| Hypoglycemia |
ACTRN12608000123347: Comparison of triple phase and lipid only intra-dialytic parenteral nutrition and survival and outcomes in malnourished haemodialysis patients to assess complications. |
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| Not yet recruiting | 4 | 30 | | | Austin Health, Austin Health, | Malnourished haemodialysis patients | | | | |
ACTRN12615000732583: Stop or Replace: Effect of stopping sulfonylureas or replacing sulfonylureas with a dipeptidyl peptidase 4 (DPP-IV) inhibitor in Type 2 diabetes patients on pre-mix insulin. |
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| Not yet recruiting | 4 | 99 | | | St Vincent's Hospital Sydney, St Vincent's Hospital Sydney, Competitive Grant from Regional Diabetes Support Scheme, Novo Nordisk | type 2 diabetes | | | | |
| Recruiting | 4 | 750 | | | HRC, Human Research Council, Medical Research Council Aust (NHMRC), Auckland Medical Research Foundation, National Women's Charitable Trust | Gestational diabetes | | | | |
ACTRN12616001158459: Comparison of the incidence and duration of hypoglycaemia assessed by Continuous Glucose Monitoring (CGM) in elderly type 2 Diabetes patients treated with two different insulin regimens (long and short acting insulin VS premixed insulin) . |
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| Recruiting | 4 | 84 | | | Western Sydney Local Health District, Sanofi Australia | Type two Diabetes Mellitus, Hypoglycaemia in elderly type two Diabetes Mellitus patients on premixed insulin treatment | | | | |
| Recruiting | 4 | 100 | | | Dr Lydia Kennedy, Department of Perinatal Medicine, Women's and Children's Hospital | Hypoglycaemia, Infant of diabetic mother | | | | |
ChiCTR2000036701: Exploratory study on the protective effect of Empagliflozin on diabetic kidney disease: a randomized controlled trial. |
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| Not yet recruiting | 4 | 32 | | Empagliflozin ;Linagliptin | Huashan Hospital, Fudan University; Huashan Hospital, Fudan University, Youth Clincal Research of Shanghai Shenkang Hospital Development Center | diabetic kidney disease | | | | |
ChiCTR-TRC-12002271: Efficacy Comparison of Sitagliptin and Acarbose on Drug-Naive 0atients with Type 2 Diabetes: A Prospective, Open-Label, Randomized Clinical Trial |
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| Completed | 4 | 60 | | sitagliptin monotherapy ;Acarbose monotherapy | Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University; Level of the institution：, Hospital | Diabetes | | | | |
ChiCTR-TRC-11001317: Organization Program of DiabEtes INsulIN ManaGement: an open, multi-center, prospective, randomized, 16-week, controlled clinical study. |
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| Completed | 4 | 1500 | | conventional diabetes education ;Subjects received structured diabetes education | Bayer Healthcare Company Ltd; Bayerhealthcare, Co.Ltd, Chinese Diabetes Society, Bayer Healthcare Company Ltd. | T2DM | | | | |
ChiCTR-TRC-12002553: Vildagliptin on glycemic control in newly diagnosed type 2 diabetes in the short-term insulin pump therapy and remission: a prospective, randomized, open, controlled single-center clinical study |
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| Completed | 4 | 60 | | CSII monotherapy ;CSII + Vildagliptin 50mg bid | Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University; Level of the institution：, Hospital | Diabetes | | | | |
ChiCTR-TRC-12002676: A comparison of the efficiency of sitagliptin(100mg) combined with once-daily insulin glargine versus twice-daily insulin aspart30 in patients with type 2 diabetes mellitus inadequately controlled on blood glucose with oral therapy: A Single-center, Prospective, Open-label, Randomized Control Clinic |
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| Completed | 4 | 80 | | sitagliptin (100mg) combined with once-daily insulin glargine ;twice-daily insulin aspart30 | Nanfang Hospitai of Southern Medical University; Nanfang Hospitai of Southern Medical University Address：, Projects fund of Nangfang hospital | type 2 diabetes mellitus | | | | |
ChiCTR-TRC-12001906: A prospective multi-center randomized controlled trial: intensive insulin therapy in severely burned patients |
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| Recruiting | 4 | 650 | | intensive insulin therapy: maintain blood glucose level between 4.4mmol/L and 7 mmol/L ;conventional insulin therapy: maintain blood glucose level between 7mmol/L and 10 mmol/L | The First Affiliated Hospital of Chinese PLA General Hospital; The First Affiliated Hospital of Chinese PLA General Hospital, Fund of Capital Medical Development and Research（2009-1025）;National Natural Science Foundation of China（81120108014） | burns | | | | |
