Linzess (linaclotide) / Ironwood Pharma, AbbVie, Astellas, AstraZeneca  >>  Phase N/A
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35 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Linzess (linaclotide) / Ironwood Pharma, AbbVie
ACTRN12625000718448: What Good Can One Session Do? Exploring the Effectiveness of Family Systemic Constellation Therapy in Individual Sessions

Recruiting
N/A
35
 
Diane Rogers, PhD, Core Insights Institute, Diane Rogers, PhD, Principal Investigator, Core Insights Institute
Depression, Anxiety, Relational Issues, Stress
 
 
NCT00493103: TG Gene Mutations and Congenital Hypothyroidism

Completed
N/A
RoW
University of Sao Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo
Congenital Hypothyroidism
 
06/07
CONFIRM, NCT01581437: Recording for Potential AF Drivers and Patient Specific Atrial Anatomy & Atrial Electrogram Maps

Completed
N/A
78
US
64 pole basket catheter, Constellation basket catheter
Virginia Commonwealth University, University of California
Atrial Fibrillation
12/13
12/13
NCT02307188: Multipolar Mapping and Atrial Arrhythmias

Completed
N/A
5
US
Constellation Full Contact Mapping Catheter
Angelo Biviano
Atrial Fibrillation or Atrial Flutter
12/15
12/15
NCT02239510: Efficacy of Linaclotide to Senna for CIC

Terminated
N/A
9
US
Senna, sennoside, Linzess, Linaclotide
TriHealth Inc.
Chronic Idiopathic Constipation
06/16
06/16
NCT02477605: Clinical Comparison of 27+® and 23-gauge ULTRAVIT® 7500 Cpm Vitrectomy Outcomes

Completed
N/A
137
US
CONSTELLATION® 27-gauge Combined Surgical Pak, CONSTELLATION® 23-gauge Combined Surgical Pak, Vitrectomy surgery
Alcon Research
Vitreoretinal Disease
06/16
08/16
NCT02360384: Caecal pH as a Biomarker for Irritable Bowel Syndrome

Unknown status
N/A
48
Europe
Linaclotide, Constella, FODMAP diet
Wingate Institute of Neurogastroenterology
Irritable Bowel Syndrome
12/16
12/16
NCT02078323: Investigation of Linaclotide's Effect on the Bi-directional Brain and Gut Axis in IBS-C Patients

Completed
N/A
39
US
Linaclotide, Placebo
Augusta University, Forest Laboratories
Irritable Bowel Syndrome With Constipation (IBS-C)
10/17
07/18
NCT03020459: Internal Limiting Membrane Peeling-reposition to Treat Idiopathic Macular Holes

Completed
N/A
30
RoW
peeling-reposition, peeling, Brilliant Blue G, BBG, postoperative posture, Constellation 23-gauge vitrectomy system
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Macular Hole, Surgery
07/19
08/19
NCT03233958: The Psychosocial Effects of Systemic / Family Constellation

Completed
N/A
182
Europe
Systemic / family constellation
Károli Gáspár University of the Reformed Church in Hungary, University of Toronto
Mild to Moderate Psychopathological Symptoms
10/20
10/20
NCT03342287: Cognitive and Psychiatric Effects of Linaclotide on Patients With Constipation

Withdrawn
N/A
0
Canada
questionnaires, cognitive evaluation, Blood, Fecal sample
McMaster University
Constipation, Irritable Bowel Syndrome
12/20
03/21
NCT03471728: Post-marketing Surveillance of Linaclotide Tablet in Patients With Irritable Bowel Syndrome With Constipation or Chronic Constipation (Excluding Constipation Due to Organic Diseases)

Completed
N/A
2475
Japan
linaclotide, Linzess, ASP0456
Astellas Pharma Inc
Chronic Constipation (CC) (Excluding Constipation Due to Organic Diseases), Irritable Bowel Syndrome With Constipation (IBS-C)
12/21
12/21
ChiCTR2100043297: A randomized controlled trial for individudal bowel preparation with Linaclotide and PEG-ELS

Recruiting
N/A
400
 
Linaclotide ;PEG-ELS
No.988 Hospitail of Joint Logistic Support Force; No.988 Hospitail of Joint Logistic Support Force, self-raised funds
Bowel preparation methods before colonoscopy
 
 
NCT04532879: HygiRelief Procedure and HygiSample Evaluation for Functional Constipation

Withdrawn
N/A
0
NA
HygiPrep (HyGIeaCare System), HygiSample (stool collection for microbiome evaluation)
HyGIeaCare, Inc.
Rome IV Functional Constipation
03/22
06/22
NCT05137145: Effect and Safety of Polyethylene Glycol Combined With Linaclotide on Colon Cleansing for Patients With Chronic Constipation

