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NCT06290856: Clinical Utility of Selected Circulating Tumor DNA Assays in Patients With Advanced Malignancy |
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| Recruiting | N/A | 100 | Europe | Multiplex PCR-test for circulating tumor DNA | Oslo University Hospital | Metastatic Colorectal Cancer, Pancreas Adenocarcinoma, Cholangiocarcinoma | 12/25 | 12/25 | | |
| Active, not recruiting | N/A | 46 | Europe | Adaptative MR-Guided Stereotactic Body Radiotherapy | Centre Georges Francois Leclerc | Radiotherapy | 01/29 | 01/29 | | |
| Recruiting | N/A | 1000 | US | | Mayo Clinic | Hepatocellular Carcinoma, Cholangiocarcinoma | 02/29 | 02/29 | | |
| Active, not recruiting | N/A | 60 | Europe | CAPECITABINE-Radiotherapy -Liver Transplantation, Neoadjuvant Radio-Chemotherapy and Liver Transplantation, RESECTION, Liver Resection | Assistance Publique - Hôpitaux de Paris | Cholangiocarcinoma | 02/24 | 09/24 | | |
| Not yet recruiting | N/A | 130 | Europe | Intraductal biliary radiofrequency ablation, RFA | Universitätsklinikum Hamburg-Eppendorf | Cholangiocarcinoma, Klatskin Tumor, Bile Duct Cancer, Liver Cancer | 01/26 | 07/26 | | |
NCT06369480: Prognostic Factors for Survival in Patients With Cholangiocarcinoma |
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| Recruiting | N/A | 2000 | Europe | Resection/Ablation of tumor, Surgery, Palliative chemotherapy, Chemotherapy, Neoadjuvant chemotherapy, Adjuvant chemotherapy, Stereotatic radiotherapy, Radiotherapy, Best supportive care, Supportive care | Rigshospitalet, Denmark | Cholangiocarcinoma | 08/24 | 08/24 | | |
NCT06290739: A Machine-learning Model to Predict Lymph Node Metastasis of Intrahepatic Cholangiocarcinoma |
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| Recruiting | N/A | 300 | RoW | lymph nodes dissection | West China Hospital | Intrahepatic Cholangiocarcinoma, Machine Learning | 03/24 | 03/24 | | |
ChiCTR2200057968: DEB-TACE combined with apatinib plus camrelizumab for advance Intrahepatic cholangiocarcinoma: a single-arm, prospective clinical study |
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| Not yet recruiting | N/A | 37 | | DEB-TACE+apatinib+camrelizumab | Fujian Provincial Cancer Hospital; Fujian Provincial Cancer Hospital, Beijing Medical Award Foundation | Cholangiocarcinoma | | | | |
CHORDA-II-p, NCT05874934: Endoscopic Drainage of Presumed Resectable pCCA Using an Intrahepatic Plastic Stent With Retrieval String |
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| Recruiting | N/A | 20 | Europe | Intrahepatic biliary stent with retrieval string | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Perihilar Cholangiocarcinoma | 02/24 | 05/24 | | |
ChiCTR2000029854: Albumin Paclitaxel plus S-1 and Anlotinib as First-Line Chemotherapy for Metastatic or Unresectable Locally Advanced Biliary Tract Carcinomas: a Phase II Clinical Trial |
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| Not yet recruiting | N/A | 30 | | nab-paclitaxel plus S-1 and anlotinib | Cancer Hospital, Chinese Academy of Medical Sciences, Shenzhen Center; Cancer Hospital, Chinese Academy of Medical Sciences, Shenzhen Center, self-financing | Biliary Tract Carcinomas | | | | |
ECCBILE, NCT06277531: Evaluation of diagnostiC Capacity of eccDNAs as Biomarkers in Indetermined biLiary Stricture |
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| Recruiting | N/A | 99 | RoW | | Peking University Third Hospital, Beijing Tsinghua Changgeng Hospital | Biliary Stricture, Bile Duct Cancer, Pancreas Cancer | 03/26 | 03/27 | | |
PIONEER, NCT03896958: The Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology) |
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| Recruiting | N/A | 1000 | US | | SpeciCare, Georgia Institute of Technology, Predictive Oncology, University of Washington, Netnoids, Northeast Georgia Hospital System | Cancer, All Types, Cancer of Liver, Cancer of Stomach, Cancer of Head and Neck, Cancer of Rectum, Cancer of Kidney, Cancer of Esophagus, Cancer of Colon, Cancer Skin, Cancer of Cervix, Cancer, Metastatic, Cancer of Larynx, Cancer of Neck, Cancer of Lung, Cancer of Brain and Nervous System, Cancer of Vulva, Disseminated, Cancer of Pancreas, Sarcoma, GIST, Small-cell Lung Cancer, Adenocarcinoma Lung, Cancer of Prostate, Cancer, Advanced, Adrenal Cancer, Testicular Cancer, Uterine Cancer, Bronchoalveolar Cell Lung Cancer, Cancer Unknown Primary, Glioblastoma Multiforme, Oligodendroglioma, Breast Cancer, Renal Cell Carcinoma, Hepatocellular Carcinoma, Cholangiocarcinoma, Squamous Cell Carcinoma, Transitional Cell Carcinoma, Cancer, Other, Cancer, Anal, Melanoma, Cancer, Bile Duct, Cancer, Bladder, Cancer Cords Vocal, Cancers Cell Neuroendocrine, Cancer Differentiated Poorly, Cancer, Anaplastic Thyroid | 03/24 | 03/24 | | |
| Recruiting | N/A | 400 | Japan, US | ELUCIDATE, ELUCIDATE (Evaluation of Liver Cholangiocarcinoma Intrahepatic) | City of Hope Medical Center | Hepatocellular Carcinoma, Intrahepatic Cholangiocarcinoma, Cholangiocarcinoma, Primary Liver Cancer, Primary Liver Carcinoma, Hepatic Cancer, Hepatic Carcinoma | 03/25 | 03/25 | | |
