Leukemia  >>  cyclosporin A microemulsion  >>  Phase 3
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11 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
cyclosporin A microemulsion / Generic mfg.
AALL0031, NCT00022737: Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia

Completed
3
220
US
filgrastim, G-CSF, Neupogen, asparaginase, ASNase, Colaspase, Crasnitin, Elspar, L-ASP, cyclophosphamide, CPM, CTX, Cytoxan, Endoxan, Endoxana, cyclosporine, ciclosporin, cyclosporin, cyclosporin A, CYSP, Sandimmune, cytarabine, ARA-C, arabinofuranosylcytosine, arabinosylcytosine, Cytosar-U, cytosine arabinoside, daunorubicin hydrochloride, Cerubidin, Cerubidine, daunomycin hydrochloride, daunorubicin, RP-13057, dexamethasone, Aeroseb-Dex, Decaderm, Decadron, DM, DXM, etoposide, EPEG, VP-16, VP-16-213, ifosfamide, Cyfos, Holoxan, IFF, IFX, IPP, imatinib mesylate, CGP 57148, Gleevec, Glivec, leucovorin calcium, CF, CFR, LV, mercaptopurine tablet, 6-mercaptopurine, 6-MP, Leukerin, MP, methotrexate, amethopterin, Folex, methylaminopterin, Mexate, MTX, pegaspargase, L-asparaginase with polyethylene glycol, Oncaspar, PEG-ASP, PEG-L-asparaginase, vincristine sulfate, leurocristine sulfate, VCR, Vincasar PFS, allogeneic bone marrow transplantation, bone marrow therapy, allogeneic, bone marrow therapy, allogenic, transplantation, allogeneic bone marrow, transplantation, allogenic bone marrow, peripheral blood stem cell transplantation, PBPC transplantation, PBSC transplantation, peripheral blood progenitor cell transplantation, transplantation, peripheral blood stem cell, umbilical cord blood transplantation, cord blood transplantation, transplantation, umbilical cord blood, UCB transplantation, radiation therapy, irradiation, radiotherapy, therapy, radiation
National Cancer Institute (NCI)
Childhood Acute Lymphoblastic Leukemia in Remission, Recurrent Childhood Acute Lymphoblastic Leukemia
10/06
 
NCT00322101: Low-Dose or High-Dose Conditioning Followed by Peripheral Blood Stem Cell Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Myelogenous Leukemia

Completed
3
25
US, Europe
total-body irradiation, TBI, allogeneic hematopoietic stem cell transplantation, cyclophosphamide, CPM, CTX, Cytoxan, Endoxan, Endoxana, mycophenolate mofetil, Cellcept, MMF, busulfan, BSF, BU, Misulfan, Mitosan, Myeloleukon, cyclosporine, ciclosporin, cyclosporin, cyclosporin A, CYSP, Sandimmune, fludarabine phosphate, 2-F-ara-AMP, Beneflur, Fludara, peripheral blood stem cell transplantation, PBPC transplantation, PBSC transplantation, peripheral blood progenitor cell transplantation, transplantation, peripheral blood stem cell, nonmyeloablative allogeneic hematopoietic stem cell transplantation, laboratory biomarker analysis, cytogenetic analysis, flow cytometry, fluorescence in situ hybridization, fluorescence in situ hybridization (FISH), pharmacological study, pharmacological studies, polymorphism analysis, tacrolimus, FK 506, Prograf, methotrexate, amethopterin, Folex, methylaminopterin, Mexate, MTX
Fred Hutchinson Cancer Center, National Cancer Institute (NCI), National Heart, Lung, and Blood Institute (NHLBI)
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Acute Myeloid Leukemia/Transient Myeloproliferative Disorder, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12), Adult Acute Myeloid Leukemia With t(16;16)(p13;q22), Adult Acute Myeloid Leukemia With t(8;21)(q22;q22), Childhood Acute Myeloid Leukemia in Remission, Childhood Myelodysplastic Syndromes, de Novo Myelodysplastic Syndromes, Myelodysplastic Syndrome With Isolated Del(5q), Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable, Previously Treated Myelodysplastic Syndromes, Recurrent Adult Acute Myeloid Leukemia, Recurrent Childhood Acute Myeloid Leukemia, Secondary Acute Myeloid Leukemia, Secondary Myelodysplastic Syndromes
04/12
10/14
NCT02461121: HLA-mismatched MST vs HLA-matched NST for AML in Intermediate-risk

