| Linzess (linaclotide) / Ironwood Pharma, AbbVie |
ACTRN12625000718448: What Good Can One Session Do? Exploring the Effectiveness of Family Systemic Constellation Therapy in Individual Sessions |
|
|
| Recruiting | N/A | 35 | | | Diane Rogers, PhD, Core Insights Institute, Diane Rogers, PhD, Principal Investigator, Core Insights Institute | Depression, Anxiety, Relational Issues, Stress | | | | |
NCT00493103: TG Gene Mutations and Congenital Hypothyroidism |
|
|
| Completed | N/A | | RoW | | University of Sao Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo | Congenital Hypothyroidism | | 06/07 | | |
CONFIRM, NCT01581437: Recording for Potential AF Drivers and Patient Specific Atrial Anatomy & Atrial Electrogram Maps |
|
|
| Completed | N/A | 78 | US | 64 pole basket catheter, Constellation basket catheter | Virginia Commonwealth University, University of California | Atrial Fibrillation | 12/13 | 12/13 | | |
| Completed | N/A | 5 | US | Constellation Full Contact Mapping Catheter | Angelo Biviano | Atrial Fibrillation or Atrial Flutter | 12/15 | 12/15 | | |
| Terminated | N/A | 9 | US | Senna, sennoside, Linzess, Linaclotide | TriHealth Inc. | Chronic Idiopathic Constipation | 06/16 | 06/16 | | |
NCT02477605: Clinical Comparison of 27+® and 23-gauge ULTRAVIT® 7500 Cpm Vitrectomy Outcomes |
|
|
| Completed | N/A | 137 | US | CONSTELLATION® 27-gauge Combined Surgical Pak, CONSTELLATION® 23-gauge Combined Surgical Pak, Vitrectomy surgery | Alcon Research | Vitreoretinal Disease | 06/16 | 08/16 | | |
NCT02360384: Caecal pH as a Biomarker for Irritable Bowel Syndrome |
|
|
| Unknown status | N/A | 48 | Europe | Linaclotide, Constella, FODMAP diet | Wingate Institute of Neurogastroenterology | Irritable Bowel Syndrome | 12/16 | 12/16 | | |
NCT02078323: Investigation of Linaclotide's Effect on the Bi-directional Brain and Gut Axis in IBS-C Patients |
|
|
| Completed | N/A | 39 | US | Linaclotide, Placebo | Augusta University, Forest Laboratories | Irritable Bowel Syndrome With Constipation (IBS-C) | 10/17 | 07/18 | | |
NCT03020459: Internal Limiting Membrane Peeling-reposition to Treat Idiopathic Macular Holes |
|
|
| Completed | N/A | 30 | RoW | peeling-reposition, peeling, Brilliant Blue G, BBG, postoperative posture, Constellation 23-gauge vitrectomy system | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | Macular Hole, Surgery | 07/19 | 08/19 | | |
NCT03233958: The Psychosocial Effects of Systemic / Family Constellation |
|
|
| Completed | N/A | 182 | Europe | Systemic / family constellation | Károli Gáspár University of the Reformed Church in Hungary, University of Toronto | Mild to Moderate Psychopathological Symptoms | 10/20 | 10/20 | | |
NCT03342287: Cognitive and Psychiatric Effects of Linaclotide on Patients With Constipation |
|
|
| Withdrawn | N/A | 0 | Canada | questionnaires, cognitive evaluation, Blood, Fecal sample | McMaster University | Constipation, Irritable Bowel Syndrome | 12/20 | 03/21 | | |
NCT03471728: Post-marketing Surveillance of Linaclotide Tablet in Patients With Irritable Bowel Syndrome With Constipation or Chronic Constipation (Excluding Constipation Due to Organic Diseases) |
|
|
| Completed | N/A | 2475 | Japan | linaclotide, Linzess, ASP0456 | Astellas Pharma Inc | Chronic Constipation (CC) (Excluding Constipation Due to Organic Diseases), Irritable Bowel Syndrome With Constipation (IBS-C) | 12/21 | 12/21 | | |
ChiCTR2100043297: A randomized controlled trial for individudal bowel preparation with Linaclotide and PEG-ELS |
|
|
| Recruiting | N/A | 400 | | Linaclotide ;PEG-ELS | No.988 Hospitail of Joint Logistic Support Force; No.988 Hospitail of Joint Logistic Support Force, self-raised funds | Bowel preparation methods before colonoscopy | | | | |
NCT04532879: HygiRelief Procedure and HygiSample Evaluation for Functional Constipation |
|
|
| Withdrawn | N/A | 0 | NA | HygiPrep (HyGIeaCare System), HygiSample (stool collection for microbiome evaluation) | HyGIeaCare, Inc. | Rome IV Functional Constipation | 03/22 | 06/22 | | |
NCT05137145: Effect and Safety of Polyethylene Glycol Combined With Linaclotide on Colon Cleansing for Patients With Chronic Constipation |
|
|
| Recruiting | N/A | 300 | RoW | Linaclotide, Compound Polyethylene Glycol Electrolyte Powder | Second Affiliated Hospital of Xi'an Jiaotong University | Bowel Preparation | 03/22 | 04/22 | | |
