Odomzo (sonidegib) / Sun Pharma, Novartis 
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15 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Odomzo (sonidegib) / Sun Pharma
2020-001309-22: Evaluation of immunological effects of the hedgehog inhibitors on basal cell carcinoma - An open label, prospective, observational biomarker study of the DeCOG. Bewertung der immunologischen Wirkung von Hedgehog-Inhibitoren auf das Basalzellenkarzinom - Eine offene und prospektive Biomarker-Beobachtungsstudie der Arbeitsgemeinschaft Dermatologische Onkologie.

Not yet recruiting
4
12
Europe
Sonidegib, Vismodegib, Capsule, hard, Odomzo, Erivedge
IQVIA Commercial GmbH & Co. OHG, Sun Pharmaceuticals Germany GmbH
Basal cell carcinoma Basalzellkarzinom, White skin cancer Weißer Hautkrebs, Diseases [C] - Skin and Connective Tissue Diseases [C17]
 
 
ACTRN12623001216606: Single-institution, single-arm, open-label phase II basket study of mutation and/or elevated hedgehog (Hh) expression-directed smoothened inhibitor sonidegib in patients with advanced solid malignancies

Recruiting
2
20
 
Northern Sydney Local Health District, RNSH Clinical Trials Unit, Sun Pharmaceutical Industries LTD
Cancer
 
 
2012-004113-13: A Phase II, Open-Label, Safety, Efficacy and Pharmacodynamic Study of oral sonidegib in patients with Basal Cell Carcinoma (BCC) and prior exposure to Hedgehog Pathway inhibitors

Ongoing
2
28
Europe
LDE225, Capsule
GZA vzw, GZA Ziekenhuizen, Sint-Augustinus, Novartis Pharma NV
Basal Cell Carcinoma, Skin cancer, Diseases [C] - Cancer [C04]
 
 
ACTRN12612000533897: Evaluation of the efficacy and safety of LDE225 in the treatment of patients with advanced or metastatic sarcomas

Completed
2
84
 
Australasian Sarcoma Study Group, Novartis
Sarcoma
 
 
SONIB, NCT03534947: A Study to Evaluate Neoadjuvant Sonidegib Followed by Surgery or Imiquimod in the Management of Basal Cell Carcinoma

Recruiting
2
20
RoW
Sonidegib, LDE225, Odomzo, Imiquimod, Aldara, Surgery, Excision of remnant invasive basal cell carcinoma, Best supportive care
Melanoma Institute Australia
Basal Cell Carcinoma, Basal Cell Carcinoma of Skin, Site Unspecified, Skin Cancer, Invasive Carcinoma
06/24
06/24
SONIBEC, NCT04806646 / 2020-002613-17: Tailored Sonidegib Schedule After Complete Response in BCC

Recruiting
2
21
Europe
Sonidegib, Odomzo
Gruppo Oncologico del Nord-Ovest
Locally Advanced Basal Cell Carcinoma
01/24
01/26
NCT04679480: Anti-PD1-antibody and Pulsed HHI for Advanced BCC

Active, not recruiting
2
20
Europe
Cemiplimab Injection [Libtayo], Sonidegib
Reinhard Dummer, Sanofi, Sun Pharmaceutical Industries Ltd
Basal Cell Carcinoma
12/24
12/24
PersoMed-I, NCT04402073 / 2020-003063-26: Personalized Risk-Adapted Therapy in Post-Pubertal Patients With Newly-Diagnosed Medulloblastoma