Completed
3
156
RoW
HLA mismatched stem cell, microtransplantation, HLA matched stem cell, nonmyeloablative transplantation, cyclosporine A, GVHD prophylaxis, Mycophenolate mofetil, Ara-C, conditioning reginmen, fludarabine, NST conditioning reginmen, anti-lymphocyte globulin, cyclophosphamide
The Affiliated Hospital of the Chinese Academy of Military Medical Sciences
Acute Myeloid Leukemia
05/13
05/13
NCT00075478: Total-Body Irradiation With or Without Fludarabine Phosphate Followed By Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer

Completed
3
87
US, Europe
Total-Body Irradiation, TBI, Total Body Irradiation, Whole-Body Irradiation, Fludarabine Phosphate, 2-F-ara-AMP, Beneflur, SH T 586, Mycophenolate Mofetil, Cellcept, MMF, Cyclosporine, 27-400, CsA, Neoral, OL 27-400, Sandimmun, Peripheral Blood Stem Cell Transplantation, PBPC transplantation, Peripheral Blood Progenitor Cell Transplantation, Peripheral Stem Cell Support, Peripheral Stem Cell Transplantation
Fred Hutchinson Cancer Center, National Heart, Lung, and Blood Institute (NHLBI), National Cancer Institute (NCI)
Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia in Remission, Aggressive Non-Hodgkin Lymphoma, Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Diffuse Large B-Cell Lymphoma, Hematopoietic and Lymphoid Cell Neoplasm, Indolent Non-Hodgkin Lymphoma, Mantle Cell Lymphoma, Myelodysplastic/Myeloproliferative Neoplasm, Plasma Cell Myeloma, Refractory Chronic Lymphocytic Leukemia, Refractory Hodgkin Lymphoma, Waldenstrom Macroglobulinemia
02/14
02/14
NCT00412360: Single vs Double Umbilical Cord Blood Transplants in Children With High Risk Leukemia and Myelodysplasia (BMT CTN 0501)

Completed
3
224
Canada, US, RoW
Single Umbilical Cord Blood Unit Transplant, Double Umbilical Cord Blood Unit Transplant, Total Body Irradiation, TBI, Cyclophosphamide, Cytoxan®, Fludarabine, Fludara, Cyclosporine A, CSA, Mycophenolate Mofetil, MMF, Cellcept®
Medical College of Wisconsin, National Heart, Lung, and Blood Institute (NHLBI), Blood and Marrow Transplant Clinical Trials Network, National Cancer Institute (NCI), National Marrow Donor Program
Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia, Chronic Myelogenous Leukemia, Myelodysplastic Syndrome, Natural Killer Cell Lymphoblastic Leukemia/Lymphoma
03/14
10/14
NCT00568633: Allogeneic HCT Using Nonmyeloablative Host Conditioning With TLI & ATG vs SOC in AML

Terminated
3
58
US
Allogeneic HSCT, Hematopoietic stem cell transplantation (HSCT), Peripheral blood stem cell (PBSC) transplantation, Anti-thymocyte globulin (ATG), Thymoglobulin, Anti-thymocyte globulin (rabbit) (ATG), Cyclosporine (CSP), Ciclosporin, cyclosporin A, cyclosporin, Mycophenolate mofetil (MMF), Cellcept, Total lymphoid irradiation (TLI), Methylprednisolone sodium succinate, Solumedrol, Medrol, Depo-Medrol, P-Care D40, P-Care D80, Best standard care, Standard of Care (physician discretion), Regular medical care
Stanford University, Genzyme, a Sanofi Company
Leukemia, Myeloid, Leukemia, Acute Myeloid Leukemia (AML)
12/15
12/15
IDBUCY, NCT01766375: the Effects and Safety of Idarubicin-strengthened Pretreatment Program and Conventional Busulfan Cyclophosphamide Pretreatment Program on High-risk Acute Myeloid Leukemia Patient