NCT05051462: Efficacy of Family Constellations in the General Population |
|
|
| Completed | N/A | 80 | Europe | Family / systemic constellation therapy | Károli Gáspár University of the Reformed Church in Hungary, University of Toronto | Mild to Moderate Psychopathological Symptoms | 04/22 | 04/22 | | |
NCT03336034: Assessment of Responsiveness to Treatment by Experience Sampling Method |
|
|
| Terminated | N/A | 16 | Europe | | Maastricht University Medical Center | Constipation-predominant Irritable Bowel Syndrome | 05/22 | 05/22 | | |
ChiCTR2100049962: The effect of linaclotide combined with compound polyethylene glycol electrolyte powder on the effect of bowel preparation before colonoscopy in the elderly-a prospective, randomized controlled study |
|
|
| Not yet recruiting | N/A | 332 | | Linaclotide combined with 2L PEG ;3L PEG | Chongqing Thirteenth People's Hospital; Chongqing Thirteenth People's Hospital, Science and technology commission of Chongqing | Colon disease | | | | |
ChiCTR2100050281: Effect of linaclopeptide combined with compound polyethylene glycol electrolyte powder on intestinal preparation before colonoscopy in elderly patients |
|
|
| Not yet recruiting | N/A | 333 | | Polyethylene glycol combined with linaclotide ;3L PEG ;2L PEG | Chongqing 13th People's Hospital; Chongqing 13th People's Hospital, Science and technology commission of Chongqing | Colon disease | | | | |
ChiCTR2000039171: Study on the effect of linaclotide on bowel preparation before colonoscopy and the comfort of patients with colonoscopy |
|
|
| Recruiting | N/A | 200 | | Linanotide+ PEG+2L water ;PEG+ 3L water | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology, self-raised | Colonic diseases | | | | |
NCT05291325: Application of Linaclotide Capsule in Bowel Preparation for Colonoscopy |
|
|
| Completed | N/A | 1607 | RoW | 3L PEG + Linaclotide, 3L PEG, 2L PEG + Linaclotide | Changhai Hospital, Shanxi Provincial People's Hospital, The 900th Hospital of the PLA, Ruijin Hospital, The First Affiliated Hospital of Nanchang University, Qilu Hospital of Shandong University, The Affiliated Hospital of Qingdao University, Ruian People's Hospital, Yueqing People's Hospital, The First Affiliated Hospital of Soochow University, The 7th Medical Center of the PLA General Hospital, The First Hospital of Jilin University, The Second Hospital of Hebei Medical University, Affiliated Hospital of Inner Mongolia Medical University, The Second Affiliated Hospital of Dalian Medical University, Ningxia Medical University General Hospital, Affiliated Hospital of Qinghai University, Yunnan First People's Hospital, Xiangya Second Hospital, Central South University, Zhongnan Hospital Affiliated to Wuhan University, Daping Hospital, Army Military Medical University, Zunyi Medical College, Huizhou Municipal Central Hospital, Affiliated Hospital of Southwest Medical University, The First Hospital of Shihezi University, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Tangdu Hospital of Air Force Military Medical University | Bowel Preparation for Colonoscopy | 08/23 | 04/24 | | |
| Completed | N/A | 3028 | RoW | | AstraZeneca | Irritable Bowel Syndrome-IBS | 02/23 | 02/23 | | |
NCT06608589: CONSTELLATIONS Living Lab: Improving the Care Transitions of Older Adults Living with Neurocognitive Disorders |
|
|
| Recruiting | N/A | 700 | Canada | CoMPAS+ MNCDs Program - Quality improvement program targeting the care transitions of patients living with a major neurocognitive disorder and their caregivers | Laval University, CISSS de Chaudière-Appalaches, Institut national d'excellence en santé et service sociaux | Alzheimer Disease, Dementia, Neurocognitive Decline | 04/26 | 04/26 | | |
NCT05379491: Application of Linaclotide Capsule in Bowel Preparation for Patients at High Risk of Inadequate Bowel Preparation |
|
|
| Completed | N/A | 720 | RoW | 3 L PEG + linaclotide, 3 L PEG + placebo | Zhiguo Liu | Colonoscopy | 06/23 | 07/23 | | |
| Active, not recruiting | N/A | 53 | Europe | System Constellation VR-Seminar | University of Witten/Herdecke, FH Münster University of Applied Sciences, The Witten Institute For Family Business | Psychological and Systems Functioning | 04/25 | 04/25 | | |
NCT06091735: Clinical Study of Bowel Preparation Before Colonoscopy |
|
|
