Tekturna (aliskiren) / PDL, Novartis  >>  Phase 1
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11 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Tekturna (aliskiren) / PDL
NCT00416468: Bioavailability of Aliskiren and Valsartan Combined as a Single Tablet vs. the Same Medications Given Separately to Healthy Subjects.

Completed
1
32
US
Aliskiren, Valsartan
Novartis
Healthy
 
 
NCT00416728: Bioavailability of Aliskiren and Valsartan as a Single Tablet vs. the Same Doses of the Two Drugs Given Separately to Healthy Subjects.

Completed
1
32
US
Aliskiren, Valsartan
Novartis
Healthy
 
 
NCT00424541: Pharmacokinetic and Pharmacodynamic Profiles of Aliskiren in Japanese Patients With Mild to Moderate Essential Hypertension

Completed
1
34
Japan
SPP100 (aliskiren)
Novartis
Hypertension
 
08/07
NCT00933920: Effect of Light Meal on Pharmacokinetic and Pharmacodynamics of Aliskiren in Patients With Mild to Moderate Hypertension

Completed
1
124
RoW
Aliskiren
Novartis Pharmaceuticals
Hypertension
12/09
 
NCT00856960: The Effect of Hypertension Medications on Renal Blood Flow Measurements in Healthy Males (MK-0000-127)

Completed
1
12
US
Aliskiren, Comparator: Losartan, Comparator: Placebo to Aliskiren, Comparator: Placebo to Losartan
Merck Sharp & Dohme LLC
Hypertension
03/10
04/10
NCT01568775: Pharmacokinetics, Safety and Tolerability of Aliskiren (SPP100) in Patients With End Stage Renal Disease on Hemodialysis and Matched Healthy Subjects

Completed
1
12
Europe
Aliskiren, SPP100
Novartis
End Stage Renal Disease
09/10
09/10
NCT01217736: Direct Renin Inhibition and the Kidney

Completed
1
22
US
aliskiren, Tekturna, placebo, VTP-27999
Vitae Pharmaceuticals, Inc., Brigham and Women's Hospital
Renal Function
11/11
11/11
2012-000855-15: Study to determine bioavailablity of 300 mg aliskiren mini-tablets vs 300 mg aliskiren market tablet.

 
1
NA
Aliskiren, SPP100, Rasilez, Rasilez
Novartis Pharma Services AG, Novartis Pharma Services AG
Hypertension
 
 
NCT01103245: Aldosterone and the Metabolic Syndrome

Completed
1
69
US
Hydrochlorothiazide (HCTZ), HCTZ, Aliskiren 150 mg (ALI 150), Tekturna, Spironolactone (SPL 25), Aldactone, Aliskiren 300 mg (ALI 300), Spironolactone 50 mg (SPL 50)
Vanderbilt University Medical Center
Metabolic Diseases, Diabetes Mellitus, Endocrine System Diseases, Glucose Metabolism Disorders
07/12
09/13
SAAVE, NCT01432106: The Study of Novel Dual Renin Angiotensin Aldosterone System (RAAS) Blockade; Valsartan/Aliskiren in African American Patients With Hypertension and the Metabolic Syndrome

Withdrawn
1
0
US
Aliskerin/Valsartan and Rampiril, Tekturna (Aliskerin), Diovan (Valsartan), Valturna (Aliskerin/Valsartan, Altace (Ramipril)
University of Michigan, Novartis Pharmaceuticals
Hypertension, Metabolic Syndrome
12/12
12/12
NCT00223717: Treatment of Supine Hypertension in Autonomic Failure

Completed
1
152
US
Clonidine, Catapres, Nitroglycerin transdermal, Nitro-Dur, Dipyridamole/ Aspirin (Aggrenox), Aggrenox, Desmopressin (DDAVP), DDAVP, Sildenafil, Viagra, Nifedipine, Adalat, Hydralazine, Hydrochlorothiazide, Microzide, Placebo, Bosentan, Tracleer, Diltiazem, Cardizem, Eplerenone, Inspra, guanfacine, Tenex, L-arginine, captopril, capoten, carbidopa, Lodosyn, losartan, cozaar, metoprolol tartrate, lopressor, nebivolol hydrochloride, Bystolic, prazosin hydrochloride, Minipress, tamsulosin hydrochloride, Flomax, Head-up tilt., HUT, aliskiren, Tekturna, Local heat stress, heating pad
Vanderbilt University
Hypertension
01/17
01/17

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