| dexmedetomidine / Generic mfg. |
ACTRN12611000794909: The effect of intravenous sedation on the lower oesophageal sphincter: A comparison between dexmedetomidine and remifentanil in healthy adult volunteers. |
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| Not yet recruiting | 3 | 16 | | | Dr Islam Elhalawani, NHMRC | Aspiration Risk during sedation, Reflux and sedation | | | | |
| Not yet recruiting | 3 | 130 | | | Department of Anaesthesia , Department of Anaesthesia | Obesity ; Post operative pain ; Post Operative Nausea and Vomiting ; Post Operative Acute Rehabilitation ; Opiate Free Total Intravenous Anaesthesia | | | | |
| Not yet recruiting | 3 | 1100 | | | University of Sydney, National Health and Medical Research Council (NHMRC) | Delirium | | | | |
ACTRN12620000198921: Improving the ways we put patients to sleep (anaesthesia) for weight loss surgery |
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| Recruiting | 3 | 130 | | | Department of Anaesthesia , Department of Anaesthesia | Obesity , Post operative pain , Post Operative Nausea and Vomiting , Post Operative Acute Rehabilitation , Opiate Free Total Intravenous Anaesthesia | | | | |
ChiCTR-TRC-11001616: The effects of dexmedetomidine premedication on propofol sedation and combined propofol with remifentanil anesthsia in Patients Undergoing laryngeal microsurgery |
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| Completed | 3 | 100 | | Pre-injection of saline before induction of anesthesia ;Pre-injection of 0.25ug/kg dexmedetomidine before induction of anesthesia ;Pre-injection of 0.5ug/kg dexmedetomidine before induction of anesthesia ;Pre-injection of 1.0ug/kg dexmedetomidine before induction of anesthesia | Dept. of Anesthesiology, Guangzhou 1st People's Hospital; Guangzhou 1st People's Hospital, Guangzhou 1st People's Hospital | Vocal cord polyp | | | | |
ChiCTR-TRC-10000860: Effect of dexmedetomidine-sevoflurane anesthesia on stress and recovery outcome variables: a comparative study with remifentanil in gynecologic videolaparoscopic surgery |
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| Completed | 3 | 60 | | sevoflurane for inhalation and remifentainl iv.at a rate of 0.3ug/kg/min for 10 minutes then 0.2 ug/kg/min to the end of the surgery ;sevoflurane for inhalation and dexmedetomidine iv.at a rate of 2ug/kg/h for 10 minutes then 0.4 ug/kg/h to the end of the surgery | The First Affiliated Hospital to Sun Yat-sen University; Level of the institution：, self-funding | patient undergoing gynecologic videolaparoscopy | | | | |
2015-002102-37: Comparative study of the efficacy of clonidine and dexmetomidina in nasal endoscopic surgery anaesthesia Estudio comparativo de la eficacia de clonidina y dexmetomidina en la anestesia de la cirugÃa endoscópica nasal |
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| Ongoing | 3 | 94 | Europe | clonidine, dexmedetomidina, Solution for injection | Fundació Parc TaulÃ, Fundació Parc Taulà | Nasosinusal endoscopic surgery in patients with chronic sinusitis and/or nasal polyposis CirugÃa endoscópica nasosinusal en pacientes con sinusitis crónica y/o poliposis nasal, Nasosinusal endoscopic surgery CirugÃa endoscópica nasosinusal, Diseases [C] - Ear, nose and throat diseases [C09] | | | | |
2010-023155-28: Dexmedetomidine pharmacokinetics-pharmacodynamicsin mechanically ventilated neonates with single-organ respiratory failure |
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| Ongoing | 3 | 60 | Europe | dexmedetomidine, Dexdor 100 µg/ml, Dexdor 100 µg/ml | Ghent University Hospital, Orion Corporation, Ghent University Hospital | Patients admitted to the neonatal intensive care unit with single-organ respiratory failure | | | | |
ChiCTR-IIR-17011093: A multicenter, random, double-blind, the placebo parallel control trial to evaluate the effectiveness and safety of the hydrochloric acid dexmedetomidine injection in the patients with endotracheal intubation and mechanical ventilation |
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| Recruiting | 3 | 240 | | dexmedetomidine ;saline | Zhongnan Hospital of Wuhan University; Zhongnan Hospital of Wuhan University, Sichuan Baili pharmaceutical Co.,Ltd | anxiety disorders | | | | |
ChiCTR-CIC-16008519: The incidence of elderly patients with rocuronium combined continuous infusion of dexmedetomidine pre injection of muscle relaxant effect and residual effect |
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| Not yet recruiting | 3 | 240 | | none | Department of Anesthesiology, Renji South Hospital, School of Medicine, Shanghai Jiao Tong University; Department of Anesthesiology, Renji South Hospital, School of Medicine, Shanghai Jiao Tong University, Chinese Medical Association | muscle relaxant effect and residual effect | | | | |
