| Frontotemporal Lobar Degeneration |
NCT06093126: Lemborexant for Insomnia in a Patient With Dementia: An N-of-1 Trial |
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| Recruiting | 4 | 1 | Canada | Lemborexant 5 MG, Lemborexant 10 MG | Nova Scotia Health Authority | Insomnia, Dementia, Frontotemporal Dementia | 12/28 | 12/28 | | |
NCT00950430: Imaging of Brain Amyloid Plaques in the Aging Population |
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| Enrolling by invitation | 4 | 8000 | US | Pittsburgh Compound B (C-11 PiB), F-18 FDG, Tau (18-F-AV-1451) | Mayo Clinic, National Institute on Aging (NIA) | Alzheimer's Disease, Dementia With Lewy Bodies, Frontotemporal Dementia, Vascular Dementia | 06/27 | 06/27 | | |
2012-004328-40: study of neuroinflammation in pathologies like Alzheimer, mild cognitive impairment, dementia and SLA studio della infiammazione della struttura dei nervi nelle malattie quali Alzheimer, declino cognitivo lieve, demenza e sclerosi laterale amiotrofica |
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| Ongoing | 3 | 40 | Europe | NA, (R)-[N-metil-11C1-PK11195(PK), Solution for injection | OSPEDALE S. RAFFAELE DI MILANO, Programma Europeo FP7-HEALTH-2011-two-stage | mild cognitive impairment, Alzheimer disease,frontotemporal dementia, SLA declino cognitivo lieve, malattia di Alzheimer, demenza frontotemporale, sclerosi laterale amiotrofica, cognitive and motor impairment disturbi cognitivi e motori, Diseases [C] - Nervous System Diseases [C10] | | | | |
2014-001315-40: Florbetapir-PET scan in subjects with a known mutation for autosomal dominant Alzheimer's Disease taking part in the ItalianDIAfN study Effettuazione della scansione PET con tracciante per l'amiloide (Florbetapir 18F-PET) in soggetti portatori di mutazione genetica patogenetica per la malattia di Alzheimer partecipanti al progetto di ricerca ItalianDIAfN |
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| Ongoing | 3 | 12 | Europe | Florbetapir (18F), Florbetapir (18F), Injection, Amyvid | IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, AVID Radiopharmaceuticals (drug supply), Ministry of Health (research support) | Autosomal Dominant Alzheimer's Disease Malattia di Alzheimer di tipo autosomico dominante, Familial Alzheimer's Disease, i.e. due to genetic mutation in the APP, PSEN1, or PSEN2 gene. Forme familiari di malattia di Alzheimer, cioè causate da una mutazione genetica in uno dei geni tra APP, PSEN1, PSEN2, Diseases [C] - Nervous System Diseases [C10] | | | | |
2006-005842-35: Efficacy and safety of treatment with N-butyl-deoxynojirimycin (NB-DNJ-miglustat) in patients with Niemann-Pick disease type C. |
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| Ongoing | 3 | 25 | Europe | ZAVESCA, ZAVESCA | Dipartimento di Pediatria Universita, di Napoli Federico II | NIEMANN-PICK DISEASE TYPE C | | | | |
ACTRN12618001807246: The effects of intranasal oxytocin on emotion processing and carer burden in individuals diagnosed with frontotemporal dementia |
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| Suspended | 3 | 40 | | | The University of Sydney , National Health and Medical Research Council | Frontotemporal Dementia, Emotion Processing | | | | |
2021-005356-10: A pivotal study of N-Acetyl-L-Leucine on Niemann-Pick disease type C |
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| Ongoing | 3 | 53 | Europe, RoW | N-acetyl-L-leucine, IB1001, Granules for oral suspension in sachet | IntraBio Ltd, IntraBio Ltd | Niemann-Pick Disease type C (NPC) Niemann-Pickovu chorobu typu C, Niemann-Pick Disease type C (NPC) Niemann-Pickovu chorobu typu C, Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | | | | |
NCT05163288: A Pivotal Study of N-Acetyl-L-Leucine on Niemann-Pick Disease Type C |
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| Active, not recruiting | 3 | 53 | Europe, US, RoW | N-Acetyl-L-Leucine, IB1001, Placebo | IntraBio Inc | Niemann-Pick Disease, Type C | 06/23 | 11/24 | | |
| Active, not recruiting | 3 | 94 | Europe, US, RoW | Hydroxypropyl-beta-cyclodextrin, Trappsol Cyclo, Placebo, 0.5N saline | Cyclo Therapeutics, Inc. | Niemann-Pick Disease, Type C1 | 06/25 | 06/26 | | |
| Active, not recruiting | 3 | 110 | Europe, Canada, US, RoW | AL001, Placebo, Open label - AL001 | Alector Inc. | Frontotemporal Dementia | 09/25 | 10/27 | | |
| Recruiting | 3 | 72 | US | FPI-2620 | University of Pennsylvania, National Institutes of Health (NIH) | Frontotemporal Lobar Degeneration, Alzheimer Disease, Cognitively Normal | 08/26 | 08/26 | | |
2015-004438-93: A clinical study to investigate the study drug Arimoclomol in a double blind, randomised, placebo-controlled study in patients diagnosed with Niemann Pick disease type C. |
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| Ongoing | 2/3 | 57 | Europe, RoW | Arimoclomol, _, Capsule, hard | Orphazyme A/S, Orphazyme ApS, Orphazyme A/S, Orphazyme ApS | Niemann Pick disease type C, Niemann-Pick Type C is a rare and inherited disease in which quantities of fatty substances accumulate in the brain and other organs. The brain, central nervous system, liver and spleen are affected., Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | | | | |
NCT02612129: Arimoclomol Prospective Study in Participants Diagnosed With Niemann-Pick Disease Type C |