NCT03819088: Effects on Quality of Life With Zinc Supplementation in Patients With Gastrointestinal Cancer |
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| Completed | N/A | 17 | US | Zinc, Zinc sulfate | Emory University, National Cancer Institute (NCI), National Institutes of Health (NIH) | Gastric Carcinoma, Liver and Intrahepatic Bile Duct Carcinoma, Unresectable Esophageal Carcinoma, Unresectable Pancreatic Carcinoma | 10/21 | 10/21 | | |
NCT06340620: EUS Examination Using EndoSound Vision System vs. Standard Echoendoscope |
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| Recruiting | N/A | 140 | US | Endoscopic ultrasound examination | Orlando Health, Inc. | Pancreatic Disease, Pancreatic Cancer, Pancreatic Cyst, Gastrointestinal Tumor, Bile Duct Diseases, Bile Duct Cancer, Lymph Node Disease, Submucosal Tumor of Gastrointestinal Tract, Gastrointestinal Cancer | 12/26 | 12/27 | | |
NCT06363123: Plasma Metabolic Biomarkers for Multi-Cancer Diagnosis |
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| Recruiting | N/A | 2700 | RoW | | Beijing Friendship Hospital | Lung Cancer, Breast Cancer, Colorectal Cancer, Thyroid Cancer, Gastric Cancer, Cervical Cancer, Liver Cancer, Pancreatic Cancer, Cholangiocarcinoma, Prostate Cancer, Esophageal Cancer, Ovarian Cancer, Renal Cell Carcinoma | 10/24 | 04/25 | | |
NCT06048289: Prospective Observational Study to Predict the Response of Biliary Tract Tumors to Immunotherapy |
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| Recruiting | N/A | 150 | RoW | Blood samples, tumor biopsy specimens will be collected | Zhejiang Cancer Hospital | Biliary Tract Tumor, Cholangiocarcinoma | 03/24 | 03/25 | | |
NCT02757859: High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery |
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| Recruiting | N/A | 845 | US | Pancreatectomy, Excision of the Pancreas, Pancreas Excision, Lavage, Irrigation, Wash | Sidney Kimmel Cancer Center at Thomas Jefferson University, National Cancer Institute (NCI) | Acinar Cell Carcinoma, Ampulla of Vater Adenocarcinoma, Cholangiocarcinoma, Duodenal Adenocarcinoma, Pancreatic Adenocarcinoma, Pancreatic Ductal Adenocarcinoma, Pancreatic Intraductal Papillary Mucinous Neoplasm, Periampullary Adenocarcinoma | 04/24 | 01/25 | | |
NCT05497531: Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers |
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| Recruiting | N/A | 15 | US | ctDNA Blood Collection | University of California, Irvine | Hepatobiliary Cancer, Pancreatic Cancer, Hepatocellular Carcinoma, Cholangiocarcinoma, Ampullary Cancer, Pancreatic Carcinoma | 10/24 | 10/24 | | |
| Active, not recruiting | N/A | 40 | Europe | Standard Liver Surgery, Indocyanine Fluorescent Image Guided Surgery (I-FIGS) | University Hospital Plymouth NHS Trust | Liver Cancer, Hepatocellular Carcinoma, Liver Metastasis Colon Cancer | 04/24 | 04/24 | | |
NCT06260943: Targeted Navigation in Hepatocellular Carcinoma (HCC) |
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| Recruiting | N/A | 50 | US | Target Navigation Pilot Program | University of Miami, The V Foundation | Hepatocellular Carcinoma, Cholangiocarcinoma, Hepatobiliary Cancer | 10/26 | 10/26 | | |
NCT03990623: CT Perfusion Scans in Detecting Changes in Blood Flow to the Liver After Portal Vein Embolization |
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| Recruiting | N/A | 22 | US | Computed Tomography Perfusion Imaging, Liver Biopsy, Biopsy of Liver | M.D. Anderson Cancer Center, National Cancer Institute (NCI) | Liver and Intrahepatic Bile Duct Carcinoma | 04/24 | 04/24 | | |
ChiCTR2200058927: The value of high frame rate contrast-enhanced ultrasound in the differential diagnosis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma and the predictive performance of microvascular invasion |
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| Recruiting | N/A | | | | Xiangya Hospital of Central South University; Xiangya Hospital of Central South University, Special funds for discipline construction | liver lesions | | | | |
| Recruiting | N/A | 200 | RoW | Hematoporphyrin, ERCP stents | Hepatopancreatobiliary Surgery Institute of Gansu Province | Cholangiocarcinoma Non-resectable | 05/24 | 05/24 | | |
Spy+IDUS, NCT06369896: Digital Single-operator Cholangioscopy and Intraductal Ultrasound for Nonicteric Biliary Strictures |
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| Not yet recruiting | N/A | 36 | NA | | Soonchunhyang University Hospital | Cholangiocarcinoma, Biliary Stricture | 12/25 | 12/26 | | |
NCT06474091: Liquid Biopsy MonitORing Of CholangioCarcinOma for Treatment Response and Prognostic Outcomes (MOROCCO) |
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| Enrolling by invitation | N/A | 500 | US | Non-Interventional Study | Mayo Clinic | Cholangiocarcinoma | 05/29 | 05/29 | | |
NCT06313554: Surufatinib Combined With Toripalimab and HAIC in the Treatment of Inoperable or Metastatic Intrahepatic Cholangiocarcinoma |
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| Not yet recruiting | N/A | 63 | NA | Surufatinib、Toripalimab、Gemcitabine、Oxaliplatin | Fudan University | Intrahepatic Cholangiocarcinoma | 05/24 | 05/27 | | |
