cyclosporin A microemulsion / Generic mfg. |
ChiCTR2100048572: Application of cyclosporin A in patients with unexplained repeated implantation failure in embryo transfer |
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| Not yet recruiting | N/A | 200 | | application with cyclosporin A ;No | Sichuan Provincial Hospital for Woman and Children; Sichuan Provincial Hospital For Woman and Children, None | unexplained repeated implantation failure | | | | |
ChiCTR-ONC-12002181: Associations of CYP3A and ABCB1 Polymorphisms with Pharmacokinetics of Cyclosporine A in Early Renal Recipients after Transplantation |
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| Completed | N/A | 126 | | after renal transplantation | Institute of Clinical Pharmacology, Central South University; Institute of Clinical Pharmacology, Central South University, Major National Funding for Drug Discovery, National Natural Science Foundation | Renal Transplantation | | | | |
ChiCTR-TRC-13003204: The multicentre, prospective, controlled study on the effection and safety of individualizing immunosuppresive program according to cytochrome P450(CYP) 3A5 gene polymorphism in liver transplant patients |
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| Completed | N/A | 100 | | FK506 ;cyclosporine A | Beijing You'An Hospital, Capital Medical University; Beijing You'An Hospital, Capital Medical University, The Ministry of health organ transplantation research project | liver transplantation | | | | |
ChiCTR-INR-16009363: 'Yu Xue Qi Huo' theory based integrated Traditional Chinese and Western Medicine in the diagnosis and treatment of stratified relapsed and refractory primary immune thrombocytopenia |
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| Recruiting | N/A | 400 | | Yangyin Traditional Chinese Medicine: brew the TCM granules in warm water, 1 pack bid p.o. 1 hour after meal for 6 months continuously ;Cyclosporin A capsules: 5mg/kg/d p.o., adjusted according to the serum CsA concentration ;Traditional Chinese Medicine for control group ;Cyclosporin A capsules: 5mg/kg/d p.o., adjusted according to the serum CsA concentration ;Yangyin Traditional Chinese Medicine: brew the TCM granules in warm water, 1 pack bid p.o. 1 hour after meal for 6 months continuously ;rhTPO: 1ug/kg/d qd for 14 days continuously, ih, until platelet count reaches 100×10^9/L ;Traditional Chinese Medicine for control group ;rhTPO: 1ug/kg/d qd for 14 days continuously, ih, until platelet count reaches 100×10^9/L | Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine; Rui Jin hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai Municipal Commission of Health and Family Planning, Office of Development of Shanghai Traditional Chinese Medicine | Immune Thrombocytopenia | | | | |
ChiCTR-OON-17014165: A clinical trial to evaluate the efficacy and safety of corticosteroids combined with cyclosporin A in the treatment of primary immune thrombocytopenia |
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| Recruiting | N/A | 200 | | Corticosteroids ;Corticosteroids combined with Cyclosporin A | Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology; Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, self-financing | Immune Thrombocytopenia | | | | |
ChiCTR2000034702: Retrospective analysis of the relationship between cyclosporine A trough concentration and GVHD incidence in children and prognosis after hematopoietic stem cell transplantation |
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| Not yet recruiting | N/A | 60 | | Nil | Hebei Yanda Lu Daopei Hospital; Hebei Yanda Lu Daopei Hospital, N/A | hematopoietic stem cell transplantation | | | | |
ChiCTR-INR-17013144: Efficacy of etoposide in Conventional Treatment–Refractory Adult-Onset Still's Disease |
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| Recruiting | N/A | 40 | | Etoposide ;cyclosporin a | Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai JiaoTong University; Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai JiaoTong University, , self-financing | Adult-Onset Still's Disease | | | | |
| Recruiting | N/A | 40 | | Cyclosporine A eye drops 3 days before and 3months after glaucoma surgery ;Subconjunctiva injection of conbercept during glaucoma surgery | Eye and ENT Hospital of Fudan University; Eye and ENT Hospital of Fudan University, Self-funding | glaucoma | | | | |
ChiCTR2000031094: Effect of cyclosporine A on Th1/ Th2 cytokines expression and pregnancy outcome in patients with immune repeated implantation failure |
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| Not yet recruiting | N/A | 90 | | cyclosporine A ;No ;No | Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University; Qilu Hospital of Shandong University, Departmental funding (support ourself) | repeated implantation failure | | | | |
