent theta-burst stimulation ;intermittent theta-burst stimulation | the Second Xiangya Hospital of Central South University; the Second Xiangya Hospital of Central South University, Natural Science Foundation of Hunan, China | Mood disorders | | | | |
| Completed | 1 | 21 | US | Repetitive Transcranial Magnetic Stimulation (rTMS) | VA Office of Research and Development | Mental Health, Depression, rTMS, Anxiety, PTSD, Psychosocial Impairment | 08/23 | 10/23 | | |
PEARL-1, NCT04540900: A Phase I Study of KB301, a Replication-Incompetent, Non-Integrating Vector Expressing Human Type III Collagen (COL3) for the Treatment of Superficial Skin Depressions |
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| Recruiting | 1 | 85 | US | KB301, Placebo | Krystal Biotech, Inc. | Skin Roughness, Wrinkle, Fine Lines, Skin Thickness | 05/24 | 05/29 | | |
ChiCTR2200059071: The effect of music therapy combined with aroma therapy on the anxiety of patients undergoing MRI examination |
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| Not yet recruiting | 1 | 200 | | Routine care ;Routine care + music therapy ;Routine care + aromatherapy ;Routine care + music therapy + aromatherapy | The First People's Hospital of Zunyi; The First People's Hospital of Zunyi, Project funding | MRI examination of anxious patients | | | | |
NCT05789186: Clinical Study of Cang Ai Volatile Oil (CAVO) on Mild to Moderate Depression in Children and Adolescents |
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| Recruiting | 1 | 108 | RoW | CAVO aromatherapy patch at 3% concentration+Fluoxetine hydrochloride mimetic, Fluoxetine hydrochloride tablet+CAVO aromatherapy patch at 0.1% concentration, Fluoxetine hydrochloride mimetic+CAVO aromatherapy patch at 0.1% concentration | Chen Qian | Depression | 09/23 | 01/24 | | |
NCT05470465: Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) and an Opioid on Ventilation |
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| Completed | 1 | 27 | US | Placebo and Oxycodone, Paroxetine and Oxycodone, Escitalopram and Oxycodone | Food and Drug Administration (FDA), Spaulding Clinical Research LLC, Leiden University | Hypercapnia, Ventilatory Depression | 09/23 | 09/23 | | |
| Recruiting | 1 | 65 | Europe | Ketamine Hydrochloride, Racemic ketamine (R, S)-Ketamine, Esketamine, (S)-Ketamine, Placebo, saline solution, Pilot study II: Esketamine, Pilot study II: Placebo, Saline solution | Medical University of Vienna | Major Depressive Disorder | 03/25 | 03/25 | | |
ChiCTR2100045639: Comparison of Brain State Indexes of Pain and Anxiety of Primipara under Labor Analgesia during Latent Period and Active Period |
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| Recruiting | 1 | 321 | | No epidural analgesia ;epidural analgesia started from latent phase ;Epidural analgesia started from active phase | Maternal and Child Health Care Hospital of Shanghai Jiading; Maternal and Child Health Care Hospital of Shanghai Jiading, Shanghai Jiading District Health Committee | Perinatal anxiety | | | | |
NCT05347199: Effects of a Single Dose of Amisulpride on Functional Brain Changes |
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| Completed | 1 | 127 | Europe | Amisulpride Pill, Placebo | Simone Grimm, Charité Research Organisation GmbH, Boehringer Ingelheim | Major Depressive Disorder | 09/23 | 09/23 | | |
NCT04449211: The Effectiveness in the Treatment of Long Bone Defect Using 3D-printed Implant |
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| Recruiting | 1 | 10 | RoW | Implantation, Bone defect implant | Cho Ray Hospital, Commonwealth Scientific and Industrial Research Organisation, Australia, 3 Dimensional Tech Vision Limited Company | Bone Loss, Defect Limb | 10/23 | 12/23 | | |
| Recruiting | 1 | 15 | US | Ketamine Infusion plus RO DBT | Washington University School of Medicine | Treatment Resistant Depression | 05/25 | 05/25 | | |
NCT06274008: Exparel vs. ACB With Bupivacaine for ACL Reconstruction |
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| Recruiting | 1 | 96 | US | Exparel | Children's Hospital of Orange County | ACL Tear, Opioid Misuse, Pain, Anxiety | 10/24 | 12/24 | | |
ChiCTR2300072805: Clinical efficacy of sleep deprivation in the treatment of major depressive disorder |
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| Recruiting | 1 | 60 | | A night of sleep deprivation + Antidepressants ;Antidepressants | The Second Affiliated Hospital of Xinxiang Medical University; The Second Affiliated Hospital of Xinxiang Medical University, no | major depressive disorder | | | | |
| Active, not recruiting | 1 | 15 | US | Psilocybin 100 mcg/kg, Psilocybine, "magic mushrooms", Psilocybin 300 mcg/kg, Lorazepam 1 mg, Ativan, Intensol | University of Arizona | Obsessive-compulsive Disorder (OCD) | 10/23 | 12/23 | | |
NCT05051449: Ketamine for OUD and Comorbid Depression (OUDCD) |
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| Terminated | 1 | 5 | US | Ketamine Hydrochloride | University of Maryland, Baltimore | Opioid Use Disorder, Depressive Disorder | 11/23 | 11/23 | | |
NCT05666687: An Open-label, Adaptive Design, Positron Emission Tomography Study in Healthy Male Participants to Characterize Receptor Occupancy by MIJ821 in the Brain |
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| Completed | 1 | 10 | Europe | MIJ821 | Novartis Pharmaceuticals | Major Depressive Disorder | 11/23 | 11/23 | | |
| Completed | 1 | 41 | RoW | BRII-297, Escalating doses of BRII-297, Placebo, Placebo to match | Brii Biosciences Limited | Postpartum Depression | 11/23 | 01/24 | | |
ChiCTR2300072079: Individualized transcranial magnetic stimulation based on resting-state functional magnetic resonance-guided precision targeting for monophasic and biphasic depression-an open study |
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| Recruiting | 1 | 20 | | Functional connection location and classical coordinate location of anterior knee cingulate gyrus were randomly assigned. | The Affiliated Hospital of Hangzhou Normal University; The Affiliated Hospital of Hangzhou Normal University, Key Medical Discipline of Hangzhou | monophasic and biphasic depression | | | | |
NCT03573349: Ketamine Associated ACC GABA and Glutamate Change and Depression Remission: |
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| Active, not recruiting | 1 | 18 | US | Ketamine | Mayo Clinic | Major Depressive Disorder, Treatment Resistant Depression, Bipolar Depression | 12/26 | 12/26 | | |