NCT04410302: Patient-Derived Xenografts to Reduce Cancer Health Disparities |
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| Recruiting | N/A | 500 | US | Biospecimen Collection | University of California, Davis, National Cancer Institute (NCI) | Bladder Carcinoma, Gastric Carcinoma, Liver and Intrahepatic Bile Duct Carcinoma, Lung Carcinoma, Malignant Neoplasm | 06/24 | 12/24 | | |
| Recruiting | N/A | 60 | | Greater Omentum Barrier Technology ;Traditional Surgery | Jiangyou People's Hospital; People's Hospital of Jiangyou City, Own expense | Pancreatic head tumor, periampullary carcinoma, lower bile duct tumor, duodenal papilla tumor | | | | |
NCT05697237: Carlizumab Plus Sovantinib in Second-line Treatment of Advanced or Metastatic Cholangiocarcinoma |
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| Not yet recruiting | N/A | 60 | NA | Carrelizumab, Solfantinib | First Affiliated Hospital Xi'an Jiaotong University | Cholangiocarcinoma | 06/24 | 12/24 | | |
EMPHATIC, NCT06434493: Evaluation of Combined Modality Protons and Hepatic Transplantation for Hilar Cholangiocarcinoma |
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| Not yet recruiting | N/A | 30 | NA | Proton Beam Therapy, Concurrent oral capecitabine chemotherapy, Cisplatin & Gemcitabine intravenous chemotherapy, Orthotropic Liver Transplant | The Christie NHS Foundation Trust, University College London Hospitals, University College, London, Royal Free Hospital NHS Foundation Trust | Cholangiocarcinoma | 01/28 | 01/29 | | |
| Not yet recruiting | N/A | 183 | NA | EchoTip AcuCore | Cook Research Incorporated | Adenocarcinoma, Neuroendocrine Tumors, Hepatocellular Carcinoma, Cholangiocarcinoma, Malignant Lymphoma, Metastasis, Chronic Pancreatitis, Autoimmune Pancreatitis | 06/25 | 06/25 | | |
| Not yet recruiting | N/A | 200 | Europe | Proteomic profile | University Hospital, Bordeaux | Cholangiocarcinoma | 02/26 | 02/26 | | |
| Not yet recruiting | N/A | 5350 | NA | | Singlera Genomics Inc., Fudan University, Hubei Cancer Hospital, Huazhong University of Science and Technology, China-Japan Friendship Hospital, Shanxi Provincial Cancer Hospital, Xuhui Central Hospital, Fudan University, Shanghai Electric Power Hospital, East Hospital, Tongji University, The First Affiliated Hospital of Xi' an Jiaotong University, GaoZhou People's Hosipital, Anhui Provincial Hospital, Beijing Friendship Hospital | Lung Cancer, Gastric Cancer, Liver Cancer, Colorectal Cancer, Pancreatic Cancer, Esophageal Cancer, Breast Cancer, Cervical Cancer, Ovarian Cancer, Endometrial Cancer, Bladder Cancer, Prostate Cancer, Cholangiocarcinoma | 02/25 | 02/25 | | |
ChiCTR2000036245: Application of serum proteomics and clinical Phenotype combined with imaging omics in the diagnosis and precision therapy of intrahepatic cholangiocarcinoma |
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| Recruiting | N/A | 280 | | N/A | Eastern Hepatobiliary Surgery Hospital; Eastern Hepatobiliary Surgery Hospital, project funds | intrahepatic cholangiocarcinoma | | | | |
ChiCTR2100044579: A trial for construction of organoids database and individual drug sensitivity test of patients with cholangiocarcinoma (intrahepatic and extrahepatic cholangiocarcinoma) |
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| Recruiting | N/A | 120 | | Treating with Gemcitabine and Cis-platinum ;Treating with Oxaliplatin and Fluorouracil ;Treating with Gemcitabine and Fluorouracil ;Treating with Gemcitabine ;Treating with Fluorouracil ;Treating with Oxaliplatin | Renji Hospital affiliated to Shanghai Jiaotong University, School of Medicine; Renji Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Self financing by researchers | cholangiocarcinoma | | | | |
ChiCTR2200056017: Single-arm, open, multicenter clinical study of Surufatinib combined with Camrelizumab in second-line treatment of patients with advanced biliary tract cancer |
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| Not yet recruiting | N/A | 42 | | Surufatinib combined with Camrelizumab | Xiangyang Central Hospital; Xiangyang First People's Hospital, Not stated | biliary tract cancer | | | | |
ChiCTR2200062209: A prospective randomized controlled study of DEB-TACE plus GEMOX in patients with unresectable intrahepatic cholangiocarcinoma |
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| Not yet recruiting | N/A | 252 | | DEB-TACE plus GEMOX ;GEMOX | First Affiliated Hospital of University of Science and Technology of China; First Affiliated Hospital of University of Science and Technology of China, BEIJING MEDICAL AWARD FOUNDATION | intrahepatic cholangiocarcinoma | | | | |
NCT06447454: Combining Chemoradiotherapy With Sintilimab in First-Line ICC |
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| Not yet recruiting | N/A | 19 | RoW | radiotherapy, RT, gemcitabine + cisplatin, GC, slulimumab, HLX10 | Shanghai Zhongshan Hospital | ICC | 12/26 | 12/28 | | |
NCT05803746: PD-L2 Targeting Nanobody Radiotracer for PET Imaging of Solid Tumor |
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| Recruiting | N/A | 20 | RoW | 18F-FDG | Peking University Cancer Hospital & Institute | Lung Cancer, Colorectal Cancer | 07/24 | 07/24 | | |