Active, not recruiting
2
20
Europe, RoW
Sonidegib, Cisplatin, Lomustine, Vincristine, radiotherapy
European Organisation for Research and Treatment of Cancer - EORTC, EORTC-BTG, Sunpharmaceuticals
Medulloblastoma
04/25
04/25
SJDAWN, NCT03434262: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Completed
1
68
US
Gemcitabine, Gemzar®, ribociclib, LEE011, LEE-011, KISQALI®, sonidegib, LDE225, LDE-225, ODOMZO®, trametinib, TMT212, TMT-212, MEKINIST(TM), filgrastim, G-CSF
St. Jude Children's Research Hospital, Novartis Pharmaceuticals
Anaplastic Astrocytoma, Anaplastic Ependymoma, Anaplastic Ganglioglioma, Anaplastic Meningioma, Anaplastic Oligodendroglioma, Pleomorphic Xanthoastrocytoma, Anaplastic, Atypical Teratoid/Rhabdoid Tumor, Brain Cancer, Brain Tumor, Central Nervous System Neoplasms, Choroid Plexus Carcinoma, CNS Embryonal Tumor With Rhabdoid Features, Ganglioneuroblastoma of Central Nervous System, CNS Tumor, Embryonal Tumor of CNS, Ependymoma, Glioblastoma, Glioma, Glioma, Malignant, Medulloblastoma, Medulloblastoma; Unspecified Site, Medulloepithelioma, Neuroepithelial Tumor, Neoplasms, Neoplasms, Neuroepithelial, Papillary Tumor of the Pineal Region (High-grade Only), Pediatric Brain Tumor, Pineal Parenchymal Tumor of Intermediate Differentiation (High-grade Only), Pineoblastoma, Primitive Neuroectodermal Tumor, Recurrent Medulloblastoma, Refractory Brain Tumor, Neuroblastoma. CNS, Glioblastoma, IDH-mutant, Glioblastoma, IDH-wildtype, Medulloblastoma, Group 3, Medulloblastoma, Group 4, Glioma, High Grade, Neuroepithelial Tumor, High Grade, Medulloblastoma, SHH-activated and TP53 Mutant, Medulloblastoma, SHH-activated and TP53 Wildtype, Medulloblastoma, Chromosome 9q Loss, Medulloblastoma, Non-WNT Non-SHH, NOS, Medulloblastoma, Non-WNT/Non-SHH, Medulloblastoma, PTCH1 Mutation, Medulloblastoma, WNT-activated, Ependymoma, Recurrent, Glioma, Recurrent High Grade, Glioma, Recurrent Malignant, Embryonal Tumor, NOS, Glioma, Diffuse Midline, H3K27M-mutant, Embryonal Tumor With Multilayered Rosettes (ETMR), Ependymoma, NOS, WHO Grade III, Ependymoma, NOS, WHO Grade II, Medulloblastoma, G3/G4, Ependymoma, RELA Fusion Positive
09/22
05/24
NCT04007744: Sonidegib and Pembrolizumab in Treating Patients With Advanced Solid Tumors

Recruiting
1
45
US
Pembrolizumab, Keytruda, Lambrolizumab, MK-3475, SCH 900475, Sonidegib, Erismodegib, LDE-225, LDE225, Odomzo, Smoothened Antagonist LDE225
Mayo Clinic, National Cancer Institute (NCI)
Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Gastric Cancer AJCC v8, Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8, Clinical Stage IV Gastric Cancer AJCC v8, Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8, Locally Advanced Gastric Adenocarcinoma, Locally Advanced Gastroesophageal Junction Adenocarcinoma, Locally Advanced Urothelial Carcinoma, Metastatic Gastric Adenocarcinoma, Metastatic Gastroesophageal Junction Adenocarcinoma, Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Solid Neoplasm, Metastatic Melanoma, Metastatic Urothelial Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma, Refractory Lung Non-Small Cell Carcinoma, Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8, Stage IV Lung Cancer AJCC v8, Unresectable Malignant Solid Neoplasm, Unresectable Melanoma
07/25
07/25
NCT05669339: AD HOC Trial: Artificial Intelligence-Based Drug Dosing In Hepatocellular Carcinoma

Recruiting
1
12
US
Irinotecan, Sonidegib, Sorafenib
University of Florida, Sun Pharmaceutical Industries Ltd
Hepatocellular Carcinoma
04/26
04/26
NCT05463757: Oral Hedgehog Inhibitors in the Treatment of Basal Cell Carcinoma in the Netherlands: a Prospective Registration Study

Recruiting
N/A
80
Europe
Vismodegib, Erivedge, Sonidegib, Odomzo
Maastricht University Medical Center, Sun Pharmaceutical Industries Limited
Basal Cell Carcinoma, Locally Advanced Basal Cell Carcinoma, Metastatic Basal Cell Carcinoma, Gorlin Syndrome, Basal Cell Nevus Syndrome, Carcinoma, Basal Cell, Carcinoma, Basal Cell Tumor, Skin Cancer, Neoplasm of Skin, Neoplasms, Basal Cell
12/24
12/24
NISSO, NCT04066504: Post-authorization Safety Study on the Long Term Safety of Sonidegib in Patients With Locally Advanced Cell Carcinoma

Active, not recruiting
N/A
323
Europe
sonidegib, LDE225
Sun Pharmaceutical Industries Limited
Basal Cell Carcinoma
03/25
11/25
ChiCTR2400081793: Sonidegib for Acute ischemic patients with large VEssel occlusion combined with Revascularization (SAVER), a multi-center, prospective, double-blind, randomized trial

Recruiting
N/A
152
 
Sonidegib plus Endovascular Treatment; Placebo plus Endovascular Treatment
The Second Affiliated Hospital of the Army Medical University; The Second Affiliated Hospital of the Army Medical University, The Special Talent Development Project of the Second Affiliated Hospital of Army Medical University
Acute ischemic stroke
 
 
ACTRN12620001200976: Sonidegib (Odomzo) neo-adjuvant therapy for participants with Gorlin syndrome – A pilot study

Not yet recruiting
N/A
6
 
Samson Clinical Pty Ltd, Samson Clinical Pty Ltd
Gorlin Syndrome
 
 

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