Ongoing

4

120

Europe

Neoral, Coated tablet, Capsule, hard, Capsule, soft, Rapamune, Prograf, Neoral

Cambridge University Hospitals NHS Foundation Trust

Patients who have undergone liver transplantation and are infected with Hepatitis C virus.

 

 

Completed

4

230

 

Prograf (routine)＋MMF＋corticosteroids ;Prograf (pretreatment)＋Progrof (routine)＋MMF＋corticosteroids

309 Hospital of Chinese PLA; Astellas Pharma China, Inc., Astellas Pharma China, Inc.

living donor kidney transplantation

 

 

Ongoing

4

30

Europe

tacrolimus, RVG222236 and RVG18107, Capsule, hard, Prograft®, tacrolimus

University Medical Center Utrecht, University Medical Center Utrecht

Heart and lung transplantation, first days after transplantation Hart en long transplantatie, eerste dagen na transplantatie, Heart and lung transplantation, first days after transplantation Hart en long transplantatie, eerste dagen na transplantatie, Body processes [G] - Physical Phenomena [G01]

 

 

Ongoing

4

70

Europe

Lyophilisate for solution for infusion, Capsule, hard, Tablet, Capsule, soft, Nulojix 250mg, Prograf 1 mg, Prograf 0.5 mg, Prograf 5 mg, Certican 0.1mg, Certican 0.25mg, Certican 0.5mg, Certican 0.75mg, Certican 1 mg, Sandimmun Optoral 10mg, Sandimmun Optoral 25 mg, Sandimmun Optoral 50 mg, Sandimmun Optoral 100 mg, Advagraf 0.5 mg, Advagraf 1 mg, Advagraf 3 mg, Advagraf 5 mg

Charité, Universitätsmedizin Berlin, Bristol-Myers Squibb GmbH & Co. KGaA

Patients after renal transplantation with signs of drug intolerance to their immunsuppressive therapy are considered to be converted to Nulojix, Patients after renal transplantation with signs of drug intolerance to their immunsuppressive therapy are considered to be converted to Nulojix, Not possible to specify

 

 

Ongoing

4

50

Europe

Capsule, Granules for oral suspension in sachet, Prograft, Modigraf

Cliniques universitaires Saint-Luc, Cliniques universitaires SAINT-LUC

PEDIATRIC LIVER TRANSPLANTATION Transplantation hépatique pédiatrique, PEDIATRIC LIVER TRANSPLANTATION Transplantation hépatique pédiatrique, Body processes [G] - Immune system processes [G12]

 

 

Ongoing

4

180

Europe

Zenapax, Cellcept, Prograf, Rapamune, Ro 24-7375, Ro 106-1443, Not available, Zenapax, Cellcept, Prograf, Rapamune, Zenapax, Cellcept, Prograf, Rapamune

Barts and the London NHS Trust

Renal Transplantation

 

 

Ongoing

4

20

Europe

Cellcept, Porgraf, Solupred, cellcept, Cellcept, Prograf, Solupred, cellcept, Cellcept, Prograf, Solupred, cellcept

Centre Hospitalier Universitaire de Montpellier

transplantation hépatique

 

 

Ongoing

4

130

Europe

Cellcept, Neoral-Sandimmun, Prograft, Cellcept, Neoral-Sandimmun, Prograft

CHU de Liège, Domaine Universitaire du Sart Tilman

liver transplant patients suffering adverse effects from treatment with calcineurin inhibitors

 

 

Ongoing

4

42

Europe

Rapamune, Rapamune, Prograf, Myfortic, Rapamune, Prograf, Myfortic

University Hospitals Leicester

Chronic Allograft Nephropathy

 

 

Ongoing

4

56

Europe

Mycophenolic acid, Ciclosporin, Tacrolimus, Azathioprine, Mycophenolate mofetil, Myfortic, Neoral, Prograf, Cellcept, Myfortic, Neoral, Prograf, Cellcept

University Hospital of South Manchester NHS Foundation Trust

Renal impairment following heart transplantation

 

 

Ongoing

4

50

Europe

Prograft, Prograf(t), Prograf(t)

Leiden University Medical Center

Effect of immunosuppressive medication on renal function following livertransplantation

 

 

Ongoing

4

130

Europe

Certican, Neoral, Prograft, Mycofenolaat mofetil, Prednisolon 5 PCH, Certican, Neoral, Prograft, Mycofenolaat mofetil CF 500, Prednisolon 5 PCH, Certican, Neoral, Prograft, Mycofenolaat mofetil CF 500, Prednisolon 5 PCH

UMCG

Renal transplantation.

