| bivalirudin / Generic mfg. |
2009-014343-36: RANDOMIZED TRIAL OF PRASUGREL PLUS BIVALIRUDIN VERSUS CLOPIDOGREL PLUS HEPARIN IN PATIENTS WITH ACUTE STEMI BAVARIAN REPERFUSION ALTERNATIVES EVALUATION [BRAVE-4] TRIAL |
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| Ongoing | 4 | 1240 | Europe | Prasugrel, Bivalirudin, Heparin, Plavix, B01AC22, Efient, Angiox, Heparin-Natrium, Plavix, Efient, Angiox, Heparin-Natrium, Plavix | Deutsches Herzzentrum | Acute myocardial infarction | | | | |
2010-023779-24: A Comparison of Drug Eluting and Bare Metal Stents with Bivalirudin during PCI or Bivalirudin for 4 hours in Acute Coronary Syndromes. The Eindhoven Reperfusion Study |
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| Ongoing | 4 | 1800 | Europe | Angiox, Angiox, Angiox | Stichting Toegepast Caridologisch Onderzoek | Patients with ACS who are scheduled for primary PCI (STEMI) or for immediate PCI < 2.5 hours or early PCI < 48 hours (NSTEMI) and who are pre-treated with HLD clopidogrel | | | | |
ChiCTR-IPR-14005315: The effect of thrombosis aspiration combined ticagrelor on myocardial perfusion and prognosis of primary PCI for STEMI |
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| Recruiting | 4 | 300 | | asprin+ticagrelor+heparin ;asprin+ticagrelor+bivalirudin ;asprin+clopidogrel+heparin | Kanghua Hospital; Kanghua Hospital, Dongguan Kanghua Hospital Heart Center Sunshine Fund | ST segment elevation myocardial infarction | | | | |
| Recruiting | 4 | 600 | | Aspirin and clopidogrel and heparin ;Aspirin and ticagrelor and bivalirudin | The Second Hospital, Hebei Medical University; The Second Hospital, Hebei Medical University, government fund | coronary heart disease | | | | |
ChiCTR-IPR-16009179: The influence of the prognosis of increasing the antiplatelet therapy of the patient of ACS before PCI |
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| Recruiting | 4 | 280 | | Bivalirudin + ticagrelor + aspirin ;Ticagrelor + aspirin + heparin ;Aspirin + clopidogrel + aspirin ;Heparin + clopidogrel + aspirin | The second hospital of Hebei Medical University; The second hospital of Hebei Medical University, self-raised | Coronary Heart Disease | | | | |
ChiCTR1800016783: Clinical efficacy and safety of bivaroxaladine in elderly patients undergoing percutaneous coronary intervention |
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| Completed | 4 | 200 | | Bivalirudin as the procedural anticoagulant agent ;Heparin as the procedural anticoagulant agent | Panzhihua Central Hospital; Panzhihua Central Hospital, Jiangsu Hengrui Medicine Co., Ltd. | coronary heart disease | | | | |
| Not yet recruiting | 4 | 1000 | | Low-dose bivalirudin only in PCI ;Low-dose bivalirudin after UFH in PCI ;UFH only in PCI | Characteristic Medical Center of People's Armed Police; Characteristic Medical Center of People's Armed Police, None | Acute Coronary Syndrome | | | | |
ChiCTR1800016751: Multi-Center Registry Trial of Bivalirudin for Chinese Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention |
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| Recruiting | 4 | 2000 | | Bivalirudin, in combination with antiplatelet agents such as aspirin, P2Y12 inhibitors, and glycoprotein IIb/IIIa inhibitors | The First Affiliated Hospital of USTC (Anhui Provincial Hospital); The First Affiliated Hospital of USTC (Anhui Provincial Hospital), the research was sponsored by Salubris Pharmaceutical Co (Shenzhen, China). | Coronary Artery Disease | | | | |
ChiCTR1900024196: Therapeutic effect of bivalirudin on interventional therapy for chronic total occlusion of coronary artery |
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| Recruiting | 4 | 100 | | Bivalirudin ;Heparin sodium injection | The Affiliated Hospital of Southwest Medical University; The Affiliated Hospital of Southwest Medical University, JIANG SU HENG RUI MEDICINE CO,.LTD | Chronic total occlusion | | | | |
ChiCTR1900022529: Effect of bivalirudin combined with ticagrelor in patients with ST-segment elevation myocardial infarction during primary percutaneous coronary intervention |
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| Recruiting | 4 | 800 | | Bivalirudin combined with ticagrelor ;heparin combined with ticagrelor | The First Affiliated Hospital of USTC (Anhui Provincial Hospital); The First Affiliated Hospital of USTC (Anhui Provincial Hospital), the open project of Anhui Provincial Cardiovascular Institute (KF2018007) | Coronary Artery Disease | | | | |
ChiCTR2000038371: Efficacy and safety of bivalirudin versus heparin in patients with atrial fibrillation and non ST segment elevation acute coronary syndrome undergoing percutaneous coronary intervention |
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| Recruiting | 4 | 454 | | Bivalirudin ;heparin | The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, Jiangsu Hengrui Pharmaceutical Co., Ltd. | Atrial fibriliation and non-st-segment elevation acute coronary syndrome | | | | |
