Congenital Abnormalities  >>  cyclosporine  >>  Phase 2
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17 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
cyclosporine / Generic mfg.
NCT00053014: S0125, Chemotherapy, Total-Body Irradiation, and Peripheral Stem Cell Transplantation in Treating Older Patients With Acute Myeloid Leukemia

Terminated
2
5
US
therapeutic allogeneic lymphocytes, cyclosporine, fludarabine, mycophenolate mofetil, MMF, peripheral blood stem cell transplantation, radiation therapy
Southwest Oncology Group, National Cancer Institute (NCI)
Leukemia
06/05
06/06
NCT00003116: High-Dose Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer

Completed
2
66
US
filgrastim, busulfan, cyclophosphamide, cyclosporine, bone marrow ablation with stem cell support, peripheral blood stem cell transplantation
Case Comprehensive Cancer Center, National Cancer Institute (NCI)
Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
03/06
06/09
NCT00089050: Gemtuzumab Ozogamicin and Cyclosporine in Treating Older Patients With Relapsed Acute Myeloid Leukemia

Completed
2
US
cyclosporine, gemtuzumab ozogamicin
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Leukemia
 
03/06
NCT00066417: Peripheral Stem Cell Transplant in Treating Patients With High-Risk Leukemia

Terminated
2
51
US
cyclophosphamide, cyclosporine, fludarabine phosphate, methylprednisolone, therapeutic allogeneic lymphocytes, thiotepa, allogeneic bone marrow transplantation, biological therapy, bone marrow ablation with stem cell support, bone marrow transplantation, chemotherapy, leukocyte therapy, non-specific immune-modulator therapy, peripheral blood lymphocyte therapy, peripheral blood stem cell transplantation, radiation therapy
National Heart, Lung, and Blood Institute (NHLBI)
Chronic Myeloproliferative Disorders, Leukemia, Myelodysplastic/Myeloproliferative Diseases
 
01/07
NCT00066794: S0301 Cyclosporine, Daunorubicin, and Cytarabine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia

Completed
2
69
US
filgrastim, sargramostim, cyclosporine, cytarabine, daunorubicin hydrochloride
Southwest Oncology Group, National Cancer Institute (NCI)
Leukemia
02/07
01/10
NCT00003335: Umbilical Cord Blood Transplantation in Treating Patients With High-Risk Hematologic Cancer

Completed
2
44
US
anti-thymocyte globulin, busulfan, cyclosporine, melphalan, methylprednisolone, umbilical cord blood transplantation, radiation therapy
Case Comprehensive Cancer Center, National Cancer Institute (NCI)
Graft Versus Host Disease, Leukemia, Lymphoma, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
11/07
01/12
NCT00317785: Total-Body Irradiation and Cyclophosphamide in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer and Other Diseases

Completed
2
50
US
cyclophosphamide, cyclosporine, methotrexate, mycophenolate mofetil, sirolimus, tacrolimus, pharmacological study, allogeneic bone marrow transplantation, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation, total-body irradiation
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Leukemia, Lymphoma, Myelodysplastic Syndromes
11/07
 
NCT00281879: Donor Stem Cell Transplant or Donor White Blood Cell Infusions in Treating Patients With Hematologic Cancer

Terminated
2
200
US
anti-thymocyte globulin, ATG, filgrastim, G-CSF, busulfan, carmustine, cyclophosphamide, cyclosporine, cytarabine, etoposide, fludarabine phosphate, melphalan, methotrexate, methylprednisolone, mycophenolate mofetil, tacrolimus, FK-506, peripheral blood stem cell transplantation, umbilical cord blood transplantation, radiation therapy
OHSU Knight Cancer Institute, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Unusual Cancers of Childhood
02/08
03/08
NCT00354172: Donor Umbilical Cord Blood Natural Killer Cells, Aldesleukin and Umbilical Cord Blood Transplant in Patients With Refractory Hematologic Cancers.

