Not yet recruiting

4

12

 

George Medicines, George Medicines (The George Institute)

Hypertension

 

 

Not yet recruiting

4

30

 

University of Queensland, University of Queensland

Hypertension

 

 

Not yet recruiting

4

80

 

Royal North Shore Hospital , Ramsay Healthcare- Ramsay Research and Education Grant

chronic hypertension , Preeclampsia, gestational hypertension

 

 

Recruiting

4

20

 

Flinders University, Flinders University

Congestive Heart Failure, Pulmonary Hypertension

 

 

Recruiting

4

200

 

The University of Queensland, Colonial Foundation Limited, NHMRC- National Health and Medical Research Council

Diabetes, Hypertension, Renal Disease

 

 

Ongoing

4

704

Europe

Methylprednisolone acetate, Triamcinolone acetonide, Injection, Solution for injection, Depo-Medrone, Kenalog

University of Oxford, NIHR Health Technology Assessment Programme

Pulmonary Hypertension, Right heart failure

 

 

Ongoing

4

868

Europe

Comirnaty, COVID-19 Vaccine AstraZeneca, COVID-19 Vaccine Moderna, Injection, Comirnaty, COVID-19 Vaccine AstraZeneca, COVID-19 Vaccine Moderna

Skåne University Hospital, department of rheumatology in Lud and Malmö, Skåne University Hospital, Department of rheumatology in Lund and Malmö

Pre-hypertension

 

 

Recruiting

4

5000

 

Songling Xuemaikang Capsule

Dongzhimen Hospital; Dongzhimen Hospital, Pharmaceutical Co., Ltd. Chengdu Nakasone

primary hypertension

 

 

Ongoing

4

24

Europe

Vasexten, Capsule*, Vasexten

Hôpital Erasme

2 groups of patients: one group of patients with systemic hypertension and one another group with control subjects free of disease

 

 

Ongoing

4

20

Europe

Tablet, Tracleer

Hôpital Erasme

healthy subjectsobstructive sleep apnea(Bosentan is used in clinic in pulmonary hypertension)

 

 

Completed

4

541

 

take salt with lower Natrium ;take common Iodine salt

The First Hospital of China Medical University; Level of the institution：, Science and technology projects of Liaoning Province

Hypertension

 

 

Completed

4

150

 

amlodipine(Norvase, 5mg/tablet) + metoprolol(Betaloc,12.5mg/tablet) ;valsartan(Diovan, 80mg/tablet) +metoprolol(Betaloc,12.5mg/tablet)

the Third Xiangya Hospital of Central South University; Hunan Science and Technology Bureau, Science and Technology Program of Hunan (2006SK2003)

Post-transplant hypertension

 

 

Completed

4

60

 

routine CPB plus NO plus iloprost ;routine CPB plus iloprost ;routine CPB plus NO ;routine CPB not taking any drugs

Department of Thoracic and Cardiovascular Surgery, West China Hospital; The National Natural Science Fundation, The National Natural Science Funds

isolated atrial septal defects and/or ventricular septal defects with/without pulmonary hypertension

 

 

Completed

4

90

 

Oral losartan by 25mg/d of the initial dose, three days latter alternate to 50mg/d ;Oral propranolol by 20mg/d of initial dose; then, progressively increase 10mg/d, max dose 120mg/d or rest heart rate reduced to the 75% of fundamental rate, or no less than 55/min ;Placebo

Department 1 of Infectious Diseases, 302 Hospital of P.L.A; Level of the institution：, self-finance

portal hypertension

 

 

Completed

4

24000

 

(Total Cholesterol concentration of participants: <4.0 or >6.1mmol/L). Amlodipine 2.5mg and compound amiloride half of a tablet. ;(Total Cholesterol concentration of participants <4.0 or >6.1mmol/L). Amlodipine 2.5mg and telmisartan 40mg. ;(Total Cholesterol concentration of participants: 4.0-6.1mmol/L). Amlodipine 2.5mg, telmisartan 40mg and simvastatin 10mg. ;(Total Cholesterol concentration of participants: 4.0-6.1mmol/L). Amlodipine 2.5mg and telmisartan 40mg, regular remedy of serum lipid decided by the doctors. ;(Total Cholesterol concentration of participants 4.0-6.1mmol/L). Amlodipine 2.5mg and compound amiloride half of a tabella and regular remedy of serum lipid decided by the doctors. ;(Total Cholesterol concentration of participants: 4.0-6.1mmol/L). Amlodipine 2.5mg, compound amiloride 2.5mg and simvastatin 10mg ;(Includes group 1, group 2, and group 5). Amlodipine 2.5mg, compound amiloride half of a tablet. ;(Includes group 3, group 4 and group 6). Amlodipine 2.5mg, telmisartan 40mg.