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| Active, not recruiting | 2/3 | 50 | Europe, US | arimoclomol, Placebo | ZevraDenmark | Niemann-Pick Disease, Type C | 06/18 | 01/25 | | |
| Completed | 2b | 56 | Europe, US, RoW | Parts A/B: Adrabetadex, 2-hydroxypropyl-β-cyclodextrin, Cyclodextrin, VTS-270, Adrabetadex, Parts A/B: Sham Control, Procedure Control, Skin prick | Mandos LLC | Niemann-Pick Disease, Type C | 03/18 | 03/18 | | |
NCT04993755: A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD |
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| Active, not recruiting | 2a | 42 | Europe, US | TPN-101, 400 mg/day, Placebo | Transposon Therapeutics, Inc. | Amyotrophic Lateral Sclerosis, Frontotemporal Dementia | 09/23 | 09/23 | | |
ACTRN12620000236998: Investigating sodium selenate as a treatment for behavioural variant frontotemporal dementia |
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| Recruiting | 2 | 120 | | | Alfred Health, NHMRC | behavioural variant frontotemporal dementia | | | | |
2011-004571-37: Amiodarone therapy for treatment of fontotemporat dementia caused by progranulin deficiency Studio sull'efficacia terapeutica dell'amiodarone nella Demenza Frontotemporale con deficit di Progranulina |
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| Ongoing | 2 | 5 | Europe | Tablet | AZIENDA OSPEDALIERA SPEDALI CIVILI DI BRESCIA, clinica neurologica Universita' degli studi di Brescia | frontotemporal dementia associated to progranulin deficit demenza frontotemporale associata a deficit di progranulina, frontotemporal dementia caused by progranulin deficit demenza frontotemporale causata da deficit di progranulina, Diseases [C] - Nervous System Diseases [C10] | | | | |
2014-000422-38: A study evaluating the diagnostic accuracy of [18F]-AV-1451 PET to detect and distinguish neurodegenerative disorders characterized by cerebral accumulation of the protein tau |
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| Ongoing | 2 | 590 | Europe | 18F-AV-1451, | Skåne University Hospital, Region Skåne, Avid Radiopharmaceuticals, Inc./Eli Lilly | Neurodegenerative disorders with Tau-pathology; including Alzheimer\'s disease, progressive supranuclear palsy, frontotemporal dementia, corticobasal degeneration and important differential diagnostic conditions. | | | | |
2005-005915-13: An Open Pilot Study of Methlythioninium Chloride (MTC) in Frontotemporal Dementia and Related Dementia Syndromes |
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| Ongoing | 2 | 20 | Europe | Methylthioninium chloride, MTC TRx0014-001 capsules, | TauRx Therapeutics PTE Ltd | Frontotemporal Dementia and related syndromes Prevention and reversal of tau protein aggregation is a novel approach to the treatment of patients with FTD and related syndromes and has the potential for slowing the disease process as well as providing symptomatic improvement in hitherto untreatable, ultimately fatal conditions. | | | | |
2015-005604-29: Imaging of tau in patients with dementia Beeldvorming van tau bij patiënten met dementie |
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| Ongoing | 2 | 200 | Europe | 18F-AV-1451, Solution for injection | VU University Medical Center, Avid Radiopharmaceuticals | Dementia inducing Alzheimer's disease, Frontotemporal dementia (FTD) and Lewy Body Dementia (DLB) Dementie als gevolg van tauopathie; de ziekte van Alzheimer, frontotemporale dementie (FTD) en Lewy Body dementie (DLB), Dementia Dementie, Diseases [C] - Nervous System Diseases [C10] | | | | |
2017-000094-36: The BioFINDER 2 study - improved diagnostics and increased understanding of the underlying mechanisms of cognitive disorders |
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| Ongoing | 2 | 1300 | Europe | 18F-RO6958948, Vizamyl, Injection, Vizamyl (flutemetamol(F-18)) | Skåne University Hospital, Hoffman La Roche Ltd., General Electric Ltd. | Neurodegenerative disorders with Tau-pathology; including, but not limited to, Alzheimer's disease, progressive supranuclear palsy,frontotemporal dementia, corticobasal degeneration and mild cognitive impairment., Diseases affecting the brain such as dementia or cognitive impairment; i.e. diseases that typically cause memory problems that the patientand/or relatives have noticed., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Diagnosis [E01] | | | | |
2018-000143-12: Efficacy of intranala oxytocin in dementia. A randomized double-blind, placebo-controlled trial. Efficacia di ossitocina intranasale per la demenza. Uno studio randomizzato in doppio cieco controllato con placebo. |
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| Ongoing | 2 | 52 | Europe | Nasal spray | ALMA MATER STUDIORUM UNIVERSITà DI BOLOGNA, AIFA - Italian Medicines Agency | Frontotemporal dementia (bvFTD) Demenza frontotemporale (bvFTD), Dementia Demenza, Diseases [C] - Nervous System Diseases [C10] | | | | |
2019-004498-18: Clinical trial to test efficacy and safety of efavirenz in patients with Niemann-Pick C disorder with cognitive impairment Ensayo Clínico para evaluar la eficàcia y Seguridad del efavirenz en pacientes con la enfermedad de Niemann pick tipo C con deterioro cognitivo |