NCT04561453: Feasibility Study of Multi-Platform Profiling of Resected Biliary Tract Cancer |
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| Recruiting | N/A | 20 | US | Multi-Platform Profiling with Organoid Drug Sensitivity Screening and ctDNA Monitoring | University of Washington, Natera, Inc., SEngine Precision Medicine, Inc. | Biliary Tract Cancer, Cholangiocarcinoma, Gallbladder Cancer, Intrahepatic Cholangiocarcinoma, Perihilar Cholangiocarcinoma, Extrahepatic Cholangiocarcinoma, Hilar Cholangiocarcinoma, Distal Bile Duct Cancer | 07/24 | 07/25 | | |
PREV-Ex, NCT05044065: Blood Flow Restriction Exercise in Patients With Pancreatic, Biliary Tract, and Liver Cancer |
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| Recruiting | N/A | 52 | Europe | Physical exercise | Karolinska Institutet, Karolinska University Hospital, Norwegian School of Sport Sciences, Oslo University Hospital | Pancreatic Cancer, Biliary Tract Cancer, Liver Cancer | 09/24 | 12/24 | | |
TAMLAPS, NCT03739164: Tampa Associating Microwave Liver Ablation With Portal Vein Ligation for Staged Hepatectomy |
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| Enrolling by invitation | N/A | 10 | US | | Florida Hospital Tampa Bay Division | Liver Cancer, Liver Tumor, Hepatocellular Carcinoma, Hilar Cholangiocarcinoma | 08/24 | 12/24 | | |
| Active, not recruiting | N/A | 1000 | US | Clinical Evaluation, Laboratory Biomarker Analysis, Liver Ultrasonographic Elastography, Fibroscan, TE, Transient Elastography, VCTE, Vibration-Controlled Transient Elastrography, Survey Administration | M.D. Anderson Cancer Center, Cancer Prevention Research Institute of Texas | Liver and Intrahepatic Bile Duct Carcinoma | 08/24 | 08/24 | | |
ChiCTR2100050196: Safety and efficacy of indocyanine green fluorescent tracer for intraoperative sentinel lymph node biopsy of biliary tract tumors |
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| Not yet recruiting | N/A | | | | Cancer Hospital of Chinese Academy of Medical Sciences; Cancer Hospital, Chinese Academy of Medical Sciences, Self-finance | intrahepatic cholangiocarcinoma | | | | |
| Active, not recruiting | N/A | 30 | Europe | Endoluminal radiofrequency ablation, Endoscopic biliary stenting | Clinical Hospital Colentina, Carol Davila University of Medicine and Pharmacy, Universitatea din Bucuresti | Perihilar Cholangiocarcinoma | 10/24 | 12/24 | | |
| Recruiting | N/A | 25 | US | Resistance Training, Aerobic Training | H. Lee Moffitt Cancer Center and Research Institute | Hepatobiliary Cancer, Cholangiocarcinoma, Liver Metastases | 09/24 | 09/24 | | |
| Withdrawn | N/A | 300 | NA | Electronic Patient Reported Outcomes platform, ePRO platform, Health Related Quality of Life Surveys, HRQoL | University of California, San Francisco | Gastrointestinal Cancers, Gastrointestinal Cancer Metastatic | 12/24 | 12/24 | | |
| Recruiting | N/A | 10000 | Europe, US | | Target PharmaSolutions, Inc. | Hepatocellular Cancer | 10/24 | 10/24 | | |
ChiCTR2000036610: Comparison of the efficacy of biliary stent with intracavitary irradiation versus External Beam Radiotherapy Combined With Expandable Metallic Stent in treating inoperable Hilar Cholangiocarcinoma: a randomized controled trial |
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| Not yet recruiting | N/A | 100 | | biliary stent with intracavitary irradiation ;External Beam Radiotherapy Combined With Expandable Metallic Stent | The Third Affiliated Hospital of Naval Military Medical University; The Third Affiliated Hospital of Naval Military Medical University, Shenkang Hostipal development center of shanghai | hilar Cholangiocarcinoma | | | | |
NCT05580328: An Exploratory Clinical Study of Photodynamic Therapy Combined With Sonodynamic Therapy in Cholangiocarcinoma |
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| Not yet recruiting | N/A | 10 | NA | Hematoporphyrin Injection actived by photodynamic therapy combined with Sonodynamic Therapy | Second Affiliated Hospital of Guangzhou Medical University | Cholangiocarcinoma | 10/24 | 10/24 | | |
NCT06115655: A Single-center, Prospective Cohort Study on the Differentiation of Benign and Malignant Bile Duct Stenosis Based on Bile and Peripheral Blood cfDNA Methylation Profiles |
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| Recruiting | N/A | 161 | RoW | cfDNA methylation detection | Air Force Military Medical University, China | Bile Duct Neoplasms, Jaundice, Obstructive, Bile Duct Diseases | 10/24 | 10/24 | | |
PERICLES, NCT04929015: Peritoneal Carcinomatosis Leveraging ctDNA Guided Treatment in GI Cancer Study ( Study) |
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| Recruiting | N/A | 30 | US | Biospecimen Collection - blood and tissue sample collection, Electronic Health Record Review | Rutgers, The State University of New Jersey, National Cancer Institute (NCI) | Appendix Carcinoma by AJCC V8 Stage, Colorectal Carcinoma by AJCC V8 Stage, Digestive System Neoplasm, Esophageal Carcinoma by AJCC V8 Stage, Gastric Carcinoma by AJCC V8 Stage, Liver and Intrahepatic Bile Duct Carcinoma, Peritoneal Carcinomatosis | 11/24 | 11/24 | | |
