| amantadine / Generic mfg. |
2009-015100-25: Cohorte multicentrique nationale de patients atteints de grippe pandémique(nouveau virus A/H1N1v d’origine porcine) |
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| Ongoing | 4 | 1500 | Europe | Tamiflu, Relenza 5mg/dose, mantadix 100mg, Rebetol, Rebetol 40mg/ml, Copegus 400 mg, Copegus 200 mg, Capsule*, Powder for nebuliser suspension, Oral solution, Tablet, Oseltamivir, Zanamivir 20mg (20 unidoses), Zanamivir 20mg (4 unidoses), Amantadine, Ribavirine 200mg (84 gélules), Ribavirine 200mg (112 gélules), Ribavirine 200mg (140 gélules), Ribavirine 200mg (168 gélules), Ribavirine, Ribavirine 400mg (14 comprimés), Ribavirine 400 mg (56 comprimés), Ribavirine 200 mg (28 comprimés), Ribavirine 200 mg (42 comprimés), Ribavirine 200mg (112 comprimés), Ribavirine 200mg (168 comprimés) | INSERM | Forme grave et forme bénigne de la Grippe A | | | | |
2012-005723-33: Efficacy of amantadine in acquired brain injury. Onderzoek naar het effect van amantadine op gedragsproblemen na hersenletsel |
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| Ongoing | 4 | 40 | Europe | Capsule, symmetrel | GGZ Oost Brabant, GGZ Oost Brabant | behavioural and emotional problems and impairment of executive functioning due to acquired brain injury to the frontal lobes gedrags- en emotionele problemen en executieve functiestoornissen veroorzaakt door verworven frontaal hersenletsel, acquired brain injury gedragsproblemen na verworven hersenletsel, Diseases [C] - Nervous System Diseases [C10] | | | | |
2006-006684-22: Evaluation des effets à long terme de l’amantadine chez le parkinsonien souffrant de dyskinésies induites par la lévodopa : Etude randomisée en double-insu versus placebo de l’arrêt d’une prescription chronique. |
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| Ongoing | 4 | 80 | Europe | MANTADIX, MANTADIX | CHU Toulouse | maladie de parkinson | | | | |
2021-004868-95: AMANTADINE AND TRANSCRANIAL MAGNETIC STIMULATION FOR TREATING FATIGUE IN MULTIPLE SCLEROSIS AMANTADINA Y ESTIMULACIÓN MAGNÉTICA TRANSCRANEAL PARA FATIGA EN LA ESCLEROSISMULTIPLE |
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| Not yet recruiting | 4 | 144 | Europe | Amantadine, Capsule, hard, Amantadine Level | Fundación para la Inv. Biomédica Hospital Clínico San Carlos, INSTITUTO CARLOS III | Fatigue in multiple sclerosis fatiga en esclerosis múltiple, Fatigue in multiple sclerosis fatiga en esclerosis múltiple, Diseases [C] - Nervous System Diseases [C10] | | | | |
APQ-TRD, NCT04936126: Comparison of Antidepressant Augmentation With Amantadine vs Pramipexole vs Quetiapine in Treatment Resistant Depression |
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| Recruiting | 4 | 150 | RoW | Quetiapine, Amantadine, Pramipexole | All India Institute of Medical Sciences, Bhubaneswar, Indian Council of Medical Research | Treatment Resistant Depression | 07/24 | 09/24 | | |
NCT04427241: Efficacy and Safety of Cerebrolysin on Prolonged Disorders of Consciousness |
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| Not yet recruiting | 4 | 12 | RoW | Cerebrolysin, Control | Konkuk University Medical Center, Ever Neuro Pharma GmbH | Disorder of Consciousness, Hemorrhagic Stroke | 07/25 | 12/25 | | |
2008-001694-15: En multicenter, randomiseret, placebo-kontrolleret studie af effekten af amantadin til fremme af bedring efter svær traumatisk hjerneskade: Amantadin-studiet |
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| Ongoing | 3 | 180 | Europe | amantadine hydrochloride, Amantadin, Tablet, Amantadin hydrochlorid | Afdeling for Traumatisk Hjerneskade | Projektets formål er at undersøge, om lægemidlet amantadin bedrer patienter som er svært bevidsthedssvækkede pga. nylig svær traumatisk hjerneskade. | | | | |
| Recruiting | 3 | 226 | Europe | Amantadine, Lactose monohydrate | Copenhagen University Hospital, Hvidovre, University of Copenhagen | Covid19 | 01/22 | 04/22 | | |
| Recruiting | 3 | 200 | Europe | Amantadine Hydrochloride, Placebo | Independent Public Clinical Hospital No. 4 in Lublin | COVID-19, SARS-CoV-2 | 03/22 | 05/22 | | |