Recruiting
N/A
300
RoW
Linaclotide, Compound Polyethylene Glycol Electrolyte Powder
Second Affiliated Hospital of Xi'an Jiaotong University
Bowel Preparation
03/22
04/22
NCT05051462: Efficacy of Family Constellations in the General Population

Completed
N/A
80
Europe
Family / systemic constellation therapy
Károli Gáspár University of the Reformed Church in Hungary, University of Toronto
Mild to Moderate Psychopathological Symptoms
04/22
04/22
NCT03336034: Assessment of Responsiveness to Treatment by Experience Sampling Method

Terminated
N/A
16
Europe
Maastricht University Medical Center
Constipation-predominant Irritable Bowel Syndrome
05/22
05/22
ChiCTR2100049962: The effect of linaclotide combined with compound polyethylene glycol electrolyte powder on the effect of bowel preparation before colonoscopy in the elderly-a prospective, randomized controlled study

Not yet recruiting
N/A
332
 
Linaclotide combined with 2L PEG ;3L PEG
Chongqing Thirteenth People's Hospital; Chongqing Thirteenth People's Hospital, Science and technology commission of Chongqing
Colon disease
 
 
ChiCTR2100050281: Effect of linaclopeptide combined with compound polyethylene glycol electrolyte powder on intestinal preparation before colonoscopy in elderly patients

Not yet recruiting
N/A
333
 
Polyethylene glycol combined with linaclotide ;3L PEG ;2L PEG
Chongqing 13th People's Hospital; Chongqing 13th People's Hospital, Science and technology commission of Chongqing
Colon disease
 
 
ChiCTR2000039171: Study on the effect of linaclotide on bowel preparation before colonoscopy and the comfort of patients with colonoscopy

Recruiting
N/A
200
 
Linanotide+ PEG+2L water ;PEG+ 3L water
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology, self-raised
Colonic diseases
 
 
NCT05291325: Application of Linaclotide Capsule in Bowel Preparation for Colonoscopy

Completed
N/A
1607
RoW
3L PEG + Linaclotide, 3L PEG, 2L PEG + Linaclotide
Changhai Hospital, Shanxi Provincial People's Hospital, The 900th Hospital of the PLA, Ruijin Hospital, The First Affiliated Hospital of Nanchang University, Qilu Hospital of Shandong University, The Affiliated Hospital of Qingdao University, Ruian People's Hospital, Yueqing People's Hospital, The First Affiliated Hospital of Soochow University, The 7th Medical Center of the PLA General Hospital, The First Hospital of Jilin University, The Second Hospital of Hebei Medical University, Affiliated Hospital of Inner Mongolia Medical University, The Second Affiliated Hospital of Dalian Medical University, Ningxia Medical University General Hospital, Affiliated Hospital of Qinghai University, Yunnan First People's Hospital, Xiangya Second Hospital, Central South University, Zhongnan Hospital Affiliated to Wuhan University, Daping Hospital, Army Military Medical University, Zunyi Medical College, Huizhou Municipal Central Hospital, Affiliated Hospital of Southwest Medical University, The First Hospital of Shihezi University, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Tangdu Hospital of Air Force Military Medical University
Bowel Preparation for Colonoscopy
08/23
04/24
Liberty, NCT04462900: Evaluate the Safety of Linaclotide in IBS-C Patients in China

Completed
N/A
3028
RoW
AstraZeneca
Irritable Bowel Syndrome-IBS
02/23
02/23
NCT06608589: CONSTELLATIONS Living Lab: Improving the Care Transitions of Older Adults Living with Neurocognitive Disorders

Recruiting
N/A
700
Canada
CoMPAS+ MNCDs Program - Quality improvement program targeting the care transitions of patients living with a major neurocognitive disorder and their caregivers
Laval University, CISSS de Chaudière-Appalaches, Institut national d'excellence en santé et service sociaux
Alzheimer Disease, Dementia, Neurocognitive Decline
04/26
04/26
NCT05379491: Application of Linaclotide Capsule in Bowel Preparation for Patients at High Risk of Inadequate Bowel Preparation

Completed
N/A
720
RoW
3 L PEG + linaclotide, 3 L PEG + placebo
Zhiguo Liu
Colonoscopy
06/23
07/23
SYSCO-VR, NCT05557890: System Constellations in Virtual Reality (VR)

Active, not recruiting
N/A
53
Europe
System Constellation VR-Seminar
University of Witten/Herdecke, FH Münster University of Applied Sciences, The Witten Institute For Family Business
Psychological and Systems Functioning
04/25
04/25
NCT06091735: Clinical Study of Bowel Preparation Before Colonoscopy

Completed
N/A
444
RoW
OSS, Sodium potassium magnesium sulfate oral concentrated solution, OSS+Linzess, sodium potassium magnesium sulfate oral concentrated solution + linaclotide, PEG-Interferon Alfa, PEG
Jinling Hospital, China
Bowel Preparation
02/24
02/24
IBSC-VR, NCT05796388: A Study of Virtual Reality and Linaclotide for IBS-C

