| Bipolar Disorder |
ACTRN12612000405819: Fish oil for mood stabilization during pregnancy in women with bipolar disorder |
|
|
| Not yet recruiting | 4 | 200 | | | Univeristy of New South Wales, Department of Health and Aging, Canberra | Bipolar disorder in pregnancy | | | | |
ACTRN12605000666628: Efficacy of 8 weeks open label aripiprazole as augmentation therapy in Bipolar II disorder |
|
|
| Recruiting | 4 | 25 | | | Bristol-Myers Squibb Pharmaceuticals, Bristol-Myers Squibb Pharmaceuticals | Bipolar II Disorder | | | | |
2007-004513-33: Comparative Evaluation of QUEtiapine-Lamotrigine combination versus quetiapine monotherapy (and folic acid versus placebo) in patients with bipolar depression |
|
|
| Ongoing | 4 | 300 | Europe | Dispersible tablet, Tablet, Lamictal, TillVal Folysra (Folic acid) | University of Oxford | Bipolar depression | | | | |
ChiCTR-TNRC-10001112: The study on clinical and biological characters of bipolar depression and the treatment scheme optimizing |
|
|
| Completed | 4 | 640 | | Lithium, Sodium valproate, Lamotrigine, MECT, Sertraline, Citalopram, Escitalopram, venlafaxine, Quetiapine, Olanzapine, Risperidone, sulpiride | Guangzhou Scientific and Technological Bureau, Guangzhou Board of Health; Guangzhou first people's hospital, The Tackling Key Problems of Guangzhou Scientific and Technological Project | bipolar depressive disorder | | | | |
ChiCTR-TRC-13003554: Olanzapine-valproate combination versus olanzapine or valproate monotherapy in the treatment of bipolar manic episodes: a randomized, controlled trial |
|
|
| Completed | 4 | 120 | | Taking valproate ;Taking olanzapine ;Taking olanzapine and valproate | Department of Psychiatric, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Second Affiliated Hospital of Zhejiang University School of Medicine, Technology Foundation of Zhejiang Province (2010C33038); Health Foundation of Zhejiang Province (2011KYA073); Medical Technology Program Foundation of Zhejiang Province (2012KYA101) | bipolar I disorder mania-episode | | | | |
| Ongoing | 4 | 40 | Europe | Priadel, Prolonged-release tablet, Priadel | University of Oxford, Wellcome Trust | Bipolar disorder with current mood instability, Mood disorder characterised by periods of abnormally high and/or low mood., Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2006-002006-60: Functional neuroanatomy and regional metabolism in depressed patients with quetiapin: An fMRI-guided MRS study on a 7 Tesla scanner |
|
|
| Ongoing | 4 | 40 | Europe | Quetiapin, | Otto-von-Guericke University | Patients with Bipolar affective disorder | | | | |
2005-005072-32: Is it possible to modify the course of manic relapse? A pilot study of the effectiveness of quetiapine in preventing the development of manic episodes in Bipolar Disorder. |
|
|
| Ongoing | 4 | 50 | Europe | Quetiapine, Seroquel 100mg, Seroquel 150mg, Seroquel 200mg, Seroquel 300mg, Seroquel 100mg, Seroquel 150mg, Seroquel 200mg, Seroquel 300mg | Kings College London (IOP) / South London and Maudsley NHS Trust (Co-sponsorship) | Bipolar Disorder | | | | |
2006-001317-15: BALANCE 2: Bipolar disorder:Antidepressant/Lamotrigine/ANtipsychotic Comparative Evaluation |
|
|
| Ongoing | 4 | 630 | Europe | Selective Serotonin Reuptake Inhibitors, SSRI, Quetiapine, Lamotrigine, Quetiapine, Lamotrigine | University of Oxford | Bipolar depression. | | | | |
2008-000370-20: Evaluation of pharmacokinetic and pharmacodynamic interactions between escitalopram and drugs used for the treatment of bipolar disorders. |
|
|
| Ongoing | 4 | 24 | Europe | Lamotrigine, Gabapentin, Carbamazepine, Oxcarbazepine, Levetiracetam, Valproic acid, CIPRALEX, LITIO CARBONATO, CIPRALEX, LITIO CARBONATO | AZIENDA OSPEDALIERA PISANA | bipolar disorders | | | | |
2008-004746-81: Effect of amiloride on lithium-induced chronic nephropathy.Comparing discontinuation of lithium treatment to adding amiloride while continuing lithium treatment. |
|
|
| Ongoing | 4 | 30 | Europe | amiloride (modamide), Modamide, Modamide | Parnassia-BAVO groep, St. Elisabeth Ziekenhuis, University Medical Center Utrecht | Renal failure due to long-term use of lithium salts in patients with bipolar disorders. | | | | |
2010-023740-32: Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder |
|
|
