| Linzess (linaclotide) / Ironwood Pharma, AbbVie |
| Completed | 4 | 10 | NA | Linaclotide 290 micrograms, Placebo | Universitaire Ziekenhuizen KU Leuven | Chronic Constipation | 02/15 | 06/15 | | |
2013-004939-73: A STUDY TO EVALUATE THE EFFECT OF LINACLOTIDE ON COLONIC MOTILITY |
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| Completed | 4 | 10 | Europe | LINACLOTIDE, Capsule, hard, CONSTELLA | KULEUVEN, KULEUVEN | COLONIC MOTILITY WILL BE STUDIED IN HEALTHY SUBJECTS, HEALTHY SUBJECTS, Body processes [G] - Physiological processes [G07] | | | | |
NCT02465385: Single-dose Linaclotide for Capsule Endoscopy Preparation |
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| Completed | 4 | 30 | US | Linaclotide, Linzess | University of Virginia | Crohn's, Ulcerative Colitis, Gastrointestinal Bleeding | 06/16 | 06/16 | | |
NCT02590432: An Open-Label, Long-term Study to Assess the Immunogenicity of LINZESS® (Linaclotide) Administered Orally to Adult Participants With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation |
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| Completed | 4 | 828 | US | Linaclotide, LINZESS® | Forest Laboratories, Ironwood Pharmaceuticals, Inc. | Irritable Bowel Syndrome With Constipation, Chronic Idiopathic Constipation | 02/18 | 02/18 | | |
NCT02837783 / 2016-000818-29: A Study of the Effect of Linaclotide on Abdominal Girth in Participants With Irritable Bowel Syndrome With Constipation (IBS-C) |
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| Terminated | 4 | 20 | Europe | Linaclotide, Placebo | Ironwood Pharmaceuticals, Inc., Manchester University NHS Foundation Trust | Irritable Bowel Syndrome Characterized by Constipation | 10/18 | 10/18 | | |
ChiCTR2100052551: A multi-center, prospective, real-world study of Linaclotide in the treatment of irritable bowel syndrome with predominant constipation |
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| Completed | 4 | 120 | | Nil | The Second Hospital of Shandong University; The Second Hospital of Shandong University, Nil | Irritable Bowel Syndrome | | | | |
2014-002017-28: INFLUENCE OF THE TYPE AND SITE OF DISTENSION IN THE EVALUATION OF DRUGS EFFICACY IN MODULATING COLON AND RECTAL FUNCTION IN MAN |
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| Completed | 4 | 23 | Europe | Linaclotide, Capsule, hard, CONSTELLA | KULEUVEN, KULEUVEN | HEALTHY SUBJECTS AND PATIENTS WITH IRRITABLE BOWEL SYNDROME, HEALTHY SUBJECTS AND PATIENTS WITH IRRITABLE BOWEL SYNDROME, Body processes [G] - Physiological processes [G07] | | | | |
ChiCTR2100050437: Develop bowel preparation strategies based on the patient's bowel habits |
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| Not yet recruiting | 4 | 315 | | 3L PEG ;3L PEG +Linaclotide (290ug) ;3L PEG | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Self-financed | N/A | | | | |
NCT05134584: Efficacy of Linaclotide in Patients With Overlapping Functional Gastrointestinal Disorders |
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| Recruiting | 4 | 78 | RoW | Linaclotide, Linzess, Lactulose, Duphalac, Omeprazol, Itopride | RenJi Hospital | Functional Dyspepsia, Constipation-predominant Irritable Bowel Syndrome | 12/21 | 02/22 | | |
ChiCTR2100043303: Clinical efficacy of Linaclotide in treatment of Parkinson′s disease with constipation |
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| Recruiting | 4 | 240 | | Linaclotide ;PEG-4000 | The 988th Hospitail of Joint Logistic Support Force; The 988th Hospitail of Joint Logistic Support Force, Self-raised funds | Constipation | | | | |
ChiCTR2100043302: Clinical efficacy of Linaclotide in treatment of Diabetic patients with constipation |
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| Recruiting | 4 | 400 | | Linaclotide ; PEG-4000 | The 988th Hospital of PLA Joint Logistics Support Force; Level of the institution：, Self-raised funds | Constipation | | | | |
ChiCTR2300069934: Linaclotide Compares with Macrogol 4000 Powder in Treatment of Functional Constipation: A Prospective Cohort Study |