| Completed | N/A | 444 | RoW | OSS, Sodium potassium magnesium sulfate oral concentrated solution, OSS+Linzess, sodium potassium magnesium sulfate oral concentrated solution + linaclotide, PEG-Interferon Alfa, PEG | Jinling Hospital, China | Bowel Preparation | 02/24 | 02/24 | | |
| Recruiting | N/A | 65 | US | Virtual Reality, Linaclotide | Mayo Clinic, Cedars-Sinai Medical Center, AbbVie, Ironwood Pharmaceuticals, Inc. | Irritable Bowel Syndrome with Constipation | 12/25 | 12/25 | | |
ChiCTR2400089466: Clinical study of Disposable Gastrointestinal Vibrating Capsule combined with polyethylene glycol to optimize bowel preparation for colonoscopy |
|
|
| Recruiting | N/A | 90 | | 1500 ml of polyethylene glycol at 8 p.m. the day before the examination + 1500 ml of polyethylene glycol solution 4h before the colonoscopy.; 1 capsule of Linaclotide was taken orally at 6:00 p.m. the day before the examination + 2000 ml of polyethylene glycol solution was taken orally in divided doses before the colonoscopy + 1 capsule of Linaclotide was taken orally again, which has been confirmed by the prior study in terms of its safety and efficacy.; 1 vibrabot capsule was taken at 7 a.m. the day before the examination, and 2,000 ml of polyethylene glycol solution was taken in divided doses before the colonoscopy. | PLA Rocket Force Characteristic Medical Center; PLA Rocket Force Characteristic Medical Center, none | Colon diseases | | | | |
ChiCTR2400080331: Effect of linalotide on intestinal dysfunction in patients with acute pancreatitis: a randomized controlled trial |
|
|
| Not yet recruiting | N/A | 114 | | In the linaclotide group, participants received 1pill linaclotide oral once daily before breakfast in addition of routine treatment,and stopped taking it after 7 days.; 50g raw rhubarb was added into 100ml warm boiled water, twice a day, orally) on the basis of conventional treatment | The First Affiliated Hospital of Nanchang University; The First Affiliated Hospital of Nanchang University, No funding | Acute pancreatitis | | | | |
ChiCTR2500110760: Effect of linaclotide combined with Simethicone and polyethylene glycol electrolyte powder on cleansing effect of bowel in patients with constipation |
|
|
| Completed | N/A | 390 | | 290 μg Linaclotide + 30ml Simethicone + 2 L PGEP; 290 μg Linaclotide + 2 L PGEP; 3L compound polyethylene glycol electrolyte solution | The People's Hospital of Jianyang City; The People's Hospital of Jianyang City, Optional Project (Self-Funded) | Constipation; Bowel preparation | | | | |
ChiCTR2500099879: A Study on the Application of Linaclotide Combined with Polyethylene Glycol for Bowel Preparation Before Colonoscopy in Patients with Risk Factors for Inadequate Bowel Preparation |
|
|
| Not yet recruiting | N/A | 320 | | | Liaoning Provincial People's Hospital; Liaoning Provincial People's Hospital | Diabetes; constipation | | | | |
| Not yet recruiting | N/A | 180 | Europe, US | UNITY VCS, UNITY® Vitreoretinal Cataract System (VCS), CONSTELLATION, CONSTELLATION® Vision System | Alcon Research, Manchester Royal Eye Hospital | Cataract, Vitreous Hemorrhage, Retinal Detachment, Macular Pucker, Macular Holes | 06/26 | 06/26 | | |
| Withdrawn | N/A | 260 | US | UNITY Vitreoretinal Cataract System (VCS), CONSTELLATION Vision System, Vitreoretinal ophthalmic surgery | Alcon Research | Epiretinal Membrane, Macular Hole, Visually Significant Vitreous Floater, Vitreomacular Traction, Vitreous Hemorrhage, Proliferative Diabetic Retinopathy, Rhegmatogenous Retinal Detachment, Retained Lens Material in the Posterior Segment | 10/26 | 02/27 | | |
| Not yet recruiting | N/A | 422 | | 2L polyethylene glycol (PEG) plus linaclotide; 4L polyethylene glycol (PEG) | The First Affiliated Hospital, Zhejiang University School of Medicine; The First Affiliated Hospital, Zhejiang University School of Medicine, self-supporting | intestinal ployps | | | | |
ChiCTR2500104889: Comparative effectiveness and tolerance of bowel preparations for colonoscopy: a single-center platform trial |
|
|
| Not yet recruiting | N/A | 1932 | | 3L PEG; 2L PEG; 4L PEG; Oral concentrated solution of sodium potassium magnesium sulfate; Compound Piccoline Sulfate Sodium Granules; linaclotide+2L PEG; linaclotide+3L PEG | The Seventh Affiliated Hospital of Sun Yat-Sen University(Shenzhen); The Seventh Affiliated Hospital of Sun Yat-Sen University(Shenzhen), 2024 open funding of Shenzhen Clinical Research Center for Gastroenterology(Gastrointestinal Surgery) | Colorectal Disease | | | | |