FETEM, NCT05809414: Amantadine and Transcranial Magnetic Stimulation for Treating Fatigue in Multiple Sclerosis |
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| Recruiting | 3 | 144 | Europe | Transcranial Magnetic Stimulation, TMS, Amantadine Hydrochloride 100 mg (milligrams) Oral Capsule | Hospital San Carlos, Madrid | Multiple Sclerosis, Fatigue | 07/24 | 02/25 | | |
NCT06052787: Combined Cerebrolysin and Amantadine Sulfate Administration for Patients With Traumatic Brain Injury in the ICU |
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| Recruiting | 3 | 150 | RoW | Cerebrolysin, amantadine sulfate, PK-MERZ | Ain Shams University | Traumatic Brain Injury | 03/25 | 09/25 | | |
| Recruiting | 2/3 | 800 | Europe | Memantine Hydrochloride Oral Solution, Trazodone Hydrochloride oral solution, Placebo oral solution, Amantadine Hydrochloride Oral Solution | University of Edinburgh, University College, London, University of Warwick, NHS Lothian | Motor Neuron Disease, Amyotrophic Lateral Sclerosis | 09/26 | 12/26 | | |
2011-005201-75: Impact d’un traitement PREcoce par aMANtadine sur les DYSKinésies induites par la L-DOPA dans la maladie de Parkinson : étude comparative avec tirage au sort versus placebo. |
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| Ongoing | 2 | 202 | Europe | amantadine, Capsule, mantadix | CHU de Toulouse, Programme Hospitalier de Recherche Clinique, Enveloppe Nationale 2011 | Maladie de Parkinson, Maladie de Parkinson, Diseases [C] - Nervous System Diseases [C10] | | | | |
ChiCTR-TRC-12002299: Changes of fMRI and EEG stimulating-reaction of patients in vegetative state or minimal consciousness state after treating by amantadine or levodopa |
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| Completed | 2 | 25 | | amantadine ;levodopa ;No treatment | Department of Neurology, Xijing Hospital, the Fourth Military Medical University; Xijing Hospital, selffinancing | patients in vegetative state or minimal consciousness state | | | | |
| Active, not recruiting | 2 | 18 | Europe | Amantadine Sulfate, physiological saline (0.9% NaCl solution) | Azienda Sanitaria dell'Alto Adige | Amantadine, Consciousness Disorders, Electroencephalography | 01/24 | 09/24 | | |
NCT03612921: Oral Amantadine, IV Amantadine and Hemodynamic Response to Laryngoscopy |
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| Recruiting | 2 | 60 | RoW | oral Amantadine sulfate, amantadine, i.v Amantadine Sulfate, PK-Merz, placebo tablet | Assiut University | Intubation, Intratracheal | 03/22 | 04/22 | | |
2022-002418-18: AmaNtadine for NeuroenhancEment in acutE patients Study - A prospective pilot proof of concept phase IIb study in intensive and intermediate care unit patients (ANNES) |
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| Not yet recruiting | 2 | 50 | Europe | Amantadin-ratiopharm®, Infusion, Amantadin-ratiopharm® | University Hospital Tübingen, University Hospital Tuebingen | Patients on Intermediate Care and Intensive Care Unit (IMC and ICU) with unresponsive wakefulness syndrome not otherwise explained, Patients on Intermediate Care and Intensive Care Unit (IMC and ICU) with unresponsive wakefulness syndrome not otherwise explained, Not possible to specify | | | | |
NCT05667077: The Effect of Amantadine on Post-COVD-19 Fatigue |
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| Not yet recruiting | 2 | 83 | RoW | Amantadine | Shahid Beheshti University of Medical Sciences | Post-COVID-19 Syndrome | 12/22 | 01/23 | | |
| Recruiting | 2 | 50 | Europe | Amantadine | University Hospital Tuebingen | Disorder of Consciousness | 10/24 | 12/24 | | |
| Recruiting | 2 | 60 | US | Amantadine, Placebo | University of Pennsylvania | Stroke, Ischemic, Stroke Hemorrhagic | 12/25 | 06/26 | | |
MR-301-T-001, NCT06253923: Study to Assess the Safety of Amantadine Hydrochloride (HCl) Intravenous (IV) Solution (MR-301) in Patients With Severe Traumatic Brain Injury (TBI). |