2014-005554-20: Visualizing beta cells in patients with postprandial hyperinsulinemic hypoglycemia after bariatric surgery Beeldvorming van beta cellen in patiënten met postprandiale hyperinsulinemische hypoglycaemie na bariatrische chirurgie |
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| Ongoing | 4 | 24 | Europe | 68-Ga-NODAGA-[K40]-Exendin4, Radiopharmaceutical precursor, solution, Byetta | Radboud University Medical Center Nijmegen, Radboud University Medical Center Nijmegen | Hyperinsulinaemic hypoglycaemia after Roux-en-Y gastric bypass surgery Hyperinsulinaemische hypoglycaemie na Roux-en-Y gastric bypass chirurgie, Hyperinsulinaemic hypoglycaemia after Roux-en-Y gastric bypass surgery Hyperinsulinaemische hypoglycaemie na Roux-en-Y gastric bypass chirurgie, Body processes [G] - Metabolic Phenomena [G03] | | | | |
2005-001693-27: Pilot Effectiveness of Randomised Mandatory Insulin Therapy |
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| Ongoing | 4 | 120 | Europe | ACTRAPID, ACTRAPID, ACTRAPID, ACTRAPID | Oxford Radcliffe Hospitals NHS Trust | Those admitted to the Intensive Care Unit for treatment and likely to remain on the unit for longer than 5 days. | | | | |
2006-002047-92: A multicentre, open-label, randomized comparison of once daily insulin detemir given pre-breakfast or bedtime, according to need, with bedtime insulin glargine in people with type 2 diabetes characterized by an asymmetric insulin requirement between the day and night. |
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| Ongoing | 4 | 74 | Europe | Levemir FlexPen, Lantus OptiSet, Levemir FlexPen, Lantus OptiSet | Newcastle Primary Care Trust | Diabetes Mellitus | | | | |
2010-022809-18: Effectiveness of Glucophage® SR as an adjunct to insulin in improving glycaemic control, without increasing the episodes of hypoglycaemia, in non-overweight patients with type-1 Diabetes. |
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| Ongoing | 4 | 30 | Europe | Glucophage SR, None, Glucophage SR (Merck Serono), Glucophage SR (Merck Serono) | Hywel Dda Health Board | Type-1 Diabetes Mellitus | | | | |
2011-006179-20: Comparative randomized clinical trial between insulin analogues and human insulin in hospitalized patients treated with artificial tube feeding and who present high blood glucose levels. INSULINE study. Ensayo clínico aleatorizado comparativo entre análogos de insulina e insulina humana en pacientes hospitalizados tratados con alimentación artificial por sonda y que presentan niveles elevados de glucosa en sangre. Estudio INSULINE. |
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| Ongoing | 4 | 100 | Europe | Apidra SoloStar, Lantus SoloStar, Actrapid Innolet, Insulatard FlexPen, Apidra SoloStar, Lantus SoloStar, Actrapid Innolet, Insulatard FlexPen | Endocrinology and Nutrition Unit. Hospital Universitari Bellvitge., Endocrinology and Nutrition Unit. Hospital Universitari Bellvitge. | Pacients receiving enteral nutrition and who present hyperglycemia. Pacientes tratados con nutrición enteral y que presenten hiperglicemia. | | | | |
2013-004631-77: Exercise and blood glucose levels in patients with type I Diabetes Blutzuckereinstellung bei Diabetes mellitus Typ I in Abhängigkeit von unterschiedlichen Belastungen |
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| Ongoing | 4 | 7 | Europe | Insulin degludec, Tresiba, Tresiba | Medizinische Universität Graz/Endokrinologie und Stoffwechsel, Medizinische Universität Graz/Endokrinologie und Stoffwechsel | Type 1 diabetes | | | | |
2014-000397-19: Effects of weight reducing surgery and liraglutide on blood glucose in diabetes. Effecten van gewichtsverminderende chirurgie en liraglutide op bloedsuikerwaarden bij diabetes |
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| Ongoing | 4 | 60 | Europe | liraglutide, liraglutide | University Medical Center Groningen, Novo Nordisk | type 2 diabetes with morbid obesity type 2 diabetes met morbide obesitas | | | | |
2014-002370-36: Glucose Control during glucocorticoid therapy in acute exacerbation of chronic obstructive pulmonary disease Behandeling van hoge bloedsuiker tijdens gebruik van glucocorticoïde medicijnenvoor een exacerbatie COPD |
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| Ongoing | 4 | 46 | Europe | Forxiga, Forxiga | Slotervaart Hospital, AstraZeneca | Glucocorticoid induced hyperglycemia Glucocorticoid geinduceerde hyperglycemie | | | | |