| Ongoing | 4 | 80 | Europe | Lithium, Orfiril, no, Lithionit, Orfiril, Lithionit, Orfiril | Haukeland University Hospital, | The goal of this work is to identify genes associated with good response of bipolar patients to two commonly used mood stabilizing agents, lithium and valproate. 1. All patients will be started on lithium, then enter the maintenance phase where they will be followed for 2 years or until relapse. Those that fail lithium will be crossed over to valproic acid (VPA). Those that fail on VPA will be again crossed-over to a standardized treatment as usual (TAU) arm. | | | | |
2012-001341-41: Propofol vs. Ketamin Propofol versus Ketamin als Anästhetikum bei Elektrokrampftherapie |
|
|
| Ongoing | 4 | 40 | Europe | Propofol-Lipuro 10 mg/ml-Emulsion zur Injektion oder Infusion, Ketanest S 5 mg/ml-Ampullen, SUB10116MIG, Propofol-Lipuro 10 mg/ml-Emulsion zur Injektion oder Infusion, Ketanest S 5 mg/ml-Ampullen, Propofol-Lipuro 10 mg/ml-Emulsion zur Injektion oder Infusion, Ketanest S 5 mg/ml-Ampullen | Universitätsklinik für Psychiatrie und Psychotherapie I, Universitätsklinik für Psychiatrie und Psychotherapie I Salzburg | major depression, bipolar disorder alle Erkrankungen, bei denen eine EKT indiziert ist | | | | |
2012-000778-46: Investigation of the drug Lithium with Brain Imaging in people with Bipolar Disorder Bildgebung des Gehirns zur Erforschung des Medikaments Lithium bei manisch-depressiven Menschen |
|
|
| Ongoing | 4 | 80 | Europe | Quilonum retard 450 mg Retard Tablets, Quilonum retard 450 mg Retard Tablets | Forschungszentrum Jülich GmbH, Forschungszentrum Jülich GmbH | Healthy volunteersBipolar patients type 1 Gesunde ProbandenBipolare Patienten Typ 1 | | | | |
2017-002097-38: SAM study: an epigenetic therapy for depression after childhood trauma |
|
|
| Ongoing | 4 | 100 | Europe | S-Adenosylmethionine, Tablet | University Medical Centre Utrecht, ZonMw, Hersenstichting, University Medical Centre Utrecht | Bipolar depression, depression, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
ChiCTR2000031256: Combination of antidepressants with mood stabilizers for the maintenance treatment of bipolar depression: a randomized controlled study. |
|
|
| Completed | 4 | 104 | | antidepressants combined with mood stabilizers ;mood stabilizers | Beijing Anding Hospital, Capital Medical University; Beijing Anding Hospital, Capital Medical University, Capital health development research project | bipolar disorder | | | | |
2017-003705-17: Hydrocortisone as co-treatment to prevent neuropsychiatric adverse effects of dexamethasone. Hydrocortison als co-medicatie om nadelige neuropsychiatrische effecten van dexamethason tegen te gaan. |
|
|
| Not yet recruiting | 4 | 180 | Europe | Tablet, Hydrocortison Tiofarma 20 mg, tabletten | LUMC, ZonMw | Neuropsychiatric adverse effects which can be caused by dexamethasone. For example delirium, anxiety, depression, mania and psychosis. But also cognitive impairment and sleep disturbance. Psychiatrische klachten die kunnen ontstaan bij dexamethason gebruik, zoals delier, angst, depressie, manie en psychoses. Ook cognitieve klachten en slaap klachten., Neuropsychiatric adverse effects which can be caused by dexamethasone. For example delirium, anxiety, depression, mania and psychosis. But also cognitive impairment and sleep disturbance. Psychiatrische klachten die kunnen ontstaan bij dexamethason gebruik, zoals delier, angst, depressie, manie en psychoses. Ook cognitieve klachten en slaap klachten., Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
ChiCTR1900027184: Valproate level variation with menstrual cycle phase in bipolar disorder |
|
|
| Recruiting | 4 | 13 | | Valproate | Jingzhou Mental Hospital; Jingzhou Mental Hospital, Hospital Research Fund | 双相情感障碍 | | | | |
ChiCTR1900027173: Therapeutic effect of rosuvastatin on metabolic syndrome in patients with bipolar disorder |
|
|
| Recruiting | 4 | 120 | | Atorvastatin and Behavioral Interventions ;Behavioral Interventions | Hefei Fourth People's Hospital; Hefei Fourth People's Hospital, Pathogenesis of bipolar disorder based on singlecell multi-omics, imaging and cognitive function | Bipolar disorder | | | | |
ACTRN12616001134415: What is the difference in the safety of Ketamine versus Propofol when used to sedate Acute Psychiatric/ Psychotic Patients who require Aeromedical Retrieval?