ChiCTR2100052367: Investigation on genomic biomarkers that negatively correlated with the clinical responses of immunotherapy |
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| Recruiting | N/A | 300 | | Liquid biopsy or puncture biopsy ;Liquid biopsy or puncture biopsy ;Liquid biopsy or puncture biopsy | The General Hospital of the People's Liberation Army; Shenzhen Haplox Biotechnology Co., Ltd, self-raised | Primary inoperable or advanced non-small cell lung cancer; Newly treated small cell lung cancer; Metastatic esophageal squamous cell carcinoma; Metastatic urothelial carcinoma; Advanced gastric cancer | | | | |
| Recruiting | N/A | 81 | Europe | Biospecimen sampling | Nicole Hildebrand, RWTH Aachen University | Cholestasis, Icterus, Cholangiocarcinoma, Pancreatic Neoplasms, Liver Metastasis Colon Cancer | 12/24 | 06/25 | | |
NCT03452774: SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry |
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| Recruiting | N/A | 50000 | US | Clinical Trial Matching | Massive Bio, Inc. | Cancer, Metastatic, Cancer, Cancer of Pancreas, Cancer of Liver, Cancer of Stomach, Cancer Liver, Cancer of Rectum, Cancer of Kidney, Cancer of Esophagus, Cancer of Cervix, Cancer of Colon, Cancer of Larynx, Cancer, Lung, Cancer, Breast, Cancer, Advanced, Cancer Prostate, Cancer of Neck, Cancer of Skin, Neuroendocrine Tumors, Carcinoma, Mismatch Repair Deficiency, BRCA Gene Rearrangement, Non Hodgkin Lymphoma, Leukemia, Non Small Cell Lung Cancer, Cholangiocarcinoma, Glioblastoma, Central Nervous System Tumor, Melanoma, Urothelial Carcinoma, Bladder Cancer, Ovarian Cancer, Endometrial Cancer, Testicular Cancer, Breast Cancer, COVID, Myelofibrosis, Myeloproliferative Neoplasm, Myeloproliferative Disorders, Follicular Lymphoma, Mantle Cell Lymphoma, Marginal Zone Lymphoma, Myelodysplastic Syndromes | 12/26 | 06/27 | | |
NCT05156515: PD-L1 Targeting Nanobody Probe for PET Imaging of Solid Tumor |
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| Recruiting | N/A | 20 | RoW | 68Ga-THP-APN09 | Peking University Cancer Hospital & Institute | Lung Cancer, Melanoma, PD-L1, PET/CT | 12/24 | 12/24 | | |
| Suspended | N/A | 40 | US | Stepped collaborative care intervention, Treatment, Enhanced Usual Care, Control | University of Pittsburgh | Cancer, Depression, Fatigue, Pain, Sleep | 02/25 | 06/27 | | |
ChiCTR2000031787: A Clinical Study to Evaluate Safety and Efficacy of ARQ 087 in Chinese Inoperable, Recurrent or Metastatic Intrahepatic Cholangiocarcinoma Subjects With Advanced Solid Tumors and FGFR2 Gene Fusion Positive Who Failed at Least First-Line Systemic Therapy |
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| Recruiting | N/A | 110 | | ARQ087 ;ARQ087 | Peking University Cancer Hospital & Institute; Sinovant Sciences Co., Ltd., self-financing | Solid Tumor and Intrahepatic Cholangiocarcinoma | | | | |
| Recruiting | N/A | 1000 | RoW | | National Health Research Institutes, Taiwan, National Cheng-Kung University Hospital | GI Cancer, Liver Cancer | 12/24 | 12/25 | | |
ChiCTR2100050688: Clinical trial of personalized mRNA cancer vaccine for treatment of advanced malignant tumors |
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| Recruiting | N/A | 10 | | inject personalized mRNA cancer vaccine | Shanghai East Hospital; Shanghai East Hospital, self-raised | malignant solid tumor | | | | |
NCT05596370: Association Between Cell-free Nucleic Acid in Blood, Urine and Microbiome in Stool With Pancreatobiliary Cancer |
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| Recruiting | N/A | 150 | RoW | cell free DNA in blood and urine, metabolite/microbiome in urine and stool | Seoul National University Hospital, DXOME CO., LTD. | Pancreatic Cancer, Cholangiocarcinoma, Gallbladder Cancer | 12/24 | 12/24 | | |
ChiCTR2200057737: Clinical study of endoscopic radiofrequency ablation for hilarcholangiocarcinoma |
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| Recruiting | N/A | 90 | | None | The Second Affiliated Hospital of Kunming Medical University; The Second Affiliated Hospital of Kunming Medical University, Agency grants | hilarcholangiocarcinoma | | | | |
ChiCTR2200065916: Safety and efficacy of chemotherapy combined with tirelizumab plus anlotinib in patients with advanced biliary tract cancer |
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| Not yet recruiting | N/A | 20 | China | chemotherapy combined with tirelizumab plus anlotinib | Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine ; Shanghai Jiaotong University School of Medicine, Renji Hospital, Beijing Medical Award Foundation | advanced biliary tract cancer | | | | |
NCT05721963: Study on the Accuracy of Proteomics in Evaluating Lymph Node Metastasis Status in Cholangiocarcinoma Patients |
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| Recruiting | N/A | 30 | RoW | No interventions. | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Cholangiocarcinoma | 12/24 | 12/24 | | |
| Recruiting | N/A | 2000 | Canada | | George Zogopoulos | Pancreas Cancer, Pancreatic Cancer, Pancreas Neoplasm, Pancreas Cyst, Pancreatic Precancerous Condition, Familial Pancreatic Cancer, Hereditary Cancer, Bile Duct Cancer, Ampullary Cancer, Duodenal Cancer, Gallbladder Cancer | 01/25 | 01/25 | | |
