| Tekturna (aliskiren) / PDL |
NCT00441064: Effect of High and Low Sodium Diets on Blood Pressure in Hypertensive Patients Treated With Aliskiren |
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| Completed | 4 | 132 | US | Aliskiren | Novartis | Hypertension | 11/07 | 11/07 | | |
NCT00654875 / 2007-002469-11: Efficacy and Safety of Once Daily Dosing of Aliskiren (300 mg (qd) Once a Day) to Twice Daily Dosing of Aliskiren (150 mg (Bid) Twice a Day) in Treating Moderate Hypertension. |
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| Completed | 4 | 328 | US, Europe | Aliskiren, Tekturna, Rasilez, Placebo to Aliskiren | Novartis | Essential Hypertension | 11/08 | 11/08 | | |
ATLAAST, NCT00739596: Blood Pressure Lowering of Aliskiren Hydrochlorothiazide (HCTZ) Versus Amlodipine in Stage 2 Hypertension in African Americans |
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| Completed | 4 | 332 | US | Aliskiren Hydrochlorothiazide (HCTZ): 8 weeks, Amlodipine: 8 weeks | Novartis Pharmaceuticals | Hypertension | 03/09 | 03/09 | | |
ATTAIN, NCT00772577: Study of the Efficacy and Safety of Aliskiren HCTZ vs Ramipril in Obese Patients (BMI ≥ 30) With Stage 2 Hypertension |
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| Completed | 4 | 386 | US | Aliskiren Hydrochlorothiazide, Ramipril | Novartis | Hypertension | 03/09 | 03/09 | | |
ACTION, NCT00760266: Blood Pressure Lowering of Aliskiren HCTZ Compared to HCTZ in Stage 2 Systolic Hypertension in Older Population |
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| Completed | 4 | 451 | US | Aliskiren, Hydrochlorothiazide | Novartis | Hypertension | 04/09 | 04/09 | | |
ALTO, NCT00542269 / 2007-003677-10: Efficacy and Safety of Aliskiren/Ramipril/Amlodipine Compared With Ramipril/Amlodipine and Aliskiren/Amlodipine in Patients With Metabolic Syndrome |
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| Terminated | 4 | 178 | Europe | Amlodipine, Aliskiren, Ramipril | Novartis | Hypertension With Metabolic Syndrome | 07/09 | 07/09 | | |
VANTAGE, NCT00809926: 8 Weeks Study to Evaluate the Efficacy and Safety of Valsartan in Combination With Aliskiren Compared to Valsartan Alone in Patients With Stage 2 Hypertension |
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| Completed | 4 | 451 | US | Valsartan/aliskiren, Valsartan | Novartis | Stage 2 Hypertension | 07/09 | 07/09 | | |
AACESS, NCT00853957: Efficacy and Safety of Aliskiren Administered in Combination With Amlodipine Versus Amlodipine Alone in African American Patients With Stage 2 Hypertension |
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| Completed | 4 | 443 | US | Aliskiren/Amlodipine, Amlodipine | Novartis | Hypertension | 08/09 | 08/09 | | |
NCT00631917: A Study Evaluating the Gastrointestinal (GI) Safety and Tolerability of Aliskiren Compared to Ramipril in Essential Hypertension |
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| Completed | 4 | 774 | US, Europe, RoW | Aliskiren, Ramipril, Placebo to Ramipril, Placebo to Aliskiren | Novartis | Hypertension | 09/09 | 09/09 | | |
AIMS, NCT00797316: Aliskiren Plus HCTZ Compared to Aliskiren in Metabolic Syndrome Patients With Stage 2 Systolic Hypertension |
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| Completed | 4 | 532 | US | Aliskiren, Hydrochlorothiazide | Novartis | Hypertension | 12/09 | 12/09 | | |
ASCENT, NCT00942994: Aliskiren/Amlodipine/Hydrochlorothiazide (HCTZ) Versus Aliskiren/Amlodipine in US Minority Patients With Stage II Systolic Hypertension |
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| Completed | 4 | 412 | US | Aliskiren/Amlodipine, Aliskiren/Amlodipine and Hydrochlorothiazide (HCTZ) | Novartis | Hypertension | 03/10 | | | |
