Sarcoma  >>  Zolinza (vorinostat)  >>  Phase 2
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10 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Zolinza (vorinostat) / Merck (MSD)
NCT00238303: Vorinostat in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme

Completed
2
103
US
vorinostat, L-001079038, SAHA, suberoylanilide hydroxamic acid, Zolinza, conventional surgery, surgery, conventional
National Cancer Institute (NCI)
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Recurrent Adult Brain Tumor
07/08
03/10
NCT00641706: Vorinostat and Bortezomib in Treating Patients With Progressive, Recurrent Glioblastoma Multiforme

Completed
2
44
US
vorinostat, L-001079038, SAHA, suberoylanilide hydroxamic acid, Zolinza, therapeutic conventional surgery, bortezomib, LDP 341, MLN341, VELCADE
National Cancer Institute (NCI)
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Recurrent Adult Brain Tumor
07/10
11/10
NCT00937495: Vorinostat and Bortezomib in Treating Patients With Advanced Soft Tissue Sarcoma

Completed
2
16
US
vorinostat, L-001079038, SAHA, suberoylanilide hydroxamic acid, Zolinza, bortezomib, LDP 341, MLN341, VELCADE
National Cancer Institute (NCI)
Recurrent Adult Soft Tissue Sarcoma, Stage III Adult Soft Tissue Sarcoma, Stage IV Adult Soft Tissue Sarcoma
08/10
06/11
SAHA-I, NCT00918489 / 2008-008513-19: Study on Efficacy and Tolerability of Vorinostat in Patients With Advanced, Metastatic Soft Tissue Sarcoma (STS)

Completed
2
40
Europe
Vorinostat
Heidelberg University, Merck Sharp & Dohme LLC
Soft Tissue Sarcoma
09/13
09/13
2016-000782-22: A study about the effects of the drug Vorinostat (Zolinza) in patients with a previously treated, recurring special form of uterine cancer (sarcoma). Vorinostat (Zolinza) zur Behandlung von Patientinnen mit einer bereits vorbehandelten, wiedergekehrten speziellen Form von Gebärmutterkrebs (Sarkom).

Ongoing
2
8
Europe
Zolinza, Capsule, hard, Zolinza
Medical University of Graz, Medical University of Graz
Uterine sarcoma Uterussarkom, A special form of uterine cancer Eine spezielle Form von Gebärmutterkrebs, Diseases [C] - Cancer [C04]
 
 
NCT03509207: Vorinostat (SAHA) in Uterine Sarcoma

Terminated
2
3
Europe
Vorinostat Oral Capsule, Zolinza
Medical University of Graz
Leiomyosarcoma, Endometrial Stromal Tumors, Carcinosarcomas Uterine
02/19
02/19
GemTax, NCT01879085: Study of Vorinostat in Combination With Gemcitabine and Docetaxel in Advanced Sarcoma

Completed
1b/2
37
US
Docetaxel, Taxotere, Gemcitabine, Gemzar, Vorinostat, Zolinza, Pegfilgrastim, Neulasta
Melissa Burgess, MD, Merck Sharp & Dohme LLC
Sarcoma
04/21
04/21
NCT00731731: Vorinostat, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Completed
1/2
125
US
3-Dimensional Conformal Radiation Therapy, 3-dimensional radiation therapy, 3D Conformal, 3D CONFORMAL RADIATION THERAPY, 3D CRT, 3D-CRT, Conformal Therapy, Radiation Conformal Therapy, Radiation, 3D Conformal, Cognitive Assessment, Laboratory Biomarker Analysis, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, TMZ, Vorinostat, L-001079038, MSK-390, SAHA, Suberanilohydroxamic Acid, Suberoylanilide Hydroxamic Acid, Zolinza
National Cancer Institute (NCI)
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
02/14
11/19
DIPG, NCT01189266: Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Completed
1/2
79
Canada, US, RoW
3-Dimensional Conformal Radiation Therapy, 3-dimensional radiation therapy, 3D Conformal, 3D CONFORMAL RADIATION THERAPY, 3D CRT, 3D-CRT, Conformal Therapy, Radiation Conformal Therapy, Radiation, 3D Conformal, Intensity-Modulated Radiation Therapy, IMRT, Intensity Modulated RT, Intensity-Modulated Radiotherapy, Radiation, Intensity-Modulated Radiotherapy, Laboratory Biomarker Analysis, Vorinostat, L-001079038, MSK-390, SAHA, Suberanilohydroxamic Acid, Suberoylanilide Hydroxamic Acid, Zolinza
National Cancer Institute (NCI)
Anaplastic Astrocytoma, Anaplastic Oligoastrocytoma, Diffuse Intrinsic Pontine Glioma, Gliosarcoma
06/17
09/21
NCT01294670: Clinical Study of Vorinostat in Combination With Etoposide in Pediatric Patients < 21 Years at Diagnosis With Refractory Solid Tumors

Completed
1/2
27
Canada, US
Vorinostat and Etoposide
Memorial Sloan Kettering Cancer Center, Merck Sharp & Dohme LLC, Phoenix Children's Hospital, Milton S. Hershey Medical Center, Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Children's Hospital Colorado, University of Florida, Alberta Children's Hospital, M.D. Anderson Cancer Center, Dana-Farber Cancer Institute, Children's Mercy Hospital & Clinics, Johns Hopkins All Children's Hospital, Arnold Palmer Hospital for Children
Solid Tumors, Relapsed/Refractory Sarcomas
12/20
12/20

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