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| Not yet recruiting | 2 | 11 | Europe | Efavirenz, Capsule, SUSTIVA efavirenz 100 mg | Dr. Jordi Gascón / Dra. Lola Ledesma, Fundación Española Niemann-Pick | Niemann Pick tipo C (NPC) Niemann Pick C type (NPC), Niemann Pick C type (NPC) is a genetic neurological disorder. Niemann Pick tipo C (NPC) es una patología genética neurodegenerativa., Body processes [G] - Genetic Phenomena [G05] | | | | |
2020-002672-12: Imaging of neuroinflammation in frontotemporal dementia by means of PET-MRI Beeldvorming van neuroinflammatie in frontotemporale dementie met behulp van PET-MRI |
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| Not yet recruiting | 2 | 32 | Europe | [18F]DPA-714, Radiopharmaceutical precursor | Erasmus Medical Center, ZonMw | Frontotemporal dementia (FTD), including symptomatic patients and presymptomatic individuals with genetic mutations predisposing to FTD at a later stage in life., Frontotemporal dementia Frontotemporale dementie, Diseases [C] - Nervous System Diseases [C10] | | | | |
2021-002251-11: A clinical study to learn whether a new drug, TPN-101, is safe when given to patients with amyotrophic lateral sclerosis or frontotemporal dementia due to a genetic mutation called C9orf72 hexanucleotide repeat expansion. |
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| Not yet recruiting | 2 | 40 | Europe | TPN-101, TPN-101, Capsule, hard | Transposon Therapeutics, Inc, Transposon Therapeutics, Inc | Amyotrophic lateral sclerosis or frontotemporal dementia due to a genetic mutation called C9orf72 hexanucleotide repeat expansion, Amyotrophic lateral sclerosis or frontotemporal dementia due to a genetic mutation called C9orf72 hexanucleotide repeat expansion, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT03759639: N-Acetyl-L-Leucine for Niemann-Pick Disease, Type C (NPC) |
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| Completed | 2 | 33 | Europe, US | IB1001, N-Acetyl-L-Leucine | IntraBio Inc | Niemann-Pick Disease, Type C | 11/22 | 11/22 | | |
2018-004331-71: To demonstrate that N-Acetyl-L-Leucine is effective in improving symptoms, functioning and quality of life in patients with Niemann-Pick Type C disease (NPC). |
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| Not yet recruiting | 2 | 39 | Europe, RoW | N-Acetyl-L-Leucine, IB1001, Powder for oral suspension, Granules for oral suspension | IntraBio Ltd, IntraBio Ltd, | To demonstrate that N-Acetyl-L-Leucine is effective in improvingsymptoms, functioning, and quality of life in patients withNiemann-Pick Type C disease (NPC)., Niemann-Pick Type C (NPC) is a rare inherited neurodegenerative disease that occurs when the cerebellum becomes inflamed or damaged., Diseases [C] - Nervous System Diseases [C10] | | | | |
PEA-FTD, NCT04489017: Palmitoylethanolamide Combined With Luteoline in Frontotemporal Dementia Patients. A Randomized Controlled Trial |
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| Completed | 2 | 50 | Europe | PEA-LUT, PLACEBO | I.R.C.C.S. Fondazione Santa Lucia | Frontotemporal Dementia | 12/22 | 06/23 | | |
NCT03260920: Intranasal Oxytocin for Frontotemporal Dementia |
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| Active, not recruiting | 2 | 112 | Canada, US | Syntocinon, Intranasal Oxytocin | Lawson Health Research Institute, Weston Brain Institute, Canadian Institutes of Health Research (CIHR), Berry Consultants | Frontotemporal Dementia | 06/23 | 12/24 | | |
RAINBOW, NCT05758922: Phase 2 Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral AZ-3102 in Patients With GM2 Gangliosidosis or Niemann-Pick Type C Disease |
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| Active, not recruiting | 2 | 13 | RoW | AZ-3102 (Dose 1), Placebo, AZ-3102 (Dose 2) | Azafaros A.G. | GM2 Gangliosidosis, Niemann-Pick Disease, Type C | 03/24 | 12/24 | | |
NCT04937452: Dopaminergic Therapy for Frontotemporal Dementia Patients |
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| Active, not recruiting | 2 | 75 | Europe | Rotigotine 4Mg/24Hrs Patch, Neupro, Rotigotine 6Mg/24Hrs Patch, Placebo | I.R.C.C.S. Fondazione Santa Lucia, Alzheimer's Drug Discovery Foundation | Frontotemporal Dementia, Dementia, Aphasia, Primary Progressive, Pick Disease of the Brain, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases, Neurocognitive Disorders, Mental Disorders, Neurodegenerative Diseases, Frontotemporal Lobar Degeneration, TDP-43 Proteinopathies, Proteostasis Deficiencies, Metabolic Disease, Aphasia, Speech Disorders, Language Disorders, Communication Disorders, Neurobehavioral Manifestations, Neurologic Manifestations | 12/23 | 04/24 | | |
NCT04220021: Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD |
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| Active, not recruiting | 2 | 18 | US | Metformin, Metformin hydrochloride sustained-release (SR) | University of Florida, ALS Association | C9orf72 Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia | 08/24 | 08/24 | | |
NCT06604520: Vortioxetine for the Treatment of Mood and Cognitive Symptoms in Frontotemporal Dementia |
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| Not yet recruiting | 2 | 50 | US | Vortioxetine, Trintellix | Johns Hopkins University, National Institute on Aging (NIA) | Fronto-temporal Dementia, Fronto-temporal Lobar Dementia, Frontotemporal Degeneration, Frontotemporal Dementia (FTD), Frontotemporal Dementia, Behavioral Variant, Frontotemporal Dementia | 05/29 | 09/29 | | |
