Not yet recruiting

4

50

 

Peter Larsen

Acute Coronary Syndrome

 

 

Not yet recruiting

4

100

 

Professor Rob Doughty, Auckland Academic Health Alliance, Heart Foundation of New Zealand

Secondary prevention post-acute coronary syndrome, cardiovascular disease

 

 

Not yet recruiting

4

1770

 

Professor Rob Doughty, NZ Health Research Council

Secondary prevention post-acute coronary syndromes; Cardiovascular Disease

 

 

Recruiting

4

80

 

Fiona Stanley Hospital, Diabetes Research WA

Diabetes mellitus, Acute coronary syndrome

 

 

Ongoing

4

80

Europe

Lescol, Diovan, PRAVASTATIN "RATIOPHARM", Tablet, Lescol, Diovan, PRAVASTATIN "RATIOPHARM"

Div. of Cardiology, Innsbruck Medical University

Acute coronary syndrome; patients with NSTEMI

 

 

Completed

4

300

 

Receive FraxiParine at a dose of 0.01 ml per kilogram of body weight twice daily by subcutaneous injection for two to eight days ;Receive fondaparinux at a dose of 2.5 mg once daily by subcutaneous injection until hospital discharge or for up to eight days.

Beijing Anzhen Hospital, Capital Medical University; Level of the institution：, Self-financing and received sponsorship from GlaxoSmithKline-China

acute coronary syndrome without ST-segment elevation

 

 

Completed

4

100

 

the normal therapy and berberine (0.5 Bid) , one month ;the normal therapy

Xin Hua Hospital affiliated to Shanghai Jiaotong University School of Medicine; Science and Technology Commission of Shanghai Municipality, Science and Technology Commission of Shanghai Municipality

acute coronary syndrome

 

 

Completed

4

 

Zhongshan Hospital, Fudan University; Level of the institution：, China National Funds for Distinguished Young Scientis(30725036)

Coronary artery disease

 

 

Ongoing

4

100

Europe

Coated tablet, EFIENT*28CPR RIV 10MG, BRILIQUE*56CPR RIV 90MG

UNIVERSITA' CAMPUS BIOMEDICO, UNIVERSITA' CAMPUS BIO-MEDICO DI ROMA

ACUTE CORONARY SYNDROME SINDROME CORONARICA ACUTA, ACUTE CORONARY SYNDROME SINDROME CORONARICA ACUTA, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Ongoing

4

25

Europe

Film-coated tablet, Tablet

A.O. UNIVERSITARIA INTEGRATA DI VERONA, Regione Veneto

Patients with acute coronary syndromes without ST-segment elevation (NSTEACS). Pazienti con sindrome coronaria acuta senza sopraslivellamento del tratto ST (NSTEACS)., Unstable coronary condition prone to ischaemic recurrences and other complications that may lead to death or myocardial infarction in the short and long term. Condizione coronarica instabile con episodi ischemici e altre complicazioni che possono portare a infarto nel breve e lungo termine, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Completed

4

210

 

Taking Danlou Tablets Capsule ;Taking Placebo

Guangdong Provincial Hospital of Traditional Chinese Medicine; Guangdong Provincial Hospital of Traditional Chinese Medicine, The Research Program jointly hosted by the Department of Science and Technology and the Academy of Traditional Chinese Medicine of Guangdong Province(No.2012A032500013)

Acute Coronary Syndrome

 

 

Completed

4

400

 

omeprazole ;lansoprazole ;Rabeprazole ;Rabeprazole

Affiliated Jiangyin Hospital, College of Medicine, Southeast University; Affiliated Jiangyin Hospital, College of Medicine, Southeast University, Supported by the Research Project and investigator

coronary heart disease

 

 

Completed

4

100

 

Ticagrelor ;clopidogrel

Cardiology of Zhujiang hospital; Level of the institution：, China cardiovascular physician research fund

Acute coronary syndrome

 

 

Ongoing

4

20

Europe

Atorvastatin, Film-coated tablet

University Hospitals of North Midlands NHS Trust

1. New onset angina 2. Acute coronary syndromes (ACS) to include ST elevation ACS and None ST elevation ACS, 1. Newly diagnosed angina2. Participants admitted with a heart attack, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Ongoing