ChiCTR2000035602: Efficacy and safety of Bivarudine in post-thrombolytic PCI in patients with ST-segment elevation myocardial infarction: a multicentre, prospective, randomized controlled trial |
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| Not yet recruiting | 4 | 624 | | Bivalirudin ;Heparin | Tangdu Hospital of Air Force Millitary Medical University; Tangdu Hospital of Air Force Millitary Medical University, CHINESE RED CROSS FOUNDATION | ST-segment elevation myocardial infarction | | | | |
NCT03664180: Comparison of Anticoagulation Prolongation vs. no Anticoagulation in STEMI Patients After Primary PCI |
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| Completed | 4 | 2989 | RoW | Bivalirudin, Enoxaparin, Unfractionated heparin, Bivalirudin placebo, Enoxaparin placebo syringe, Unfractionated heparin placebo | Beijing Anzhen Hospital, Chinese Academy of Medical Sciences, Fuwai Hospital, ACTION Study Group (Pitié-Salpêtrière Hospital), Paris, France | STEMI - ST Elevation Myocardial Infarction | 11/22 | 11/22 | | |
PCI, NCT05984537: A Study on the Impact of Bivalirudin Usage During for High-risk Plaques on Post- Coronary Microcirculation. |
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| Recruiting | 4 | 70 | RoW | Bivalirudin, bivalirudin anticoagulation, standard heparin, standard heparin anticoagulation | Peking University First Hospital | Coronary Microvascular Dysfunction | 03/25 | 03/25 | | |
ChiCTR2200064363: Bivalirudin infusion at standard or low regimen during elective percutaneous coronary intervention in patients with acute coronary syndrome: a prospective, single-center, randomized controlled study |
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| Recruiting | 4 | 2510 | | Bivalirudin infusion at standard regimen ;Bivalirudin infusion at low (standard of 80 percent) regimen | The PLA Northern Theater Command General Hospital ; General Hospital of Northern Theater Command, None | acute coronary syndrome | | | | |
2012-003515-58: Comparative effectiveness of 1 month of ticagrelor plus aspirin followed by ticagrelor on its own versus a current-day intensive antiplatelet therapy with 2 antiplatelet drugs in patients who are having a stent inserted into their coronary artery. |
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| Ongoing | 3/4 | 2000 | Europe | Brilique, Aspirin, Clopidogrel, Acetylsalicylic Acid, Brilique, Brilique | ECRI, , European Cardiovascular Research Institute, Biosensors Europe SA, Astra Zeneca, The Medicines Company, | Subjects either male or female eligible for percutaneous coronary intervention (PCI) with lesions suitable for stent implantation who meet all eligibility criteria and provide written informed consent will be included. Of note, inclusion criteria will be kept comprehensive to reflect routine clinical practice (i.e. “real world, all-comers” patients). | | | | |
2012-001952-20: UTILIZZO DELLA BIVALIRUDINA PIU' IMPIANTO DI STENT IN LESIONI CORONARICHE LUNGHE NEL PREVENIRE LA MIONECROSI PERIPROCEDURALE UTILIZZO DELLA BIVALIRUDINA PIU' IMPIANTO DI STENT IN LESIONI CORONARICHE LUNGHE NEL PREVENIRE LA MIONECROSI PERIPROCEDURALE |
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| Ongoing | 3 | 204 | Europe | Powder for solution for injection, Solution for injection, ANGIOX*EV 10F 250MG, EPARINA BMS*1FL 5ML 5000UI/ML | AZIENDA UNIVERSITARIA POLICLINICO UMBERTO I DI ROMA, POLICLICNICO UMBERTO I | patients with coronary artery disease after stent implantation in coronary long lesions (>25 mm) and undergoing non urgent percutaneous coronary intervention. Pazienti con malattia coronarica caratterizzata da stenosi di lunghezza superiore a 25 mm e rivascolarizzati mediante angiopolastica coronarica percutanea elettiva ed impianto di stent., patients with coronary artery disease after stent implantation in coronary long lesions (>25 mm) and undergoing non urgent percutaneous coronary intervention. Pazienti con malattia coronarica caratterizzata da stenosi di lunghezza superiore a 25 mm e rivascolarizzati mediante angiopolastica coronarica percutanea elettiva ed impianto di stent., Diseases [C] - Cardiovascular Diseases [C14] | | | | |
BUILD, NCT04532333: Efficacy and Safety of Bivalirudin Versus Heparin During Coil Embolization in Patients With Ruptured Intracranial Aneurysms |
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| Not yet recruiting | 3 | 236 | NA | Bivalirudin 250 MG Injection, Heparin | Changhai Hospital, The First Affiliated Hospital of Zhengzhou University, Zhejiang University, Wuhan University, Qilu Hospital of Shandong University, The First People's Hospital of Changzhou | Subarachnoid Hemorrhage, Aneurysmal | 05/21 | 06/21 | | |
ChiCTR2300068895: Comparative study on anticoagulant effect of bivalirudin and heparin in thrombolytic therapy of acute deep venous thrombosis of lower extremities |
