| tenofovir disoproxil fumarate / Generic mfg. |
ACTRN12611001236987: Asses the safety and efficacy of switching to tenofovir and lamivudine therapy in patients who have been receiving Hepatitis B Immunoglobulin and lamivudine prophylasix post liver transplant. |
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| Recruiting | 4 | 40 | | | Professor Peter Angus | prevent Hepatitis B virus re-infection following liver transplantation with the use of tenofovir and lamivudine, withdrawing HBIG. | | | | |
ACLF, NCT01074645: Randomized Controlled Trial of Tenofovir in Patients of Reactivation of Hepatitis B Presenting as Acute on Chronic Liver Failure |
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| Completed | 4 | 27 | RoW | Tenofovir disoproxil fumarate (TDF) | Govind Ballabh Pant Hospital | Acute on Chronic Liver Failure, Hepatitis B | 06/09 | 10/09 | | |
NCT00662545: Entecavir Intensification for Persistent HBV Viremia in HIV-HBV Infection |
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| Completed | 4 | 10 | US | Entecavir with continued standard of care antiretroviral therapy, Baraclude, Tenofovir, Truvada, Viread, 3TC, FTC, Epivir, Emtriva, continued standard of care with tenofovir in addition to emtricitabine or lamivudine, Tenofovir, Truvada, Viread, 3TC, FTC, Epivir, Emtriva | University of California, San Francisco, Bristol-Myers Squibb | HIV Infections, Hepatitis B | 02/10 | 05/10 | | |
NCT00736190: A Study to Evaluate Tenofovir Disoproxil Fumarate (DF) in Asian-American Adults With Chronic Hepatitis B Infection |
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| Completed | 4 | 90 | US | Tenofovir disoproxil fumarate, Viread | Gilead Sciences | Chronic Hepatitis B | 07/10 | 07/10 | | |
NCT00651209 / 2007-004845-14: A Single-arm Study Evaluating the Efficacy and Safety of Telbivudine With or Without add-on Tenofovir in Adults With HBeAg-positive Chronic Hepatitis B (CHB) |
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| Completed | 4 | 105 | Europe, RoW | Tenofovir, Sebivo, Tyzeka, Viread | Novartis Pharmaceuticals | Hepatitis B, Chronic | 12/11 | | | |
NCT01588912: Efficacy of Telbivudine With or Without add-on Tenofovir According to Roadmap Strategy Compare With Entecavir |
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| Unknown status | 4 | 104 | RoW | Telbivudine, Sebivo, Tenofovir, Viread, Entecavir, Baraclude | Pusan National University Yangsan Hospital | Chronic Hepatitis B | 12/13 | 12/14 | | |
NCT01594905: Entecavir Plus Tenofovir Combination in Subjects With Multi-drug Resistant Chronic Hepatitis B Virus Infection |
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| Unknown status | 4 | 90 | NA | Entecavir + Tenofovir (MDR group), Entecavir 1.0mg - Braclude, Tenofovir 300mg - Viread | Yonsei University, Bristol-Myers Squibb, Seoul St. Mary's Hospital, The Catholic University of Korea | Chronic Hepatitis B | 04/14 | 04/14 | | |
NCT01488526: Tenofovir in Late Pregnancy to Prevent Vertical Transmission of Hepatitis B Virus |
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| Completed | 4 | 200 | RoW | TDF treatment, Viread, Tenofovir, TDF, Hepatitis B-IgG, Hepatitis B vaccine | New Discovery LLC, Gilead Sciences | Hepatitis B Infection, Chronic Infection, Viremia | 04/14 | 06/18 | | |
NCT01597934: Antiviral Efficacy of Switching to ETV Plus TDF |
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| Unknown status | 4 | 104 | NA | Group A (Zeffix, Sebivo, Hepsera), Zeffix, Sebivo, Hepsera, Group B (Baraclude, Viread), Baraclude, Viread | Yonsei University, Bristol-Myers Squibb, Seoul St. Mary's Hospital, The Catholic University of Korea, Soonchunhyang University Hospital, Pusan National University Hospital, Kyungpook National University Hospital, Hallym University Medical Center, Chonbuk National University Hospital | Chronic Hepatitis B | 05/14 | 05/14 | | |