4

90

Europe

Ticagrelor, EFIENT, Film-coated tablet, BRILIQUE - 90 MG - COMPRESSE RIVESTITE CON FILM - USO ORALE - BLISTER(PVC/PVDC/ALU) 56 COMPRESSE (CONF. CALENDARIZZATA), EFIENT - 10MG - COMPRESSA RIVESTITA CON FILM - USO ORALE BLISTER (ALL) 90X1 COMPRESSE

UMBERTO I - POLICLINICO DI ROMA, Fondi propri

Patients with acute coronary syndrome Pazienti con sindromi coronariche acute, Patients with acute myocardial infarction and instable angina Pazienti con infarto miocardico acuto e angina instabile, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Ongoing

4

24

Europe

INSPRA (eplerenona), ALDACTONE, INSPRA (eplerenona), ALDACTONE (espironolactona), INSPRA (eplerenona), ALDACTONE (espironolactona)

Fundación Investigación y Desarrollo en el Area Cardiovascular

Disfunción ventricular leve-moderada post-infarto agudo de miocardio en pacientes diabéticos con hipertensión arterial no controlada.Low-moderate ventricular dysfunction in post-acute coronary syndrome patients with diabetes and non-controlled arterial hypertension.

 

 

Ongoing

4

1500

Europe

Efient, Efient

Hospital of the University of Munich, Grosshadern, Klinikum der Universität München, Roche Diagnostics International AG

Troponin positive acute coronary syndrome after successful percutaneous coronary intervention with an indication for a standard treatment of 12 month with prasugrel

 

 

Recruiting

4

390

 

sodium tanshinone IIA sulfonate and standard thera ;standard therapy

2nd Affiliated Hospital of Guangzhou University of Chinese Medicine; 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, 2013 Specific fund of clinical medical research of Bethune Medical Experts Committee

acute coronary syndrome

 

 

Not yet recruiting

4

400

Europe

Eliquis, Marcumar, ASS, Plavix, Film-coated tablet, , Tablet, Eliquis

Klinikum der Universitaet Muenchen AoeR, Deutsches Zentrum für Herz-Kreislauf-Forschung, Bristol-Myers Squibb

Patients with acute coronary syndrome and atrial fibrillation Patienten mit akutem Koronarsyndrom und Vorhofflimmern, Patients with acute coronary syndrome and atrial fibrillation Patienten mit akutem Koronarsyndrom und Vorhofflimmern, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Unknown status

4

 

Beijing anzhen hospital, capital medical university; Beijing Anzhen hospital, , GE Pharmaceutical company offer

Coronary atherosclerosis

 

 

Recruiting

4

120

 

pivastatin 4mg po. pernight ;atrovastatin 20mg po. pernight

second hospital of hebei medical university; The second hospital of Hebei medical university, self-financing

acute coronary syndrome

 

 

Completed

4

65

 

bolus injection of 2ml volume of 0.9% saline ;bolus injection of 2ml volume of nicorandil (1mg/ml)

Qilu Hospital, Shandong University; Qilu Hospital, Shandong University, Shandong Province Natural Science Fund (ZR2014CM010) gave financial support.

acute coronary syndrome

 

 

Ongoing

4

70

Europe

Film-coated tablet, Jardiance

Karolinska Institutet, Stockholm, Sweden, Karolinska Institutet, Karolinska Institutet

Patients with acute coronary syndromes (myocardial infarction or unstable angina pectoris) with newly detected glucose perturbations (impaired glucose tolerance or type 2 diabetes), Patients with a recent heart attack and abnormal glucose metabolism, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Completed

4

100

 

Rivaroxaban (15mg 1/ d) + clopidogrel (75mg 1/ d)

The second hospital of hebei medical university; the Second Hospital of Hebei Medical University, None

coronary heart disease

 

 

Recruiting

4

1000

 

Patients were administered 300mg loading dose of clopidogrel before PCI and received a 75-mg/d maintenance dosage of clopidogrel and 100 mg/d of aspirin for a year.