Fu Wai Hospital for Cardiovascular Disease; The Ministry of Science and Technology of the People's Republic of China, The Ministry of Science and Technology of the People's Republic of China

Hypertension

 

 

Completed

4

300

 

the control group are given extended release nifedipine tablets 10mg bid and Enalapril Maleate Tablets 10mg bid.and if the participent couln't resist the adverse reaction,change to indapamide tablet 2.5mg qd. ;on the basic medication of the control group ,the treatment group are given different herbal medicine according to the syndrome differentiation

Xiyuan Hospital of Chinese Academy of Medical Science; State Administration of Traditonal Chinese Medicine of The People’s Republic of China, National Key Technology R&D Program of China

senile hypertension

 

 

Completed

4

1000

 

no ;antihypertensive drug

Institute of Clinical Pharmacology, Central South University; Institute of Clinical Pharmacology, Central South University, Self-financing

Hypertension

 

 

Completed

4

4800

 

telmesartan capsule 40mg/day ;Beijing 0 tablets 0.5#/qd ;placebo tablets 0.5#/qd ;Indapamide 1.5mg/capsule, once two days

Beijing Double-Crane Pharmaceutical Co., Ltd.; Ministry of Science and Technology of The People's Republic of China, 11th National Five-Year Plan + Sponsorship

Hypertension, Cardiovascular diseases

 

 

Completed

4

30

 

Besides the basic treatment aspirin on awakening for 2weeks and then taking aspirin at bedtime for 2 weeks ;aspirin at bedtime for 2weeks，and then taking aspirin on awakening for 2weeks.

The Second Hospital of Hebei Medical University; The Second Hospital of Hebei Medical University, Department of Cardiology

coronary heart disease

 

 

Completed

4

1325

 

Hydrochlorothiazide ;Hydrochlorothiazide+Felodipine

Institute of Clinical Pharmacology, Central South University; Institute of Clinical Pharmacology, Central South University, 863 project

Hypertension

 

 

Completed

4

70

 

antihypertension drugs

Institute of Clinical Pharmacology in Central South Univiersity; Institute of Clinical Pharmacology in Central South Univiersity, the "863" Project (No. 2012AA02A518)

essential hypertension

 

 

Completed

4

200

 

Calcium (600mg/d)+vitamin D (800IU/d) ;Calcium (1200mg/d)+vitamin D (400IU/d) ;Calcium (600mg/d)+vitamin D (400IU/d) ;Calcium (1200mg/d)+vitamin D (800IU/d)

The first hospital affiliated to Xinjiang Medical University; The first hospital affiliated to Xinjiang Medical University, Evidence-based medicine special fund of the first hospital affiliated to Xinjiang Medical University

primary hypertension

 

 

Completed

4

9000

 

The enrolled patients aged 18-70 will be treated with nitrendipine/atenolol combination tablets for 6 months(some of them will be treated for 12 months). The initial dose comprised two tablets of nitrendipine(5 mg)/atenolol(10 mg) between 8:00 am and 10:00 am once a day.; If the blood pressure is higher than that of baseline at the end of the second week, the drugs may increase to 3 tablets(taking an additional tablet of drug at about 18:00 pm). If the blood pressure are poor controlled (≥ 140/90 mmHg) at the end of the fourth week, the drugs taken in the afternoon may increase to 2 tablets.; If the blood pressure are poor controlled (≥ 140/90 mmHg) at the end of the second month, the patients may take other antihypertensive drugs (other CCB and β-blockers are not allowed to take). If dose-related intolerance symptoms, suspected or definite low blood pressure occur in patients,the drugs taken may be reduced gradually.

The Beijing Hypertension League Institute; Fuwai Hospital PUMC & CAMS, Jiangsu Jiberer Pharmaceutical Company Limited

Primary hypertension

 

 

Completed

4

400

 

All eligible subjects will receive OLM 20mg/d additionally on the treatment of AML 5mg/d to lower the blood pressure at least for 8 weeks. If target blood pressure (SeDBP<90mmHg, SeDBP<80mmHg for DM subjects) is not achieved, up titrate to OLM 40mg/d with AML 5mg/d or add HCTZ 12.5mg/d on OLM 20mg/d (fixed combination tablet of OLM/HCTZ) and AML 5mg/d according to the judgment of investigators.