NCT04705584: Topical Immuonosuppressant Drugs in Spring Catarrh |
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| Not yet recruiting | N/A | 180 | RoW | Prednisolone (as Acetate), Predforte Eye drops, CycloSPORINE Ophthalmic Suspension, LTacrolimus Topical | Assiut University | Vernal Keratoconjunctivitis | 10/21 | 02/22 | | |
OnceDaily, NCT02426502: Once Daily Dosing to Improve Medication Adherence and Patient Satisfaction in Kidney Transplant Recipients |
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| Active, not recruiting | N/A | 76 | Canada | Conversion to Advagraf, Prograf, Cyclosporine (Neoral), Advagraf, conversion of non-immunosuppressant drugs to once daily, anti-hypertensive medications, non-immunosuppressant drugs, Conversion to once daily MPA, Mycophenolate Mofetil, Myfortic, Azathioprine, Prednisone | University of British Columbia, Astellas Pharma Canada, Inc. | End-Stage Renal Disease | 08/22 | 12/24 | | |
NCT06512766: a Retrospective Study on the Systemic Treatment of LPP and FFA |
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| Completed | N/A | 315 | Europe | Hydroxychloroquine, Methotrexate, Cyclosporine A, Retinoids | Erasmus Medical Center | Cicatricial Alopecia, Lichen Planopilaris, Lichen Plano-Pilaris, Frontal Fibrosing Alopecia, Hair Diseases, Scarring Alopecia, Hair Loss/Baldness | 02/23 | 02/23 | | |
ChiCTR1900027753: Efficacy and safety of cyclosporine and azathioprine in patients with refractory ITP |
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| Not yet recruiting | N/A | 90 | | Using cyclosporine A for treatment ;Using azathioprine for treatment ;Treatment with glucocorticoids | the Second Affiliated Hospital of Kunming Medical University; the Second Affiliated Hospital of Kunming Medical University, the Second Affiliated Hospital of Kunming Medical University | Primary Immune Thrombocytopenia | | | | |
ChiCTR2000035473: Efficacy and Safety of Cyclosporine A Combined with Eltrombopag in Adults with Lower-risk Myelodysplastic Syndrome---A prospective , open-label, controlled, multicenter study |
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| Not yet recruiting | N/A | 264 | | CsA ;CsA+Epag | The Sixth People's Hospital Affiliated to Shanghai Jiaotong University; Rujin Hospital North Campus, Shanghai Jiao Tong University School of Medicine, Shanghai Shenkang Hospital Development Center's Three-year Action Plan for Promoting Clinical Skills and Clinical Innovation in Municipal Hospitals (2020-2022) Major Clinical Research Projects | Myelodysplastic Syndrome | | | | |
NCT04101578: Clinical Prognosis and Progression of Myasthenia Gravis Patients |
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| Recruiting | N/A | 2000 | RoW | Symptomatic Treatment, Steroids, Immunosuppressive Agents, Plasma Exchange(PE), Intravenous Immunoglobulin(IVIg), Pyridostigmine Bromide, Prednisone, Methylprednisolone, Azathioprine, Tacrolimus, Cyclosporin A, Cyclophosphamide, Mycophenolate Mofetil, Methotrexate | Da, Yuwei, M.D. | Myasthenia Gravis | 06/23 | 12/24 | | |
NCT05957211: Improving Drop Instillation Comfort of a Cyclosporine A Solution |
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| Completed | N/A | 40 | Canada | 0.09% cyclosporine A ophthalmic solution, Cequa | University of Waterloo, Sun Pharmaceutical Industries Limited | Dry Eye Disease | 02/24 | 02/24 | | |
ChiCTR2100042465: Improvement of ocular surface environment in patients with moderate to severe dry eye by cyclosporine A eye gel |
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| Recruiting | N/A | 40 | | Cyclosporin A eye gel, Hypromellose eye drops ;Placebo | The Second Affiliated Hospital of Anhui Medical University; The Second Affiliated Hospital of Anhui Medical University, Clinical Research Incubation Progra | Dry eye | | | | |
ChiCTR2100051791: Cyclosporine A intervention for unexplained repeated implant failure: a propective cohort study |
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| Not yet recruiting | N/A | 166 | | Cyclosporine A ;Conventional luteal support scheme | Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital); Suzhou Municipal Hospital, Gusu School of Nanjing Medical University | Unexplained repeated implant failure | | | | |
NCT03791827: Multicenter Registry of Pediatric Lupus Nephritis in China |