 

 

Ongoing

4

250

Europe

Prograft, Prograft, Prograft

Erasmus Medical Center

Kidney transplantation

 

 

Ongoing

4

210

Europe

ADVAGRAF*30CPS 0,5MG R.P., ADVAGRAF*30CPS 1MG R.P., ADVAGRAF*50CPS 5MG R.P., ADVAGRAF*30CPS 0,5MG R.P., ADVAGRAF*30CPS 1MG R.P., ADVAGRAF*50CPS 5MG R.P.

UO Divisione Nefrologia, Dialisi e Trapianto renale

Kidney transplant patients

 

 

Ongoing

4

120

Europe

Everolimus 0.25 mg, Cyclosporin 100 mg, Tacrolimus 0.5 mg, Everolimus 0.75, Everolimus 1.0 mg, Cyclosporin 25 mg, Cyclosporin 50 mg, Everolimus 0.5 mg, Cyclosporin 10 mg, Tacrolimus 1.0 mg, Tacrolimus 5 mg, 001773-Z913, Certican 0.25mg, Sandimmun 100 mg, Prograf 0.5 mg, Certican 0.75mg, Certican 1.00 mg, Sandimmun 25 mg, Sandimmun 50 mg, Certican 0.5mg, Sandimmun 10 mg, Prograf 1.0 mg, Prograf 5 mg, Certican 0.25mg, Sandimmun 100 mg, Prograf 0.5 mg, Certican 0.75mg, Certican 1.00 mg, Sandimmun 25 mg, Sandimmun 50 mg, Certican 0.5mg, Sandimmun 10 mg, Prograf 1.0 mg, Prograf 5 mg

Medizinische Hochschule Hannover

Polyoma BK-virus nephropathy is a viral complication after renal transplantation attacking up to 10% of renal transplants and causing transplant failure in 45% of cases. No virustatic treatment exists. Modifying the infection is usually tried by lowering immunosuppression, which may lead to transplant failure by rejection as well. A randomized switch of immunosuppression to everolimus vs general lowering of immunosuppression has to be tested (prospect. random. parallel group comparison).

 

 

Ongoing

4

120

Europe

Prograft, Advagraf, Envarsus, Capsule, Tablet, Prograft, Advagraf, Envarsus

Erasmus MC, Chiesi

kidney transplantation, kidney transplantation, Body processes [G] - Immune system processes [G12]

 

 

Recruiting

4

50

 

0.1% FK506 + 0.1% sodium hyaluronate eye drops Twice a day for 30 days ;0.5% of chlorine for spilt + 0.1% sodium hyaluronate Twice a day for 30 days ;0.1%FK506+0.5%Chloromethyl+0.1%Sodium hyaluronate Twice a day, every time a drop, 30 days

Eye Institute of Xiamen University; Eye Institute of Xiamen University, Senju Pharmaceutical Co., Ltd.

dry eye

 

 

Ongoing

4

60

Europe

Prograft, Capsule, Prograft

Erasmus MC, Stichting de Merel

kidney transplantation nier transplantatie, kidney transplantation nier transplantatie, Body processes [G] - Immune system processes [G12]

 

 

Not yet recruiting

4

40

Europe

Prograf, 301601, Capsule, Prograf

Oslo University Hospital – Rikshospitalet, Oslo University Hospital – Rikshospitalet

Development of renal interstitial fibrosis in renal transplant recipients, Development of kidney toxicity in renal transplant recipients, Not possible to specify

 

 

Not yet recruiting

4

300

 

induction therapy + standard Prograf + conversion Advagraf ;induction therapy + delayed Prograf + conversion Advagraf

Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology; Astellas Pharma China, Inc., Pharmaceutical Enterprise

DCD kidney transplantation.

 

 

Not yet recruiting

4

200

 

Treatment with FK506 ;Treatment with 0.1% Flurometholone ;Treatment with Fk506 + Azelastine eye drops ;Treatment with 0.1%Flurometholone+Azelastine Hydrochloride eye drop

Eye and ENT Hospital of Fudan University; Eye and ENT Hospital of Fudan University, Research funds

Allergic conjunctivitis

 

 

Not yet recruiting

4

100

Europe

Capsule, hard, Tablet, Prograf, CellCept

Oslo University Hospital - Rikshospitalet, Oslo University Hospital - Rikshospitalet

Kidney transplantation, Patients above 18 years transplanted with a kidney from either a living- or deceased donor, Diseases [C] - Immune System Diseases [C20]

 

 

Completed

4

150

RoW

Tacrolimus, FK506, MTX, methotrexate

Qiang Shu

Arthritis, Rheumatoid

09/22

12/22

Recruiting

4

800

RoW

Busulfan, Bu, Cyclophosphamide, Cy, Fludarabine, Flu, Thymoglobulin, ATG, cyclosporine A, CsA, Mycophenolate mofetil, MMF, Tacrolimus, FK506, Methotrexate, MTX, Basiliximab, Simulect, Ruxolitinib