2015-002309-12: To compare gliclazide with linagliptin on the frequency of hypoglycaemia among patients with type II diabetes and chronic kidney disease stage 3b and 4. |
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| Ongoing | 4 | 50 | Europe | Linagliptin, Gliclazide, Linagliptin, gliclazide, Linagliptin, gliclazide | Imperial College London, Joint Research Compliance Office, Boehringer Ingelheim Ltd. | Diabetes Mellitus and chronic kidney disease | | | | |
2015-003032-13: A Short Study in older patients with tablettreateddiabetes to assess the frequency if any of low sugar levels duringroutine treatment with two commonly used treatments Un breve studio nei pazienti più anziani affetti da diabete trattati con ipoglicemizzanti orali per valutare la frequenza di ipoglicemia durantetrattamento di routine con due farmaci comunemente utilizzati |
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| Ongoing | 4 | 40 | Europe | amaryl, Tablet, GLUCOPHAGE - 500 MG COMPRESSE RIVESTITE 30 COMPRESSE, AMARYL - 4 MG COMPRESSE 20 COMPRESSE IN BLISTER PVC/AL | A.O.U. Università degli Studi della Campania "Luigi Vanvitelli", Merck (MSD) Research Laboratories, Global Center, Diabetes Frail Ltd | Type 2 Diabetes Mellitus Diabete Mellito di tipo 2, sugar diabetes Condizione di alterati livelli plasmatici di glucosio, Diseases [C] - Hormonal diseases [C19] | | | | |
BEYOND III/FPG GOAL, ChiCTR-IPR-15006894: Titration target for Chinese type 2 diabetes mellitus patients using insulin glargine to achieve glycaemic goals: an assessment of three different fasting plasma glucose targets |
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| Completed | 4 | 934 | | Insulin glargine (Lantus) treatment ;Insulin glargine (Lantus) treatment ;Insulin glargine (Lantus) treatment | China-Japan Friendship Hospital; Sanofi (Beijing) Pharmaceuticals Co., Ltd, Sanofi (Beijing) Pharmaceuticals Co., Ltd | Type 2 diabetes mellitus | | | | |
2018-000684-82: The effect of lactate administration on cerebral blood flow during hypoglycemia |
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| Ongoing | 4 | 10 | Europe | sodium lactate, Solution for infusion, Sodium lactate | Radboud university medical center, The Dutch Diabetes Research Foundation | Type 1 diabetes mellitus (T1DM), diabetes, Diseases [C] - Immune System Diseases [C20] | | | | |
2017-004454-42: An interventional study to arrest the progression of cognitive decline in diabetic patients at high risk of developing Alzheimer's disease by reducinghypoglycemic events (low blood glucose). Estudio de intervención para detener o frenar la progresión del deteriorocognitivo en pacientes diabéticos con alto riesgo de desarrollar enfermedadde Alzheimer mediante la disminución de las hipoglucemias (niveles deazúcar bajos). |
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| Ongoing | 4 | 188 | Europe | GLARGINE, NPH, LANTUS, INSULATARD, Solution for injection in pre-filled pen, Tresiba, Levemir, Lantus, Insulatard | Vall d'Hebron Research Institute, Vall d'Hebron Research Institute | Cognitive decline in patients affected with mild cognitive impairment Se investiga la progresión del deterioro cognitivo en pacientes con deterioro cognitivo incipiente, The progression of a condition named mild cognitive impairment (which antedates dementia) is investigated. Se investiga la progresión del deterioro cognitivo incipiente, que es una condición que antecede a la demencia., Diseases [C] - Nervous System Diseases [C10] | | | | |
| Active, not recruiting | 4 | 40 | US | canagliflozin, Invokana, placebo, inactive substance | Foundation for Atlanta Veterans Education and Research, Inc., Janssen Scientific Affairs, LLC | Diabetes Mellitus, Type 2 | 07/18 | 12/22 | | |
| Recruiting | 4 | 880 | | Insulin glargine (Lantus) treatmen ;Insulin glargine (Lantus) treatmen | Peking University People's Hospital; Sanofi （Beijing）Pharmaceutical Co., Ltd., Sanofi (Beijing) Pharmaceuticals Co., Ltd | Type 2 diabetes mellitus | | | | |
ChiCTR-IOR-17011994: Effect of oral carbohydrate drink on rate of cesarean delivery in parturients with epidural labor analgesia |
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| Completed | 4 | 2000 | | After initiating epidural labor analgesia, parturients in the carbohydrate drink group were provided with an oral carbohydrate-rich solution (Outfast: 285 mOsm/kg, 14.2% carbohydrate, 0.58 kcal/ml; Yichang Humanwell Pharmaceutical Co, Ltd, Hubei, China) and were advised to drink as will during labor. ;After initiating epidural labor analgesia, Parturients in the clear liquid drink group were advised to intake commercial sports drinks as will (Pocarisweat: 0.26 kcal/ml, Otsuka Pharmaceutical Co. Ltd, Tokyo, Japan; Gatorade, 0.24 kcal/ml, PepsiCo, Chicago, IL, USA; or Mizone: 0.21 kcal/ml, Danone, Guangzhou, Guangdong. | Anesthesiology Department of Peking University First Hospital; Anesthesiology Department of Peking University First Hospital, self-finance | rate of cesarean delivery | | | | |