Terminated
2
16
US
aldesleukin, IL-2, interleukin-2, filgrastim, granulocyte colony-stimulating factor (G-CSF), natural killer cell (NK) therapy, NK cells, cyclophosphamide, Cytoxan, cyclosporine, cyclosporin, fludarabine phosphate, Fludara, methylprednisolone, Medrol, Solu-Medrol, Depo-Medrol, methylprednisolone sodium succinate, mycophenolate mofetil, mycophenolic acid, Umbilical Cord Blood Transplantation (UCBT), allogeneic transplant, Total body irradiation (TBI), radiation
Masonic Cancer Center, University of Minnesota
Leukemia, Myelodysplastic Syndromes
08/08
08/08
NCT00027560: Melphalan, Fludarabine, and Alemtuzumab Followed by Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer

Completed
2
51
US
alemtuzumab, Campath, cyclosporine, fludarabine phosphate, melphalan, allogeneic bone marrow transplantation, peripheral blood stem cell transplantation
Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI)
Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
04/09
04/09
NCT00619645: Donor Peripheral Stem Cell Transplant, Fludarabine, and Busulfan in Treating Patients With Hematologic Cancers

Completed
2
8
US
busulfan, cyclosporine, fludarabine phosphate, mycophenolate mofetil, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation
University of California, Davis
Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
10/13
11/13
NCT00081055: OTI-010 for Graft-Versus-Host Disease Prophylaxis in Treating Patients Who Are Undergoing Donor Peripheral Stem Cell Transplantation for Hematologic Malignancies

Withdrawn
2
0
US
autologous expanded mesenchymal stem cells OTI-010, busulfan, cyclophosphamide, cyclosporine, methotrexate, peripheral blood stem cell transplantation, radiation therapy
Mesoblast International Sàrl, National Cancer Institute (NCI)
Graft Versus Host Disease, Leukemia, Myelodysplastic Syndromes
 
 
NCT01020734: Donor Stem Cell Transplant or Bone Marrow Transplant in Treating Patients With Acute Myeloid Leukemia in Remission

Completed
2
263
RoW
anti-thymocyte globulin, busulfan, cyclophosphamide, cyclosporine, fludarabine phosphate, methotrexate, allogeneic hematopoietic stem cell transplantation
Asan Medical Center
Leukemia
07/15
07/15
NCT00365287: Combination Chemotherapy and Total-Body Irradiation Before Donor Umbilical Cord Blood Transplant in Treating Patients With Advanced Hematologic Cancer, Metastatic Breast Cancer, or Kidney Cancer

Completed
1/2
148
NA
anti-thymocyte globulin, cyclophosphamide, cyclosporine, fludarabine phosphate, mycophenolate mofetil, radiation therapy, umbilical cord blood transplantation
Masonic Cancer Center, University of Minnesota, National Cancer Institute (NCI)
Breast Cancer, Kidney Cancer, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
12/05
12/05
NCT00054340: Combination Chemotherapy and Antithymocyte Globulin in Reducing Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplantation For Myelodysplastic Syndrome or Myeloproliferative Disorder

Completed
1/2
US
anti-thymocyte globulin, busulfan, cyclophosphamide, cyclosporine, methotrexate, allogeneic bone marrow transplantation, peripheral blood stem cell transplantation
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
 
09/06
NCT00816413: Donor Stem Cell Transplant, Pentostatin, and Total-Body Irradiation in Treating Patients With Hematological Cancer

Withdrawn
1/2
0
NA
cyclosporine, Gengraf, Neoral, and Sandimmune, mycophenolate mofetil, CellCept, pentostatin, Nipent, cytogenetic analysis, fluorescence in situ hybridization, protein analysis, flow cytometry, immunoenzyme technique, laboratory biomarker analysis, reduced-intensity transplant conditioning procedure, nonmyeloablative allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation (PBSC), total-body irradiation
University of Nebraska, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Myelodysplastic Syndromes, Nonmalignant Neoplasm
02/10
02/10
NCT00245037: Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer

Completed
1/2
147
US
therapeutic allogeneic lymphocytes, busulfan, cyclosporine, fludarabine phosphate, mycophenolate mofetil, peripheral blood stem cell transplantation, Total Body Irradiation (TBI), Granulocyte colony-stimulating factor (G-CSF), Phenytoin, Methotrexate
OHSU Knight Cancer Institute, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Precancerous Condition
08/15
08/15

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