ChiCTR2100044131: Radionuclide-labeled tumor-associated fibroblast activation protein (FAP) inhibitor in PET imaging of solid tumors |
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| Recruiting | N/A | | | | The Affiliated Hospital of Southwest Medical University; The Affiliated Hospital of Southwest Medical University, Self-funded | Solid Tumors | | | | |
NCT04753996: Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients |
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| Recruiting | N/A | 300 | US | | Mayo Clinic, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Primary Sclerosing Cholangitis, PSC, Cholangiocarcinoma | 01/25 | 01/25 | | |
NCT05053555: High Dose-Rate Brachytherapy for the Treatment of Both Primary and Secondary Unresectable Liver Malignancies |
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| Recruiting | N/A | 60 | US | high dose rate brachytherapy | M.D. Anderson Cancer Center | Liver Malignant Tumors, Cholangiocarcinoma Metastatic, Pancreatic Cancer, Melanoma | 01/25 | 01/25 | | |
| Not yet recruiting | N/A | 60 | NA | Carrilizumab, Albumin-bound paclitaxel, Apatinib | First Affiliated Hospital Xi'an Jiaotong University | Cholangiocarcinoma | 01/25 | 01/26 | | |
| Recruiting | N/A | 200 | Europe | Endoscopic Ultrasound registration | Erasmus Medical Center | Hilar Cholangiocarcinoma, Intrahepatic Cholangiocarcinoma, Common Bile Duct Neoplasms, Cholangiocarcinoma, Adenocarcinoma | 02/25 | 02/26 | | |
NCT05694845: Evaluation of the Patient's Experience in Medical Studies for Cholangiocarcinoma |
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| Not yet recruiting | N/A | 500 | NA | | Power Life Sciences Inc. | Cholangiocarcinoma | 02/25 | 02/26 | | |
NCT05706974: Looking At Bile Duct Cancer Patient Experience Patterns in Medical Trials |
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| Not yet recruiting | N/A | 500 | NA | | Power Life Sciences Inc. | Bile Duct Cancer | 02/25 | 02/26 | | |
| Recruiting | N/A | 18 | US | Stereotactic Body Radiation Treatment | University of Kansas Medical Center, Varian Medical Systems | Liver Cancer | 02/25 | 02/25 | | |
ChiCTR2300069126: To explore the efficacy and safety of piamprilizumab combined with anrotinib in the treatment of biliary tract tumors in the second line and above |
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| Not yet recruiting | N/A | 27 | | Penpulimab combined with anlotinib | The Second Affiliate Hospital of Air Force Medical University/Tangdu Hospital; The Second Affiliate Hospital of Air Force Medical University/Tangdu Hospital, self-financing | Tumor of biliary system | | | | |
NCT03637569: The Relationship Between Triceps Skinfold and Overall Survival of Pancreas, Bile Duct, Gallbladder Cancer |
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| Recruiting | N/A | 1000 | RoW | Measurement of triceps skinfold thickness | Samsung Medical Center | Pancreas Cancer, Cholangiocarcinoma, Gallbladder Cancer | 04/25 | 12/26 | | |
ChiCTR2300071611: The efficacy and safety of CAR-T cell injection in the treatment of advanced solid tumors——an open, single center, single arm clinical study |
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| Not yet recruiting | N/A | 20 | | Infusion of anti DR5 CAR-T or NKG2D CAR-T cells | Shenzhen Hospital of Chinese Academy of Sciences; Shenzhen Hospital of Chinese Academy of Sciences, Shenzhen Binde Biotechnology Co., Ltd. | Advanced tumor | | | | |
NCT04378023: Liver Transplant Combined With Neoadjuvant Chemo-radiotherapy in the Treatment of Unresectable Hilar Cholangiocarcinoma. A Prospective Multicenter Study. |
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| Recruiting | N/A | 34 | Europe | Neoadjuvant Chemo-radiotherapy, Liver Transplantation | Hospital Vall d'Hebron | Unresectable Cholangiocarcinoma | 06/25 | 06/25 | | |
NCT04445532: Hepatobiliary Tumors Tissue Samples Acquisition |
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| Recruiting | N/A | 450 | RoW | Gene expression analysis, Genomic analysis, Protein expression analysis, Proteomic profiling, Polymerase chain reaction, Mass spectrometry, Immunohistochemistry, Metabolomics profiling, Methylation and epigenetic analysis, Liquid biopsy analysis, Laboratory biomarker analysis | Peking Union Medical College Hospital, OrigiMed, GeneCast Biotechnology Co., Ltd., YuceBio Technology Co., Ltd., Geneplus-Beijing Co. Ltd. | Hepatocellular Carcinoma, Cholangiocarcinoma, Gallbladder Cancer, Biliary Tract Cancer, Liver Cancer, Precancerous Condition, Benign Hepatobiliary Disease, Healthy, no Evidence of Disease | 06/25 | 06/25 | | |
NCT04907643: Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes |
