| Tekturna (aliskiren) / PDL |
NCT00219024 / 2004-000240-25: Clinical Study to Evaluate the Efficacy and Safety of Aliskiren Alone and in Combination With Hydrochlorothiazide in Patients With Essential Hypertension. |
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| Completed | 3 | 2775 | US, Europe | aliskiren | Novartis | Hypertension | 06/05 | 06/05 | | |
NCT00219089 / 2004-001062-40: A Clinical Study to Evaluate the Safety and Efficacy of Aliskiren Alone and in Combination With Ramipril in Hypertensive, Diabetic Patients. |
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| Completed | 3 | 839 | US, Europe | aliskiren | Novartis | Hypertension, Diabetes Mellitus | 08/05 | 08/05 | | |
NCT00219037: Long Term Safety of Aliskiren Alone or With the Optional Addition of Hydrochlorothiazide in Patients With Essential Hypertension |
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| Completed | 3 | 1955 | Europe | aliskiren | Novartis | Hypertension | 10/05 | 10/05 | | |
NCT00219076 / 2004-002410-11: A Clinical Study to Evaluate the Safety and Efficacy of the Combination of Aliskiren and Amlodipine in Hypertensive Non Responders Patients |
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| Completed | 3 | 504 | US, Europe | aliskiren | Novartis | Hypertension | 10/05 | | | |
NCT00219154 / 2004-004015-38: A Clinical Study to Compare Long-term Efficacy and Safety of an Aliskiren Based Regimen to a Hydrochlorothiazidebased Treatment Regimen With Optional Addition of Amlodipine |
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| Completed | 3 | 1125 | Europe | aliskiren | Novartis | Hypertension | 01/06 | 01/06 | | |
| Completed | 3 | 355 | Europe | aliskiren | Novartis | Hypertension | 02/06 | 02/06 | | |
NCT00219115 / 2004-003905-26: A Clinical Study to Compare Combination of Aliskiren+ HCTZ to Irbesartan+ HCTZ or Amlodipine+ HCTZ or HCTZ Alone in Obese Hypertensive Not Responsive to HCTZ 25 mg |
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| Completed | 3 | 493 | US, Europe | aliskiren | Novartis | Hypertension | 03/06 | 03/06 | | |
NCT00219063 / 2004-001061-17: A Clinical Study to Compare an Aliskiren Based Hypertensive Regimen With a Ramipril Based One Followed by a Randomized Withdrawal. |
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| Completed | 3 | 844 | US | aliskiren | Novartis | Hypertension | 03/06 | 03/06 | | |
NCT00294710: A Clinical Study to Compare Long-term Efficacy and Safety of an Aliskiren Based Regimen to a Hydrochlorothiazide Based Treatment Regimen With Optional Addition of Amlodipine |
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| Completed | 3 | 976 | US, Europe | Aliskiren | Novartis | Hypertension | 07/06 | 07/06 | | |
| Completed | 3 | 693 | Europe | Aliskiren | Novartis | Hypertension | 08/06 | 08/06 | | |
NCT00219180 / 2005-000039-73: Clinical Study to Evaluate Efficacy and Safety of Aliskiren (150mg & 300mg) Administered Alone and in Combo With Valsartan (160mg and 320mg) in Patients With High Blood Pressure |
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| Completed | 3 | 1797 | US, Europe | aliskiren | Novartis | Hypertension | 09/06 | 09/06 | | |
NCT00219193 / 2005-002635-27: A Clinical Study to Evaluate the Safety and Efficacy of the Combination of Aliskiren and Valsartan in Hypertensive Non Responders Patients |
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| Completed | 3 | 641 | US, Europe | aliskiren | Novartis | Hypertension | 01/07 | 01/07 | | |
NCT00343551 / 2005-004993-26: Efficacy and Safety of Aliskiren 300mg Compared to Irbesartan 300mg and Ramipril 10 mg in the Setting of a Missed Dose for Patients With Essential Hypertension. |
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| Completed | 3 | 654 | Europe | Aliskiren | Novartis | Essential Hypertension | 01/07 | | | |