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| Completed | 4 | 141 | | linaclotide ;macrogol 4000 powder | Chengdu Integrated TCM & Western Medicine Hospital; Chengdu Integrated TCM & Western Medicine Hospital, self-finance | functional constipation | | | | |
ChiCTR2100041992: Effect of Linaclotide on bowel preparation for colonoscopy: a multicenter prospective randomized controlled trial |
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| Recruiting | 4 | 838 | | Linaclotide+2L PEG ;3L PEG | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Raise independently | Bowel preparation | | | | |
ChiCTR2300069936: Study on linaclotide in the treatment of Irritable Bowel Syndrome with predominant constipation: a prospective cohort |
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| Completed | 4 | 145 | | linaclotide ;macrogol 4000 powder + Otilonium bromide ;Maren pils +Otilonium bromide | Chengdu Integrated TCM & Western Medicine Hospital; Chengdu Integrated TCM & Western Medicine Hospital, self-finance | Irritable Bowel Syndrome with predominant constipation | | | | |
ChiCTR2200057301: Effect of linaclotide combined with polyethylene glycol electrolytes on bowel cleanliness in patients with chronic constipation |
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| Not yet recruiting | 4 | 100 | | add Linaclotide | The Affiliated People’s Hospital of Ningbo University; The Affiliated People’s Hospital of Ningbo University, the Yinzhou District Science and Technology Bureau | Bowel Preparation | | | | |
ChiCTR2200064244: The effect of linaclotide combined with polyethylene glycol electrolytes powder on bowel preparation for colonoscopy |
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| Not yet recruiting | 4 | 450 | | 1 Linaclotide+2L PEG ;3L PEG ;2 Linaclotide+1L PEG | Chongqing General Hospital; Chongqing General Hospital, Raise independently | Bowel preparation | | | | |
ChiCTR1900027934: Effect of oral linaclotide on gut flora in patients with constipation type irritable bowel syndrome |
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| Completed | 4 | 60 | | Linaclotide | Department of Gastroenterology, the Second Affiliated Hospital of the Army Military Medical University; The second Affiliated Hospital of Army Medical University, Self raising of departments | Irritable bowel syndrome of constipation type | | | | |
ChiCTR2100053273: The effect of linaclotide combined with low-volume polyethylene glycol for bowel preparation in low-risk patients: a multicenter randomized controlled trial |
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| Recruiting | 4 | 596 | | Linaclotide + 1L PEG ;2L PEG | The Third People's Hospital of Chengdu; The Third People's Hospital of Chengdu, Self-funded | Inadequate bowel preparation | | | | |
ChiCTR2200065832: Effect of linalotide combined with compounded polyethylene glycol electrolyte dispersion in bowel preparation prior to colonoscopy: a randomized, controlled, single-blind, single-centre, non-inferiority trial |
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| Not yet recruiting | 4 | 126 | | The day before colonoscopy, 290ug linalotide was taken orally before lunch/dinner, and 2L PEG was taken orally 4~6 hours before the operation on the same day ;Oral administration of 580ug linaclotide before dinner the day before colonoscopy, and oral administration of 2L PEG 4~6 hours before the procedure on the same day ;Take 1L PEG orally the night before colonoscopy, and 2L PEG 4~6 hours before the same-day operation | General Hospital of the Northern Theater of the Chinese People's Liberation Army; General Hospital of the Northern Theater of the Chinese People's Liberation Army, Self-financing | Intestinal diseases | | | | |
ChiCTR2200057368: Study on the Equivalence of Linaclotide +2L-PEG Regimen and Divided dose 3L-PEG Regimen in Bowel Preparation before Colonoscopy |
