Anemia, Aplastic  >>  cyclosporine  >>  Phase 2
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9 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
cyclosporine / Generic mfg.
MINI HEME, NCT00636909: Nonmyeloablative Allo SCT for the Treatment of Hematologic Disorders

Completed
2
25
NA
Cyclophosphamide, fludarabine, cyclosporine, methotrexate, G-CSF
Beth Israel Deaconess Medical Center, Amgen
AML, ALL, CML Chronic Phase, Accelerated Phase, or Blast Crisis, CLL, MDS, RELAPSED NON-HODGKIN'S OR HODGKIN'S LYMPHOMA, APLASTIC ANEMIA, MULTIPLE MYELOMA, MYELOPROLIFERATIVE DISORDER (P Vera, CMML, ET)
03/06
 
NCT00533923: Nonmyeloablative Allogeneic Stem Cell Transplantation From HLA-Matched Unrelated Donor for the Treatment of Hematologic Disorders

Completed
2
25
US
Cyclophosphamide; Fludarabine; Cyclosporin; CAMPATH-1H (Alemtuzumab); GM-CSF, Cytoxan;, Fludara;, Leukine;
Beth Israel Deaconess Medical Center, Bayer
AML, ALL, CLL, Myelodysplastic Syndrome, Non-Hodgkin's Lymphoma, Hodgkin's Lymphoma, Multiple Myeloma, Aplastic Anemia, Myeloproliferative Disorder
01/07
01/07
NCT00005852: Bone Marrow Transplantation in Treating Patients With Severe Aplastic Anemia or Rejection of Previous Bone Marrow Transplant

Terminated
2
US
anti-thymocyte globulin, filgrastim, muromonab-CD3, cyclophosphamide, cyclosporine, methylprednisolone, allogeneic bone marrow transplantation
H. Lee Moffitt Cancer Center and Research Institute, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
07/07
07/07
NCT00301834: Alemtuzumab, Fludarabine, and Busulfan Followed By Donor Stem Cell Transplant in Treating Young Patients With Hematologic Disorders

Completed
2
35
US
alemtuzumab, busulfan, cyclosporine, fludarabine phosphate, methotrexate, methylprednisolone, allogeneic bone marrow transplantation, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation, umbilical cord blood transplantation
University of California, San Francisco, National Cancer Institute (NCI)
Congenital Amegakaryocytic Thrombocytopenia, Diamond-blackfan Anemia, Leukemia, Myelodysplastic Syndromes, Severe Congenital Neutropenia
09/11
09/11
NCT01530555: Prospective Phase II Study of Rabbit Antithymocyte Globulin (ATG, Thymoglobuline®, Genzyme) With Ciclosporin for Patients With Acquired Aplastic Anaemia

Completed
2
35
US, RoW
Rabbit ATG, Thymoglobuline (Genzyme)
King Faisal Specialist Hospital & Research Center
Acquired Aplastic Anaemia
07/13
07/13
NCT00260689: Three Immunosuppressive Treatment Regimens for Severe Aplastic Anemia

Completed
2
136
US
Anti-thymocyte globulin (rabbit), Anti-thymocyte globulin (horse), Cyclosporine, Alemtuzumab, Campath
National Heart, Lung, and Blood Institute (NHLBI)
Immunosuppresion, Thrombocytopenia, Pancytopenia, Neutropenia
05/16
05/16
NCT00987480: Hematopoietic Stem Cell Transplantation for the Treatment of Patients With Fanconi Anemia Lacking a Genotypically Identical Donor, Using a Chemotherapy Only Cytoreduction With Busulfan, Cyclophosphamide and Fludarabine

Completed
2
45
US
Busulfan, fludarabine, & cyclophosphamide with immunosuppression with ATG and cyclosporine., CliniMACS device
Memorial Sloan Kettering Cancer Center, Boston Children's Hospital, Children's Hospital Medical Center, Cincinnati, Children's Hospital and Health System Foundation, Wisconsin, Rockefeller University, Fred Hutchinson Cancer Center
Aplastic Anemia, Leukemia, Myelodysplastic Syndrome
07/17
07/17
NCT00816413: Donor Stem Cell Transplant, Pentostatin, and Total-Body Irradiation in Treating Patients With Hematological Cancer

Withdrawn
1/2
0
NA
cyclosporine, Gengraf, Neoral, and Sandimmune, mycophenolate mofetil, CellCept, pentostatin, Nipent, cytogenetic analysis, fluorescence in situ hybridization, protein analysis, flow cytometry, immunoenzyme technique, laboratory biomarker analysis, reduced-intensity transplant conditioning procedure, nonmyeloablative allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation (PBSC), total-body irradiation
University of Nebraska, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Myelodysplastic Syndromes, Nonmalignant Neoplasm
02/10
02/10
NCT01193283: Cyclophosphamide Plus Cyclosporine in Treatment-Naive Severe Aplastic Anemia

Completed
1/2
22
US
Cyclophosphamide, Cytoxan, Cyclosporine, Gengraf, Neoral, Sandimmune
National Heart, Lung, and Blood Institute (NHLBI)
Aplastic Anemia, Neutropenia, Pancytopenia, Severe Aplastic Anemia
09/14
09/14

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