Institute of Clinical Pharmacology, Central South University; Institute of Clinical Pharmacology, Central South University, Chinese National Science Foundation (81422052) and Special topic of the major subject of national science and technology (2013ZX09509107)

acute coronary syndromes

 

 

Not yet recruiting

4

100

Europe

Bictravy, EU/1/18//1289/001, Film-coated tablet, Bictravy

University of Liverpool, Gilead Pharmaceuticals,

Human immunodeficiency virus (HIV) and cardiovascular disease (CVD), Human immunodeficiency virus (HIV) and cardiovascular disease (CVD), Diseases [C] - Cardiovascular Diseases [C14]

 

 

Recruiting

4

200

 

Tegrilol 90 mg, b.i.d. ;Tegrilol 60 mg, b.i.d.

Fuwai Central China Cardiovascular Hospital; Fuwai Central China Cardiovascular Hospital, Fuwai central China hospital cardiovascular hospital medical research development center

acute coronary syndrome

 

 

Not yet recruiting

4

192

 

atorvastatin 20mg/d ;atorvastatin 20mg/d combined with ezetimibe10mg/d ;atorvastatin 40mg/d ;atorvastatin 40mg/d combined with ezetimibe 10mg/d

The First Affiliated Hospital of China Medical University; The First Affiliated Hospital of China Medical University, the National Natural Science Foundation of china (grant nos. 81670320 and 81800232) and the Natural Science Foundation of Liaoning Province (grant no. 201602826).

NSTE-ACS

 

 

Recruiting

4

300

 

aspine plus clopidogrel ;aspine plus rivaroxaban ;clopidogrel plus rivaroxaban

Tianjin Union Medical Center; Tianjin Union Medical Center, self-raised

Acute coronary syndrome

 

 

Not yet recruiting

4

150

 

Oral standard dose and time of dual antiplatelet drugs ;The duration of dual antiplatelet therapy was shortened to standard dose ticagrelor monoclonal antiplatelet therapy ;The duration of dual antiplatelet therapy was shortened to low dose ticagrelor monoclonal antiplatelet therapy

Tianjin Union Medical Center; Tianjin Union Medical Center, self-raised funds

acute coronary syndrome

 

 

Recruiting

4

1000

 

metoprolol

Chinese PLA General Hospital; None, Bejing Health Promotion Association

acute coronary syndrome

 

 

Not yet recruiting

4

500

Europe

anticoagulant, not applicable

Centre hospitalier de PAU, Unité de Recherche Clinique du CH de PAU

acute coronary syndrome and atrial fibrillation, acute coronary syndrome and atrial fibrillation, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Ongoing

4

52

Europe

Citalopram, Tablet, Citalopram

Amsterdam UMC, None

Chest pain can be divided in cardiac or non-cardiac chest pain (NCCP). To establish the diagnosis NCCP, acute coronary disease has to be ruled out first. NCCP can be caused by functional chest pain (FCP). NCCP in the absence of musculoskeletal abnormalities, major esophageal motor disorders, gastroesophageal reflux or eosinophilic esophagitis is called FCP., Functional chest pain is chest pain without any evidence of cardiac or gastrointestinal disorders., Diseases [C] - Symptoms and general pathology [C23]

 

 

Not yet recruiting

4

106

 

Tanshinone IIA sodium sulfonate injection ;placebo

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Project of Administration of Traditional Chinese Medicine of Guangdong Province of China; The Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine

Acute coronary syndrome

 

 

Not yet recruiting

4

100

Europe

Tablet, Forxiga

CHU Saint Pierre, Cardiology Department CHU Saint Pierre, Brussels

Coronary macrovascular and microvascular function of type 2 diabetic patients with stable coronary artery disease and acute coronary syndrome (excluding ST elevation myocardial infarction)., Coronary function of type 2 diabetic patients with stable coronary artery disease and acute coronary syndrome (excluding ST elevation myocardial infarction)., Diseases [C] - Cardiovascular Diseases [C14]

 

 

Not yet recruiting

4

3264

 

The dosage of iodixanol depends on the type of examination, age, weight, cardiac output and the patient's general condition and the technique used. From 12 hours before the contrast injection to 24 hours after the contrast agent is used, the oral water should be taken orally to replenish water. ;The dosage of iodixanol depends on the type of examination, age, weight, cardiac output and the patient's general condition and the technique used. From 12 hours before the contrast medium injection to 24 hours after the contrast medium is used, intravenous infusion of normal saline is used. The injecti ;The dosage of ioverol depends on the type of examination, age, weight, cardiac output and the patient's general condition and the technology used. From 12 hours before the contrast injection to 24 hours after the contrast agent is used, the oral water is used for rehydration, and the replenishment a ;The dosage of ioverol depends on the type of examination, age, weight, cardiac output, and the patient's general condition and the technique used. From 12 hours before the contrast medium injection to 24 hours after the contrast medium, normal saline is injected intravenously. Liquid flow rate ≥100ml/h.

