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| Completed | N/A | 208 | | Ganciclovir Ophthalmic in situ forming Gel; Ganciclovir Ophthalmic Gel | Eye and ENT Hospital of Fudan University; Eye and ENT Hospital of Fudan University, Shenyang Xingqi Pharmaceutical Co., Ltd. | Herpes Simplex Keratitis | | | | |
ChiCTR2000037247: Evaluation of the safety and efficacy of biological keratoprothesis in the treatment of infective keratitis |
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| Completed | N/A | 72 | | keratoplasty was performed using the biologic keratoprothesis | Wenzhou Medical University Eye Hospital; Wenzhou Medical University Eye Hospital, Guangzhou Youvision Biotechnology Co. Ltd. | Infectious keratitis | | | | |
ChiCTR1800018011: Efficacy of Acyclovir Combined with Dexamethasone Eye Drops in the Treatment of Recurrent Herpes Stromal Keratitis |
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| Completed | N/A | 119 | | topically administrated with 0.1% acyclovir (ACV) combined with dexamethasone (reduced from 0.06% to 0.03%) eyedrops with the stepladder approach ;topically administered with 0.1% ACV eyedrops and 0.3% tobramycin combined with 0.1% dexamethasone eyedrops | Tongji Hospital affiliated with Tongji University School of Medicine; Tongji Hospital affiliated with Tongji University School of Medicine, None | Herpetic stromal keratitis | | | | |
ChiCTR-INR-16008830: Clinical study of the low-temperature plasma surgery system for the treatment of infectious keratitis |
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| Recruiting | N/A | 150 | | low-temperature plasma (PLA) surgery system treatment ;Corneal scraping ;Antifungus medical treatment | Eye and ENT Hospital, Fudan University; Eye and ENT Hospital, Fudan University, Cost of scientific research | infectious keratitis | | | | |
ChiCTR-ONN-16009353: Pre-clinical Application Study of Novel Stem Cell to Treat Incurable Eye Disease |
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| Not yet recruiting | N/A | 180 | | No treatment ;autologous mesenchymal stem cells treatment ;eye drops ;autologous limbus stomal stem cell tratment | Shanghai Tenth People's Hospital; Shanghai Tenth People's Hospital, Developing center of Shanghai Shenkang hospital | Retinitis pigmentosa，corneal ulcer | | | | |
ChiCTR-OOC-17013709: Multi-center study of clinical features and management of viral keratitis after cataract surgery |
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| Not yet recruiting | N/A | 70 | | Nil | the Eye Hospital of Wenzhou Medical University; the Eye Hospital of Wenzhou Medical University, Supporting funds of the National Natural Science Foundation of China | viral keratitis | | | | |
NCT05123014: Lenticule Implantation and Autologous Serum New Approach in Treatment of Adenoviral Keratitis Disease |
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| Active, not recruiting | N/A | 45 | RoW | relex smile | Eye Hospital Pristina Kosovo | Adenoviral Keratoconjunctivitis | 02/19 | 02/25 | | |
ChiCTR1900023720: Evaluation of the feasibility of applying internal transcribed spacer identification (ITSI) as a complementary-method in the diagnosis of fungal keratitis |
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| Not yet recruiting | N/A | | | | Qingdao Eye Hospital; Qingdao Eye Hospital, Shandong Province Major Science and Technology Innovation Project | Fungal keratitis | | | | |
ChiCTR1900023651: Study for Bacterial Polymorphism in Ocular Surface with Bacterial Keratitis |
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| Not yet recruiting | N/A | 32 | | collect cotton swab samples | Qingdao Eye Hospital; Qingdao Eye Hospital, National Natural Science Foudation of China | Bacterial Keratitis | | | | |
ChiCTR-ONC-17013979: Evaluation of the efficacy and safety of acellular porcine corneal matrix cornea for the treatment of ineffective non-perforated corneal ulcer |
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| Recruiting | N/A | 100 | | acellular corneal stroma corneal transplantation | 2nd Affiliated Hospital, Zhejiang University, School of Medicine; 2nd Affiliated hospital, Zhejiang University, School of Medicine, no | Corneal ulcer | | | | |
ChiCTR1900026147: Clinical observation for the effect of corneal crosslinking combined with keratoplasty in the treatment of acanthamoeba keratitis |
