cyclosporine / Generic mfg. |
ChiCTR1900023476: Multicenter, prospective and open clinical study for rapamycin in the treatment of autoimmune hemolytic anemia |
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| Not yet recruiting | N/A | 80 | | glucocorticoid ;glucocorticoid & Ciclosporin ;glucocorticoid & rapamycin ;rapamycin | Tianjin Medical University General Hospital; Tianjin Medical University General Hospital, Clinical Founding | Autoimmune | | | | |
ChiCTR1800015455: Lidocaine intravenous infusion versus cyclosporine in treatment of severe atopic dermatitis aged 12-70: a multicentered, randomized, paralleled trial |
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| Not yet recruiting | N/A | 120 | | lidocaine intravenous infusion ;oral cyclosporine | Shanghai Jiaotong University School of Medecin, Xinhua hospital; Shanghai Jiaotong University School of Medecin, Xinhua hospital, Shanghai Jiaotong University School of Medecin | Atopic dermatitis | | | | |
ChiCTR1800019308: Efficacy and tolerability of multitarget therapy with NHMX for systemic lupus erythematosus |
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| Recruiting | N/A | 150 | | One kind of non-steroid anti-inflammatory drugs combines with hydroxychloroquine sulfate(≤200mg/bid) and methotrexate(7.5-20mg/w), with addition of glucocorticoid (≤0.5mg/kg·d) or cyclosporine (maintaining the drug concentration between 30-90ug/l) ;hydroxychloroquine sulfate(≤200mg/bid) and methotrexate(7.5-20mg/w), with addition of glucocorticoid (≤0.5mg/kg·d) or cyclosporine(maintaining the drug concentration between 30-90ug/l) | The Third Affiliated Hospital, Southern Medical University; The Third Affiliated Hospital, Southern Medical University, Guangdong Project of Science and Technology | systemic lupus erythematosus | | | | |
ChiCTR-IOR-16008738: A single center, randomized, controlled, opened label study for evaluating Cyclosporin alone or combined with Stanozolol in the treatment of aplastic anemia |
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| Recruiting | N/A | 200 | | Cyclosporin ;Cyclosporin and Stanozolol | The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University, The First Affiliated Hospital of Zhengzhou University Dr.Scientific Research Foundation | aplastic anemia | | | | |
ChiCTR1900024692: Comparison of the efficacy of azathioprine and cyclosporine in myasthenia gravis immune modification |
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| Recruiting | N/A | 100 | | bromopyramine + hormone ;bromopyramine + hormone + azathioprine ;bromopyramine + hormone + cyclosporine ;bromopyramine + hormone + azathioprine ;bromopyramine + hormone + cyclosporine | Neurology Department of the 940th Hospital of Joint Logistics Support force of Chinese People's Liberation Army; The 940th Hospital of the People's Liberation Army Joint Service Support Force, The National Natural Science Foundation of China (81200247) and the Natural Science Foundation of Gansu Province (1606RJZA190; 1506RJZA302) | Myasthenia Gravis | | | | |
ChiCTR1800019487: A clinical study for different infusion methods of mesenchymal stem cells in the treatment of aplastic anemia |
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| Recruiting | N/A | 60 | | Treatment regimen of ATG combined with cyclosporin immunosuppression ;MSCs+Treatment regimen of ATG combined with cyclosporin immunosuppression | Jiangmen Central Hospital; Jiangmen Central Hospital, Wu Jieping medical association foundation | Aplastic anemia | | | | |
ChiCTR2000038744: To explore the intervention effect of Xiaoyu Xiezhuo Yin on chronic cyclosporin nephropathy in patients with aplastic anemia based on autophagy and ACE2-Ang(1-7)-Mas axis |
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| Not yet recruiting | N/A | 60 | | none ;none ;Conventional treatment ;Conventional treatment+traditional Chinese medicine | The First Affiliated Hospital of ZheJiang Chinese Medical University; The First Affiliated Hospital of ZheJiang Chinese Medical University, Self-funded | Chronic cyclosporine nephropathy | | | | |
ChiCTR1900027553: Clinical therapies for patients in subtypes of non-severe aplastic anemia |
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| Not yet recruiting | N/A | 490 | | Cyclosporine ;Cyclosporine ;Cyclosporine+Danazol ;CSA+TPO+G-CSF | Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences, Tianjin Major Disease Prevention and Control Science and Technology Project | non-severe aplastic anemia | | | | |
ChiCTR2000029262: Clinical study on the relationship between SLC35 gene variation and psoriasis |
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| Not yet recruiting | N/A | 360 | | Acitretin Capsule ;Methotrexate Tablets ;ciclosporin soft capsules | Dermatology Hospital of Southern Medical University; Dermatology Hospital of Southern Medical University, Horizontal project start-up funding | psoriasis | | | | |