| Active, not recruiting | 2 | 45 | Canada | Nabilone, Nabilone Oral Capsule, TEVA Nabilone, Placebo | Simon Ducharme, MD, Alzheimer's Drug Discovery Foundation | Frontotemporal Dementia, Frontotemporal Dementia, Behavioral Variant, Primary Progressive Aphasia, bvFTD, PPA, FTD | 05/25 | 12/25 | | |
| Active, not recruiting | 2 | 40 | Europe, Canada, US | AL001 | Alector Inc. | Frontotemporal Dementia | 01/26 | 06/26 | | |
PROBIO_HA114, NCT06051123: Effects of Probiotics in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia Spectrum Disorder (ALS-FTDSD) Patients |
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| Not yet recruiting | 2 | 150 | Canada | Probiotic, Placebo | Centre hospitalier de l'Université de Montréal (CHUM), Lallemand Health Solutions | ALSFTD | 02/27 | 02/27 | | |
| Terminated | 1b/2a | 35 | Europe, Canada, RoW | WVE-004, Placebo | Wave Life Sciences Ltd. | ALS, FTD | 06/23 | 06/23 | | |
NCT01372228: Phase I/II Pilot Study of Mixed Chimerism to Treat Inherited Metabolic Disorders |
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| Terminated | 1/2 | 3 | US | hematopoietic stem cell infusion | Talaris Therapeutics Inc., Duke University | Hurler Syndrome (MPS I), Hurler-Scheie Syndrome, Hunter Syndrome (MPS II), Sanfilippo Syndrome (MPS III), Krabbe Disease (Globoid Leukodystrophy), Metachromatic Leukodystrophy (MLD), Adrenoleukodystrophy (ALD and AMN), Sandhoff Disease, Tay Sachs Disease, Pelizaeus Merzbacher (PMD), Niemann-Pick Disease, Alpha-mannosidosis | 04/16 | 04/16 | | |
2021-005733-16: A 3 Part first-in-human study of DNL593 in healthy volunteers and patients with frontotemporal dementia (FTD) Estudio de 3 partes de primera administración en humanos de DNL593 en voluntarios sanos y en pacientes con demencia frontotemporal (DFT). |
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| Not yet recruiting | 1/2 | 42 | Europe | DNL593 Sterile Lyophilisate, DNL593, Lyophilisate for solution for infusion | Denali Therapeutics Inc., Denali Therapeutics Inc, Denali Therapeutics Inc. | Frontotemporal Dementia (FTD) Demencia Frontotemporal (DFT), FTD - condition of the brain associated with loss of brain cells, affecting behaviour, judgement, language, memoryand motor skills DFT - condición del cerebro asociada a la pérdida de células cerebrales, afectando al comportamiento, al proceso de juicio, lenguaje, memoria yhabilidades motoras., Diseases [C] - Nervous System Diseases [C10] | | | | |
2022-002568-62: A study to test whether AVB-101 is both safe and efficacious in a sub-population of genetically defined FTD patients that currently have no other treatment options Un estudio para probar si AVB-101 es seguro y eficaz en una subpoblación de pacientes con DFT genéticamente definidos que actualmente no tienen otras opciones de tratamiento. |
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| Not yet recruiting | 1/2 | 15 | Europe | Recombinant AAV-9 vector expressing the human progranulin protein, AVB-101, Solution for injection | AviadoBio Ltd, AviadoBio Limited | Frontotemporal Dementia With Progranulin Mutations (FTD-GRN) Demencia Frontotemporal con mutaciones en el gen de la progranulina (DFT-GRN), Dementia Demencia, Diseases [C] - Nervous System Diseases [C10] | | | | |
2022-002267-29: An Open-label Extension (OLE) Study of WVE-004 in Patients with C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD) |
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| Not yet recruiting | 1/2 | 42 | Europe | WVE-004, Powder for solution for injection | Wave Life Sciences UK Limited, Wave Life Sciences UK Limited | Amyotrophic Lateral Sclerosis and Frontotemporal Dementia, motor neuron disease; dementia where the front and sides of the brain has been affected, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT05683860: Open-label Extension (OLE) Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD) |
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| Terminated | 1/2 | 8 | Europe | WVE-004 | Wave Life Sciences Ltd. | ALS, FTD | 06/23 | 06/23 | | |
NCT03471143: Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease, Type C |
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| Recruiting | 1/2 | 12 | US | adrabetadex (2-Hydroxypropyl-Beta-Cyclodextrin), VTS-270, HP-Beta-CD | Washington University School of Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Niemann-Pick Disease, Type C | 06/24 | 06/24 | | |
upliFT-D, NCT04747431: A Study of PBFT02 in Patients With Frontotemporal Dementia and Progranulin Mutations (FTD-GRN) |
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| Recruiting | 1/2 | 15 | Europe, Canada, US, RoW | PBFT02 | Passage Bio, Inc. | Frontotemporal Dementia, FTD, FTD-GRN, Dementia Frontotemporal | 08/24 | 08/27 | | |
NCT05374278: First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia |
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| Recruiting | 1/2 | 102 | US | [18F]RP-115 PET/MRI or PET/CT and MRI | David Wilson, Rio pharmaceuticals Inc. | Alzheimer Disease, Frontotemporal Dementia, Dementia | 04/25 | 07/26 | | |
FTD-GRN, NCT05262023: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia |