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| Recruiting | N/A | 15 | | corneal crosslinking | Shandong Eye Hospital; Shandong Eye Hospital, money from the patient himself | Acanthamoeba keratitis | | | | |
| Enrolling by invitation | N/A | 35 | RoW | Relex-Smile | Eye Hospital Pristina Kosovo | Stromal Keratitis | 01/20 | 01/25 | | |
NCT05809245: Corneal Neurotization as a Treatment for Neurotrophic Keratopathy |
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| Terminated | N/A | 4 | US | Corneal neurotization | Stanford University | Neurotrophic Corneal Ulcer, Neurotrophic Keratitis, Cranial Nerve V Diseases | 02/20 | 02/20 | | |
ChiCTR2000032542: Evaluation of Alterations about Microbiome between Healthy and Microbial Keratitis Ocular Surface and the Feasibility of Combining High Throughput Sequencing with Artificial Intelligence to Distinguish Microbial Keratitis |
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| Not yet recruiting | N/A | 200 | | Nil | State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences; Qingdao Eye Hospital, the Key Science and Technology Innovation Project of Shandong Province (2018CXGC1205), the Taishan Scholar Program (ts20190983), National Natural Science Foundation of China (81970788) | Microbial Keratitis | | | | |
ChiCTR2000031875: To evaluate the characteristics of bacterial flora on the ocular surface of healthy and different types of infectious keratitis and the feasibility of using high-throughput sequencing technology combined with artificial intelligence as a supplementary diagnostic method for infectious keratitis |
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| Not yet recruiting | N/A | 200 | | None ;Nil | Shandong First Medical University (Shandong Academy of Medical Sciences) Shandong Institute of Ophthalmology; Key Laboratory of Ophthalmology of Shandong Province - national key laboratory cultivation; Qingdao Eye Hospital, the Key Science and Technology Innovation Project of Shandong Province (2018CXGC1205), the Taishan Scholar Program (ts20190983), National Natural Science Foundation of China (81970788) | Microbial Keratitis | | | | |
| Not yet recruiting | N/A | 120 | NA | Corneal impression membrane (Millicell Cell Culture Insert, 12mm, hydrophilic PTFE 0.4µm (PICM01250)) | University of Edinburgh | Corneal Ulcer (Diagnosis) | 02/26 | 02/26 | | |
| Recruiting | N/A | 60 | | Nil ;Nil | The first affiliated Hospital of Northwestern University, Xi'an No.1 Hospital; Xi'an No.1 Hospital, Researcher funds | Infectious keratitis | | | | |
ChiCTR1900027108: Study for the safety and efficacy of hypochlorite eye drops in the treatment of infectious keratitis |
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| Recruiting | N/A | 200 | | 抗生素滴眼 Antibiotic eye drops ;Antibiotics + Hypochlorite Eye Drops ;Antifungal drugs ;Antifungal Drugs + Hypochlorite Eye Drops | Affiliated Hospital of Xuzhou Medical University; Affiliated Hospital of Xuzhou Medical University, Doctoral Research Initiation Funds | Infectious keratitis | | | | |
| Recruiting | N/A | 800 | Europe | | University Hospital, Montpellier | Corneal Diseases, Keratoconus, Corneal Ulcer, Corneal Trauma, Corneal Dystrophies | 12/21 | 12/21 | | |
ChiCTR2100044068: Relationship between Corneal Sensation, Blinking and Tear Film in Patients with Neurotrophic Keratitis |
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| Recruiting | N/A | 60 | | none ;none | Tianjin Medical University Eye Hospital; Tianjin Medical University Eye Hospital, Project funding | Neurotrophic Keratitis | | | | |
NCT04969640: Role of Anterior Segment Optical Coherence Tomography in Infectious Keratitis |
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| Completed | N/A | 23 | RoW | Optical coherence tomography | Minia University | Infective Keratitis | 12/21 | 12/21 | | |
ChiCTR2000040372: Bilateral Limbal Stem Cells alterations in patients with unilateral herpes simplex keratitis with in vivo confocal microscopy clinical study |
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| Recruiting | N/A | 150 | | Nil | First Ward in Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University; First Ward in Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin, China, None | infectious keratitis | | | | |
ChiCTR2000040565: Clinical changes in the contralateral unaffected eyes of patients with unilateral infectious keratitis: An in vivo confocal microscopy study |
