| methotrexate / Generic mfg. |
ACTRN12621001695897: A randomised controlled trial to compare drug dose reduction strategies in adults with rheumatoid arthritis and psoriatic arthritis for safer and more efficient drug use |
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| Recruiting | 4 | 324 | | | University of Sydney, Australian Government, Department of Health, National Health and Medical Research Council, Medical Research Future Fund (MRFF) | Rheumatoid arthritis, Psoriatic arthritis | | | | |
ChiCTR-TRC-09000377: Multicentered Clinical Evaluation Studies on Treating Active Rheumatoid Arthritis by the Method of Clearing Heat and Promoting Blood Flow |
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| Completed | 4 | 230 | | Methotrexate Tablets: 10mg 1/w ;The Formula of Clearing Away Damp-heat and Promoting Blood Flow: 200ml bid; Methotrexate Tablets: 10mg 1/w ;The Formula of Clearing Away Damp-heat and Promoting Blood Flow: 200ml bid | China Academy of Chinese Medical Science Guang'an Men Hospital; Governing Board of Capital Fund for Medical Science Developing and Researching, Capital Fund for Medical Science Developing and Researching | rheumatoid arthritis | | | | |
2009-015403-95: A pilot trial of noninvasive assessment of methotrexate hepatotoxicity in the course of pharmacokinetically guided pharmacotherapy of psoriasis with methotrexate and folic acid |
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| Ongoing | 4 | 90 | Europe | ACIDUM FOLICUM LECIVA, methotrexate 2.5 mg tablets, EU/1/99/116/001, Coated tablet, Powder for solution for injection, Powder for injection*, Tablet, ACIDUM FOLICUM LECIVA, REMICADE 100 MG, ENBREL 50 MG | Faculty Hospital Hradec Králové | moderate-severe and severe plaque psoriasis | | | | |
| Ongoing | 4 | 100 | Europe | INFLIXIMAB, ETANERCEPT, METHOTREXATE SODIUM TABLETS, CICLOSPORIN A CAPSULES, HYDROXYCARBAMIDE, ACITRETIN, CALCIPOTRIOL, HYDROMOL, SHORT CONTACT DITHRANOL IN HYDROMOL, DITHRANOL IN LASSAR'S PASTE, STRONG COAL TAR SOLUTION IN HYDROMOL, PUVASORALEN-8, Powder for injection*, Powder and solvent for solution for injection, Tablet, Capsule*, Cream, Ointment, REMICADE, ENBREL, METHOTREXATE, NEORAL, HYDREA, NEOTIGASON, DOVONEX CREAM, DOVONEX OINTMENT, HYDROMOL OINTMENT, METHOXSALEN | The Newcastle upon Tyne Hospitals NHS Trust | Psoriasis | | | | |
ChiCTR-TRC-10000989: A 24 Week Randomized Controlled Study to Evaluate the Clinical Outcomes of Rheumatoid Arthritis Treated with Chinese Medicines –the Second Trial |
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| Completed | 4 | 480 | | Methotrexate Tablets, once per week, for first tim ;Leigongtengduogan Pian, 10mg per time, 3 times per day, Yishen Juanbi Wan, 8g per time, 3 times per day, for oral administration, after meals ; | The Ministry of Science and Technology of the People's Republic of China; Level of the institution：, Key Projects in the National Science & Technology Program Funds | rheumatoid arthritis | | | | |
ChiCTR-IPR-14005684: Compare with methotrexate tablets to evaluate the randomized double-blind, multicenter clinical trial to trial the efficacy and safety of the injection technetium "99Tc" methylene diphosphonate treatment for active rheumatoid arthritis. |
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| Completed | 4 | 180 | | Yunke 16.5mg (5.5mg*3 sets) / time for each course of treatment, 100ml saline intravenous drip after dissolution and dilution, once a day for 7 successive days ;Four oral tablets each time, and gradually increase to 6 tablets each time in four weeks or to the maximum tolerated dose of the patients ;Yunke group+MTX group | Shanghai Renji Hospital; Chengdu Yunke Pharmaceutical Co., Ltd, Supported by Chengdu Yunke Pharmaceutical Co., Ltd | Rheumatoid arthritis | | | | |
ChiCTR-TRC-12003593: Use of Oral Methotrexate plus Glucocorticoid for the Treatment of bullous pemphigoid:A multicenter,randomized and controlled clinincal trial |
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| Completed | 4 | 180 | | This group receives systemic glucocorticoid, initially, with prednisone at 1mg/kg/day. Then we adjust the dose of glucocorticoid according to the patients' responses. ;This group receives systemic glucocorticoid plus MTX and starts with prednisone at 1mg/kg/day and MTX IV drip infusion at 15mg/week. Then we adjust the dose of glucocorticoid according to the patients' responses. | Institute of dermatology; Chinese Academy of Medical Sciences; Institute of dermatology, Chinese Academy of Medical Sciences, Ministry of Finance of the People's Republic of China | bullous pemphigoid | | | | |
ChiCTR-TRC-12003539: Use of Oral Methotrexate plus Glucocorticoid for the Treatment of Pemphigus:A multicenter,randomized and controlled clinincal trial |