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| Active, not recruiting | 1/2 | 106 | Europe, RoW | DNL593, Placebo | Denali Therapeutics Inc., Takeda | Frontotemporal Dementia | 11/25 | 11/25 | | |
ASPIRE-FTD, NCT06064890: A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN) |
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| Recruiting | 1/2 | 9 | Europe, US | Intrathalamic AAV.PGRN administration, Intrathalamic AVB-101 | AviadoBio Ltd | Frontotemporal Dementia, FTD, FTD-GRN, Dementia, Frontotemporal | 04/26 | 10/30 | | |
FTD-GRN, NCT04408625: Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations |
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| Recruiting | 1/2 | 30 | Europe, US, RoW | LY3884963, Methylprednisolone, Optional Sirolimus, Optional Prednisone | Prevail Therapeutics, Eli Lilly and Company | Frontotemporal Dementia | 08/29 | 08/29 | | |
NCT03893071: Open-Label Study of Long-Term Safety and Efficacy of Intravenous Trappsol Cyclo (HPβCD) in Niemann-Pick Disease Type C |
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| Active, not recruiting | 1 | 12 | US | Hydroxypropyl-β-cyclodextrin, Hydroxypropyl-β-cyclodextrin (HP-β-CD), Trappsol® Cyclo | Cyclo Therapeutics, Inc. | Niemann-Pick Disease, Type C1 | 03/22 | 03/22 | | |
| Recruiting | 1 | 10 | US | Abatacept plus Aldesleukin | The Methodist Hospital Research Institute | Frontotemporal Degeneration | 04/26 | 04/26 | | |
DUOC-01, NCT02254863: UCB Transplant of Inherited Metabolic Diseases with Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells |
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| Recruiting | 1 | 40 | US | DUOC-01 | Joanne Kurtzberg, MD, The Marcus Foundation | Adrenoleukodystrophy, Batten Disease, Mucopolysaccharidosis II, Leukodystrophy, Globoid Cell, Leukodystrophy, Metachromatic, Neimann Pick Disease, Pelizaeus-Merzbacher Disease, Sandhoff Disease, Tay-Sachs Disease, Brain Diseases, Metabolic, Inborn, Alpha-Mannosidosis, Sanfilippo Mucopolysaccharidoses | 10/25 | 10/25 | | |
| Recruiting | 1 | 64 | US | Verdiperstat, BHV-3241 | Peter Ljubenkov, MD, National Institutes of Health (NIH), Alzheimer's Association, National Institute on Aging (NIA) | Semantic Dementia | 06/26 | 09/26 | | |
| Active, not recruiting | 1 | 12 | RoW | ET-STEM | Samsung Medical Center | Frontotemporal Dementia | 12/26 | 12/26 | | |
NCT06179979: PET Study With 11 C-PIB to Evaluate Amyloid Protein Deposits in Mild Cognitive Disorder, Alzheimer's Disease and Early Frontotemporal Degeneration. |
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| Completed | N/A | 60 | NA | PET/CT with 11C-PiB | IRCCS San Raffaele | Alzheimer Disease | 07/08 | 07/08 | | |
| Withdrawn | N/A | 1000 | Europe, RoW | | CENTOGENE GmbH Rostock | Niemann-Pick Disease, Niemann-Pick Disease, Type C | 02/21 | 02/21 | | |
NCT05917886: Auditory Beat Stimulation and Behavioural Variant of Frontotemporal Dementia |
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| Completed | N/A | 11 | Europe | Auditory beat stimulation: 8Hz monaural beat stimulation | University Hospital, Bonn | Anxiety, bvFTD | 08/21 | 09/21 | | |
DEGERWD, NCT06209515: Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study |
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| Active, not recruiting | N/A | 61292 | Europe | | Kuopio University Hospital | Neurodegenerative Diseases, Alzheimer Disease, Frontotemporal Dementia, Lewy Body Disease, Vascular Dementia, Parkinson Disease, Progressive Supranuclear Palsy, Corticobasal Degeneration, Multiple System Atrophy, Amyotrophic Lateral Sclerosis, Huntington Disease | 12/27 | 12/27 | | |
NCT05004558: Effects of Remote-based Resistance Training on Cardiometabolic Risk Factors, Cognitive Function, and Quality of Life in Adults Living With Alzheimer's Disease and/or Related Dementias |
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| Not yet recruiting | N/A | 36 | NA | Remote-based Resistance Exercise Training | Drexel University, Mercy Health | Dementia, Alzheimer Disease, Dementia, Vascular, Lewy Body Disease, Frontotemporal Dementia, Mild Cognitive Impairment, Aging, Hypertension, Obesity, Abdominal, Obesity, Body Weight, Blood Pressure, Blood Glucose, High, Blood Glucose, Low, Dyslipidemias, Quality of Life, Cognitive Impairment | 03/22 | 06/22 | | |
| Completed | N/A | 186 | Europe | Neurological Soft Signs | University of Milano Bicocca | Alzheimer Disease, Dementia With Lewy Bodies, Frontotemporal Dementia, Corticobasal Degeneration | 11/23 | 02/24 | | |
| Completed | N/A | 40 | Europe | Metacognition tests | University Hospital, Grenoble | Semantic Dementia, Alzheimer Disease, Healthy | 04/22 | 04/22 | | |
| Enrolling by invitation | N/A | 75 | Canada | Educational Brochure | University Health Network, Toronto | Neuro-Degenerative Disease, Dementia, Caregiver Burnout, Alzheimer Disease, Frontotemporal Lobar Degeneration, Parkinson Disease, Vascular Dementia | 07/22 | 07/22 | | |
RHAPSODY, NCT04939818: Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorders |
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| Completed | N/A | 172 | Europe | | Novoic Limited, King's College London | Alzheimer Disease, Mild Cognitive Impairment, Dementia With Lewy Bodies, Dementia, Vascular, Frontotemporal Dementia, Primary Progressive Aphasia, Parkinson Disease, Motor Neuron Disease, Major Depressive Disorder, Bipolar Disorder, Amyotrophic Lateral Sclerosis | 09/22 | 09/22 | | |