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| Completed | N/A | 90 | | No | Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University; the First Affiliated Hospital of Harbin Medical University, None | infectious keratitis | | | | |
| Not yet recruiting | N/A | 20 | NA | Crosslinking with Riboflavin and UV-A | Assiut University | Infectious Keratitis | 01/22 | 01/23 | | |
ChiCTR2100046030: Evaluation of changes of conjunctiva associated lymphoid tissue in eye diseases by in vivo confocal microscopy |
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| Recruiting | N/A | 200 | | N/A ;Nil | Eye Hospital, the First Affiliated Hospital of Harbin Medical University; Eye Hospital, the First Affiliated Hospital of Harbin Medical University, self-raised | Keratitis, diabetes,cornea transplantation, MGD, pterygium | | | | |
ChiCTR2100044767: An observational study on the QAC gene carrying rate of common pathogenic bacteria isolated from conjunctival sac in children orthokeratology wearers in Wenzhou |
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| Recruiting | N/A | 258 | | Nil ;Nil ;Nil | Eye Hospital Affiliated to Wenzhou Medical University; Eye Hospital Affiliated to Wenzhou Medical University, Research group funds | Microbial keratitis | | | | |
ChiCTR2100050565: Effectiveness of Continuous Infusion of Voriconazole combined with topical medication therapy in the management of moderate to severe fungal keratitis |
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| Recruiting | N/A | 80 | | Continuous Infusion of Voriconazole combined with topical medication therapy ;topical medication therapy | The Second Xiangya Hospital, Central South University; The Second Xiangya Hospital, Central South University, self-raising fund | fungal keratitis | | | | |
NCT05924893: The Use of Naltrexone Hydrochloride to Promote Healing in Patients With Resistant Non-infectious Corneal Ulcer |
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| Completed | N/A | 50 | RoW | Naltrexone Hydrochloride, NTX, Carboxy methyl cellulose, Carboxy methyl cellulose sodium 0.5% | Minia University | Cornea Ulcer | 06/22 | 12/22 | | |
ChiCTR2100044197: The efficacy and safety of foscarnet in the management of refractory herpes simplex virus keratitis: a prospective multicentric controlled study |
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| Recruiting | N/A | 50 | | Foscarnet ( IV.) ;acyclovir（IV.） | School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University; School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, National key research and development project | herpes simplex virus keratitis | | | | |
NCT05655689: The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study |
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| Completed | N/A | 123 | RoW | Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution, Vigamox®, Ceftazidime 5% + vancomycin 5%, (CAZ-VAN), Gentamicin 1.4% + vancomycin 5%, (GEN-VAN), Natamycin 5% Oph Susp, Voriconazole 1%, Vfend®, Natamycin 5% + voriconazole 1%, (NT-VRC), Natamycin 5%+ ceftazidime 5% + vancomycin 5%, (NT-CAZ-VAN), Voriconazole 1% + ceftazidime 5% + vancomycin 5%, (VRC-CAZ-VAN) | Alexandria University | Bacterial Keratitis, Fungal Keratitis, Mixed Bacterial and Fungal Keratitis, Microbial Keratitis | 01/23 | 01/23 | | |
NCT04573647: OCT Evaluation of Neurotrophic Ulcer Following Treatment With Oxervate |
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| Recruiting | N/A | 10 | US | Cenegermin-Bkbj 0.002% Ophthalmic Solution [OXERVATE] | Sight Medical Doctors PLLC, Dompé, US, Inc. | Neurotrophic Ulcer, Neurotrophic Keratitis, Neurotrophic Corneal Ulcer, Neurotrophic Keratoconjunctivitis | 06/24 | 12/24 | | |
ChiCTR2200065031: New onset of herpes simplex keratitis after keratoplasty: Discussion on clinical characteristics and virus source |
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| Not yet recruiting | N/A | 19 | | None | Qingdao Eye Hospital of Shandong First Medical University; Qingdao Eye Hospital of Shandong First Medical University, Raise independently | New onset of herpes simplex keratitis after keratoplasty | | | | |
ChiCTR2000033968: A randomized, blind, and positive controlled clinical trial to evaluate the safety and efficacy of 1% voriconazole eye drops in the treatment of fungal keratitis |
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| Recruiting | N/A | 144 | | 1% voriconazole eye drops ;Natamycin eye drops | Shenyang Sinqi Eye Hospital Co., Ltd; Shenyang Sinqi Eye Hospital Co., Ltd, Shenyang SinQi Eye Hospital Co., Ltd | Fungal keratitis | | | | |