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| Recruiting | N/A | 360 | US | PICO G2 4k | Cedars-Sinai Medical Center, National Cancer Institute (NCI) | Cancer Pain, Visceral Pain, Gastrointestinal Neoplasms, Cancer of Gastrointestinal Tract, Small Intestine Cancer, Pancreas Cancer, Liver Cancer, Colon Cancer, Biliary Tract Cancer, Stomach Cancer, Rectum Cancer, Peritoneal Cancer, Gastrointestinal Cancer Metastatic, Gastrointestinal Cancers - Anus, Gastrointestinal Cancers - Stomach, Gastrointestinal Cancers - Colorectal, Gastrointestinal Cancers - Small Intestine, Small Intestine Cancer Stage III, Small Intestine Cancer Stage IV, Small Intestine Cancer, Recurrent, Pancreas Cancer, Stage III, Pancreas Cancer, Stage IV, Pancreas Cancer, Metastatic, Pancreas Cancer, Recurrent, Liver Cancer Stage IIIa, Liver Cancer Stage IIIb, Liver Cancer Stage IIIc, Liver Cancer Stage IV, Colon Cancer Stage III, Colon Cancer Stage IV, Stomach Cancer Stage III, Stomach Cancer Stage IV, Stomach Cancer Recurrent, Rectum Cancer, Recurrent, Gastrointestinal Cancers - Liver, Anal Cancer, Anal Cancer Stage III, Anal Cancer Stage IV, Anal Cancer Recurrent, Anal Cancer Metastatic, Anal Cancer, Stage IIIA, Anal Cancer, Stage IIIB, Appendix Cancer, Ampullary Cancer, Bile Duct Cancer, Bile Duct Cancer Stage III, Bile Duct Cancer Stage IV, Bile Duct Cancer Stage IVA, Bile Duct Cancer Stage IVB, Bile Duct Cancer Recurrent, Carcinoid Tumor, Carcinoid Tumor of Pancreas, Carcinoid Tumor of Large Intestine, Carcinoid Tumor of GI System, Carcinoid Tumor of Colon, Carcinoid Tumor of Liver, Carcinoid Tumor of Cecum, Carcinoid Tumor of Ileum, Carcinoid Tumor of Rectum, Carcinoid Tumor of the Small Bowel, Carcinoid Tumor of the Stomach, Large Intestine Cancer, Esophagus Cancer, Esophagus Cancer, Stage III, Esophagus Cancer, Stage IV, Esophagus Cancer, Recurrent, Gallbladder Cancer, Gallbladder Cancer Stage III, Gallbladder Cancer Stage IV, Gastric (Stomach) Cancer, Neuroendocrine Tumor, Peritoneum Cancer, Rectal Cancer, Esophagus Cancer, Stage I, Esophagus Cancer, Stage II, Gallbladder Cancer Stage I, Gallbladder Cancer Stage II, Bile Duct Cancer Stage I, Bile Duct Cancer Stage II | 06/25 | 03/26 | | |
| Recruiting | N/A | 200 | | Hepatocellular carcinoma resection ;Hepatocellular carcinoma transplantation ;Intrahepatic cholangiocarcinoma resection ;Intrahepatic cholangiocarcinoma resection+adjuvant treatment | Shanghai Jiaotong University School of Medicine, Renji Hospital; Level of the institution：, Project of Shanghai Clinical Medical Center, Shanghai Municipal Health Planning Commission | Primary liver cancer | | | | |
ChiCTR-INR-17011501: A multicenter, prospective, RCT study of the surgical methods for resectable HCC with BDTT |
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| Not yet recruiting | N/A | 200 | | Anatomical hepatectomy combined with bile duct resection ;Anatomical hepatectomy combined with bile duct thrombectomy | Sun Yat-sen Memorial Hospital, Sun Yat-sen University; Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Sun Yat-sen Memorial Hospital, Sun Yat-sen University | Hepatocellular carcinoma | | | | |
| Recruiting | N/A | 200 | US | | Travera Inc, xCures | Pleural Effusion, Malignant, Ascites, Malignant, Carcinoma, Carcinoma, Hepatocellular, Carcinoma, Renal Cell, Carcinoma, Renal, Carcinoma, Small Cell, Carcinoma, Non-Small-Cell Lung, Carcinoma, Pancreatic Ductal, Carcinoma, Neuroendocrine, Carcinoma, Thymic, Carcinoma, Pancreatic, Carcinoma Breast, Carcinoma, Ovarian, Carcinoma Bladder, Carcinoma of Unknown Primary, Carcinoma of the Head and Neck, Carcinoma of the Oropharynx, Carcinoma of the Larynx, Carcinoma of the Bladder, Carcinoma of Esophagus, Carcinoma of the Nasopharynx, Carcinoma of the Penis, Carcinoma of the Cervix, Carcinoma of the Anus, Carcinoma of the Vulva, Carcinoma of the Appendix, Carcinoma of the Oral Cavity, Cholangiocarcinoma, Melanoma, Mesothelioma, Pancreatic Cancer | 07/25 | 07/26 | | |
ADBoard, NCT05681949: Therapeutic Assistance and Decision-making Algorithms in Hepatobiliary Tumor Boards |
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| Not yet recruiting | N/A | 1200 | Europe | ADBoard | Charite University, Berlin, Germany, German Research Center for Artificial Intelligence | Hepatocellular Carcinoma, Fibrolamellar Hepatocellular Carcinoma, Cholangiocarcinoma, Perihilar, Intrahepatic Cholangiocarcinoma, Metastasis to Liver, Gallbladder Carcinoma | 07/25 | 07/25 | | |
ChiCTR2100045377: The Clinical Efficiency of Laparoscopic Radical Resection of Hilar Cholangiocarcinoma: A Prospective, Multicenter Non-randomized Concurrent Controlled Trial |
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| Recruiting | N/A | 500 | | Laparoscopic surgery ;Laparotomy | Affiliated Hospital of North Sichuan Medical College; Affiliated Hospital of North Sichuan Medical College, Self-raised | Hilar cholangiocarcinoma | | | | |
ChiCTR2200063254: A single arm, multi-center, open lable, exploratory study of Tirelizumab combined with Nab-Paclitaxel and Gemcitabine in the treatment of patients with advanced biliary tract cancer |
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| Not yet recruiting | N/A | 30 | China | Tirelizumab + Nab-Paclitaxel + Gemcitabine | Shanghai Xuhui Central Hospital ; Shanghai Xuhui Central Hospital, BeiGene (Beijing) Co., Ltd.; Qilu Pharmaceutical Co., Ltd. | biliary tract cancer | | | | |
NCT00373347: Identification of New Serum Diagnostic Markers of Hepatocellular Carcinoma |
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| Recruiting | N/A | 300 | US | | Stanford University | Liver Cancer | 12/25 | 12/25 | | |