ChiCTR2000036709: Study on early warning of rapid progressive interstitial lung disease in dermatomyositis |
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| Not yet recruiting | N/A | 30 | | Glucocorticoid + cyclophosphamide + cyclosporin ;Glucocorticoid + cyclophosphamide + Tofacitinib | Zhongshan Hospital of Fudan University; Zhongshan Hospital of Fudan University, Shanghai Shenkang Hospital development Center | Dermatomyositis | | | | |
ChiCTR2100053501: Dexamethasone, rituximab plus cyclosporine in the treatment of adults with primary immune thrombocytopenia |
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| Recruiting | N/A | 30 | | Combination therapy | The 967th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army ; The 967th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, self-financed | primary immune thrombocytopenia (ITP) | | | | |
ChiCTR2000036690: Clinical study on precise clinical classification and treatment strategy verification of adult onset still's disease |
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| Not yet recruiting | N/A | 80 | | MTX; Cyclosporin | Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shengkang Shanghai | adult onset still's disease | | | | |
ChiCTR2000029921: Sirolimus combined with calcineurin inhibitors for steroid-ineffective/dependent cGVHD: multicenter, single-arm study |
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| Not yet recruiting | N/A | 78 | | given sirolimus capsules combined with ciclosporin(CsA) or tacrolimus(FK506) capsules | The Hematology Department of Xinqiao Hospital, the Second Affiliated Hospital of The Army Medical University; Level of the institution:, Army medical university clinical innovation training program | Steroid- ineffective/dependent cGVHD | | | | |
ChiCTR2200058433: Belimumab in combination with cyclosporine for corticosteroid-refractory primary immune thrombocytopenia in adults |
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| Not yet recruiting | N/A | 37 | | belimumab and cyclosporine | The Second Affiliated Hospital of Kunming Medical University; The Second Affiliated Hospital of Kunming Medical University, Self-financing | Primary immune thrombocytopenia | | | | |
NCT05782933: Efficacy of Rituximab Combined With Cyclosporine in the Treatment of Idiopathic Membranous Nephropathy |
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| Recruiting | N/A | 2 | RoW | Rituximab, Modified Ponticelli regimen | Beijing Friendship Hospital | Idiopathic Membranous Nephropathy | 12/23 | 12/23 | | |
NCT05571332: Efficacy and Safety of Avatrombopag Combined With IST for the Treatment of HAAA and SAA With Abnormal Liver Function |
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| Recruiting | N/A | 39 | RoW | Avatrombopag 20 MG Oral Tablet, porcine ATG, Cyclosporine(CsA) | Institute of Hematology & Blood Diseases Hospital | Aplastic Anemia | 12/23 | 06/24 | | |
ChiCTR2200065012: A Prospective Randomized Controlled Clinical Study on the Intervention of Primary Membranous Nephropathy by Strengthening the Spleen, Benefiting the Kidney and Dispelling the Wind |
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| Recruiting | N/A | 228 | | Use the following regimens in addition to basic treatment: 0-24 weeks (trial): the subjects take Moshen granule, one bag Bid, after meals. 24-48 weeks (follow-up) :Continue to use a scale of 0-24 weeks Experimental group. ;Use the following regimens in addition to basic treatment: 0-24 weeks (trial): the subjects take Moshen granule simulant, once in the morning and evening, one bag at a time, after meals. 24-48 weeks (follow-up) :Continue to use a scale of 0-24 weeks. ;Membranous kidney Membranous kidney granules, 1 bag Bid, after meals. Cyclosporine was also taken orally in two equal doses with an interval of 12 hours. Week 24-48 (follow-up) : The 0-24 week regimen was continued. ;Moshen granule simulant 1 bag Bid, after meals. Cyclosporine was also taken orally in two equal doses with an interval of 12 hours. Week 24-48 (follow-up) : The 0-24 week regimen was continued. | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Science and Technology Ministry,National key research and development program-Special Research Project on Modernization of traditional Chinese Medicine | Primary membranous nephropathy | | | | |
NCT02845596: Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia |
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| Active, not recruiting | N/A | 40 | US | cyclosporine, Matched Unrelated Donor Hematopoietic Stem Cell Transplant, horse anti-thymocyte globulin (ATG), ATGAM, rabbit anti-thymocyte globulin (ATG), Thymoglobulin, methotrexate, fludarabine, cyclophosphamide, low-dose total body irradiation (TBI), Immunosuppressive Therapy (IST) | Michael Pulsipher, MD | Severe Aplastic Anemia | 04/24 | 04/24 | | |