ChiCTR2000034467: Clinical research on innovative treatment of fungal keratitis: a randomized controlled trial. |
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| Recruiting | N/A | 174 | | Conventional medication ;Corneal collagen cross-linking ;Continuous ocular lavage with antifungal | Beijing Aier Intech Eye Hospital; Beijing Aier Intech Eye Hospital, Capital Health Development Research Special Fund, Beijing Aier Intech Eye Hospital | Fungal keratitis | | | | |
| Completed | N/A | 55 | US | Lotrafilcon A contact lenses, AONDA, AIR OPTIX® NIGHT & DAY® AQUA | Alcon Research | Bullous Keratopathy, Corneal Erosion, Entropion, Corneal Edema, Corneal Dystrophy, Corneal Ulcer, Foreign Body in Cornea, Bell Palsy, Keratoconjunctivitis, Filamentary Keratitis, Sicca Syndrome; Keratoconjunctivitis (Etiology) | 07/23 | 07/23 | | |
NCT05940376: Topical Insulin in Neurotrophic Keratopathy After Diabetic Vitrectomy |
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| Not yet recruiting | N/A | 30 | RoW | rapid acting insulin | Benha University | Corneal Ulcer, Neurotrophic Corneal Ulcer, Diabetes Mellitus | 08/23 | 08/23 | | |
NCT06364878: Non-invasive Diagnostics of Microbial Keratitis |
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| Recruiting | N/A | 125 | Europe | In vivo confocal microscopy, IVCM, Tear film sampling | Sorlandet Hospital HF | Infectious Keratitis | 03/25 | 04/28 | | |
NCT03461978: Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures |
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| Enrolling by invitation | N/A | 60 | Europe | Ultrahigh resolution Spectral Domain OCT | Medical University of Vienna | Meibomian Gland Dysfunction, Cataract, Glaucoma, Corneal Transplantation, Demodicosis, Conjunctival Pathologies, Acanthamoeba Keratitis, Aniridia | 09/23 | 10/23 | | |
NCT06229379: The Effects of a Large Language Model on Clinical Questioning Skills |
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| Recruiting | N/A | 84 | RoW | "Digital twin patient", Interaction with real patients | Sun Yat-sen University | Cataract, Glaucoma, Diabetic Retinopathy, Keratitis, Conjunctivitis | 02/24 | 06/24 | | |
NCT06070883: Efficacy of Mutilayered Fresh Amnoitic Membrane Transplantation in Resistant Fungal Keratitis |
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| Completed | N/A | 26 | RoW | Amniotic membrane transplantation | Al-Azhar University | Keratitis | 09/23 | 10/23 | | |
NCT05538793: Deep Learning for the Discrimination Among Different Types of Keratits: a Nationwide Study |
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| Completed | N/A | 10369 | RoW | | Ningbo Eye Hospital | Keratitis, Automatic Judgement, Image | 09/23 | 10/23 | | |
ChiCTR2200064658: A preliminary study on the treatment of epithelial simplex virus keratitis based on confocal microscopy |
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| Not yet recruiting | N/A | 46 | | Conventional treatment plus 0.05% cyclosporine eye drops ;Conventional therapy | Wuhan Aier Ophthalmology Hanyang Hospital; Wuhan Aier Ophthalmology Hanyang Hospital, Aier Eye Hospital Group Research Fund | Epithelial herpes simplex keratitis | | | | |
PROSIKA, NCT04701086: 3 Month Study of Cationorm Pro Versus Vismed in Adults With Dry Eye Disease Related to Keratitis or Keratoconjunctivitis |
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| Recruiting | N/A | 80 | Europe | Cationorm Pro, Ocutears Pro+, Vismed | Santen SAS | Dry Eye Syndromes | 12/24 | 12/24 | | |
| Enrolling by invitation | N/A | 108 | US | Quantitative Sensory Test | Tufts Medical Center, Dompé Farmaceutici S.p.A | Corneal Disease, Neuropathy, Dry Eye Disease, Neurotrophic Keratitis | 10/24 | 06/25 | | |
| Active, not recruiting | N/A | 223671 | RoW | Corneal ulcer prevention program | University of California, San Francisco, National Eye Institute (NEI), Seva Foundation, Bharatpur Eye Hospital | Corneal Ulcer | 01/25 | 01/25 | | |
| Recruiting | N/A | 40 | US | Cenegermin Ophthalmic Solution [Oxervate] | University of California, Los Angeles | Neurotrophic Keratitis | 12/24 | 12/24 | | |
ALHENA, NCT04685109: 3 Month Study of Alocross Versus Vismed in Adults With Dry Eye Disease Related to Keratitis or Keratoconjunctivitis |
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| Recruiting | N/A | 80 | Europe | Alocross 0.2% Unit Dose, Vismed, HA 0.18% hypotonic solution | Santen SAS | Dry Eye Syndromes | 12/24 | 12/24 | | |