NCT01277601 / 2010-024586-45: Efficacy & Safety of Tenofovir Disoproxil Fumarate (TDF) Plus Peginterferon α-2a (Peg-IFN) Versus TDF or Peg-IFN Monotherapy in Chronic Hepatitis B |
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| Completed | 4 | 751 | US, Canada, Europe, RoW | TDF, Viread®, Peg-IFN, Pegasys® | Gilead Sciences | Chronic Hepatitis B | 08/14 | 07/15 | | |
NCT01711567: Tenofovir Disoproxil Fumarate vs. Entecavir in Chronic Hepatitis B Patients With Partial Virologic Response to Entecavir |
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| Completed | 4 | 60 | RoW | tenofovir, tenofovir (viread), entecavir, entecavir(baraclude) 0.5 mg qd | Korea University, Gilead Sciences | Chronic Hepatitis B | 12/15 | 11/16 | | |
2011-000629-55: CLINICAL TRIAL WITH TENOFOVIR VERSUS LAMIVUDINE PLUS ADEFOVIR DIPIVOXIL IN LAMIVUDINE-RESISTANT CHRONIC HEPATITIS-B PATIENTS WITH UNDETECTABLE VIRAL LOAD ENSAYO CLÍNICO DE SIMPLIFICACIÓN CON TENOFOVIR EN PACIENTES CON HEPATITIS CRÓNICA B RESISTENTES A LAMIVUDINA Y CARGA VIRAL INDETECTABLE EN TRATAMIENTO CON LAMIVUDINA MÁS ADEFOVIR DIPIVOXIL (Estudio TENOSIMP-B) |
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| Ongoing | 4 | 100 | Europe | VIREAD, ZEFFIX, HEPSERA, J05AF07, VIREAD, ZEFFIX, HEPSERA, VIREAD, ZEFFIX, HEPSERA | Manuel Rodríguez García, Gilead Sciences, Inc. | CHRONIC HEPATITIS B HEPATITIS CRÓNICA B | | | | |
2011-000905-30: CLINICAL TRIAL WITH PROPHYLACTIC TENOFOVIR FOR HAEMATOLOGICAL CANCER PATIENTS SHOWING A HBc-Ab POSITIVE AND HBs-Ag PATTERN AND TO BE TREATED WITH RITUXIMAB (PREBLIN STUDY) ENSAYO CLÍNICO DE TENOFOVIR EN PROFILAXIS DE PACIENTES HEMATOLÓGICOS ANTI-HBc POSITIVO Y AgHBs NEGATIVO EN TRATAMIENTO CON RITUXIMAB (Estudio PREBLIN) |
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| Ongoing | 4 | 98 | Europe | VIREAD, J05AF07, VIREAD, VIREAD | Rafael Esteban Mur, Gilead Sciences, Inc. | CHRONIC HEPATITIS B HEPATITIS CRÓNICA B | | | | |
2011-004201-25: The BOKITO-1B Study: Tenofovir DF bone and kidney toxicity in patients with viral liver infection with hepatitis B virus. De BOKITO-1B studie: Tenofovir DF bot- en niertoxiciteit bij patienten met virale leverontsteking door infectie met het hepatitis B virus. |
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| Ongoing | 4 | 50 | Europe | Viread, Viread, Viread | Erasmus MC, Erasmus MC | Chronic hepatitis B Chronische hepatitis B | | | | |
2011-004272-11: The BOKITO-2B Study: Tenofovir DF Bone and Kidney Toxicity in patients with viral liver infection with hepatitis B virus. Incidence and reversibility. De BOKITO-2B studie: Tenofovir bot- en niertoxiciteit bij patienten met virale leverontsteking door infectie met hepatitis B virus. Voorkomen en reversibiliteit. |
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| Ongoing | 4 | 180 | Europe | viread, baraclude, EMEA/H/C/000419, Viread, baraclude, Viread, baraclude | Erasmus MC, Erasmus MC | Chronic hepatitis B Chronische hepatitis B | | | | |
| Completed | 4 | 241 | Europe, RoW | telbivudine, LDT600, tenofovir disoproxil fumarate | Novartis Pharmaceuticals | Chronic Hepatitis B | 12/15 | 12/15 | | |
NCT02039362: Prevention of Hepatitis B Virus Vertical Transmission by Serovaccination and Tenofovir During Pregnancy |
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| Completed | 4 | 37 | Europe | Tenofovir DF | Hopital Lariboisière | Pregnancy, HBV | 01/16 | 07/16 | | |
NCT01732367: TDF VS LAM + ADV in LAM + ADV Treated LAM-resistant CHB Patients With Undetectable Hepatitis B Virus DNA |
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| Completed | 4 | 171 | RoW | Lamivudine plus adefovir, Zeffix, Hepsera, Tenofovir, Viread | Keimyung University Dongsan Medical Center, Kyungpook National University Hospital, Daegu Catholic University Medical Center, DongGuk University, Pusan National University Hospital, Yeungnam University Hospital | Chronic Hepatitis B | 03/16 | 04/16 | | |
| Completed | 4 | 43 | Europe | TDF, Viread®, Stop TDF | Gilead Sciences | Chronic Hepatitis B | 07/16 | 08/16 | | |