| Recruiting | N/A | 10000 | US | Biological Sample Collection | New York Stem Cell Foundation Research Institute | ALS, Amyotrophic Lateral Sclerosis, Alzheimer Disease, Alzheimer Disease, Early Onset, Alzheimer Disease, Late Onset, Batten Disease, Corticobasal Degeneration, Dementia, Frontotemporal Dementia, Huntington Disease, Lewy Body Disease, Multiple Sclerosis, Multiple System Atrophy, Parkinson Disease, Parkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy, INAD, Diabetes, Diabetes Mellitus, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Macular Degeneration, Ovarian Cancer, Cervical Cancer, Uterine Cancer, Vaginal Cancer, Vulvar Cancer, PTSD, Post Traumatic Stress Disorder | 11/45 | 11/45 | | |
| Completed | N/A | 31 | Europe | Better living with non-memory led dementia course | University College, London | Primary Progressive Aphasia, Frontotemporal Dementia, Alzheimer Disease | 02/23 | 02/23 | | |
NCT06221202: Stories in the Moment: Dance Program for People Living With Dementia |
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| Recruiting | N/A | 72 | US | Stories in the Moment Dance Program - Online | DanceStream Projects, Alzheimer's Association | Dementia, Mild Cognitive Impairment, Alzheimer Disease, Lewy Body Disease, Frontotemporal Dementia, Vascular Dementia | 05/24 | 10/24 | | |
| Active, not recruiting | N/A | 13 | Canada | Home-based multicomponent exercise intervention program | Montreal Heart Institute | Primary Progressive Aphasia, Neurodegenerative Diseases, Logopenic Progressive Aphasia, Semantic Dementia, Non-fluent Aphasia | 06/24 | 08/24 | | |
NCT05444244: A Relational Research Recruitment and Engagement Intervention for Cognitive Aging Research |
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| Completed | N/A | 182 | US | Relational Research Recruitment and Engagement Intervention, Brain Health Community Registry Recruitment Intervention | University of Wisconsin, Madison, National Institute on Aging (NIA) | Dementia, Cognitive Dysfunction, Alzheimer Disease, Lewy Body Disease, Frontotemporal Dementia | 05/23 | 05/23 | | |
IBC, NCT05524181: Telehealth-enabled Integrated Palliative Care for People With Dementia |
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| Active, not recruiting | N/A | 50 | US | Telehealth Integrated Primary Care (TIPC), TIPC | Thomas Jefferson University, Independence Blue Cross | Dementia of Alzheimer Type, Alzheimer Disease, Frontotemporal Degeneration, Lewy Body Dementia, Vascular Cognitive Impairment, Vascular Dementia, Mixed Dementia | 08/24 | 08/24 | | |
| Available | N/A | | US | Arimoclomol | ZevraDenmark | Niemann-Pick Disease, Type C | | | | |
NCT04748666: PST for Care Partners of Adults With Alzheimer's and Alzheimer'S-related Dementia |
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| Completed | N/A | 94 | US | Problem Solving Training | University of Texas Southwestern Medical Center, University of Texas Rio Grande Valley, Texas A&M University | Alzheimer Disease, Frontotemporal Degeneration (FTD), Lewy Body Dementia (LBD), Vascular Contributions to Cognitive Impairment and Dementia (VCID), Mixed Etiology Dementias (MED), Mild Cognitive Impairment (MCI) | 07/23 | 07/23 | | |
| Recruiting | N/A | 280 | Europe | Telephone-based neuropsychological assessment - ALS, Telephone-based neuropsychological assessment - AD, LBD, FTD and CVD, Telephone-based and in-person cognitive screening - NIs | Istituto Auxologico Italiano | Amyotrophic Lateral Sclerosis, Alzheimer's Disease, Lewy Body Dementia, Frontotemporal Degeneration, Cerebrovascular Disorders | 10/26 | 10/26 | | |
| Completed | N/A | 418 | US | Building Better Caregivers Workshop, Attention Control | University of California, San Francisco, National Institute on Aging (NIA) | Depression, Stress, Psychological, Self Efficacy, Loneliness, Social Isolation, Health Care Utilization, Dementia, Dementia Alzheimers, Dementia of Alzheimer Type, Dementia, Vascular, Dementia Frontal, Dementia, Lewy Body, Dementia, Mixed, Dementia in Parkinsons Disease, Dementia, HIV, Dementia Frontotemporal, Dementia, Multi-Infarct | 10/23 | 10/23 | | |
NCT00344331: Evaluation of Biochemical Markers and Clinical Investigation of Niemann-Pick Disease, Type C |
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| Recruiting | N/A | 900 | US | | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Niemann-Pick Disease, Type C | | | | |
CRND TorCA, NCT06529744: Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling |
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| Recruiting | N/A | 500 | Canada | | University Health Network, Toronto, Sunnybrook Health Sciences Centre, Baycrest, Centre for Addiction and Mental Health, Toronto Dementia Research Alliance (TDRA), University of Toronto | Dementia, Alzheimer Disease, Dementia With Lewy Bodies, Vascular Dementia, Frontotemporal Dementia, Mild Cognitive Impairment, Corticobasal Syndrome, Progressive Supranuclear Palsy, Parkinson Disease, Primary Progressive Aphasia | 11/26 | 11/27 | | |
STIM-SD, NCT03481933: Evaluation of a Transcranial Stimulation With Direct Current on Language Disorders in Semantic Dementia |