ChiCTR2300074054: Validation of a symptom management program for patients with corneal ulcer |
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| Not yet recruiting | N/A | 76 | | Mobile Health Management ;usual care | The First Affiliated Hospital of Army Medical University; The First Affiliated Hospital of Army Medical University, Military Nursing Innovation and Cultivation Special Program（2021HL010） | Corneal ulcer | | | | |
| Not yet recruiting | N/A | 60 | RoW | Riboflavin, Antibotice.g vigamox ED Antifungal e.g Dflucan, pack cross linking | Sohag University | Infectoius Keratitis | 04/24 | 06/24 | | |
VICTORIA, NCT05620264: Validation of Interleukins and Other Cytokines Together With OCT Imaging for Rapid Infectious Keratitis Assessment |
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| Recruiting | N/A | 392 | Europe | Tear Sample Probe | Johannes Kepler University of Linz | Keratitis Bacterial, Keratitis Fungal | 04/24 | 10/24 | | |
| Not yet recruiting | N/A | 151 | NA | | IRCCS Ospedale San Raffaele | Acanthamoeba Keratitis, Artificial Intelligence | 10/24 | 04/25 | | |
| Not yet recruiting | N/A | 80 | | Collect conjunctival sac swab | Eye Hospital, Wenzhou Medical University; Eye Hospital, Wenzhou Medical University, temporary absence | infectious keratitis | | | | |
| Recruiting | N/A | 700 | US, RoW | Visual Acuity | University of Michigan, National Eye Institute (NEI) | Keratitis | 07/24 | 07/24 | | |
IIR, NCT06364657: Differences in Corneal Structure and Function in Patients With Sjogrens vs. Non-Sjogrens Dry Eye |
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| Not yet recruiting | N/A | 120 | US | Eye Exam | Johns Hopkins University | Sjogren's Syndrome, Dry Eye, Neurotrophic Keratitis | 07/25 | 07/27 | | |
ChiCTR2200061595: Correlation between corneal neuromorphology and corneal sensitivity in different stages of herpes simplex virus keratitis |
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| Not yet recruiting | N/A | 30 | | None ;None | Qingdao Eye Hospital, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Science; Qingdao Eye Hospital, Open project of Qingdao Eye Hospital | Kerotoplasty | | | | |
| Recruiting | N/A | 37 | US | Cenegemin in the DEFENDO Study, OXERVATE™ | Dompé Farmaceutici S.p.A | Neurotrophic Keratitis | 09/24 | 09/24 | | |
| Recruiting | N/A | 149 | Europe | NGS for endohtalmitis / Multiplex PCR for keratitis, Bundle of intervervention to optimizing diagnosis of ocular complex infections | Assistance Publique - Hôpitaux de Paris | Endophthalmitis, Keratitis | 11/24 | 05/25 | | |
NCT04700657: The Prevalence of Hypoesthesia Related Keratitis in Ocular Graft Vs. Host Disease (GVHD) Patients |
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| Recruiting | N/A | 30 | US | | Indiana University | Ocular GVHD | 12/24 | 12/24 | | |
NCT05888883: Microbial Keratitis Sampling for Biomarker Discovery |
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| Recruiting | N/A | 70 | Europe | | University of Edinburgh, NHS Lothian | Microbial Keratitis | 12/24 | 01/28 | | |
ChiCTR1900027014: Application of SMILE lenticule tissue in the treatment of corneal diseases |
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| Not yet recruiting | N/A | 125 | | none ;none ;none ;none | Shandong Eye Instiute, Qingdao Eye Hospital; Shandong Eye Instiute, Qingdao Eye Hospital, none | Keratoconus, corneal dystrophy, corneal ulcer, corneal trauma | | | | |
ChiCTR2100043003: Etiological diagnosis and image marker mining of infectious keratitis based on multimodal ocular surface image |
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| Not yet recruiting | N/A | | | | GuangDong Provincial People’s hospital（GuangDong Academy of Medical Sciences）; GuangDong Provincial People’s hospital（GuangDong Academy of Medical Sciences）, Research fuding | Infectious keratitis | | | | |
| Recruiting | N/A | 46 | Europe | PCR multiplex by FilmArray | CHU de Reims | Infectious Keratitis, Microbial Keratitis, Corneal Infection | 07/25 | 02/26 | | |
| Not yet recruiting | N/A | 120 | | Take the diseased cornea removed during the operation ;Extraction of remaining blood samples from biobanks ;Take the donor's remaining limbus ;Extraction of remaining blood samples from biobanks | Eye Hospital, Wenzhou Medical University; Eye Hospital, Wenzhou Medical University, Project funding | herpes simplex keratitis | | | | |