| Completed | 4 | 102 | RoW | Tenofovir, Viread, Entecavir, Baraclude | Asan Medical Center, Samsung Medical Center, Konkuk University Medical Center, Korea University Guro Hospital, Seoul National University Hospital | Chronic Viral Hepatitis B Without Delta-agent | 09/17 | 09/17 | | |
NCT03468907: The Safety of Anti-viral Therapy in Preventing HBV MTCT in Pregnant Women After Discontinuation |
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| Completed | 4 | 111 | NA | Telbivudine 600mg, Sebivo, Tenofovir disoproxil fumarate 300mg, Viread | Third Affiliated Hospital, Sun Yat-Sen University | Hepatitis B, Chronic | 12/17 | 12/17 | | |
| Terminated | 4 | 30 | Europe | Tenofovir DF, Viread®, DEXA Scan | Gilead Sciences | Hepatitis B | 02/18 | 04/18 | | |
| Completed | 4 | 88 | RoW | Tenofovir, Viread, Entecavir, Baraclude | Asan Medical Center, Samsung Medical Center, Konkuk University Medical Center, Korea University Guro Hospital, Seoul National University Hospital | Chronic Viral Hepatitis B Without Delta-agent | 03/18 | 03/18 | | |
NCT02195518: Tenofovir Disoproxil Fumarate (TDF) 300mg 3 Years RD Therapy Chinese Chronic Hepatitis B (CHN) CHB Multiple Nucleos(t)Ide Analogues (NAs) Failure Points Pts PH4 PMS Study |
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| Completed | 4 | 213 | RoW | Tenofovir disoproxil fumarate | GlaxoSmithKline | Hepatitis B, Chronic | 08/18 | 08/18 | | |
| Completed | 4 | 160 | RoW | tenofovir disoproxil fumarate 300mg per day, Viread® (Gilead Sciences Inc), Placebo | E-DA Hospital, Gilead Sciences, Taipei Institute of Pathology | Chronic Hepatitis B | 11/18 | 12/18 | | |
POWER, NCT02308319: Prompt Or Watchful Monitoring for Hepatitis B Virus Related Hepatocellular Carcinoma Without Elevated viRal Load |
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| Unknown status | 4 | 124 | NA | Tenofovir disoproxil fumarate, Viread(R) | Samsung Medical Center | Carcinoma, Hepatocellular | 12/18 | 06/19 | | |
NCT02973646: Peginterferon Alfa-2b Treatment in HBeAg(+) Chronic Hepatitis b Patients Based on Interferon Gene Mutation and Receptor Detection |
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| Unknown status | 4 | 100 | RoW | Entecavir or Tenofovir, Baraclude, Viread, Peginterferon Alfa-2B | Third Affiliated Hospital, Sun Yat-Sen University | Chronic Hepatitis b | 12/18 | 12/18 | | |
NCT03258710: A Study of Switching From Entecavir to Tenofovir Disoproxil Fumarate in Subjects With Chronic Hepatitis B |
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| Completed | 4 | 75 | Japan | Tenofovir Disoproxil Fumarate | GlaxoSmithKline | Hepatitis B, Chronic | 12/18 | 11/19 | | |
NCT02463019: Roll-over After 3-year Trial for Tenofovir in Mild Chronic Hepatitis B |
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| Unknown status | 4 | 160 | NA | Tenofovir Disoproxil Fumarate, Viread | E-DA Hospital, Taipei Institute of Pathology | Chronic Hepatitis B, Antiviral Treatment | 01/19 | 01/20 | | |
NCT05282407: A phase4 Clinical Study to Evaluate the Safety and Efficacy of Switching to Tenofovir Disoproxil From Tenofovir Disoproxil Fumarate in Patients With Chronic Hepatitis B |
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| Completed | 4 | 118 | RoW | Tenofovir disoproxil 245mg, Tenofovir disoproxil fumarate 300mg | Samjin Pharmaceutical Co., Ltd. | Chronic Hepatitis B | 04/19 | 04/19 | | |
NCT03253250: The Investigation of Peginterferon Alfa-2a on the RFS of the Subjects With HCC Who Have Been Treated by Resection |
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| Unknown status | 4 | 432 | RoW | ETV；TDF；ADV, entecavir;tenofovir disoproxil fumarate;adefovir, Peginterferon Alfa-2a, pegasys | Huashan Hospital | Chronic Hepatitis b, Hepatic Carcinoma | 06/19 | 12/19 | | |
2018-000724-34: Norwegian Nucleoside Analogue Stop Study (Nuc-STOP) - A trial in chronic hepatitis B, aiming at achieving a functional cure |