First Affiliated Hospital of Guangxi Medical University, Peking University People's Hospital, Ruijin Hospital, The 923th Hospital of People's Liberation Army, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou General Hospital, Hainan General Hospital, The Affiliated Hospital Of Guizhou Medical University, The First People's Hospital of Yunnan

Thalassemia Major

05/22

05/23

Completed

4

44

Europe

LCP-tacrolimus, Envarsus®, twice-daily tacrolimus, Prograf®

University Hospital Tuebingen

Posttransplant Diabetes Mellitus

08/23

12/23

Recruiting

4

60

US

Extended Release Tacrolimus Tablets, LCPT, Envarsus XR®, Immediate Release Tacrolimus Capsule, IR-TAC, Prograf®

Roy D. Bloom, MD, Veloxis Pharmaceuticals

Kidney Transplant; Complications

03/25

09/25

4

40

Canada

Prograf, Envarsus

University Health Network, Toronto, Paladin Labs Inc.

Liver Transplant Rejection, Immune System Suppression

Recruiting

4

124

Canada

Tacrolimus, Immediate Release, Oral, Tacrolimus, Sandoz, Prograf, Tacrolimus Extended Release Oral Tablet, Envarsus

University of British Columbia, Paladin Labs Inc.

Liver Transplantation, Immunosuppression, Neurotoxicity, Tremor, Tacrolimus

01/26

12/26

Not yet recruiting

4

20

 

Pretreatment scheme for full-sib compatibility: C5 McAb 600 mg for -9 days.Fludarabine (FLU) 30 mg/m2/d x 6 d (-7 to -2D) + CY 50 mg/kg/d x 2D (-4 to -3D) + ATG 2.5mg/kg/d x 5 d (-8 to -4D). ;Alternative donor (unrelated donor, haplotype donor) conditioning regimen: C5 McAb 600 mg for -9 days. Busulfan (BU) 3.2 mg/kg/d (0.8 mg/kg, q6h) x 2D (-7 to -6d) + cyclophosphamide (CY) 50 mg/kg/d x 4D (-5 to -2D) + ATG 2.5 mg/kgd x 4D (-5 to -2D). ;Treatment regimen for GVHD: Grade II treatment, methylprednisolone 1-2 mg/kg, divided into two doses, second-line drugs can be selected as appropriate: FK506, MMF, MTX, ATG, CD25 monoclonal antibody, etc. Hormone reduction as appropriate ;Symptomatic and supportive treatment: Transplant-related complications such as infection, bleeding, hemorrhagic cystitis, epilepsy and mucositis, as well as immunoglobulin and nutritional support were routinely given to the participating units. ;Other concomitant therapy: For hemoglobin < 60 g/L or red blood cell transfusion therapy is allowed in emergency. Hormones are allowed to control acute hemolysis, hematopoietic and erythropoietic drugs are allowed, and G-CSF can be used when neutrophils are less than 1 x 10^9/L. In the case of organ dysfunction, the use of drugs to protect organs is allowed. Anti-infective drugs are permitted in the presence of infection.

Hongci Hematology Branch of the First Affiliated Hospital of Soochow University; Hongci Hematology Branch of the First Affiliated Hospital of Soochow University, Self-funded

Classic PNH and PNH with bone marrow failure

 

 

Not yet recruiting

4

90

 

C5 McAb 600 mg was administered once a week for 4 weeks, and C5 McAb 900 mg was administered once every two weeks from the fifth week, and then long-term administration. ;Pretreatment scheme for full-sib compatibility: Fludarabine (FLU) 30 mg/m2/d x 6 d (- 7 to -2D) + CY 50 mg/kg/d x 2D (-4 to -3D) + ATG 2.5 mg/kg/d x 5d (-8 to -4D). ;Alternative donor (unrelated donor, haplotype donor) conditioning regimen: Busulfan (BU) 3.2 mg/kg/d (0.8 mg/kg, q6h) x 2D (-7 to -6d) + cyclophosphamide (CY) 50 mg/kg/d x 4D (-5 to -2D) + ATG 2.5 mg/kg per day x 4D (-5 to -2D). ;Treatment regimen for GVHD: Grade II treatment, methylprednisolone 1-2 mg/kg, divided into two doses, second-line drugs can be selected as appropriate: FK506, MMF, MTX, ATG, CD25 monoclonal antibody, etc.Hormone reduction as appropriate. ;Symptomatic and supportive treatment: Transplant-related complications such as infection, bleeding, hemorrhagic cystitis, epilepsy and mucositis, as well as immunoglobulin and nutritional support were routinely given to the participating units.

Hongci Hematology Branch of the First Affiliated Hospital of Soochow University; Hongci Hematology Branch of the First Affiliated Hospital of Soochow University, Self-funded

Classic PNH and PNH with bone marrow failure