NCT00344110: Study Comparing SPP100 (Aliskiren) 150mg to Placebo and to Losartan 50mg in Patients With Mild to Moderate Essential Hypertension |
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| Completed | 3 | 768 | Japan | Aliskiren | Novartis | Hypertension | 04/07 | 04/07 | | |
NCT00299832: SPP100 (Aliskiren) Regimen in Hypertensive Patients With Renal Dysfunction |
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| Completed | 3 | 40 | Japan | Aliskiren | Novartis | Hypertension | 05/07 | 05/07 | | |
NCT00386139 / 2005-004579-39: A Safety and Efficacy Trial of the Combination of Aliskiren / Hydrochlorothiazide (HCTZ)(300/12.5 mg and 300/25 mg) Compared to Aliskiren 300 mg in Hypertensive Patients |
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| Completed | 3 | 881 | US, Europe | Aliskiren/HCTZ | Novartis | Hypertension | 07/07 | 07/07 | | |
NCT00518765: Hemodynamic Effects of Aliskiren Compared to Captopril on the Kidney in Healthy Volunteers on a Low- and High- Sodium Diet |
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| Completed | 3 | 32 | US | Aliskiren, SPP100, Aliskiren plus placebo | Novartis | Hypertension | 08/07 | | | |
NCT00387517 / 2005-004580-40: Safety/Efficacy of Combo Therapy With Aliskiren & Hydrochlorothiazide vs Therapy With Hydrochlorothiazide Alone in Patients With Hypertension |
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| Completed | 3 | 726 | US, Europe | Aliskiren/HCTZ | Novartis | Hypertension | 08/07 | 08/07 | | |
ALLAY, NCT00219141 / 2005-000856-34: Aliskiren in Combination With Losartan Compared to Losartan on the Regression of Left Ventricular Hypertrophy in Overweight Patients With Essential Hypertension |
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| Completed | 3 | 460 | US, Europe, RoW | Aliskiren 150/300 mg, Losartan 50/100 mg, Aliskiren placebo, Losartan 50/100 mg placebo | Novartis Pharmaceuticals | Hypertension, Left Ventricular Hypertrophy, Overweight | 11/07 | 11/07 | | |
NCT00368277: A Safety and Efficacy Trial of Aliskiren 150mg , 300 mg Compared to Ramipril 5mg, 10mg in the Elderly |
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| Completed | 3 | 901 | US | Aliskiren, Ramipril, Hydrochlorothiazide, Amlodipine | Novartis Pharmaceuticals | Hypertension | 02/08 | 02/08 | | |
NCT00402103: An Assessment of Long Term Safety of the Combination of Aliskiren / Amlodipine in Patients With High Blood Pressure |
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| Completed | 3 | 556 | US, Europe, RoW | Aliskiren, Amlodipine, Hydrochlorothiazide | Novartis | Hypertension | 04/08 | 04/08 | | |
NCT00386607: A Safety and Tolerability Study of the Combination of Aliskiren/Valsartan in Patients With High Blood Pressure, Followed by Long-term Safety and Tolerability of Aliskiren, Valsartan and Hydrochlorothiazide. |
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| Completed | 3 | 601 | US, Canada, Europe | Aliskiren, Valsartan, Hydrochlorothiazide (HCTZ) | Novartis | Hypertension | 07/08 | 07/08 | | |
NCT00529451: Safety and Efficacy of Aliskiren 300 mg, 150 mg and 75 mg in Patients With Essential Hypertension Compared to Ramipril 5 mg |
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| Completed | 3 | 1613 | RoW | Aliskiren, Ramipril | Novartis | Hypertension | 07/08 | 07/08 | | |
ACQUIRE, NCT00705575 / 2008-000862-21: Efficacy and Safety of the Combination Aliskiren (300 mg) and Hydrochlorothiazide (25mg) to Aliskiren (300mg) Monotherapy in Patients With Staged II Hypertension |
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| Completed | 3 | 688 | US, Europe, RoW | Aliskiren/hydrochlorothiazide (HCTZ) (300/25 mg), Aliskiren (300 mg) | Novartis | Hypertension | 04/09 | 04/09 | | |