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| Ongoing | 4 | 130 | Europe | Tenofovir disoproxil, Entecavir, Tablet, Tenofovir disoproxilfumarate, Entecavir | Oslo University Hospital HF, Helse Sør-Øst (grant number 2018092) | HBeAg negative chronic hepatitis B, HBeAg negative chronic hepatitis B, Diseases [C] - Virus Diseases [C02] | | | | |
NCT02081469: Prophylaxis of CHB Patients With Malignant Tumor Receiving Chemotherapy |
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| Completed | 4 | 100 | RoW | TDF, viread | Chang Gung Memorial Hospital, Gilead Sciences | Hepatitis B, Chronic, Tumor | 08/19 | 08/19 | | |
| Completed | 4 | 90 | Europe, Canada | Peginterferon alfa-2a, Pegasys, Nucleos(t)ide analogue, Entecavir (Baraclude), Tenofovir (Viread), Adefovir (Hepsera) | Foundation for Liver Research, Hoffmann-La Roche | Chronic Hepatitis B | 10/19 | 10/19 | | |
NCT03485534: Evaluate the Efficacy and Safety to Tenofovir Disoproxil in Chronic Hepatitis B Patients |
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| Completed | 4 | 189 | RoW | Tenofovir Disoproxil Fumarate, Viread, Tenofovir Disoproxil, Virehepa | Daewoong Pharmaceutical Co. LTD., C&R Research, Inc. | Hepatitis B, Chronic | 11/19 | 11/19 | | |
NCT01491295: Switch to Tenofovir Versus Continue Lamivudine/Adefovir Treatment in Lamivudine-resistance Chronic Hepatitis B Patients |
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| Unknown status | 4 | 160 | RoW | Tenofovir disoproxil fumarate, Viread, Lamivudine plus adefovir, Zeffix, Hepsera | Taipei Veterans General Hospital, Taiwan, Kaohsiung Medical University Chung-Ho Memorial Hospital, China Medical University Hospital, Chi Mei Medical Hospital, Chiayi Christian Hospital | Chronic Hepatitis B | 12/19 | 12/19 | | |
| Completed | 4 | 179 | RoW | Tenofovir Disoproxil Fumarate, Viread, Monovalent HBV vaccine, Engerix-B | University of North Carolina, Chapel Hill, Kinshasa School of Public Health, Ohio State University | Hepatitis B, Vertical Transmission of Infectious Disease | 03/20 | 08/20 | | |
| Unknown status | 4 | 933 | RoW | Tenofovir disoproxil fumarate, TDF, Rapid tests HBe Ag | ANRS, Emerging Infectious Diseases | Hepatitis B Chronic Infection, Pregnancy | 03/20 | 03/20 | | |
NCT02774837: Tenofovir Versus Tenofovir + Telbivudine for Chronic Hepatitis B |
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| Unknown status | 4 | 146 | RoW | Tenofovir disoproxil, Viread, Telbivudine, Sebivo | Seng Gee Lim, National Medical Research Council (NMRC), Singapore, Singapore Clinical Research Institute | Chronic Hepatitis B | 07/20 | 07/20 | | |
NCT05286346: Clinical Study to Evaluate the Safety and Efficacy of Switching to Tenofovir Disoproxil From Tenofovir Disoproxil Fumarate in Patients With Chronic Hepatitis B |
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| Completed | 4 | 113 | RoW | Tenofovir disoproxil 245mg, Tenofovir disoproxil fumarate 300mg | Samjin Pharmaceutical Co., Ltd. | Chronic Hepatitis b | 08/20 | 08/20 | | |
NCT02224456: Efficacy and Safety Study of Tenofovir Disoproxil Fumarate (TDF) in Chinese Chronic Hepatitis B (CHB) Subjects With Advanced Fibrosis & Compensated Cirrhosis |
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| Completed | 4 | 197 | RoW | Tenofovir disoproxil fumarate | GlaxoSmithKline | Hepatitis B, Chronic | 12/20 | 12/20 | | |
NCT03476083: Tenofovir Disoproxil Fumarate in Combination of Hepatitis B Vaccine for Preventing Hepatitis B Vertical Transmission |
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| Recruiting | 4 | 280 | RoW | Tenofovir Disoproxil Fumarate (TDF) 300 mg oral daily., HBIg 200 IU im for infants in the group B, HBV vaccine 10 ug im for all infants | New Discovery LLC | Hepatitis B Infection, Congenital Malformation, Birth Defect, Viremia, Chronic Infection | 05/21 | 05/24 | | |
| Not yet recruiting | 4 | 170 | NA | Tenofovir Disoproxil Fumarate | University of Oxford | Hepatitis B | 06/21 | 06/21 | | |