Unknown status
3
200
RoW
Cyclosporin A,mycophenolate mofetil,Methotrexate
Guangxi Medical University
Acute Myeloid Leukemia
01/16
06/16
2006-006577-25`ACTRN12615000820505: A prospective randomized study comparing rapamune and tacrolimus vs. cyclosporine and methotrexate as immune prophylaxis in allogeneic hematopoietic stem cell transplantation, using HLA-A, -B, -DRB1 identical related or unrelated donors. A Nordic multicenter study.

Ongoing
3
200
Europe
Rapamune, Prograf, Sandimmun Neoral, Methotrexate, Rapamune, Prograf, Sandimmun Neoral, Methotrexate, Rapamune, Prograf, Sandimmun Neoral, Methotrexate
Karolinska Institutet, Nordic Bone Marrow Transplant Group (NBMT), Federation University
Stress, Anxiety, Depression
 
 
NCT01231412: Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant

Completed
3
174
Europe, US
Allogeneic Hematopoietic Stem Cell Transplantation, allogeneic stem cell transplantation, HSC, HSCT, Cyclosporine, 27-400, Ciclosporin, CsA, Cyclosporin, Cyclosporin A, Gengraf, Neoral, OL 27-400, Sandimmun, Sandimmune, SangCya, Fludarabine Phosphate, 2-F-ara-AMP, 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-, Beneflur, Fludara, SH T 586, Mycophenolate Mofetil, Cellcept, MMF, Peripheral Blood Stem Cell Transplantation, PBPC transplantation, Peripheral Blood Progenitor Cell Transplantation, Peripheral Stem Cell Support, Peripheral Stem Cell Transplantation, Sirolimus, AY 22989, RAPA, Rapamune, RAPAMYCIN, SILA 9268A, WY-090217, Total-Body Irradiation, TOTAL BODY IRRADIATION, Whole-Body Irradiation
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Aggressive Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, Diffuse Large B-Cell Lymphoma, Hematopoietic and Lymphoid Cell Neoplasm, Indolent Non-Hodgkin Lymphoma, Mantle Cell Lymphoma, Myelodysplastic Syndrome, Myeloproliferative Neoplasm, Prolymphocytic Leukemia, Recurrent Chronic Lymphocytic Leukemia, Recurrent Plasma Cell Myeloma, Refractory Chronic Lymphocytic Leukemia, Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Refractory Hodgkin Lymphoma, Small Lymphocytic Lymphoma, T-Cell Chronic Lymphocytic Leukemia, Waldenstrom Macroglobulinemia
10/16
06/17
NCT04547049: A Study Comparing Haploidentical Hematopoietic Stem Cell Transplantations (HSCTs) From Young Non-first-degree and Older First-degree Donors in Hematological Malignancies

Recruiting
3
160
RoW
Cytarabine, Busulfan, Cyclophosphamide, Me-CCNU, Rabbit antithymocyte globulin, Allogeneic HSCT, Cyclosporin A, Mycophenolate Mofetil, MTX
First Affiliated Hospital of Zhejiang University
Leukemia
09/25
12/25
NCT02707393 / 2008-000569-50: Allogeneic Stem Cell Transplantation for Children With CML

Completed
2/3
13
Europe, RoW
Fludarabine, Fludara, Thiotepa, Thioplex, TESPA, Melphalan, Alkeran, ATG, Thymoglobulin, Cyclosporine A, Sandimmune, Mycophenolate mofetil, CellCept, bone marrow or peripheral blood stem cells
St. Anna Kinderkrebsforschung
Chronic Myeloid Leukemia
12/20
12/20

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