ChiCTR-IIR-17011018: Study of efficacy and safety of higher starting dose of insulin glargine in overweight and obese newly-diagnosed hospitalized patients with type 2 diabetes |
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| Not yet recruiting | 4 | 100 | | higher starting dose of insulin glargine (0.4U/kg) ;standard starting dose of insulin glargine (0.2U/kg) | Shenzhen Second People's Hospital; Shenzhen Second People's Hospital, Shenzhen Second People's Hospital | diabetes mellitus | | | | |
ChiCTR2000030731: A randomized, controlled trial for the effects of repeated intranasal insulin administration on delirium after general anesthesia in elderly patients |
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| Completed | 4 | 80 | | Saline ;20U insulin / time | The General Hospital of Western Theater Command; The General Hospital of Western Theater Command, 2016 Army Logistics Scientific Research Project, CCD16J001 | Postoperative delirium | | | | |
ChiCTR1900023199: Multiple Daily Injections compared with Insulin pump treatment for treatment of type 2 diabetes with continuous blood glucose monitor: a randomised open-label cross-controlled non-inferior clinical trial |
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| Recruiting | 4 | 152 | | Phase I: MDI regimen; Phase II: CSII regimen. ;Phase I: CSII regimen; Phase II: MDI regimen | Zhujiang Hospital, Southern Medical University; Zhujiang Hospital of Southern Medical University, Self-financing | Type 2 Diabetes Mellitus | | | | |
ChiCTR1800015822: Effects of dapagliflozin combined with intensive insulin therapy on beta cell function in patients with newly diagnosed type 2 diabetes mellitus |
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| Recruiting | 4 | 60 | | dapagliflozin+intensive insulin therapy ;intensive insulin therapy | Tungwah Hospital of Sun Yat-sen University; Tungwah Hospital of Sun Yat-sen University, Dongguan science and technology project (201850715046822). | Newly diagnosed type 2 diabetes mellitus | | | | |
ChiCTR1900021231: The therapeutic effect of SGLT2 inhibitor Canagliflozin in type 2 diabetes mellitus with hyperuricemia |
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| Not yet recruiting | 4 | 34 | | Canagliflozin | Beijing Luhe Hospital, Capital Medical University; Beijing Luhe Hospital, Capital Medical University, Scientific Research Funds | Type 2 Diabetes Mellitus | | | | |
ChiCTR1900022073: Double-Blind Comparison of Patient Profile with Glycemic Control and Hypoglycemia with Insulin or Oral Antihyperglycemic Drugs in Type 2 Diabetes |
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| Recruiting | 4 | 1004 | | with Insulin ;Oral Antihyperglycemic Drugs | Nanjing Integrated Traditional Chinese and Western Medicine Hos-pital Affiliated with Nanjing University of Chinese Medicine; Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated with Nanjing University of Chinese Medicine, raise independently | Type 2 Diabetes | | | | |
ChiCTR-IIR-17014234: A 26-week, multi-center, open-label, randomized, parallel-group study to evaluate the efficacy and safety of two treatment regimens in patients with type 2 diabetes after short-term intensive insulin therapy: basal insulin based treatment versus twice-daily premixed insulin |
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| Not yet recruiting | 4 | 400 | | basal insulin based treatment ;twice-daily premixed insulin | The General Hospital of People's Liberation Army; Sanofi (Beijing) Pharmaceutical Co., Ltd., Sanofi (Beijing) Pharmaceutical Co., Ltd. | Type 2 Diabetes mellitus | | | | |
ChiCTR1900025788: Exploratory study on the protective effect of Empagliflozin for diabetic kidney disease |
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| Not yet recruiting | 4 | 32 | | Empagliflozin ;Linagliptin | Huashan Hospital, Fudan University; Huashan Hospital, Fudan University, Clinical Science and Technology Innovation Project of Shanghai Shenkang Hospital Development Center | Diabetic Kidney Disease | | | | |
ChiCTR2000032703: Comparision of insulin degludec and insulin glargine on blood glucose variability in northern Chinese patients with type 1 diabetes |