2018-001650-98: Alpha-2 Agonists for sedation to produce better outcomes from critical illness (‘A2B Trial’) |
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| Not yet recruiting | 3 | 1737 | Europe | Dexdor, Catapres, Diprivan, Solution for injection/infusion, Solution for injection, Emulsion for injection/infusion | University of Edinburgh and NHS Lothian, NHS Lothian, NIHR HTA | Any patient requiring intensive care treatment due to critical illness., Any patient requiring treatment in an intensive care unit., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
NCT06185127: Dexmedetomidine-ketamine Combination Versus Fentanyl-midazolam During Bronchoscopy |
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| Completed | 3 | 50 | Europe | Dexmedetomidine, Dexmedetomidine administration, Ketamine, Ketamine administration, Midazolam, Midazolam administration, Fentanyl, Fentanyl administration | University of Patras | Lung Diseases, Diagnosis, Anesthesia | 05/20 | 08/20 | | |
2017-002803-81: Study aimed at comparing the impact on long-term neurocognitive development of the use of low dose sevoflurane, dexmedetomidine and remifentanil anaesthesia compared to current anaesthesia with standard dosage of sevoflurane Studio finalizzato a confrontare l’impatto sullo sviluppo neurocognitivo a lungo termine dell’utilizzo di sevoflurano a basso dosaggio, dexmedetomidina e remifentanil rispetto all’attuale anestesia con dosaggio standard di sevoflurano |
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| Ongoing | 3 | 450 | Europe | dexmedetomidina, Remifentanil, Sevoflurano, [na], Concentrate for solution for infusion, Powder for solution for infusion, Inhalation vapour, liquid | IRCCS ISTITUTO GIANNINA GASLINI, AIFA - Italian Medicines Agency | Children under the age of 2 years having surgery lasting at least 2 hours Bambini sotto i due anni sottoposti ad intervento chirurgico della durata di almeno di 2 ore, Children under the age of 2 years having surgery lasting at least 2 hours Bambini sotto i due anni sottoposti ad intervento chirurgico della durata di almeno di 2 ore, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
NCT04709315: Rapid Sequence Induction: Succinyl Choline vs Rocuronium After Pretreatment With Dexmedetomidine |
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| Enrolling by invitation | 3 | 240 | RoW | dexemedetomidine and rocuronium, 0.9% saline and succinyl choline 1mg/ kg | South Valley University | Rapid Sequence Induction | 01/21 | 01/21 | | |
2020-002126-90: Opioid-Free Anesthesia in Cardiac Surgery Anesthésie avec/sans opioïdes en chirurgie cardiaque |
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| Not yet recruiting | 3 | 268 | Europe | Lidocaïne, Dexmedetomidine, Remifentanil, Solution for injection/infusion, Powder for solution for injection/infusion, XYLOCARD 20 mg/ml, Ultiva 2mg | Direction de la Recherche Clinique et de l’Innovation – CHU de Rouen, Direction de la Recherche Clinique et de l’Innovation – CHU de Rouen | Patients undergoing cardiac surgery under extracorporeal circulation with at least one aorto-coronary bypass and the removal of at least one internal mammary artery Patients opérés d’une chirurgie cardiaque sous circulation extra-corporelle avec au moins un pontage aorto-coronarien et le prélèvement d’au moins une artère mammaire interne, Patients undergoing cardiac surgery under extracorporeal circulation with at least one aorto-coronary bypass and the removal of at least one internal mammary artery Patients opérés d’une chirurgie cardiaque sous circulation extra-corporelle avec au moins un pontage aorto-coronarien et le prélèvement d’au moins une artère mammaire interne, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
NCT04668456: Subtenon and Intravenous Dexmedetomidine Effect on Patients Undergoing Cataract Surgery |
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| Active, not recruiting | 3 | 75 | RoW | Dexmedetomidine, lidocaine 2%, bupivacine 0.5%, Normal saline | Menoufia University | Acute Postoperative Pain | 03/21 | 03/21 | | |
2020-004802-70: Impact of post-Acute respiratory distress syndrome COVID sedation on late neuroinflammation Impact de la sédation post-syndrome de détresse respiratoire aiguë COVID sur la neuroinflammation tardive |