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| Not yet recruiting | 3 | 28 | | bivarudine ;low molecular weight heparin | Guangdong Provincial People's Hospital; Guangdong Provincial People's Hospital, no | acute deep venous thrombosis of lower extremities | | | | |
| Not yet recruiting | 2 | 80 | RoW | Unfractionated heparin, Heparin, Bivalirudin | Sydney Local Health District | Extracorporeal Membrane Oxygenation Complication | 09/25 | 05/26 | | |
ChiCTR-OO-13003478: Pharmacokinetics and Pharmacodynamics Study of Bivalirudin in Healthy Chinese Adult Subjects |
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| Completed | 1 | 30 | | 0.5mg/kg ;0.25mg/kg ;0.75mg/kg | Second Affiliated hospital of Tianjin University of Traditional Chinese Medicine; Level of the institution：, the Construction of traditional Chinese medicine clinical evaluation of new drug research technology platform (2012ZX09303-010) | percutaneous transluminal coronary angioplasty | | | | |
ChiCTR-TQR-14004752: A tolerability, pharmacokinetics and phamacodynamics phase Ⅰclinical trial of intravenous infusions of Recombinant Neutrophil inhibitory factor and Hirulog Hbrid in healthy volunteers |
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| Not yet recruiting | 1 | 42 | | Recombinant Neutrophil inhibitory factor and Hirul ;0.9% NS | West China Hospital, Sichuan University; West China Hospital，Sichuan University, Chongqing Fagen biomedical INC, | stroke | | | | |
ChiCTR-TRC-13003607: The effect of Low molecular heparin or Bivalirudin on platelets during the use of Intra-Aortic Balloon Pumps |
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| Completed | N/A | 60 | | the Low molecular heparin; Bivalirudin | Guangzhou Military Hospital; Level of the institution：, Project funding | The association of thrombocytopenia with the IABP | | | | |
ChiCTR1800017280: Intracoronary vs Intravenous of Full Loading dose Bivalirudin Followed by Standard Intravenous Infusion in PPCI of STEMI: A prospective, Randomized, Contronelled Trial |
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| Recruiting | N/A | 460 | | Intracoronary loading dose of Bivalirudin ;Intravenous loading dose of Bivalirudin | Guangzhou Red Cross Hospital; Guangzhou Red Cross Hospital, NONE | STEMI | | | | |
ChiCTR2000034771: Bivalirudin versus Unfractionated Heparin during Percutaneous Coronary Intervention in Patients at High Risk of Bleeding with Acute Coronary Syndrome in Contemporary Practice |
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| Not yet recruiting | N/A | 800 | | N/A | The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University, N/A | coronary atherosclerotic heart disease | | | | |
| Recruiting | N/A | 168 | | Use Bivalirudin in TAVI ;Ordinary heparin | West China Hospital; West China Hospital, Sichuan University, Shenzhen Xinlitai Pharmaceutical Co., Lt | Aortic stenosis | | | | |
| Not yet recruiting | N/A | 166 | | Bivalirudin as the procedural anticoagulant agent ;Heparin as the procedural anticoagulant agent | West China Hospital, Sichuan University; West China Hospital, Shenzhen salubris pharmaceuticals Limited by Share Ltd | aortic stenosis | | | | |
BRIGHT-4, NCT03822975: Bivalirudin With Prolonged Full Dose Infusion Versus Heparin Alone During Emergency PCI |
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| Active, not recruiting | N/A | 6016 | RoW | Bivalirudin, unfractionated Heparin | Shenyang Northern Hospital | ST Elevation Myocardial Infarction | 05/22 | 05/23 | | |
NCT04475835: Safety and Efficacy of Bivalirudin During Short-term Intervention of Non-infarction Related Artery After PPCI of STEMI |
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| Recruiting | N/A | 100 | RoW | Bivalirudin, Heparin | First Affiliated Hospital Xi'an Jiaotong University | STEMI With Multivessel Coronary Disease | 12/22 | 12/22 | | |
NCT06275555: Use of Bivalirudin for Anticoagulation in Patients With Extracorporeal Membrane Oxygenation |
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| Not yet recruiting | N/A | 154 | RoW | bivalirudin, unfractionated heparin | Xiaotong Hou | Extracorporeal Membrane Oxygenation Complication | 03/25 | 12/25 | | |
NCT03532399: Pharmacokinetics of Bivalirudin for Pediatric Anticoagulation |
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| Recruiting | N/A | 30 | US | Bivalirudin | Boston Children's Hospital | Drug Effect | 05/26 | 05/26 | | |
NCT03537586: A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction |
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| Recruiting | N/A | 165 | US | Bivalirudin, Angiomax, Adenosine, Adenoscan, Heparin, Pressure-Temperature Sensor Guidewire, Pressure Wire X, Guiding Catheter, 6F Launcher Guide Catheter | NYU Langone Health | Coronary Microvascular Disease, Ischemic Heart Disease, Myocardial Ischemia | 06/25 | 06/26 | | |