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| Recruiting | 4 | 20 | | phase I: insulin glargine; phase II: insulin degludec ;phase I: insulin degludec; phase II: insulin glargine. | The First Affiliated Hospital of Harbin Medical University; The First Affiliated Hospital of Harbin Medical University, Postgraduate research fund | Type 1 Diabetes | | | | |
ChiCTR1900021970: Efficacy and safety of beinaglutide (formerly known as benaglutide) versus insulin aspart 30 as add-on therapy in patients with type 2 diabetes inadequately controlled with metformin alone: a prospective, multi-centric, randomized, open-labeled, parallel-group study. |
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| Recruiting | 4 | 420 | | benaglutide plus metformin ;biphasic insulin aspart 30 plus metformin | Peking University People's Hospital; Shanghai Benemae Pharmaceutical Corporation, Shanghai Benemae Pharmaceutical Corporation | Type 2 Diabetes | | | | |
ChiCTR-IPR-17014103: DPP-4 inhibitor on blood glucose fluctuation and incident hypoglycemia in type 1 diabetes subjects |
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| Not yet recruiting | 4 | 40 | | DPP-4 inhibitor 3 weeks+washout period 2 weeks+Placebo 3 weeks ;Placebo 3 weeks+washout period 2 weeks+DPP-4 inhibitor 3 weeks | Sun Yat-sen Memorial Hospital, Sun Yat-sen University; Sun Yat-sen Memorial Hospital, Sun Yat-sen University, All funding are from Sun Yat-sen Memorial Hospital, Sun Yat-sen University | Type 1 Diabetes | | | | |
NCT04664764: Intermediate and Long Acting Insulin Young Children Type 1 Diabetes. |
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| Recruiting | 4 | 60 | RoW | Degludec, Glargine, NPH insulin | Ain Shams University | Type 1 Diabetes Mellitus With Hypoglycemia, type1diabetes | 02/21 | 03/21 | | |
2019-001631-31: Automated blood glucose control with insulin and glucagon in patients with type 1 diabetes Automatisk regulering af blodsukkeret med insulin og glukagon hos patienter med type 1 diabetes |
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| Not yet recruiting | 4 | 13 | Europe | GlucaGen, FiAsp, SUB02347MIG, SUB08195MIG, Powder and solution for solution for injection, Solution for injection/infusion, GlucaGen, FiAsp(R), insulin aspart | Steno Diabetes Center Copenhagen, Steno Diabetes Center Copenhagen | Patients with type 1 diabetes, Metabolic disease in which a person has high blood glucose values due to insufficient insulin production, Diseases [C] - Hormonal diseases [C19] | | | | |
| Recruiting | 4 | 432 | | Insulin / metformin + acarbose chewable tablets ;Insulin / metformin | The First Affiliated Hospital of Zhengzhou University; Hangzhou Sino-US East China Pharmaceutical Co., Ltd., Hangzhou Sino-US East China Pharmaceutical Co., Ltd. | type 2 diabetes | | | | |
ChiCTR2100048515: Effect of intranasal insulin pretreatment on sleep quality and postoperative delirium in patients undergoing rheumatic heart valve replacement surgeryt |
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| Not yet recruiting | 4 | 68 | | Saline ;20U insulin / time | The General Hospital of Western Theater Command; The General Hospital of Western Theater Command, 2019 Military Logistics Research Project (CLB19J051) | Postoperative delirium | | | | |
ChiCTR2000036872: Comparison of the efficacy and safety Lispro 50 and Lispro 25 after 16 weeks in Chinese patients with type 2 diabetes who received basal insulin therapy with substandard blood glucose |
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| Not yet recruiting | 4 | 480 | | Lispro 50 ;Lispro25 | Sun Yat-sen Memorial Hospital, Sun Yat-sen University; Sun Yat-sen Memorial Hospital, Sun Yat-sen University, normal treatment costs | type 2 diabetes | | | | |
2019-004222-22: Adjustment of the dose of long acting insulin (Degludec) to reduce low glucose after exercise in patients with type 1 diabetes Aanpassing van de dosis langwerkende insuline (Degludec) om lage bloedsuikerwaarden na inspanning te verminderen bij patiënten met type 1 suikerziekte |
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| Not yet recruiting | 4 | 18 | Europe | Insulin Degludec, EU/1/12/807/001, Solution for injection in pre-filled pen, Tresiba | Radboud University Medical Center, Novo Nordisk | type 1 diabetes mellitus type 1 diabetes mellitus, type 1 diabetes mellitus type 1 suikerziekte, Diseases [C] - Nutritional and Metabolic Diseases [C18] | | | | |
2021-001167-24: Comparison among SGLT-2 inhibitors in elderly patients with type 2 diabetes. Confronto tra farmaci inibitori di SGLT-2 in pazienti anziani affetti da diabete tipo 2. |