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| Recruiting | N/A | 1200 | RoW | Corticosteroid, Steroid, Prednisone, Methylprednisone, Prednisolone, Hydroxychloroquine, Cyclophosphamide, Mycophenolate Mofetil, Azathioprine, Tacrolimus, Cyclosporine A, Rituximab, anti-CD20 antibody | Xiqiang Dang, The Children's Hospital Affiliated to Suzhou University, Shandong Provincial Hospital, Guizhou Provincial People's Hospital, LanZhou University, The First Affiliated Hospital of Inner Mongolia Medical College, People's Hospital of Zhangjiajie, Puyang Oilfield General Hospital, The First Affiliated Hospital of Anhui Medical University, Guizhou Maternal and Child Health Care Hospital, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Shenzhen Children's Hospital, The Second Affiliated Hospital of Harbin Medical University, Yichang Central People's Hospital, Xian Children's Hospital, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, The First People's Hospital of Yunnan, The First Affiliated Hospital of Xiamen University, The First Affiliated Hospital of Xinxiang Medical College, Shanxi Provincial Maternity and Children's Hospital, Liaocheng People's Hospital, Fujian Provincial Hospital, First Affiliated Hospital of Guangxi Medical University, Second Hospital of Lanzhou University, Guangzhou First People's Hospital, The Second Hospital of Shandong University, Children's Hospital of Hebei Province, Beijing Children's Hospital, Zhengzhou Children's Hospital, The Children's Hospital of Chongqing Medical University, Wuxi Children's Hospital, The Children's Hospital of Fudan University, Shanghai Children's Medical Center, Qilu Children's Hospital of Shandong University | Lupus Nephritis, Children, Steroid, Immunosuppressive Treatment | 11/23 | 11/24 | | |
NCT06147375: Efficacy and Safety of Immunosuppressive Withdrawal After Pediatric Liver Transplantation |
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| Not yet recruiting | N/A | 47 | RoW | Tacrolimus or Cyclosporine A, immunosuppression withdrawal | Wei Gao | Immune Tolerance, Immunosuppression, Liver Transplant; Complications | 12/26 | 12/28 | | |
| Recruiting | N/A | 318 | Europe | Topical corticosteroids, Systemic cyclosporine, Neoral, Systemic dupilumab, DUPIXENT | Erasmus Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development | Dermatitis, Atopic | 01/24 | 01/25 | | |
CMV, NCT06362720: The Comparison the Infection and Reactivation After Allogeneic Hematopoietic Stem Cell Transplantation Between Standard Regimen, Methotrexate Plus Cyclosporin A, and Post-transplant Cyclophosphamide-based Regimen |
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| Not yet recruiting | N/A | 158 | NA | | Siriraj Hospital | CMV Infection or Reactivation After Allogenic HSCT | 10/24 | 12/24 | | |
ChiCTR2200062120: Synergistic effect of low-dose cyclosporine A on eltrombopag in the management of multiline failed immune thrombocytopenia patients: a single-center, self-control study |
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| Not yet recruiting | N/A | 50 | | low-dose cyclosporine A combined with EPAG | Zhejiang Provincial Hospital of Traditional Chinese Medicine; Zhejiang Provincial Hospital of Traditional Chinese Medicine, Self-funded,National Key Disciplines Funding | immune thrombocytopenia | | | | |
NCT01962636: Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases |
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| Recruiting | N/A | 200 | US | Fludarabine, Fludara, Cyclophosphamide, Cytoxan, Total Body Irradiation, Cyclosporine A, CSA, Mycophenylate mofetil, MMF, Umbilical cord blood, UCB | Masonic Cancer Center, University of Minnesota | Acute Myeloid Leukemia (AML), Acute Lymphocytic Leukemia (ALL), Chronic Myelogenous Leukemia, Plasma Cell Leukemia, Myelofibrosis, Myelodysplasia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Marginal Zone B-Cell Lymphoma, Follicular Lymphoma, Lymphoplasmacytic Lymphoma, Mantle-Cell Lymphoma, Prolymphocytic Leukemia, Diffuse Large B Cell Lymphoma, Lymphoblastic Lymphoma, Burkitt's Lymphoma, Non-Hodgkin Lymphoma, Multiple Myeloma | 10/24 | 10/25 | | |
ChiCTR2200064051: Study on the intestinal mechanism of Jianpi Qushi Heluo Fang in regulating intestinal bacteria AHR agonist host immunity in treating IMN |
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| Not yet recruiting | N/A | 60 | | Traditional Chinese medicine ;Cyclosporin A | Xiyuan Hospital, China Academy of Chinese Medical Sciences; Xiyuan Hospital, Science and Technology Innovation Project of China Academy of Chinese Medical Sciences | Idiopathic membranous nephropathy | | | | |
| Recruiting | N/A | 750 | Europe | Adalimumab, Humira, Etanercept, Enbrel, Infliximab, Remicade, Ustekinumab, Stelara, Cyclosporine A, Fumaric acids, Methotrexate, Other anti-psoriatic systemic treatments | Swiss Dermatology Network for Targeted Therapies | Psoriasis | 06/32 | 06/33 | | |
| Enrolling by invitation | N/A | 197 | Europe | ATGAM plus CsA with or without Eltrombopag, hATG+CsA +/- Revolade | European Group for Blood and Marrow Transplantation | Severe Aplastic Anemia | 12/33 | 12/34 | | |