NCT00739973: Study to Evaluate the Efficacy and Safety of Aliskiren Alone and in Combination With Amlodipine in Essential Hypertension |
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| Completed | 3 | 2694 | US, Canada, Europe, RoW | Placebo, Aliskiren 150 mg tablet, Aliskiren 300 mg tablet, Amlodipine 5 mg capsule, Amlodipine 10 mg capsule, Aliskiren/amlodipine 150/5 mg tablet, Aliskiren/amlodipine 150/10 mg tablet, Aliskiren/amlodipine 300/5 mg tablet, Aliskiren/amlodipine 300/10 mg tablet | Novartis Pharmaceuticals | Hypertension | 05/09 | 05/09 | | |
NCT00777946 / 2006-006066-42: Study to Evaluate the Efficacy and Safety of Combination Aliskiren/Amlodipine in Patients Not Adequately Responding to Aliskiren Alone |
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| Completed | 3 | 818 | Europe, RoW | Aliskiren 300 mg, Aliskiren/Amlodipine 300/5 mg, Aliskiren/Amlodipine 300/10 mg, Placebo to Aliskiren, Placebo to Aliskiren/Amlodipine | Novartis | Hypertension | 05/09 | 05/09 | | |
NCT00778921 / 2006-006068-44: Study to Evaluate the Efficacy and Safety of Combination Aliskiren/Amlodipine in Patients With Hypertension Not Adequately Responding to Amlodipine Alone |
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| Completed | 3 | 847 | Europe, RoW | Amlodipine 10 mg, Aliskiren 150, Amlodipine 300 | Novartis | Hypertension | 06/09 | 06/09 | | |
| Completed | 3 | 1191 | US, Canada, Europe, RoW | Aliskiren, Amlodipine, Hydrochlorothiazide (HCTZ), Placebo | Novartis | Hypertension | 08/09 | 08/09 | | |
| Completed | 3 | 186 | Europe | Candesartan+HCTZ - Phase 1, Aliskiren+HCTZ - Phase 2, Aliskiren+HCTZ+amlodipine - Phase 3 | Novartis | Hypertension | 08/09 | 08/09 | | |
| Completed | 3 | 820 | US, Canada, Europe, RoW | Aliskiren, Tekturna®, placebo | Novartis | Myocardial Infarction | 09/09 | 07/11 | | |
NCT00841672 / 2008-005216-40: Efficacy and Safety of the Combination of Aliskiren (300 mg) and Amlodipine (10 mg) Compared to Amlodipine (10 mg) Monotherapy in Patients With Moderate to Severe Hypertension |
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| Completed | 3 | 485 | Europe, RoW | Aliskiren/amlodipine 300/10 mg tablet, Amlodipine 10 mg capsule | Novartis | Moderate to Severe Hypertension | 09/09 | 09/09 | | |
| Completed | 3 | 347 | Europe | Aliskiren/Amlodipine and Aliskiren/Amlodipine/HCTZ | Novartis | Essential Hypertension | 10/10 | | | |
NCT01067326: The Effect of Tekturna on Endothelial Function and Endothelial Progenitor Cells in Patients With Early Atherosclerosis |
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| Terminated | 3 | 22 | US | Aliskiren, Tekturna, Rasilez, Placebo | Mayo Clinic, National Institute on Aging (NIA), National Heart, Lung, and Blood Institute (NHLBI), Novartis | Endothelial Dysfunction | 12/11 | 12/11 | | |
NCT01237873: Long Term Safety of SPA100 (Fixed-dose Combination of Aliskiren/Amlodipine) in Patients With Essential Hypertension |
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| Completed | 3 | 150 | Japan | Ali/Amlo 150/2.5 mg | Novartis Pharmaceuticals | Essential Hypertension | 02/12 | 02/12 | | |
| Completed | 3 | 267 | US, Europe, RoW | Aliskiren (6.25/12.5/25 mg), Aliskiren (37.5/75/150 mg), Aliskiren (150/300/600 mg) | Novartis Pharmaceuticals | Hypertension | 08/14 | 08/14 | | |
NCT01151410 / 2009-017029-20: An Extension Study to Evaluate the Long Term Safety, Tolerability and Efficacy of Aliskiren Compared to Enalapril in Pediatric Hypertensive Patients 6-17 Years of Age |
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| Completed | 3 | 208 | US, Europe, RoW | Aliskiren, Enalapril | Novartis Pharmaceuticals | Hypertension | 08/15 | 08/15 | | |
| Terminated | 2/3 | 71 | US | Aliskiren, Tekturna, Placebo, Sugar Pill | Ohio State University, Novartis | Atherosclerosis | 12/11 | 01/12 | | |