| Completed | 4 | 822 | Canada, Europe, RoW | Aliskiren, Telmisartan, Placebo to Aliskiren, Placebo to Telmisartan | Novartis | Hypertension | 06/10 | 06/10 | | |
ViVID, NCT00927394: Aliskiren and Valsartan vs Valsartan Alone in Patients With Stage II Systolic Hypertension and Type II Diabetes Mellitus |
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| Completed | 4 | 1143 | US | Aliskiren, Valsartan, Placebo for Aliskiren, Placebo for Valsartan | Novartis | Hypertension | 10/11 | 10/11 | | |
ANDROMEDA, NCT01056731: A Clinical Study With Aliskiren Alone or in Combination Therapy With Diuretic Hctz in Venezuelan Hypertensive Patients. |
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| Completed | 4 | 253 | RoW | Aliskiren and HCTZ | Novartis | High Blood Pressure | 10/11 | 10/11 | | |
REALITY, NCT01060865: Evaluation of Aliskiren Efficacy by Different Methods of Blood Pressure Measurements |
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| Terminated | 4 | 50 | RoW | Aliskiren, Blood Pressure, Ambulatory Blood Pressure monitor, Self measured home blood pressure | Meir Medical Center, Novartis Pharmaceuticals | Blood Pressure, High | 10/11 | 12/11 | | |
NCT00974922: Vitamin D Deficiency in Patients With Hypertension |
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| Terminated | 4 | 40 | US | Aliskiren, Tekturna, Cholecalciferol, Vitamin D3, Placebo | UConn Health, Novartis | Vitamin D Deficiency, Hypertension | 12/11 | 12/11 | | |
NCT01349114: Effect of the Direct Renin Inhibitor Aliskiren on Endothelial Function and Arterial Stiffness in Diabetic Subjects |
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| Terminated | 4 | 21 | US | aliskiren 300 mg once daily, Tekturna, Placebo/sugar pill | University of Alabama at Birmingham, Novartis | Diabetes, Pre-hypertension, Hypertension | 01/12 | 01/12 | | |
NCT01284114: Effects of Aliskiren in Elderly Hypertensive Chronic Kidney Disease (CKD) Patients |
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| Completed | 4 | 23 | Japan | Aliskiren, Direct renin inhibitor | Jichi Medical University | Hypertension, Chronic Kidney Disease | 05/12 | 05/12 | | |
NCT01570686 / 2011-005297-36: 8-week Randomized, Open-label Study to Evaluate Food Effect on Efficacy and Safety of Oral Aliskiren 300 mg in Patients With Hypertension |
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| Completed | 4 | 589 | US, Canada, Europe, RoW | Aliskiren, Tekturna, rasilez | Novartis Pharmaceuticals | Hypertension | 11/12 | 11/12 | | |
NCT01235910: Clinical Pharmacology of Aliskiren in Combination With Cyclosporine in Cardiac Transplantation |
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| Terminated | 4 | 1 | US | Aliskiren, Tekturna (aliskiren), Neoral (cyclosporine) | University of Colorado, Denver, American Heart Association | Hypertension, Cardiac Transplantation | 12/12 | 12/12 | | |
| Completed | 4 | 74 | Europe | Aliskiren, Rasilez, Losartan, Amlodipine, Hydrochlorothiazide (HCTZ) | Novartis Pharmaceuticals | Hypertension, Left Ventricle Hypertrophy | 04/13 | 04/13 | | |
NCT01409408: Comparison of Amlodipine and Aliskiren in Diabetic Hypertensive Patient With Blood Pressure Not Controlled by Losartan |
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| Withdrawn | 4 | 0 | RoW | Aliskiren, Rasilez., Amlodipine, Norvasc. | Hospital Universitario Pedro Ernesto, Novartis | Hypertension, Diabetes Mellitus | 04/13 | 12/13 | | |
| Completed | 4 | 24 | Europe | RAS blockade discontinuation, Aliskiren, Rasilez, Candesartan, Atacand | Medical University of Vienna | Hypertension, Chronic Kidney Disease, Proteinuria | 02/16 | 02/16 | | |
| Withdrawn | 4 | 0 | US | Aliskiren, Rasilez, Tekturna, Amlodipine, Ramipril, Hydrochlorothiazide | Novartis Pharmaceuticals | Hypertension | 06/18 | 06/18 | | |