|
|
|
| Terminated | 4 | 400 | | | CareFlight Limited, Emergency Medicine Foundation | Suicidal Ideation, Depression, Acute Psychosis, Schizophrenia, Attempted Suicide, Post Natal Depression, Self Harm, Personality Disorder, Bipolar Disorder | | | | |
ChiCTR1900025061: Population Pharmacokinetics of Valproic Acid in Patients with Bipolar Disorder and its Application in Individualized Dosage Regimen |
|
|
| Not yet recruiting | 4 | 400 | | valproic acid | Beijing Anding Hospital, Capital Medical University; Beijing Anding Hospital, Capital Medical University, Capital's Funds for Health Improvement and Research | Biplar Dsorder | | | | |
| Recruiting | 4 | 189 | RoW | Perospirone hydrochloride tablets, Lithium carbonate + perospirone hydrochloride, Lithium Carbonate Pill | Shanghai Mental Health Center, University of Leipzig, Department of Psychiatry | Depressive Disorder | 06/21 | 06/21 | | |
2021-000862-14: Effects of low dose Aspirin in bipolar disorder – a randomized controlled trial |
|
|
| Not yet recruiting | 4 | 250 | Europe | Capsule, Hjertemagnyl | Copenhagen Affective Disorder research Center (CADIC),, Region Hovedstadens Psykiatri | Bipolar disorder, Bipolar disorder is a common psychiatric disorder, formerly known as manio-depressive disorder.It has a life-long course characterized by high risk of recurrence of manic and depressive episodes., Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
ACTRN12618001939280: Sofosbuvir/Velpatasvir and Mental Health Impact in people with Lived Experience and Hepatitis C infection - SMILE-C Trial |
|
|
| Terminated | 4 | 150 | | | The University of Adelaide, Gilead Sciences, Inc. | Hepatitis C virus infection, Schizophrenia, Schizoaffective disorder, Bipolar disorder, Cognitive dysfunction | | | | |
ChiCTR2300070268: Adjunct therapy with probiotics for depressive episodes of bipolar disorder type I: a randomized placebo-controlled trial |
|
|
| Completed | 4 | 98 | | taking probiotics + conventional treatment ;taking placebo + conventional treatmen | The Second Affiliated Hospital of Nanchang University; The Second Affiliated Hospital of Nanchang University, Self-financing | bipolar disorder | | | | |
| Recruiting | 4 | 30 | Europe | Venlafaxine | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | Major Depressive Disorder, Bipolar Affective Disorder, Currently Depressed, Moderate | 03/24 | 04/24 | | |
NCT04011280: Novel Pharmacotherapy Approaches in Smokers With Serious Mental Illness |
|
|
| Completed | 4 | 39 | US | Varenicline, Acceptance and Commitment Therapy | University of California, San Diego, Veterans Medical Research Foundation, University of California | Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, Nicotine Dependence | 03/22 | 03/22 | | |
2021-006706-69: Lithium versus cariprazine in the treatment of bipolar depression |
|
|
| Not yet recruiting | 4 | 122 | Europe | Cariprazine, lithium citrate, Capsule, hard, Tablet, Reagila, Litarex | Psychiatry – Aalborg University Hospital, Unit for Psychiatric Research, Danske Regioner, Region Nordjylland | Bipolar disorder, current depressive episode. -Bipolar affektiv lidelse, aktuel depressiv episode, Patients with a diagnoses of bipolar disorder who have a depressive episode, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2021-003676-13: Comparison of anesthesia with methohexital to anesthesia with a mixture of propofol and ketamin for electroconvulsive therapy |
|
|
| Ongoing | 4 | 100 | Europe | Brevimytal, Ketanest S, Propfol Fresenius 1%, Powder for solution for injection/infusion, Solution for injection, Emulsion for injection, Brevimytal, Ketanest S, Propofol "Fresenius" 1% | Medical University of Vienna, Medical University of Vienna | severe uni- or bipolar depression (F32.2, F32.2, F33.2, F33.3, F31.4, F31.5), Depression, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