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| Recruiting | N/A | 80 | Europe | Transcranial stimulation | Assistance Publique - Hôpitaux de Paris | Semantic Dementia | 09/24 | 09/24 | | |
| Recruiting | N/A | 70 | Europe, US | Transcranial Alternating Current Stimulation (tACS), Non-invasive Brain Stimulation, Neuroelectrics Starstim, Sham Transcranial Alternating Current Stimulation (sham tACS) | Massachusetts General Hospital, Alzheimer's Drug Discovery Foundation | Frontotemporal Dementia | 12/25 | 12/25 | | |
NCT06528964: Proteinopathies Expression in Skin of Neurodegenerative Disorders |
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| Recruiting | N/A | 40 | RoW | Immunohistochemistry and immunofluorescence | Universidad Autonoma de San Luis Potosí, Hospital Central "Dr. Ignacio Morones Prieto" | Alzheimer Disease, Frontotemporal Dementia, Parkinson Disease, Atypical Parkinsonism, Amyotrophic Lateral Sclerosis, Normal Pressure Hydrocephalus | 10/24 | 11/24 | | |
| Recruiting | N/A | 150 | Canada | | University of Alberta, McGill University, Laval University, University of Toronto, Simon Fraser University | Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis, Progressive Muscular Atrophy, Frontotemporal Degeneration | 12/24 | 07/25 | | |
NCT05508646: Group-Based Telehealth Music Therapy Intervention for Patients With Dementia: A Pilot Study |
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| Completed | N/A | 48 | US | Music therapy intervention, Personalized music CD | Geisinger Clinic | Behavioral and Psychiatric Symptoms of Dementia, Alzheimer Disease, Lewy Body Disease, Frontotemporal Dementia | 01/24 | 01/24 | | |
| Recruiting | N/A | 200 | Europe | Patient with splenomegaly or splenectomy | Fundación Española de Hematología y Hemoterapía | Gaucher Disease, Acid SphingoMyelinase Deficiency, ASMD, Niemann-Pick Diseases, Splenomegaly | 10/24 | 12/25 | | |
GENIALITY, NCT06595212: Genetics and Environment INtersection in the ALS-FTD Spectrum: an Italian Twins Cohort StudY with a Multi-Omics Approach |
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| Recruiting | N/A | 45 | Europe | multiomic profile to assess genetic and environmental risk factiors | Azienda Ospedaliero-Universitaria di Modena, A.O.U. Città della Salute e della Scienza - Molinette Hospital, Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria Careggi, Firenze | ALS, FTD | 01/26 | 01/26 | | |
NCT02945774: Molecular Neuroimaging of Neuroinflammation in Neurodegenerative Dementias |
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| Recruiting | N/A | 40 | Canada | (18F)-FEPPA | Lawson Health Research Institute | Frontotemporal Dementia | 02/24 | 08/25 | | |
| Enrolling by invitation | N/A | 200 | Europe | Early adoption of blood-based biomarkers for Alzheimer's disease | Hospital del Mar Research Institute (IMIM) | Alzheimer Disease, Cognitive Impairment, Dementia, Neurodegenerative Diseases, Frontotemporal Dementia, Lewy Body Disease, Vascular Dementia | 05/25 | 12/25 | | |
NCT04287738: Care Ecosystem: Navigating Patients and Families Through Stages of Care, Extension Trial |
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| Completed | N/A | 912 | NA | Navigated Care | University of California, San Francisco, University of Nebraska, National Institute on Aging (NIA), Centers for Medicare and Medicaid Services | Dementia, Alzheimer Disease, Dementia, Vascular, Lewy Body Disease, Frontotemporal Lobar Degeneration, Memory Disorders | 05/22 | 05/22 | | |
NCT04165213: Care of Persons With Dementia in Their Environments (COPE) in Programs of All-Inclusive Care of the Elderly (PACE) |
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| Completed | N/A | 88 | US | Care of Persons in their Environment (COPE) online module clinician training, COPE online, Care of Persons in their Environment (COPE) instructor-led/in-person clinician training, COPE traditional training | University of Pennsylvania, Drexel University, Thomas Jefferson University | Frontotemporal Dementia, Dementia, Multi-Infarct Dementia, Vascular Dementia, Mixed Dementia, Alzheimer Disease, Lewy Body Disease, Pick Disease, Neurocognitive Disorders | 05/24 | 05/24 | | |
| Recruiting | N/A | 80 | Europe | | Ludwig-Maximilians - University of Munich | Neurodegenerative Diseases, Frontotemporal Degeneration | 04/24 | 04/24 | | |
OBS18020, NCT06192576: A Real-world Long-term Safety and Immunogenicity Study of Olipudase Alfa Therapy in Pediatric Patients Less Than 2 Years of Age With Acid Sphingomyelinase Deficiency (ASMD) |
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| Recruiting | N/A | 10 | US | Olipudase alfa, Xenpozyme® | Sanofi, Pulse Infoframe Ltd. | Niemann-Pick Diseases, Acid Sphingomyelinase Deficiency | 01/29 | 01/29 | | |
| Not yet recruiting | N/A | 120 | NA | SCANN | University Hospital, Lille, France Alzheimer | Alzheimer's Disease, Frontotemporal Degeneration (Semantic & Behavioral Variants) | 05/27 | 05/27 | | |
NCT05165186: Care Planning for a Loved One With Dementia: Knowledge, Preparing for Decisions, and Emotions |