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| Not yet recruiting | 4 | 330 | | Linaclotide 290ug×1 tablet+compound polyethylene glycol electrolyte powder 68.56g×1 bag (1L) orally (21: 00 the night before colonoscopy)+linaclotide 290ug×1 tablet+compound polyethylene glycol electrolyte powder 68.56g×1 bag (1L) orally (6 hours before colonoscopy) ;Compound polyethylene glycol electrolyte powder 68.56g×2 bags (2L) orally (21: 00 the night before colonoscopy)+compound polyethylene glycol electrolyte powder 68.56g×1 bags (1L) orally (6 hours before colonoscopy) | Department of Gastroenterology, the First Affiliated Hospital of Shantou University Medical College; the First Affiliated Hospital of Shantou University Medical College, Self-financing | Intestinal diseases | | | | |
ChiCTR2200063143: Clinical efficacy of Linaclotide in treatment of mental disease with constipation |
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| Not yet recruiting | 4 | 224 | | Linaclotide ;Polyethylene glycol 4000 powder | 984 Hospitail of Joint Logistic Support Force; 984 Hospitail of Joint Logistic Support Force, Self-raised | Constipation | | | | |
NCT03119584: Efficacy of Linaclotide in Type II Diabetics With Chronic Constipation |
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| Active, not recruiting | 4 | 23 | US | linaclotide or placebo, Linzess | Texas Tech University Health Sciences Center, El Paso | Chronic Constipation, Diabete Mellitus | 10/24 | 01/25 | | |
ChiCTR2400081524: Application of linaclotide in bowel preparation before colonoscopy in patients with constipation |
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| Recruiting | 4 | 320 | | A:Patients need to take 1 capsule of linaclotide (290ug/capsule) 30 minutes before the first meal every day 3 days before colonoscopy for 3 days, and do not take it on the day of colonoscopy. Take 1L of PEG solution at 20 o'clock the night before the examination and finish it within 1-4 hours; Take 2L of PEG solution 6 hours before colonoscopy for routine bowel preparation; B:Patients do not take linacretide. Take 2L of PEG solution at 20 o'clock the night before the examination, and finish within 1-4 hours; Take 2L of PEG solution 6 hours before colonoscopy for routine bowel preparation | The First Bethune Hospital of Jilin University; The First Bethune Hospital of Jilin University, The First Bethune Hospital of Jilin University | bowel preparation | | | | |
ChiCTR2400083515: Effect of linaclotide combined with compound polyethylene glycol electrolyte powder in bowel preparation before colonoscopy in patients with constipation |
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| Recruiting | 4 | 240 | | On the morning of the examination, 2 boxes of compound polyethylene glycol electrolyte powder were taken orally, dissolved in 3000 mL of warm water to make a solution, and taken within 2 hours.; Take 1 tablet of linaclotide at 7:00~8:00 two days before the examination, and then take 2 boxes of compound polyethylene glycol electrolyte powder orally at 7:00~9:00 on the examination day, dissolve in 2000 mL of warm water Make up a solution and take it within 2 hours.; Take 1 tablet of linaclotide each at 7:00~8:00 four days before the examination, and then take 2 boxes of compound polyethylene glycol electrolyte powder orally at 7:00~9:00 on the examination day, dissolve in 2000 mL of warm water Make up a solution and take it within 2 hours. | The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, 3000 | bowel preparation | | | | |
NCT06748638: Clinical Study on the Application of Lactulose Combined with Linaclotide in Bowel Preparation for Colonoscopy |
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| Enrolling by invitation | 4 | 444 | RoW | Lactulose, Lactulose+ linaclotide, polyethylene glycol (PEG) | Haifeng Lan | Lactulose, Bowel Preparation | 10/25 | 10/25 | | |
ChiCTR2400090039: The effects of combined use of linaclotide and polyethylene glycol electrolyte solution in colonoscopy preparation for patients undergoing endoscopic mucosal resection or endoscopic submucosal dissection |