Tianjin People's Hospital; Tianjin People's Hospital, CHINA HEALTH PROMOTION FOUNDATION

Acute Coronary Syndrome

 

 

Active, not recruiting

4

3008

Japan

1-months DAPT, 12-month DAPT

Kyoto University, Graduate School of Medicine

Acute Coronary Syndrome, Acute Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention, Platelet Aggregation Inhibitors

12/21

03/26

Not yet recruiting

4

200

 

atorvastatin（10mg）plus ezetimibe（10mg） ;atorvastatin 10mg plus ezetimibe 10mg

Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University; Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Clinical Vascular Grant In Chinese Physicians

coronary artery disease

 

 

Recruiting

4

312

 

Basic treatment and Xin-Nao-Ning capsule ;Basic treatment and Xin-Nao-Ning capsuleplacebo

Affiliated Hospital of Shandong University of TCM; Affiliated Hospital of Shandong University of TCM, self-raised

the residual risk of Post- acute coronary syndrome state complicated with carotid artery plaque

 

 

Recruiting

4

454

 

Bivalirudin ;heparin

The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, Jiangsu Hengrui Pharmaceutical Co., Ltd.

Atrial fibriliation and non-st-segment elevation acute coronary syndrome

 

 

Recruiting

4

9078

 

anticoagulant therapy ;anticoagulant therapy

China Health Promotion Foundation; China PLA General Hospital, China health promotion foundation

NSTE-ACS

 

 

Completed

4

1038

Canada

Ticagrelor 90mg, Brilinta, Clopidogrel 75mg, Plavix, acetylsalicylic acid (ASA) 81mg, Aspirin

McGill University Health Centre/Research Institute of the McGill University Health Centre, Canadian Institutes of Health Research (CIHR)

Acute Coronary Syndrome

04/22

04/23

Not yet recruiting

4

3090

Europe

Acetylsalicylic acid, Acetylsalicylic acid, Tablet, Acetylsalicylic acid

Amsterdam UMC, ZonMw

non-ST-segment elevation acute coronary syndrome, non-ST-segment elevation acute coronary syndrome, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Recruiting

4

120

 

Ticagrelor

The First Affiliated Hospital of Guangzhou Medical University; The First Affiliated Hospital of Guangzhou Medical University, none

Acute coronary syndrome

 

 

Recruiting

4

410

 

Conventional treatment ;Conventional treatment + Naoxintong capsule

The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine; The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Buchang Pharmaceutical Co. LTD

Acute coronary syndrome

 

 

Recruiting

4

80

 

Statins + Ezetimibe + PCSK9 inhibitor ;Statins + Ezetimibe

the First Affiliated Hospital, Sun Yat-Sen University; The First Affiliated Hospital of Sun Yat-Sen University, Suzhou Industrial Park Xinxin Cardiovascular Health Foundation

Acute coronary syndrome

 

 

Not yet recruiting

4

896

 

Evolocumab and standard treatment ;standard treatment

Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University; Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 300,000 yuan was funded by Yat-Sen clinical research project of Sun Yat-Sen University + 100, 000 yuan by Amgen Manufacturing Limited (AML) company

acute coronary syndrome

 

 

Not yet recruiting

4

438

 

Fondaparinux anticoagulation therapy ;Low molecular weight heparin anticoagulation therapy

The Second Hospital of Shandong University; The Second Hospital of Shandong University, China Red Cross Foundation

ACS

 

 

Not yet recruiting

4

2600

RoW

Vonoprazan-based dual eradication therapy for two weeks, amoxicillin, Pantoprazole

Qilu Hospital of Shandong University

Acute Coronary Syndrome, Helicobacter Pylori Infection

01/23

06/23

Completed

4

359

US

Cangrelor, Kengreal, Prasugrel, Effient

University of Florida, Scott R. MacKenzie Foundation

Coronary Artery Disease, Acute Coronary Syndrome

02/23

05/23