ChiCTR2000031716: Study of cyclosporine in improving the prognosis of recurrent pregnancy with unexplained recurrent spontaneous abortion |
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| Not yet recruiting | N/A | 572 | | Cyclosporine ;Dydrogesterone | Obstetrics & Gynecology Hospital of Fudan University; Obstetrics & Gynecology Hospital of Fudan University, Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | unexplained recurrent spontaneous abortion | | | | |
ChiCTR2200059843: Computer simulation model based on physiologically based pharmacokinetic to guide the individualized drug administration strategy of posaconazole in pediatric |
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| Not yet recruiting | N/A | 278 | | Before the 7th day of medication, blood samples were collected for the determination of posaconazole concentration ;Before the 7th day of medication, blood samples were collected for the determination of posaconazole and cyclosporine concentrations ;PBPK model prediction were used to guide the individual prescription of Posaconazole ;Before the 7th day of medication, blood samples were collected for the determination of posaconazole concentration ;PBPK model prediction were used to guide the individual prescription of Posaconazole and cyclosporine ;Before the 7th day of medication, blood samples were collected for the determination of posaconazole and cyclosporine concentrations | Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University; Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai Health Commission Clinical Research Fund | Prevention or treatment of invasive fungal disease | | | | |
| Active, not recruiting | N/A | 249 | Europe | Cyclosporine, Sandimmun Neural, Mycophenolate mofetil (MMF), Cellcept, Rabbit Anti thymocyte globulin, Thymoglobulin®, Corticosteroids, Methylprednisolon, Tacrolimus, Advagraf® | Vastra Gotaland Region, Oslo University Hospital, Helsinki University Central Hospital, Skane University Hospital, Copenhagen University Hospital, Denmark | Lung Transplantation, Allografts | 10/25 | 10/26 | | |
TOCASU, NCT05112263: Tofacitinib Versus Cyclosporine for Steroid Refractory Acute Severe Ulcerative Colitis |
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| Not yet recruiting | N/A | 96 | NA | Tofacitinib, Cyclosporine | Postgraduate Institute of Medical Education and Research, All India Institute of Medical Sciences, New Delhi | Ulcerative Colitis | 12/25 | 06/26 | | |
ChiCTR2300070171: Clinical Multicenter Study of Tocilizumab in the Treatment of sJIA-MAS |
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| Not yet recruiting | N/A | 90 | | Cyclosporin ;Tocilizumab (Use on the fourth day) ;Tocilizumab (For use on the eighth day) | Children's Hospital, Zhejiang University School of Medicine; Children's Hospital, Zhejiang University School of Medicine, Zhejiang Lingyan Project | Juvenile idiopathic arthritis complicated with macrophage activation syndrome | | | | |
NCT05936086: A Randomized Controlled Study of High-dose Cyclophosphamide Induction Therapy in Adult Patients With HLH |
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| Recruiting | N/A | 160 | RoW | Cytoxan, Etoposide, VP16, Dexamethasone, Cyclosporine (CSA) | shifeng Lou | Hemophagocytic Syndrome | 04/26 | 05/27 | | |
| Recruiting | N/A | 38 | | | Sinclair Dermatology, Australia Alopecia Areata Foundation | Alopecia areata | | | | |
NCT05588869: Cyclosporine Adverse Outcomes in Steroid Dependent and Frequent Relapsing Nephrotic Syndrome in Children;Single Center Study |
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| Not yet recruiting | N/A | 30 | RoW | observation of the adverse outcomes of Cyclosporine in steroid dependent and frequent relapsing nephrotic syndrome in children | Sohag University | Steroid Dependent and Frequent Relapsing Nephrotic Syndrome | 04/23 | 04/23 | | |
NCT05120687: Corticosteroid Combining Noncorticosteroid Systemic Immunomodulatory Therapy in VKH |
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| Recruiting | N/A | 200 | RoW | noncorticosteroid systemic immunomodulatory therapy (NCSIT), Methotrexate, Adalimumab, cyclophosphamide, Cyclosporin, Mycophenolate Mofetil | Sun Yat-sen University | Vogt Koyanagi Harada Disease (VKH) | 10/24 | 10/25 | | |
pSS, NCT05605314: Clinical Cohort Study in Patients With Different Subtypes of Primary Sjogren Syndrome Related Dry Eye |
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| Recruiting | N/A | 500 | RoW | Cyclosporine | Peking University Third Hospital | Dry Eye | 01/27 | 01/28 | | |
| Recruiting | N/A | 2500 | Europe | Ciclosporin, Methotrexate, Dupilumab, Corticosteroids, Omalizumab, Baricitinib, Upadacitinib, Tralokimumab, Topical corticosteroids | Fundación Academia Española de Dermatología | Dermatitis, Atopic | 01/29 | 01/29 | | |