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| Recruiting | 4 | 450 | | drink 2L PEG the night before the procedure starting at 7 PM, drink 2L PEG at 7Am on the day of the procedure.; take 290ug linaclotide at 7AM the day before the procedure, drink 2L PEG the night before the procedure starting at 7 PM, take 290ug linaclotide at 5AM on the day of the procedure, and drink 1L PEG at 7AM on the day of the procedure; take 290ug linaclotide at 7AM 2 days before the procedure, take 290ug linaclotide at 7AM the day before the procedure, drink 1L PEG the night before the procedure starting at 7 PM, take 290ug linaclotide at 5AM on the day of the procedure, and drink 1L PEG at 7AM on the day of the procedure | Beijing Shijitan Hospital, Capital Medical University; Beijing Shijitan Hospital, Capital Medical University, Youth Fund of Beijing Shijitan Hospital, Capital Medical University | Colonoscopy Cleaning | | | | |
ChiCTR2400083154: A prospective, randomised controlled clinical study of the efficacy, safety and mechanism of action of rupiprostenone in the treatment of diabetic constipation |
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| Not yet recruiting | 4 | 90 | | Rupiprostenone capsules, 24μg/capsule, 1 capsule/dose, 2 times a day, taken orally with food and water with breakfast and dinner, swallowed whole, not to be split or chewed, for 8 weeks.; Linaclotide, 290 μg/capsule, 1 capsule/dose, 1 day, half an hour before breakfast, swallowed whole, not to be split or chewed, for 8 weeks.; Bifidobacterium bifidum Live Bacteria Capsules, 210mg/capsule, 2 capsules/dose, 2 times a day, after breakfast and dinner, swallowed whole, not to be split or chewed, for 8 weeks. | Binzhou Medical University Hospital; Binzhou Medical University Hospital, Funds for the construction of provincial key clinical specialties in Shandong Province | Diabetic constipation | | | | |
ChiCTR2500101833: Real-world study on the safety and efficacy of Linaclotide combined with Ultra-low-volume Polyethylene Glycol for bowel preparation in Low-Risk Patients |
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| Not yet recruiting | 4 | 8364 | | Linaclotide + 1L PEG; 2L PEG | The Third People's Hospital of Chengdu; The Third People's Hospital of Chengdu, Self-funded | bowel preparation | | | | |
ChiCTR2500096394: The effects of combined use of linaclotide and oral sulfate solution in bowel preparation for chronic constipation patients undergoing colonoscopy |
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| Not yet recruiting | 4 | 195 | | (1) take 1d-linaclotide at 7AM on the day before the procedure, (2)ingested diluted OSS followed by 1L water on the night before the procedure starting at 7 PM, OSS were dissolved in approximately 500 ml water, (3) take 1d-linaclotide at 5AM on the day of the procedure, and (4) drink 500mL diluted OSS and 1L water on the day of the procedure, starting at 7AM and completed at least 4 hours before the colonoscopy.; (1) take 1d-linaclotide at 7AM two days before the procedure, (2) 1d-linaclotide at 7AM on the day before the procedure, (3) ingested diluted OSS followed by 1L water on the night before the procedure starting at 7 PM, OSS were dissolved in approximately 500ml water, (4) take 1d-linaclotide at 5AM on the day of the procedure, and (5) drink 500mL diluted OSS and 1L water on the day of the procedure, starting at 7AM and completed at least 4 hours before the colonoscopy.; ingested diluted OSS followed by 1L water on the night before the procedure starting at 7 PM, OSS were dissolved in approximately by 500ml water, and (2) drink 500mL diluted OSS and 1L water on the day of the procedure, starting at 7Am and completed at least 4 hours before the colonoscopy. | Beijing Shijitan Hospital, Capital Medical University; Beijing Shijitan Hospital, Capital Medical University, Youth Fund of Beijing Shijitan Hospital, Capital Medical University | Chronic constipation | | | | |