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| Completed | 4 | 180 | | This group receives systemic glucocorticoid , initially ,with prednisone at 1mg/kg/day. Then we adjust the dose of glucocorticoid according to the patients' responses. ;This group receives systemic glucocorticoid plus MTX and starts with prednisone at 1mg/kg/day and MTX oral intake at 15mg/week. Then we adjust the dose of glucocorticoid according to the patients' responses. | Institute of dermatology, Chinese Academyof Medical Sciences; Institute of dermatology, Chinese Academy of Medical Sciences, Ministry of Finance of China | Pemphigus | | | | |
2005-000871-16: Methotrexate in adults with severe atopic dermatitis: a double-blind, randomised, parallel-group, placebo-controlled trial |
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| Ongoing | 4 | 48 | Europe | methotrexate, Not applicable, Maxtrex, Maxtrex | Dr John Berth-Jones | Severe atopic dermatitis in adults | | | | |
2016-003592-21: Evaluating the benefits of using secukinumab rather than standard treatments as the first systemic treatment in moderate to severe psoriasis |
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| Ongoing | 4 | 148 | Europe | Secukinumab, Methotrexate 2.5mg tablets, Methotrexate 10 mg tablets, CICLOSPORIN 10mg capsule, CICLOSPORIN 25mg capsule, CICLOSPORIN 50mg capsule, CICLOSPORIN 100mg capsule, AIN457, Solution for injection in pre-filled syringe, Tablet, Capsule, COSENTYX | Novartis Pharmaceuticals UK Limited, Novartis Pharmaceuticals UK Limited | Moderate to severe plaque psoriasis, Moderate to severe plaque psoriasis. Psoriasis looks like red, raised scaly areas of skin., Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
ChiCTR1900025165: Treatment of Kunxian Capsule for moderate to severe plaque psoriasis: a multi-center, randomized, double-blinded, double-dummy, positive-drug, parallel-controlled clinical trial |
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| Not yet recruiting | 4 | 72 | | Kunxian Capsule ( 0.3g per capsule): 2 capsules per dose, t.i.d, taken with meal, treated for 12 weeks; Methotrexate tablets placebo(2.5mg per tablet): 3 tablets a week. ;Kunxian Capsule placebo: 2 capsule per dose, t.i.d, taken with meal, treated for 12 weeks; Methotrexate tablets(2.5mg per tablet): 3 tablets a week. | Shanghai Tenth People's Hospital; Guangzhou Baiyunshan Pharmaceutical Co. Chenliji, Guangzhou Baiyunshan Pharmaceutical Co. Chenliji | Moderate to severe plaque psoriasis | | | | |
ChiCTR1900026079: Wangbi capsule combined methotrexate tablets for treatment of Rheumatoid Arthritis: A Randomized,Double-blind,Single analog,Positive Drug Parallel-group controlled clinical study |
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| Recruiting | 4 | 120 | | Wangbi capsule combined methotrexate tablets ;Simulation of Wangbi capsule combined methotrexate tablets | Longhua Hospital Shanghai University of Traditional Chinese Medicine; Longhua Hospital Shanghai University of Traditional Chinese Medicine, China Resources Sanjiu Medical & Pharmaceutical Co., Ltd | Rheumatoid Arthritis | | | | |
ChiCTR2100050865: Observation on the efficacy of Tripterygium wilfordii polyglycosides tablets combined with Adamumab in the treatment of rheumatoid arthritis |
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| Recruiting | 4 | 60 | | Tripterygium wilfordii polyglycoside tablets + Adamu monoclonal antibody ;Methotrexate tablets + Adamu monoclonal antibody | The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine; The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Biaotai Biological Pharmaceutical Co., Ltd. | rheumatoid arthritis | | | | |
NCT04299971: Efficiency of Methotrexate and Tofacitinib in Mild and Moderate Patients |
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| Recruiting | 4 | 130 | RoW | Methotrexate Tablets, methotrexate pills, Tofacitinib tablet, Xeljanz | Shanghai Zhongshan Hospital | Takayasu Arteritis, Methotrexate, Inhibition, Treatment | 12/22 | 12/23 | | |
PREDMETH, NCT04314193: Effectiveness of Methotrexate Versus Prednisolone as First-line Therapy for Pulmonary Sarcoidosis |
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| Active, not recruiting | 4 | 138 | Europe | Methotrexate, Prednisolone | Erasmus Medical Center, St. Antonius Hospital, Longfonds | Sarcoidosis, Pulmonary | 07/24 | 07/26 | | |
ChiCTR2100048769: Prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial of Qufengzhitong capsule in the treatment of rheumatoid arthritis |
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| Not yet recruiting | 4 | 204 | | Methotrexate tablets+Qufengzhitong capsule ;Methotrexate tablets+Qufeng Zhitong Capsule Placebo | Guang'anmen Hospital, China Academy of Chinese Medical Sciences; Shandong Buchang Medicine Sales Co., Ltd., Provided by the sponsor | rheumatoid arthritis | | | | |