| Completed | 4 | 153 | US | mixed amphetamine salts-extended release (MAS-XR), AdderallXR, Placebo | University of Cincinnati, National Institute of Mental Health (NIMH) | Attention Deficit Hyperactivity Disorder | 08/22 | 12/22 | | |
| Completed | 4 | 1565 | US | Metformin, GLUCOPHAGE, healthy lifestyle intervention (LIFE), LIFE | Melissa Delbello, Patient-Centered Outcomes Research Institute | Bipolar Disorder | 12/22 | 06/23 | | |
NCT02582905: Clinical Medication Development for Bipolar Disorder and Alcohol Use Disorders |
|
|
| Completed | 4 | 96 | US | Placebo, Sugar pill, Citicoline, CDP-Choline, cytidine diphosphate-choline, Pregnenolone, pregn-5-en-3β-ol-20-one | Sherwood Brown, MD, PhD, University of Miami, University of Texas Rio Grande Valley | Alcohol Use Disorder, Bipolar Disorder, Schizo Affective Disorder-Bipolar Type | 05/23 | 05/23 | | |
2022-000034-42: Pilot trial estimating the correct 12-hour lithium blood concentration |
|
|
| Not yet recruiting | 4 | 20 | Europe | Coated tablet, Lithiumcarbonat Litarex | Aarhus University Hospital - Psychiatry, Department of Affective Disorders, Aarhus University Hospital - Psychiatry, Department of Affective Disorders | Bipolar disorder Unipolar Depression, Bipolar disorderUnipolar Depression, Body processes [G] - Physiological processes [G07] | | | | |
| Completed | 4 | 131 | RoW | Vortioxetine, Brintellix®, valprote, Depakine | First Affiliated Hospital of Zhejiang University, Zhejiang University | Bipolar Depression | 06/23 | 08/23 | | |
ChiCTR2000038166: Lithium carbonate and lamotrigine monotherapy or combination therapy as maintenance treatment for childbearing women with bipolar disorder in remission: a randomized controlled study. |
|
|
| Recruiting | 4 | 110 | | Lithium carbonate combined with Lamotrigine ;Lamotrigine | Beijing Anding Hospital Affiliated to Capital Medical University; Beijing Anding Hospital Affiliated to Capital Medical University, Capital health development research project | Bipolar disorder | | | | |
NCT06417437: Non-invasive BCI and Application Verification for Depressed People |
|
|
| Recruiting | 4 | 400 | RoW | SSRI, rTMS, Neuro-Feedback, Game Regulation | Shanghai Mental Health Center, The Fourth People's Hospital of Chengdu, Shanghai Jiao Tong University School of Medicine, University of Electronic Science and Technology of China, East China Normal University | Depression, Major Depressive Disorder, Bipolar Depression | 07/27 | 07/27 | | |
ChiCTR2100049426: A randomized and controlled study of ruracidone in the treatment of bipolar depression in adolescents and early adulthood |
|
|
| Not yet recruiting | 4 | 60 | | treatment with lurasidone ;treatment with quetiapine | Beijing AnDing Hospital, Capital Medical University; Beijing AnDing Hospital, Capital Medical University, Beijing Hospital Authority | bipolar disorder | | | | |
NCT05529576: Multi-factor Model Constraction for Early Warning and Diagnosis of MDD |
|
|
| Recruiting | 4 | 600 | RoW | Omega 3 fatty acid, Ω-3 fatty acids | Shanghai Mental Health Center, Qingdao Mental Health Center, Harbin Medical University | Major Depressive Disorder, Bipolar Disorder, Omega-3 Fatty Acids | 12/23 | 12/23 | | |
AMIND, NCT05044611: AMIloride for the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar Disorder Treated With Lithium |
|
|
| Recruiting | 4 | 148 | Europe | Anhydrous Amiloride Hydrochloride, Placebo | Assistance Publique - Hôpitaux de Paris | Bipolar Disorder | 01/25 | 11/25 | | |
NCT06041646: Tachyphylaxis, Tolerance, & Withdrawal Post Treatment With Igalmi for Agitation in Schizophrenia or Bipolar Disorder |
|
|
| Completed | 4 | 23 | US | Sublingual film containing Igalmi, Dexmedetomidine, BXCL501 | BioXcel Therapeutics Inc, Lotus Clinical Research, LLC | Bipolar Disorder, Schizophrenia, Agitation,Psychomotor, Schizo Affective Disorder, Schizophreniform Disorders | 04/24 | 04/24 | | |