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| Recruiting | 2 | 45 | US | Amantadine Hydrochloride, Placebo | SHINKEI Therapeutics, Inc, Duke Clinical Research Institute | Traumatic Brain Injury | 09/24 | 11/24 | | |
NCT06234462: A Study of Amantadine for Cognitive Dysfunction in Patients With Long-Covid |
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| Recruiting | 2 | 30 | US | Amantadine, Physical, Occupational, Speech Therapy, Provider Counseling, Medications for symptoms management | University of Texas Southwestern Medical Center | Long COVID, Post-Acute COVID-19 Syndrome | 05/25 | 06/25 | | |
| Recruiting | 1 | 60 | US | Amantadine | Ohio State University | Long COVID, Post-COVID19 Condition, Post-Acute COVID19 Syndrome | 04/25 | 05/25 | | |
NCT04173832: Clinical Study on Treatment of L-DOPA-Induced Dyskinesia With Tianqi Pingchan Granule Combined With Amantadine |
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| Recruiting | N/A | 100 | RoW | Tianqi Pingchan Granule Combined With Amantadine, Placebo Combined With Amantadine | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai Municipal Hospital of Traditional Chinese Medicine, Wenzhou Central Hospital, The Affiliated Hospital of Qingdao University, Nanjing Hospital of Chinese Medicine affiliated to Nanjing University of Chinese Medicine, The Affiliated Hospital of Xuzhou Medical University | L-DOPA-Induced Dyskinesia | 12/20 | 12/21 | | |
| Recruiting | N/A | 120 | Canada | Amantadine, Systemic chemotherapy | University of Manitoba, BioMark Technologies Inc., St. Boniface Hospital | Cancer | 12/21 | 12/21 | | |
ChiCTR1900022352: Amantadine Effects in Patients with Chronic Disorders of Consciousness |
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| Recruiting | N/A | 40 | | Amantadine | Neurosurgery Department, Yijishan Hospital, Wannan Medical College; Yijishan Hospital, Wannan Medical College Young and Mid-career Key Research Project Development Fund (WK2018ZF07). | Chronic Disorders of Consciousness | | | | |
NCT04367883: Influenza Vaccination, ACEI and ARB in the Evolution of SARS-CoV2 Infection |
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| Recruiting | N/A | 3000 | Europe | Antihistamine, Antihistamines for COVID, Amantadine, Amantadine for COVID, ACEI, ACEI and COVID, ARB, ARB and COVID, Influenza vaccine and COVID | Consorci Sanitari de Terrassa, Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina, Institut Català de la Salut | COVID19, Influenza Vaccination, ACE Inhibitors, ARB, Antihistamine Allergy, Amantadine | 09/24 | 12/24 | | |
NCT02331290: Excretion of Acetylamantadine (AA) by Lung Cancer Patients During a Chemotherapy Regimen |
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| Recruiting | N/A | 20 | Canada | | University of Manitoba, CancerCare Manitoba | Lung Cancer | 12/23 | 12/23 | | |
NCT04530006: Acetyl-Amantadine as a Biomarker in Patients With Glioblastoma |
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| Recruiting | N/A | 20 | Canada | Amantadine Hydrochloride | CancerCare Manitoba, University of Manitoba, The Metabolomics Innovation Centre, BioMark Diagnostics Inc., Canadian Institutes of Health Research (CIHR) | Glioblastoma Multiforme | 12/24 | 08/25 | | |
| Recruiting | N/A | 120 | US | Anti-Parkinson medication, Carbidopa/levodopa, pramipexole, ropinirole, amantadine, tolcapone, entacapone, Deep Brain Stimulation | Beth Israel Deaconess Medical Center | Parkinson's Disease, Parkinsonian Disorders, Atypical Parkinson Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Corticobasal Degeneration, Gait, Frontal, Huntington Disease | 06/25 | 06/25 | | |
NCT05504057: Antihistamines, Amantadine and Evolution of the SARS-CoV-2 Infection |
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| Recruiting | N/A | 170000 | Europe | Antihistamine, Antihistamine as crhonic treatment and COVID19 infection., Amantadine, Amantadine as chronic treatment and COVID19 infection. | Consorci Sanitari de Terrassa, Institut Català de la Salut | COVID-19 | 09/24 | 06/25 | | |