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| Recruiting | N/A | 150 | US | Video Intervention Arm | Massachusetts General Hospital, National Institutes of Health (NIH), National Institute on Aging (NIA) | Dementia, Dementia Frontotemporal, Dementia Alzheimers, Dementia, Mild, Dementia Moderate, Dementia Severe, Caregiver Burnout, Caregiver Stress Syndrome | 05/24 | 05/24 | | |
| Recruiting | N/A | 1200 | US | | University of Miami, Muscular Dystrophy Association, National Institute of Neurological Disorders and Stroke (NINDS), National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) | Amyotrophic Lateral Sclerosis, ALS-Frontotemporal Dementia, Primary Lateral Sclerosis, Progressive Muscular Atrophy | 06/25 | 06/25 | | |
| Active, not recruiting | N/A | 610 | US | | University of Miami, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS) | Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, ALS-Frontotemporal Dementia, Primary Lateral Sclerosis, Progressive Muscular Atrophy | 06/25 | 06/25 | | |
| Recruiting | N/A | 300 | US, RoW | | University of Miami, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS) | Amyotrophic Lateral Sclerosis, Hereditary Spastic Paraplegia, Primary Lateral Sclerosis, Progressive Muscular Atrophy, Frontotemporal Dementia | 08/25 | 08/26 | | |
NCT06377033: Using the EHR to Advance Genomic Medicine Across a Diverse Health System |
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| Recruiting | N/A | 1000 | US | Behavioral nudge | University of Pennsylvania | Genetic Predisposition, Paraganglioma, Pheochromocytoma, ALS, Parkinson Disease, Polyneuropathies, Frontotemporal Dementia, Alzheimer Disease, Cardiomyopathy Non-ischemic, Thoracic Aortic Aneurysm | 06/27 | 06/27 | | |
NCT04881617: Treatment for Speech and Language in Primary Progressive Aphasia |
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| Active, not recruiting | N/A | 60 | US | Lexical Retrieval Training (LRT), Video-Implemented Script Training for Aphasia (VISTA) | University of Texas at Austin, National Institute on Deafness and Other Communication Disorders (NIDCD), University of California, San Francisco | Primary Progressive Aphasia, Semantic Dementia, Semantic Memory Disorder, Logopenic Progressive Aphasia, Nonfluent Aphasia, Progressive, Aphasia, Aphasia, Progressive | 06/24 | 06/24 | | |
| Active, not recruiting | N/A | 4500 | Europe, RoW | Genetic Screening | CENTOGENE GmbH Rostock | Frontotemporal Dementia | 06/24 | 09/24 | | |
| Recruiting | N/A | 500 | US, RoW | Intravenous and Intranasal BMSC, IV and IN BMSC | MD Stem Cells | Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders, Stroke, Traumatic Brain Injury, Cadasil, Chronic Traumatic Encephalopathy, Cerebral Infarction, Cerebral Ischemia, Cerebral Stroke, Cerebral Hemorrhage, Parkinson, Multi-System Degeneration, MSA - Multiple System Atrophy, Progressive Supranuclear Palsy, ALS, Amyotrophic Lateral Sclerosis, Neuropathy, Diabetic Neuropathies, Alzheimer Disease, Dementia, Frontotemporal Dementia, Lewy Body Disease, Cognitive Impairment, Lewy Body Variant of Alzheimer Disease | 07/25 | 07/26 | | |
NCT04363684: ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) |
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| Recruiting | N/A | 2100 | Canada, US | | Mayo Clinic, University of California, San Francisco, National Institute on Aging (NIA), National Institute of Neurological Disorders and Stroke (NINDS) | Frontotemporal Lobar Degeneration (FTLD), Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD), Behavioral Variant Frontotemporal Dementia (bvFTD), Semantic Variant Primary Progressive Aphasia (svPPA), Nonfluent Variant Primary Progressive Aphasia (nfvPPA), FTD With Amyotrophic Lateral Sclerosis (FTD/ALS), Amyotrophic Lateral Sclerosis, Oligosymptomatic PSP (oPSP), C9orf72, GRN Related Frontotemporal Dementia, MAPT Gene Mutation, TBK1 Gene Mutation, Oligosymptomatic Progressive Supranuclear Palsy | 06/25 | 06/25 | | |
| Enrolling by invitation | N/A | 100000 | US | Confirmatory Testing | Albert Einstein College of Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Alexion Pharmaceuticals, Inc., Ara Parseghian Medical Research Foundation, BioMarin Pharmaceutical, Cure Sanfilippo Foundation, Danas Angels Research Trust (DART), Mirum Pharmaceuticals, Inc., Orchard Therapeutics, Passage Bio, Inc., Genzyme, a Sanofi Company, Sio Gene Therapies, Takeda Pharmaceuticals North America, Inc., The FireFly Fund, The Noah's Hope - Hope 4 Bridget Family Foundations, Travere Therapeutics, Inc., Ultragenyx Pharmaceutical Inc | Acid Sphingomyelinase Deficiency, Ceroid Lipofuscinosis, Neuronal, 2, Cerebrotendinous Xanthomatosis, Fabry Disease, GM1 Gangliosidosis, Gaucher Disease, Lysosomal Acid Lipase Deficiency, Metachromatic Leukodystrophy, Mucopolysaccharidosis II, Mucopolysaccharidosis III-B, Mucopolysaccharidosis IV A, Mucopolysaccharidosis VI, Mucopolysaccharidosis VII, Niemann-Pick Disease, Type C | 08/29 | 08/29 | | |
| Not yet recruiting | N/A | 80 | Europe | Skin biopsy | Nantes University Hospital | Frontotemporal Lobar Degeneration | 04/27 | 12/27 | | |
NCT05916664: Efficacy Study of Kinto Care Coaching for Dementia Family Caregivers |
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| Completed | N/A | 495 | US | Kinto Care Coaching | Kinto, Alzheimer's Association | Dementia, Alzheimer Disease, Lewy Body Disease, Vascular Dementia, Frontotemporal Dementia, Mixed Dementia | 04/24 | 04/24 | | |