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| Not yet recruiting | 4 | 1167 | Europe | Dapagliflozin, Canagliflozin, Empagliflozin, [Dapagliflozin], [Canagliflozin], [Empagliflozin], Film-coated tablet | SID - Società Italiana di Diabetologia e Malattie del Metabolismo, AIFA - Italian Medicines Agency | Type 2 diabetes mellitus Diabete mellito di tipo 2, diabetes Diabete, Diseases [C] - Nutritional and Metabolic Diseases [C18] | | | | |
2021-000667-74: The effect of bile acid binding with colesevelam on blood sugar levels in patients after gastric bypass surgery and galbladder surgery : meal test study Het effect van galzuurbinding met Colesevelam op glucose waarden in het bloed bij patiënten die een gastric bypass en een galblaasoperatie hebben gehad: maaltijd test |
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| Ongoing | 4 | 20 | Europe | Tablet, Cholestagel | Medisch Centrum Leeuwarden BV, stichting CON-VOLUME research | Post Bariatric Hypoglycemia post bariatrie hypoglycaemie, development of low blood sugar levels after gastric bypass surgery and galbladder surgery lage bloedsuikers (hypoglycaemie) welke ontstaan na een maagverkleiningsoperatie en galblaasoperatie, Body processes [G] - Metabolic Phenomena [G03] | | | | |
ChiCTR2000037600: The efficacy and safety of Type 2 Diabetes Mellitus switch from three times-daily pre-mixed insulin or basal–bolus insulin to twice-daily Insulin degludec/aspart |
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| Recruiting | 4 | 44 | | Insulin degludec/aspart | Peking Union Medical College Hospital; Peking Union Medical College Hospital, Self-raised funds | Type 2 disease | | | | |
| Not yet recruiting | 4 | 300 | | glimepiride ;sitagliptin | The Second Affiliated Hospital, Guangzhou Medical University; The Second Affiliated Hospital, Guangzhou Medical University, The Second Affiliated Hospital, Guangzhou Medical University | Type 2 diabetes | | | | |
ChiCTR2000036076: Comparison of the efficacy and safety of pioglitazone/metformin (FDC) in combination with dapagliflozin therapy versus basal insulin in combination with metformin therapy in patients with inadequately controlled type 2 diabetes mellitus |
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| Not yet recruiting | 4 | 150 | | pioglitazone-metformin (FDC) + dapagliflozin ;basal insulin + metformin | Shanghai General Hospital; Hangzhou Sino-US East China Pharmaceutical Co., Ltd, Hangzhou Sino-US East China Pharmaceutical Co., Ltd | type 2 diabetes | | | | |
ChiCTR2100043770: A Randomized Controlled Study of Dapagliflozin in Reversing Newly Diagnosed Type 2 Diabetes Mellitus |
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| Recruiting | 4 | 360 | | Dapagliflozin ;Metformin ;Dapagliflozin+Metformin ;Insulin Mendon Injection+Insulin Glargine Injection ;Duolapeptide Injection | Jiangsu Hospital of Integrated Traditional Chinese and Western Medicine; Jiangsu Hospital of Integrated Traditional Chinese and Western Medicine, Not Yet | Type 2 Diabetes Mellitus | | | | |
ChiCTR2100054245: Effect of repeated intranasal administration of different doses of insulin on postoperative delirium, serum TAU protein and Aβ protein in elderly patients undergoing radical esophageal cancer surgery |
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| Recruiting | 4 | 90 | | Saline ;20U insulin ;30U insulin | The General Hospital of Western Theater Command; The General Hospital of Western Theater Command, Hospital Management Issues of the General Hospital of Western Theater Command in 2021 | Postoperative delirium (POD) | | | | |
NCT05331469: Difference of Basal Insulin Titration Method in Reducing HbA1c Among Type 2 Diabetes Mellitus (T2DM) Patients. |
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| Recruiting | 4 | 70 | RoW | NPH basal insulin titration | University of Malaya | to Identify Which Titration Regimen of Basal Insulin (Being Daily Titration vs 3 Daily Titration) is Better in Reducing hba1c and Have Lesser Hypoglycemia | 08/22 | 04/23 | | |
ChiCTR2000035887: A Randomized controlled trial for liraglutide plus linagliptin in improving neurological function of patients with acute ischemic stroke and hyperglycemia |
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| Not yet recruiting | 4 | 680 | | Liraglutide plus Liraglutide ;Standard hypoglycemic therapy | Shanghai 6th People's Hospital; Shanghai 6th People's Hospital, Shanghai Shenkang Hospital Development Center | acute ischemic stroke | | | | |
ChiCTR2200056906: A randomized, controlled study of intranasal insulin preconditioning to reduce postoperative delirium by inhibiting NLRP3/Caspase-1/IL-1β signaling pathway |
