Zyclara (imiquimod) / Mochida, Viatris, Bausch Health  >>  Phase 1
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14 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Zyclara (imiquimod) / Mochida, Viatris, Bausch Health
2014-003025-18: Vaccination with peptides (molecules) and other ingredients which stimulate the anticancer immune system in patients with advanced cancers

Ongoing
1
30
Europe
Human telomerase reverse transcriptase peptides, Aldara 5% cream, Not applicable, Cyclophosphamide 50, Not applicable, Concentrate for solution for injection, Cream, Capsule, hard, Tablet, Aldara 5% cream, Celebrex 100mg and 200 mg capsules
King's College London, Guy's and St Thomas NHS Foundation Trust, Candles, charity, Candles - charity
Advanced malignancies, Cancers which are no longer responding to treatment, Diseases [C] - Cancer [C04]
 
 
NCT01803152: Dendritic Cell Vaccine for Children and Adults With Sarcoma

Active, not recruiting
1
19
US
Dendritic Cells Vaccine, DC Vaccine, Lysate of Tumor, Lysate, Tumor Lysate, Gemcitabine, Gemzar, Imiquimod, Aldara, Leukapheresis, Pheresis
Macarena De La Fuente, MD
Sarcoma, Soft Tissue Sarcoma, Bone Sarcoma
09/19
07/24
NCT03196180: Topical Fluorouracil and Imiquimod in Treating Patients With High-Grade Cervical Intraepithelial Neoplasia

Active, not recruiting
1
13
US
Imiquimod, Aldara, R 837, S 26308, Zyclara, Topical Fluorouracil, Actino-Hermal, Arumel, Carac, Cytosafe, Efudex, Efurix, Fiverocil, Fluoroplex, Flurox, Timazin, Tolak
National Cancer Institute (NCI)
Cervical Intraepithelial Neoplasia Grade 2/3, Cervical Squamous Cell Carcinoma In Situ, Cervical Squamous Intraepithelial Neoplasia 2, High Grade Cervical Intraepithelial Neoplasia
11/20
11/24
NCT03276832: Imiquimod and Pembrolizumab in Treating Patients With Stage IIIB-IV Melanoma

Active, not recruiting
1
7
US
Imiquimod, Aldara, R 837, S 26308, Zyclara, Biopsy, Pembrolizumab, Keytruda, Lambrolizumab, MK-3475, SCH 900475, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized Tomography, CT, CT Scan, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, Nuclear Magnetic Resonance Imaging, NMRI, Structural MRI, sMRI
Mayo Clinic, National Cancer Institute (NCI)
Metastatic Melanoma, Stage IIIB Cutaneous Melanoma AJCC v7, Stage IIIC Cutaneous Melanoma AJCC v7, Stage IV Cutaneous Melanoma AJCC v6 and v7
10/21
06/24
NCT00788164: Vaccine Therapy With or Without Imiquimod in Treating Patients With Grade 3 Cervical Intraepithelial Neoplasia

Completed
1
75
US
TA-HPV, pNGVL4a-Sig/E7(detox)/HSP70 DNA vaccine, imiquimod
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, National Cancer Institute (NCI)
Cervical Cancer, Precancerous Condition, HPV Disease, Human Papilomavirus
08/23
08/23
NCT04883645: Topical Aldara (Imiquimod) for Oral Cancer

Active, not recruiting
1
15
US
Imiquimod 5% Cream
Medical University of South Carolina
Oral Cancer
06/23
09/24
NCT06305910: CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults

Recruiting
1
24
US
Treatment with CD200AR-L, Imiquimod, GBM6-AD, Single dose of radiation (300 cGy)
OX2 Therapeutics
Diffuse Midline Glioma, H3 K27M-Mutant, Recurrent High Grade Glioma
09/25
01/27
NCT03872947: A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors

Recruiting
1
187
Europe, US
TRK-950, Irinotecan, Leucovorin, 5-FU, Gemcitabine, Cisplatin, Carboplatin, Ramucirumab, Paclitaxel, Nivolumab, Pembrolizumab, Imiquimod Cream, Bevacizumab, PLD
Toray Industries, Inc
Solid Tumor, Colorectal Cancer, Cholangiocarcinoma, Bladder Cancer, Ovarian Cancer, Gastric Cancer, Palpable Subcutaneous Malignant Lesions, Renal Cell Carcinoma, Melanoma, Epithelial Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer
03/25
03/25
NCT03370406: Intralesional 5-Fluorouracil (5FU), Topical Imiquimod Treatment for SCC

Recruiting
1
30
US
5-fluorouracil, Adrucil, Tolak, Efudex, Carac, Fluoroplex, PremierPro Rx Fluorouracil, Fluorouracil Novaplus, 5FU, Imiquimod 5% cream, Aldara, Zyclara
Melissa Pugliano-Mauro, National Cancer Institute (NCI)
Carcinoma, Squamous Cell
08/24
09/24
CoGA, NCT05468606: Coadministration of GA2 Sporozoites With Adjuvants

Recruiting
1
45
Europe
GA2, BCG, YF-17D (fractional ID dose), Stamaril, Imiquimod, Aldara, Mock immunization
Leiden University Medical Center
Malaria,Falciparum
12/24
12/24
NCT01795313: Immunotherapy for Recurrent Ependymomas in Children Using Tumor Antigen Peptides With Imiquimod

Recruiting
1
24
US
HLA-A2 restricted synthetic tumor antigen, Imiquimod, enzyme-linked immunosorbent assay, flow cytometry, immunohistochemistry staining method, laboratory biomarker analysis
James Felker, Solving Kids' Cancer, National Cancer Institute (NCI)
Ependymoma
12/24
12/25
INTERCEPT-H3, NCT04808245: A MultIceNTER Phase I Peptide VaCcine Trial for the Treatment of H3-Mutated Gliomas

Recruiting
1
15
Europe
Tecentriq 1200 MG in 20 ML Injection, Atezolizumab, H3K27M peptide vaccine, Imiquimod (5%), Aldara
German Cancer Research Center, Johannes Gutenberg University Mainz, Charite University, Berlin, Germany, Roche Pharma AG, German Cancer Aid
Newly Diagnosed H3-mutated Glioma
03/25
03/25
NCT02600949: Personalized Peptide Vaccine in Treating Patients With Advanced Pancreatic Cancer or Colorectal Cancer

Recruiting
1
150
US
Imiquimod, Aldara, R 837, S 26308, Zyclara, Pembrolizumab, Keytruda, Lambrolizumab, MK-3475, SCH 900475, Sotigalimab, APX 005, APX 005M, APX-005M, APX005M, CD40 Agonistic Monoclonal Antibody APX005M, EPI-0050, Synthetic Tumor-Associated Peptide Vaccine Therapy, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, CT, Magnetic Resonance Imaging, Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR Imaging, MRI, MR, MRI Scan, Nuclear Magnetic Resonance Imaging, NMR, NMRI, NMR Imaging
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Metastatic Colorectal Adenocarcinoma, Metastatic Pancreatic Ductal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v7, Stage IV Pancreatic Cancer AJCC v6 and v7, Stage IVA Colorectal Cancer AJCC v7, Stage IVB Colorectal Cancer AJCC v7
05/25
05/25
NCT05838599: Combining Topical Imiquimod With Local Radiotherapy for Treatment of Mycosis Fungoides

Recruiting
1
25
US
Imiquimod, Radiation Therapy
Northwestern University
Mycosis Fungoides
08/25
02/26

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