Ruijin Hospital Affiliated to The Shanghai Jiao Tong University Medical School; Daiichi Sankyo Pharmaceutical (Shangjhai) Co., LTD., Daiichi Sankyo Corporation

Hypertension

 

 

Completed

4

1800

 

telmisartan ;ndapamide

Institute of Clinical Pharmacology, Central South University; Institute of Clinical Pharmacology, Central South University, 863 project

Hypertension

 

 

Completed

4

300

 

Urapidil injection titrated to target dose within 6 hours. Treatment lasts for 48 hours.

Department of Cardiology, Xuanwu Hospital, Capital Medical University; China International Medical Communicational Foundation, Funds obtained from collaboration project

Acute Heart Failure with hypertension

 

 

Ongoing

4

15

Europe

Tablet, Amlodipine, Chlortalidone

Hypertension, induced by the use of a Calcineurin Inhibitor (CNI) Hypertensie, geïnduceerd door het gebruik van een Calcineurine Remmer (CNI), Hypertension, high blood pressure Hypertensie, hoge bloeddruk, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Ongoing

4

15

Europe

Ventavis, Inhalation solution, Iloprost

Royal Brompton and Harefield NHS Foundation Trust, Bayer PLC

Pulmonary Arterial Hypertension Eisenmenger syndrome, PAH Eisenmenger, Diseases [C] - Respiratory Tract Diseases [C08]

 

 

Completed

4

120

 

patients treated with drug A(Fudosteine or placebo ;patients treated with drug A(Fudosteine or placebo)

Jiangsu Geriatric Hospital; Level of the institution：, Project of 2012 Jiangsu provincial clinical medicine technology

hypertension complicated with obstructive sleep apnea syndrome

 

 

Recruiting

4

300

 

Basic treatment (Irbesartan 150mg each time, once a day) + Bai'ai capsules (0.5g each tablet) 3 tablets each time, 2 times a day, taking pills in the morning and 0.5-1 hours after dinner,last for 12 consecutive weeks. ;Basic treatment (Irbesartan 150mg each time, once a day) + placebo (0.5g each tablet) 3 tablets each time, 2 times a day, taking pills in the morning and 0.5-1 hours after dinner,last for 12 consecutive weeks.

Affiliated Huashan Hospital of Fudan University; Level of the institution：, Fund of Shanghai Association of Integrative Medicine

Hypertension associated with the metabolic syndrome

 

 

Completed

4

25

 

amlodipine/atorvastatin 5mg/10mg

Peking university third hospital cadiology department; Peking university third hospital, National Natural Science Foundation of China (No: 81300076); the Beijing Natural Science Foundation (No: 7132195); Hisun Pfizer Inc researchers sponsored funds (number: WS1931003)

hypertension and hyperlipidemia

 

 

Recruiting

4

32

 

telmisartan

Institute of Clinical Pharmacology, Xiangya Hospitol, Central South University; Institute of Clinical Pharmacology, Central South University, 863 project

Hypertension

 

 

Completed

4

300

 

Routine treatment combined with arotinolol ;Routine treatment

Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine; Sumitomo Pharmaceuticals (Suzhou) Co., Ltd., Sumitomo Pharmaceuticals (Suzhou) Co.,Ltd.

End-stage renal disease on maintenance hemodialysis with hypertension

 

 

Ongoing

4

20

Europe

Primacor 1mg/ml Solution for Injection, Solution for injection/infusion, Primacor 1mg/ml Solution for Injection

Royal College of Surgeons in Ireland, The Rotunda Hospital

Persistent Pulmonary Hypertension of the Newborn, High Blood Pressure in the Lungs of Newborn Babies, Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]

 

 

Completed

4

75

 

0.9%saline muscular injection monthly ;20mg long-acting octreotide muscular injection monthly ;40mg long-acting octreotide muscular injection monthly

Shanghai Sixth People's Hospital; Level of the institution：, self-funding

liver cirrosis, portal hypertension

 

 

Ongoing

4

10

Europe

LERCANIDIPINE, ZANIDIP, ZANIDIP

HOSPITAL 12 OCTUBRE

HYPERTENSION

 

 

Ongoing

4

140

Europe

COZAAR PLUS (losartán / hydrochlorothiazide), COZAAR PLUS, COZAAR PLUS

Catalan Society of Family Medicine, represented by Dr Mariano de la Figuera Von Wichman and Gabriel

Stage II arterial Hypertension

 

 

Ongoing

4

40

Europe

Viagra, Isosorbide mononitrate, Viagra, Angeze 10 Isosorbide mononitrate 10 mg Kentipine 10 Cibral tablets 10, Angeze 20 mg Isosorbide mononitrate 20 mg Cibral tablets 20 mg, Viagra, Angeze 10 Isosorbide mononitrate 10 mg Kentipine 10 Cibral tablets 10, Angeze 20 mg Isosorbide mononitrate 20 mg Cibral tablets 20 mg