Recruiting
N/A
65
US
Virtual Reality, Linaclotide
Mayo Clinic, Cedars-Sinai Medical Center, AbbVie, Ironwood Pharmaceuticals, Inc.
Irritable Bowel Syndrome with Constipation
12/25
12/25
ChiCTR2400089466: Clinical study of Disposable Gastrointestinal Vibrating Capsule combined with polyethylene glycol to optimize bowel preparation for colonoscopy

Recruiting
N/A
90
 
1500 ml of polyethylene glycol at 8 p.m. the day before the examination + 1500 ml of polyethylene glycol solution 4h before the colonoscopy.; 1 capsule of Linaclotide was taken orally at 6:00 p.m. the day before the examination + 2000 ml of polyethylene glycol solution was taken orally in divided doses before the colonoscopy + 1 capsule of Linaclotide was taken orally again, which has been confirmed by the prior study in terms of its safety and efficacy.; 1 vibrabot capsule was taken at 7 a.m. the day before the examination, and 2,000 ml of polyethylene glycol solution was taken in divided doses before the colonoscopy.
PLA Rocket Force Characteristic Medical Center; PLA Rocket Force Characteristic Medical Center, none
Colon diseases
 
 
ChiCTR2400080331: Effect of linalotide on intestinal dysfunction in patients with acute pancreatitis: a randomized controlled trial

Not yet recruiting
N/A
114
 
In the linaclotide group, participants received 1pill linaclotide oral once daily before breakfast in addition of routine treatment,and stopped taking it after 7 days.; 50g raw rhubarb was added into 100ml warm boiled water, twice a day, orally) on the basis of conventional treatment
The First Affiliated Hospital of Nanchang University; The First Affiliated Hospital of Nanchang University, No funding
Acute pancreatitis
 
 
ChiCTR2500110760: Effect of linaclotide combined with Simethicone and polyethylene glycol electrolyte powder on cleansing effect of bowel in patients with constipation

Completed
N/A
390
 
290 μg Linaclotide + 30ml Simethicone + 2 L PGEP; 290 μg Linaclotide + 2 L PGEP; 3L compound polyethylene glycol electrolyte solution
The People's Hospital of Jianyang City; The People's Hospital of Jianyang City, Optional Project (Self-Funded)
Constipation; Bowel preparation
 
 
ChiCTR2500099879: A Study on the Application of Linaclotide Combined with Polyethylene Glycol for Bowel Preparation Before Colonoscopy in Patients with Risk Factors for Inadequate Bowel Preparation

Not yet recruiting
N/A
320
 
Liaoning Provincial People's Hospital; Liaoning Provincial People's Hospital
Diabetes; constipation
 
 
CTV678-H003, NCT07228091: Surgical Procedure Efficiency Evaluation stuDy

Not yet recruiting
N/A
180
Europe, US
UNITY VCS, UNITY® Vitreoretinal Cataract System (VCS), CONSTELLATION, CONSTELLATION® Vision System
Alcon Research, Manchester Royal Eye Hospital
Cataract, Vitreous Hemorrhage, Retinal Detachment, Macular Pucker, Macular Holes
06/26
06/26
NCT07054281: UNITY VCS Vitreoretinal Surgery

Withdrawn
N/A
260
US
UNITY Vitreoretinal Cataract System (VCS), CONSTELLATION Vision System, Vitreoretinal ophthalmic surgery
Alcon Research
Epiretinal Membrane, Macular Hole, Visually Significant Vitreous Floater, Vitreomacular Traction, Vitreous Hemorrhage, Proliferative Diabetic Retinopathy, Rhegmatogenous Retinal Detachment, Retained Lens Material in the Posterior Segment
10/26
02/27

Not yet recruiting
N/A
422
 
2L polyethylene glycol (PEG) plus linaclotide; 4L polyethylene glycol (PEG)
The First Affiliated Hospital, Zhejiang University School of Medicine; The First Affiliated Hospital, Zhejiang University School of Medicine, self-supporting
intestinal ployps
 
 
ChiCTR2500104889: Comparative effectiveness and tolerance of bowel preparations for colonoscopy: a single-center platform trial

Not yet recruiting
N/A
1932
 
3L PEG; 2L PEG; 4L PEG; Oral concentrated solution of sodium potassium magnesium sulfate; Compound Piccoline Sulfate Sodium Granules; linaclotide+2L PEG; linaclotide+3L PEG
The Seventh Affiliated Hospital of Sun Yat-Sen University(Shenzhen); The Seventh Affiliated Hospital of Sun Yat-Sen University(Shenzhen), 2024 open funding of Shenzhen Clinical Research Center for Gastroenterology(Gastrointestinal Surgery)
Colorectal Disease
 
 

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