| Recruiting | 4 | 200 | Europe | Lithium Carbonate, lithium citrate, Lamotrigine | Mental Health Services in the Capital Region, Denmark | Bipolar II Disorder | 12/27 | 12/27 | | |
NCT06093451: Evaluating Sublingual Dexmedetomidine For Moderate To Severe Agitation In Inpatients With Schizophrenia Or Bipolar Disorder |
|
|
| Recruiting | 4 | 32 | US | Dexmedetomidine, Igalmi, Lorazepam 2 MG/ML, Ativan | Temple University, BioXcel Therapeutics Inc | Schizophrenia Agitation, Schizo Affective Disorder, Bipolar Disorder, Dexmedetomidine | 07/24 | 07/24 | | |
DUAG9, NCT05913947: Lithium Versus Cariprazine in the Acute Phase Treatment of Bipolar Depression |
|
|
| Recruiting | 4 | 122 | Europe | Lithium, Litarex, ATC; N05AN01, Cariprazine, Reagila, ATC: N05AX15 | Aalborg University Hospital, Mental Health Center, Glostrup, Mental Health Center North Zealand, Mental Health Department Odense, University Clinic, Psychiatric Center Copenhagen, Rigshospitalet | Depression, Bipolar | 09/24 | 09/24 | | |
NCT05648591: Safety and Tolerability of Open-Labeled Iloperidone in Adolescents |
|
|
| Recruiting | 4 | 100 | US | Iloperidone, VYV-683, FANAPT | Vanda Pharmaceuticals | Schizophrenia, Bipolar I Disorder | 09/24 | 09/24 | | |
| Not yet recruiting | 4 | 2726 | Canada, US | Cariprazine, Vraylar, Aripiprazole/Escitalopram combination, Abilify/ Lexapro, Quetiapine, Seroquel, Lurasidone, Latuda | Massachusetts General Hospital, Patient-Centered Outcomes Research Institute | Bipolar I Disorder, Depression | 02/30 | 02/30 | | |
NCT04640636: IM Ketamine vs Midazolam for Suicidal ER Patients |
|
|
| Active, not recruiting | 4 | 90 | US | Ketamine hydrochloride injection, Midazolam injection | New York State Psychiatric Institute, National Institute of Mental Health (NIMH) | Depression, Unipolar, Depression, Bipolar, Suicidal Ideation | 12/25 | 03/26 | | |
NCT05859698: Study of the Effectiveness of Valbenazine on Patient- and Clinician-Reported Outcomes in Participants With Tardive Dyskinesia |
|
|
| Active, not recruiting | 4 | 59 | US | Valbenazine, NBI-98854 | Neurocrine Biosciences | Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder, Tardive Dyskinesia | 01/25 | 01/25 | | |
NCT05060549: Dopamine D3 Receptor Occupancy in Bipolar Depression |
|
|
| Not yet recruiting | 4 | 8 | US | Cariprazine, Vraylar | New York State Psychiatric Institute | Bipolar Depression | 10/25 | 10/25 | | |
| Recruiting | 4 | 232 | US | Placebo and fMRI, inactive medication, Lorazepam and fMRI, Ativan | University of Michigan, National Institute of Mental Health (NIMH) | Schizophrenia, Bipolar Disorder, Healthy, Psychosis, Schizophreniform Disorders, Schizo Affective Disorder, Major Depression With Psychotic Features | 02/25 | 02/25 | | |
| Recruiting | 4 | 130 | Europe | Clonidine, Verum, Placebo | Insel Gruppe AG, University Hospital Bern, University of Bern | Major Depressive Disorder, Catatonia, Bipolar Disorder, Delirium Postseizure | 04/25 | 05/25 | | |
NCT05974527: Pilot Study 1: Efficacy and Safety of Sublingual Dexmedetomidine (BXCL501) for the Treatment of Agitation in the Emergency Department |
|
|
| Not yet recruiting | 4 | 30 | NA | Sublingual film containing dexmedetomidine (BXCL501) | Brigham and Women's Hospital | Agitation, Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorders, Bipolar Disorder | 09/25 | 06/26 | | |
NCT04057378: Optimal Electrical Stimulus During Electroconvulsive Therapy |
|
|
| Recruiting | 4 | 800 | Europe | Electroconvulsive therapy, ECT | Region Örebro County | Depressive Disorder, Major, Depression, Bipolar | 11/25 | 11/25 | | |
| Recruiting | 4 | 524 | US | clozapine, Clozaril, risperidone, Risperdal | University of Texas Southwestern Medical Center, National Institute of Mental Health (NIMH), Beth Israel Deaconess Medical Center, Hartford Hospital, University of Georgia, University of Chicago | Schizophrenia, Schizoaffective Disorder, Bipolar 1 Disorder | 12/25 | 03/26 | | |