University of Edinburgh

Hypertension

 

 

Ongoing

4

200

Europe

Fibro-Vein, PL 0398/5000, Fibro-Vein STD Pharmaceutical Products LTD Fields Yard Plough Lane Hereford England HR4 0EL, Fibro-Vein STD Pharmaceutical Products LTD Fields Yard Plough Lane Hereford England HR4 0EL

Gloucestershire Hospitals NHS Foundation Trust

We will include patients with insufficiency of the long and/or short saphenous vein as underlying cause of their venous leg ulcer. These patients may or may not have visible varicose veins of the long and/or short saphenous vein.According to ICD classification:Chronic venous hypertension with ulcer ICD-9-CM-459.31Chronic ulcer of the skin ICD-9-CM-707

 

 

Ongoing

4

115

Europe

Zanidip, Diovan, Doxazosin \"Stada\", Moxonidin \"Alpharma\", Visken, Sparkal, Selo-Zok, Myonil Retard, Isodur, Centyl med kaliumchlorid, Angicor, Zanidip, Diovan, Doxazosin \"Stada\", Moxonidin \"Alpharma\", Visken, Sparkal, Selo-Zok, Myonil Retard, Isodur, Centyl med kaliumchlorid, Angicor

Århus Sygehus

Patienter med hypertension og angina pectoris og ingen signifikante stenoser ved koronararteriografi (KAG).

 

 

Ongoing

4

50

Europe

Revatio Cialis Levitra, Revatio Cialis Levitra

Medical Sciences, Akademiska sjukhuset

 Pulmonell hypertension med kvarstående förhöjt medeltryck i arteria pulmonalis överstigande 25 mmHg i vila eller >30 mmHg under ansträngning vid hjärtkateterisering definierad av National Institute of Health (NIH). Patienten skriver på för skriftligt samtycke (Informed Consent) Patienten över 18 år

 

 

Ongoing

4

45

Europe

tracleer, Tracleer, Tracleer

St Georges Hospital

Pulmonary Hypertension secondary to Chronic Obstructive Pulmonary Disease and secondary to SarcoidPatients devolop pulmonary hypertension for various reasons, two common causes are Chronic Obstructive Pulmonary disease and Sarcoid. Once developed it may go on to cause right heart failure and severe breathlessness and eventually death.We believe that the use of bosentan may lower the pulmonary hypertension and improve symptoms.

 

 

Ongoing

4

20

Europe

Atacand, Selokeen, Atacand, Selokeen

Department of Cardiology

Aortic coarctation and late hypertension

 

 

Ongoing

4

13

Europe

Atorvastatin, lipitor, lipitor

Radboud University Medical Center Njmegen

hypertension and sympathoexcitation

 

 

Ongoing

4

60

Europe

Doxazosin, Bisoprolol, Candesartan, Isosorbide mononitrate modified release, Doxazosin,

Cambridge University Hospitals NHS Foundation Trust jointly with University of Cambridge

Essential hypertension

 

 

Ongoing

4

50

Europe

Atenolol, Atenolol, Nebliet, Atenolol, Nebliet

Imperial College London

Hypertension

 

 

Ongoing

4

60

Europe

Rosuvastatine, Olmetec, ZD4522, Crestor, Olmetec, Crestor, Olmetec

academisch ziekenhuis Maastricht

hypertensionmild renal insufficiency

 

 

Ongoing

4

24

Europe

INSPRA (eplerenona), ALDACTONE, INSPRA (eplerenona), ALDACTONE (espironolactona), INSPRA (eplerenona), ALDACTONE (espironolactona)

Fundación Investigación y Desarrollo en el Area Cardiovascular

Disfunción ventricular leve-moderada post-infarto agudo de miocardio en pacientes diabéticos con hipertensión arterial no controlada.Low-moderate ventricular dysfunction in post-acute coronary syndrome patients with diabetes and non-controlled arterial hypertension.

 

 

Ongoing

4

60

Europe

Nebilet, Talliton, Betaloc Zok, Nebilet, Talliton, Betaloc Zok

Hungarian Kidney Foundation

Patients with hypertension and/or ischemic heart disease

 

 

Ongoing

4

100

Europe

NEBILOX, ATENOLOL BIOGARAN 50 mg, NEBILOX, ATENOLOL BIOGARAN 50 mg

Laboratoires NEGMA

Hypertension artérielle