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| Not yet recruiting | 4 | 60 | | Saline ;insulin30u | The General Hospital of Western Theater Command; The General Hospital of Western Theater Command, Hospital management issues of the General Hospital of Western Theater Command in 2021 | Postoperative delirium | | | | |
ChiCTR2200056907: A randomized, controlled clinical study on the effect of repeated intranasal insulin administration on postoperative delirium and serum miRNA490-3P and neurog2 in elderly patients with radical esophagectomy |
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| Not yet recruiting | 4 | 60 | | Saline ;insulin30u | The General Hospital of Western Theater Command; The General Hospital of Western Theater Command, Hospital management issues of the General Hospital of Western Theater Command in 2021 | Postoperative delirium | | | | |
2019-003209-89: An investigation of two long-acting insulins around multiple spontaneous physical exercise sessions in people with type 1 diabetes: a comparison of insulin Glargine U300 (IGlar-U300) to insulin Degludec U100 (IDeg-U100) |
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| Not yet recruiting | 4 | 25 | Europe | Toujeo, Tresiba, A10AE04, A10AE06, Solution for injection, Toujeo 300 units/ml SoloStar, solution for injection in a pre-filled pen, Insulin degludec (Tresiba® 100 U/mL) in 3 mL FlexTouch® | Medical University of Graz, Sanofi | Type 1 Diabetes, Participants in this study have type 1 diabetes which is defined as the lack of an own insulin production., Diseases [C] - Nutritional and Metabolic Diseases [C18] | | | | |
ChiCTR2100042914: The efficacy and safety of twice-a-day Insulin degludec /insulin aspart compared with the traditional intensive treatment regimen of four times a day in newly diagnosed type 2 diabetes mellitus |
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| Recruiting | 4 | 400 | | Insulin degludec/Insulin aspart therapy ;insulin detemir combined Insulin aspart therapy | Xichang People's Hospital; Xichang People's Hospital, Unit self-raised | diabetes | | | | |
ChiCTR2200058174: Efficacy and safety of dapagliflozin in patients with primary nephropathy treated with glucocorticoids: A pilot study |
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| Not yet recruiting | 4 | 264 | | Dapagliflozin ;None | Shanghai Changzheng Hospital; Shanghai Changzheng Hospital, Self-funded by researchers | Nephropathy | | | | |
NCT04599075: Intravenous Insulin vs Subcutaneous Insulin Infusion in Intrapartum Management of Type 1 Diabetes Mellitus |
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| Completed | 4 | 70 | US | Insulin, Insulin via IV Infusion, Insulin via Pump | Gianna Wilkie | Type 1 Diabetes, Pregnancy, High Risk | 05/23 | 05/23 | | |
ChiCTR2200063658: Efficacy and safety of canagliflozin in patients with type 2 diabetes and proteinuria after renal transplantation |
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| Not yet recruiting | 4 | 56 | | Canagliflozin oral ;None | Renji Hospital affiliated to Shanghai Jiao Tong University Medical College; Renji Hospital affiliated to Shanghai Jiao Tong University Medical College, None | Kidney transplant | | | | |
NCT04869709: Late Preterm Corticosteroids and Neonatal Hypoglycemia |
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| Not yet recruiting | 4 | 210 | US | Betamethasone Sodium Phosphate, Celestone | University of Southern California | Neonatal Hypoglycemia, Prematurity | 07/23 | 07/24 | | |
ChiCTR2000037825: Objective to evaluate the clinical efficacy and changes of intestinal flora in overweight / obese patients with type 2 diabetes mellitus |
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| Recruiting | 4 | 20 | | insulin and intestinal flora ;insulin | Shantou Longhu People's Hospital; Longhu People's Hospital, Shantou Longhu People’s Hospital | Type 2 diabetes mellitus | | | | |
| Completed | 4 | 82 | US | Tandom t:slim X2 with HCL or PLGS, Tandom t:slim X2 with Control-IQ Technology, Tandom t:slim X2 with Basal-IQ Technology | Jaeb Center for Health Research, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), DexCom, Inc., Tandem Diabetes Care, Inc., University of Minnesota - Advanced Research and Diagnostic Laboratory, Mayo Clinic, University of Pennsylvania, AdventHealth Diabetes Institute, Washington State University | Type 1 Diabetes Mellitus | 09/23 | 01/24 | | |
NCT03608163: Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF) |
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| Active, not recruiting | 4 | 17 | US | Naloxone, NARCAN Nasal Spray, Diazoxide, Placebo (for Naloxone), Placebo (for Diazoxide) | Albert Einstein College of Medicine, National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Diabetes Mellitus, Type 1, Hypoglycemia, Hypoglycemia Unawareness | 12/23 | 12/23 | | |