NCT02531607: Lipidomics, Proteomics, Micro RNAs and Volatile Organic Compounds (VOC) |
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| Active, not recruiting | N/A | 500 | US | blood and bile | AdventHealth | Pancreatic Neoplasms | 12/25 | 12/25 | | |
ChiCTR1800020066: A historical cohort study for the prognostic factors in 354 cases of hilar cholangiocarcinoma |
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| Completed | N/A | 354 | | Different surgical treatments | The Affiliated Hospital of Qingdao University; Level of the institution：, the National Natural Science Foundation (81272362) | Cholangiocarcinoma | | | | |
NCT04572711: Prospective Evaluation of Biliary Tissue Sampling With ERCP |
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| Enrolling by invitation | N/A | 500 | US | | Mayo Clinic | Cholangiopancreatography, Endoscopic Retrograde, Biliary Stricture, Biliary Tract Diseases, Cholangiocarcinoma | 12/25 | 05/26 | | |
NCT03104569: Effect of 37℃ Non-ionic Contrast Agent During ERCP Procedure in Hilar Cholangiocarcinoma |
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| Not yet recruiting | N/A | 100 | RoW | Injection of 37℃ contrast agent | Hepatopancreatobiliary Surgery Institute of Gansu Province | Cholangitis | 12/25 | 12/25 | | |
| Recruiting | N/A | 300 | US | Ablative local therapy | University of California, Davis, National Cancer Institute (NCI) | Esophageal Cancer, Small Bowel Cancer, Gastroesophageal-junction Cancer, Gastric Cancer, Colorectal Cancer, Appendiceal Cancer, Biliary Cancer, Gall Bladder Cancer, Intrahepatic Cholangiocarcinoma, Extrahepatic Cholangiocarcinoma, Oligoprogressive | 12/25 | 01/31 | | |
NCT04145141: National Translational Science Network of Precision-based Immunotherapy for Primary Liver Cancer |
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| Recruiting | N/A | 500 | US | | National Cancer Institute (NCI) | Hepatocellular Carcinoma, Liver Cancer, Cholangiocarcinoma | 12/25 | 12/25 | | |
ChiCTR2100044562: A trial for construction of gallbladder carcinoma organoids database, individual drug sensitivity test and combined immunotherapy |
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| Not yet recruiting | N/A | 90 | | Treating with Gemcitabine and GEMOX ;Treating with Fluorouracil and GEMOX ;Treating with Cis-platinum and GEMOX ;Treating with Gemcitabine and FOLFIRINOX ;Treating with Fluorouracil and FOLFIRINOX ;Treating with Cis-platinum and FOLFIRINOX ;Treating with Gemcitabine ;Treating with Fluorouracil ;Treating with Cis-platinum | Renji Hospital affiliated to Shanghai Jiaotong University, School of Medicine; Renji Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Self financing by researchers | gallbladder carcinoma | | | | |
ChiCTR2200066839: Basic and clinical research on the etiology and prognosis of liver cancer |
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| Recruiting | N/A | 250 | | NA ;NA ;NA | East Branch of Shandong Provincial Hospital; East Branch of Shandong Provincial Hospital, Self-funded | Liver cancer | | | | |
ChiCTR2200066720: Study on adjuvant therapy for advanced cholangiocarcinoma based on drug sensitivity of organoid |
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| Not yet recruiting | N/A | 36 | | Administration of drugs to subjects according to drug sensitivity results of organoid | The Sixth Affiliated Hospital of Sun Yat-sen University; The Sixth Affiliated Hospital of Sun Yat-sen University, Hospital self-raised | Advanced cholangiocarcinoma | | | | |
NCT05519319: Safety and Efficacy of PDT vs RFA vs PDT+RFA for the Treatment of Extrahepatic Cholangiocarcinoma |
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| Recruiting | N/A | 70 | RoW | RFA, ERCP guided, PDT, RFA combined with PDT | First People's Hospital of Hangzhou | Extrahepatic Cholangiocarcinoma, Bile Duct Cancer | 12/25 | 06/26 | | |
ChiCTR2300070425: Efficacy and safety of simultaneous radiotherapy and chemotherapy combined with immunotherapy for conversion therapy of unresectable biliary tract tumors |
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| Recruiting | N/A | 25 | | Tegafur + gemcitabine + anti-PD-1 monoclonal antibody combined with synchronous radiotherapy | Nanjng Drum Tower Hospital; Nanjng Drum Tower Hospital, The General Medical Science and Technology Development Project of Nanjing | Biliary tract tumor | | | | |
NCT05932836: An Organoid-on-chips Technique Based on Biopsy Samples and Its Efficacy in Predicting the Response to HAI in HCC |
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| Recruiting | N/A | 165 | RoW | No interventions. | Xiangya Hospital of Central South University | Hepatocellular Carcinoma | 12/25 | 02/26 | | |
NCT06106750: Endoscopic Scissors Cutting Nasobiliary Duct VS Bilateral Plastic Stent |
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| Recruiting | N/A | 122 | RoW | Endoscopic nasobiliary duct cutting, Bilateral plastic stent | First People's Hospital of Hangzhou | Cholangiocarcinoma, Hilar, Biliary Stricture, Hilar Cholangiocarcinoma, Klatskin Tumor, Biliary Disease, Bile Duct Diseases, Bile Duct Stenosis | 01/26 | 01/26 | | |