NCT04202536: Switching From Tenofovir Disoproxil Fumarate to Besifovir Dipivoxil Maleate |
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| Unknown status | 4 | 152 | RoW | Besifovir Dipivoxil Maleate, Tenofovir disoproxil fumarate(TDF) | IlDong Pharmaceutical Co Ltd | Hepatitis B, Besifovir Dipivoxil Maleate, Tenofovir Disoproxil Fumarate | 06/21 | 10/21 | | |
ChiCTR2000031665: An open, multicenter, comparative study of pegylated interferon alpha-2a combined with tenofovir disoproxil fumarate in treatment of chronic hepatitis B postpartum women. |
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| Not yet recruiting | 4 | 220 | | Peg-IFN alpha-2a+TDF ;TDF | Southern Hospital Affiliated to Southern Medical University; Nanfang Hospital, Southern Medical University, Self-funded | Chronic hepatitis B | | | | |
NCT05355467: Efficacy and Safety of Ricovir® in Maintaining Durability of Viral Response in Chronic Hepatitis B Patients Who Have Been Treated With Viread® and Have Undetectable HBV DNA in Serum |
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| Completed | 4 | 40 | RoW | Tenofovir disoproxil fumarate, Historical Data | Mylan (Taiwan) Ltd | Chronic Hepatitis B Infection | 07/21 | 07/21 | | |
| Recruiting | 4 | 240 | | Tenofovir will be administered orally from 24 to 28 weeks of gestation. The newborns will be given hepatitis B vaccine 10 ug, 0-1-6 months, and hepatitis B immunoglobulin 100 IU at birth. ;Antiviral drugs will not be taken during pregnancy. The newborns will be given hepatitis B vaccine 10 ug, 0-1-6 months, and hepatitis B immunoglobulin 100 IU at birth. | Beijing Youan Hospital, Capital Medical University; Beijing You'an Hospital, Capital Medical University, China Primary Health Care Foundation-Youan Foundation of Liver Disease and AIDS | vertical transmission of hepatitis B virus | | | | |
NCT03357822: A Real-World Study of Pegylated Interferon In Nucleoside-treated Patients With Chronic Hepatitis B |
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| Unknown status | 4 | 2000 | RoW | Pegylated interferon, Pegylated interferon (PegIFN), Entecavir, Entecavir (ETV), Tenofovir disoproxil fumarate, Tenofovir disoproxil fumarate (TDF) | Tongji Hospital | Chronic Hepatitis B | 01/22 | 07/22 | | |
NCT05313477: The Effects of Vitamin D and Calcium Supplementation to Parathyroid Hormone in CHB Patients Treated With TDF |
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| Completed | 4 | 64 | RoW | Ergocalciferol Capsules, Calcium carbonate | Mahidol University | Parathyroid Hormone, Tenofovir Disoproxil Fumarate, Chronic Hepatitis B Virus, Vitamin D | 08/23 | 11/23 | | |
ChiCTR1800019508: A real world study for the effectiveness and safety of tenofovir tablets in the treatment of patients with chronic hepatitis B |
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| Not yet recruiting | 4 | 3000 | | Tenofovir Disoproxil Fumarate，300mg Qd | Beijing You'an Hospital, Capital Medical University; Beijing You'an Hospital, Capital Medical University, Wu Jieping Medical Foundation | Chronic Hepatitis B | | | | |
ChiCTR2100048953: A prospective control study on blood lipids in patients with chronic hepatitis B treated with nucleos(t)ide analogue(s) |
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| Not yet recruiting | 4 | 417 | | enticavir ;tenofovir disoproxil fumarate ;alafenamide tenofovir | Shanghai Public Health Clinical Center; Shanghai Public Health Clinical Center, self-funded | chronic hepatitis B | | | | |
| Recruiting | 4 | 560 | RoW | Tenofovir Disoproxil Fumarate 300 MG, Viread, Hepatitis B monovalent vaccine, Hepatitis B birth-dose vaccine, Engerix-B, Placebo | University of North Carolina, Chapel Hill, Doris Duke Charitable Foundation, Université Protestant au Congo, Abbott, Albert Einstein College of Medicine | Hepatitis B, Vertical Transmission of Infectious Disease | 06/25 | 06/25 | | |