ChiCTR2100049656: Efficacy and safety evaluation of short interval cyclophosphamide pulse infusion in patients with refractory idiopathic inflammatory myopathy: a double-blind, multicenter randomized clinical trial |
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| Not yet recruiting | 4 | 192 | | Short interval cyclophosphamide pulse infusion and oral placebo ;Short interval normal saline pulse infusion and oral methotrexate | Qilu Hospital, Shandong University; Qilu Hospital, Shandong University, Clinical Research Center of Shandong University（No.2020SDUCRCA014） | Idiopathic inflammatory myopathy | | | | |
FORWARD OL, NCT04762498: A Phase 4, Open-label Study of KRYSTEXXA® (Pegloticase) Co-administered With Methotrexate (MTX) in Patients With Uncontrolled Gout |
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| Completed | 4 | 50 | US | Pegloticase, Methotrexate (MTX) | Amgen | Uncontrolled Gout, Chronic Gout | 05/23 | 12/23 | | |
NCT05393050: Efficacy and Safety of Colquhounia Root Tablet in Patients With Rheumatoid Arthritis |
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| Not yet recruiting | 4 | 120 | RoW | Colquhounia Root Tablet, Methotrexate tablets | Quan Jiang | Rheumatoid Arthritis | 12/23 | 06/24 | | |
ChiCTR2300072896: Cost-effectiveness of adalimumab "reduction strategies" in the treatment of rheumatoid arthritis: a multicenter, prospective, real-world observational study |
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| Not yet recruiting | 4 | 1000 | | None ;Adalimumab tapering combined with methotrexate therapy. The recommended dosage of adalimumab is as follows: Adalimumab, 40 mg/2 weeks, subcutaneous injection, reduce the dose after full dose treatment after reaching low disease activity. The dose reduction is carried out as follows: to extend the duration of administration and limiting the maximum duration of administration interval to 6 weeks (it is recommended to extend the duration of administration interval to 3, 4 or 6 weeks). The recommended dose of methotrexate is as follows: Methotrexate, taken orally, 10-30 mg once a week. ;triple therapy is applied. According to the patient's condition and willingness of patients, three traditional synthetic anti-rheumatic drug combination treatment could be applied, including but not limited to: methotrexate, leflunomide, sulfasalazine, hydroxychloroquine, etc. Recommended usage and dosage are as follows: Methotrexate, oral, 10-30 mg each time, once a week; Leflunomide, 10-20 mg once daily; Sulfasalazine, orally, 500 mg-1,000 mg each time, 3-4 times a day; Hydroxychloroquine, orally, 0.2 g to 0.4 g, once a day. | The First Affiliated Hospital of Chengdu Medical College; The First Affiliated Hospital of Chengdu Medical College, Self-funded | rheumatoid arthritis | | | | |
ChiCTR2200060763: Multicenter randomized double-blind clinical trial of Qufeng Zhitong Capsule combined with Methotrexate tablets in the treatment of rheumatoid arthritis |
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| Not yet recruiting | 4 | 200 | | Methotrexate tablet + qufeng analgesic capsule ;Methotrexate tablet + qufeng analgesic capsule simulato | Guang'anmen Hospital, China Academy of Traditional Chinese Medicine; Shandong Buchang Pharmaceutical Sales Co., LTD, Provided by the sponsor | rheumatoid arthritis | | | | |
| Active, not recruiting | 4 | 672 | Europe, Canada, US, RoW | Treatment Algorithm A, vedolizumab, Treatment Algorithm B, Treatment Algorithm C | Alimentiv Inc., Takeda Development Center Americas, Inc. | Colitis, Ulcerative | 03/26 | 03/26 | | |
| Recruiting | 4 | 153 | Europe | Methotrexate Tablets, Placebo, Folic Acid 1 MG | Diakonhjemmet Hospital, Oslo University Hospital | Hand Osteoarthritis, Erosive Osteoarthritis | 06/25 | 12/25 | | |
NCT05626348: The Clinical Efficacy of Immunomodulators in RA Patients |
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| Recruiting | 4 | 400 | RoW | Iguratimod, IGU, T-614, Methotrexate, MTX, Adalimumab Injection, adalimu, Leflunomide, LEF, Hydroxychloroquine, HCQ | Qilu Hospital of Shandong University | Arthritis, Rheumatoid | 06/25 | 12/26 | | |
2008-003235-20: Protocol for Treatment of Children (1.0 - 17.9 years of age) with AcuteLymphoblastic Leukemia Gydymo protokolas vaikų (1-17.9 metų amžiaus) ūmiai limfoblastineileukemijai gydyti |
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| Ongoing | 3/4 | 450 | Europe, RoW | Methotrexate, Mercaptopurine, Asparaginase, DepoCyte, Methotrexate, Mercaptopurine, Asparaginase, DepoCyte, Methotrexate, Mercaptopurine, Asparaginase, DepoCyte | Rigshospitalet, NOPHO, Landspítali Háskólasjúkrahús | Acute lymphoblastic leukemia | | | | |