| Not yet recruiting | 4 | 1167 | NA | Canagliflozin, Dapagliflozin, Empagliflozin | Center for Outcomes Research and Clinical Epidemiology, Italy, Italian Society of Diabetology | Diabetes Mellitus, Type 2 | 12/23 | 12/23 | | |
| Active, not recruiting | 4 | 28 | US | Spironolactone, Placebo, Hypoglycemic Hyperinsulinemic Clamp, Hypoglycemic Hyperinsulinemic Clamp Procedure, Euglycemic Hyperinsulinemic Clamp, Euglycemic Hyperinsulinemic Clamp Procedure | Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, National Heart, Lung, and Blood Institute (NHLBI) | Hypoglycemia, Healthy | 01/24 | 01/24 | | |
NCT04332393: Metformin to Treat Corticosteroids-induced Hyperglycemia |
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| Recruiting | 4 | 323 | RoW | Metformin | The Baruch Padeh Medical Center, Poriya | Pregnancy Preterm, Glycemic Control, Corticosteroids Induced Hyperglycemia | 04/24 | 12/24 | | |
NCT06370715: A Study of LY900014 in Adult Participants With Type 2 Diabetes Mellitus in India |
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| Recruiting | 4 | 112 | RoW | Insulin Lispro-aabc, LY900014, Insulin Glargine | Eli Lilly and Company, Cipla Ltd. | Diabetes Mellitus, Type 2 | 07/25 | 07/25 | | |
HumAn-1, NCT05614089: Human Versus Analogue Insulin for Youth With Type 1 Diabetes in Low-Resource Settings |
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| Active, not recruiting | 4 | 400 | RoW | Insulin Glargine, NPH or premixed 70/30 (human insulin) | Jing Luo, The Leona M. and Harry B. Helmsley Charitable Trust | Diabetes Mellitus, Type 1, Type 1 Diabetes | 06/24 | 12/24 | | |
DECIDE, NCT06445946: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes |
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| Not yet recruiting | 4 | 1572 | US | Metformin, Insulin | Ohio State University, Patient-Centered Outcomes Research Institute, The George Washington University Biostatistics Center | Gestational Diabetes Mellitus, Pregnancy, High Risk | 12/29 | 12/30 | | |
NCT05750459: Pharmacokinetic Study of IV Artesunate to Treat Children With Severe Malaria |
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| Recruiting | 4 | 100 | RoW | Artesunate | National Institute of Allergy and Infectious Diseases (NIAID), University of Maryland, Baltimore, Makerere University | Plasmodium Falciparum Infection | 11/24 | 12/24 | | |
| Recruiting | 4 | 573 | Europe | Prednisone, Placebo Arm | University Hospital, Basel, Switzerland, Kantonsspital Baselland Bruderholz, Swiss National Science Foundation, HEMMI Stiftung Switzerland | Inflammatory Disorder, Autoimmune | 12/24 | 12/24 | | |
| Not yet recruiting | 4 | 224 | | IDegAsp BID ;IDegAsp QD+2IAsp | Beijing Hospital; Beijing Hospital, Beijing Research Association for Chronic Disease Control and Health Education | Type 2 diabetes | | | | |
ChiCTR2200062954: Pioglitazone in spontaneous subarachnoid hemorrhage: A multicentre, double-blind, randomised trial |
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| Not yet recruiting | 4 | 400 | | Pioglitazone treatment ;Placebo treatment | 904th Hospital of Joint Logistic Support Force; 904th Hospital of Joint Logistic Support Force, Natural Science Foundation of Jiangsu Province; Wuxi key demonstration project | Spontaneous subarachnoid hemorrhage | | | | |
ChiCTR2300074046: Weight Management with Hengagliflozin Proline in Obese Populations: A Randomized, Double-blind, Placebo-controlled Multicenter Clinical Study |
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| Not yet recruiting | 4 | 249 | | 5mg or 10mg of proline Hanger-on and exercise diet treatment ;Placebo and diet-exercise therapy | The First Affiliated Hospital of University of Science and Technology of China; The First Affiliated Hospital of University of Science and Technology of China, Jiangsu Hengrui Medicine Co., Ltd. | Obesity | | | | |
ChiCTR2300074691: Short-Term Beinaglutide (rGLP-1) treatment in Acute Ischemic Stroke (STB-AIS) with hyperglycemia: a randomized, open-label, parallel-group study |
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| Recruiting | 4 | 60 | | Beinaglutide ;Routine stroke treatment | Peking University First Hospital; Peking University First Hospital, Shanghai Benemae Pharmaceutical Corporation | Acute Ischemic Stroke | | | | |
| Recruiting | 4 | 416 | US | Insulin | Medical College of Wisconsin, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Gestational Diabetes | 03/26 | 10/26 | | |