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| Not yet recruiting | 3 | 62 | Europe | dexmedetomidine, dexmedetomidine, Concentrate for dispersion for infusion, dexmedetomidine, all available commercial specialties may have been used (originator or generic) | Assistance Publique – Hôpitaux de Paris, DGOS | All patients who have developed and survived ARDS linked to COVID-19 infection, admitted to intensive care units, meeting the study's inclusion criteria may be included in this research. L’ensemble des patients ayant développé et survécu à un SDRA lié à une infection COVID-19, admis dans les services de réanimation, répondant aux critères d’inclusion de l’étude pourront être inclus dans cette recherche., All patients who have developed and survived ARDS linked to COVID-19 infection, admitted to intensive care units, meeting the study's inclusion criteria may be included in this research. Patients ayant développé et survécu à un SDRA lié à une infection COVID-19, admis dans les services de réanimation, répondant aux critères d’inclusion de l’étud., Diseases [C] - Virus Diseases [C02] | | | | |
NCT04576975: Ketamine Infusion vs Dexmedetomidine Infusion in Obese Patients Undergoing Bariatric Surgery |
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| Active, not recruiting | 3 | 90 | RoW | Ketamine, Dexmedetomidine, Normal Saline 0.9% | Ain Shams University, Ministry of Health, Kuwait | Morbid Obesity, Surgery | 12/21 | 07/22 | | |
NCT05335655: IV Dexmedetomidine in the Duration of Spinal Anesthesia With Hyperbaric Bupivacaine: Double Blind Randomized Trial. |
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| Recruiting | 3 | 60 | RoW | Dexmedetomidine injection, Precedex infusion, Sodium Chloride 0.9% infusion, Placebo | Hospital Central "Dr. Ignacio Morones Prieto" | Anesthesia, Dexmedetomidine | 06/22 | 06/22 | | |
NCT05489900: Immunomodulatory Effect of Dexmedetomidine as an Adjuvant Drug in Laparoscopic Cholecystectomies |
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| Recruiting | 3 | 52 | RoW | Dexmedetomidine Hydrochloride | Universidade Federal do Rio de Janeiro | Physiological Effects of Drugs | 07/22 | 10/22 | | |
| Completed | 3 | 90 | RoW | nefopam, ketoprofen, paracetamol, saline infusion, ketoprofen, paracetamol | American University of Beirut Medical Center | Cholecystectomy, Pain, Postoperative, Opioid Use | 10/22 | 10/22 | | |
NCT04082767: Sedation Efficacy of Dexmedetomidine Versus Midazolam in Critically Ill Ventilated Children |
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| Recruiting | 3 | 120 | Canada | Precedex, dexmedetomidine, Midazolam | Douglas Fraser | Mechanically Ventilated, Critically Ill Children | 09/24 | 09/24 | | |
NCT05311722: Comparsion of IV Dexmedetomidine, Tramdol and Ketamine for Post Spinal Anesthesia Shivering. |
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| Not yet recruiting | 3 | 71 | NA | Dexmedetomidine, Ketamine, Tramadol | Sheikh Zayed Medical College | Post-Surgical Complication | 12/22 | 02/23 | | |
NCT05481281: Comparison Of Dexmedetomidine & Ketamine For Control Of Shivering In Vaginal Hysterectomy Under Spinal Anesthesia |
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| Not yet recruiting | 3 | 104 | NA | Dexmedetomidine, Ketamine | Hamdard University | Chills | 01/23 | 01/23 | | |
NCT05099055: Dexmedetomine as Adjuvant for Spinal Anesthesia in Elective Cesarian Sections : a Pilot Study |
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| Completed | 3 | 42 | Canada | Dexmedetomidine 0.004 MG/ML [Precedex], Opioids | St. Justine's Hospital | Analgesia, Analgesics, Opioid, Anesthesia, Obstetrical, Anesthesia, Spinal, Analgesics, Non-Narcotic, Dexmedetomidine, Analgesia, Obstetrical | 01/23 | 05/23 | | |
| Terminated | 3 | 32 | Europe | Dexmedetomidine 100 Mcg/mL Intravenous Solution, 5% glucose Infusion solution | Centre Hospitalier Universitaire Dijon | Septic Shock, Vasopressor Resistance | 01/23 | 03/23 | | |
NCT04955158: Dexmedetpmidine Versus Ketamine for Postoperative Sore Throat in Sinus Surgery |
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| Completed | 3 | 143 | RoW | Dexmedetomidine, Precedex, Ketamine, ketalar, saline 0.9%, Normal saline | Assiut University | Sore Throat | 02/23 | 02/23 | | |
NCT06386770: Systemic Versus Local Dexmedetomidine as An Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Block |
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| Recruiting | 3 | 75 | RoW | Dexmedetomidine Injection [Precedex], Bupivacaine Hydrochloride, Dexmedetomidine in 0.9 % NaCl 200 Mcg/50 mL (4 Mcg/mL) INTRAVEN INFUSION BOTTLE (ML) | Aswan University | Erector Spinae Block, Dexmedetomidine | 06/24 | 06/24 | | |
2021-003703-18: The benefit of opioid free anesthesia on postoperative pain in patient undergoing hip surgery. Intérêt de l'anesthésie sans opioïdes sur la douleur postopératoire des patients opérés d'une prothèse de hanche. |
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| Not yet recruiting | 3 | 80 | Europe | Solution for infusion, Solution for injection, Dexmedetomidine 100 µg/ml, Sufentanil 5 µg/ml | CMC Ambroise Paré, CMC Ambroise Paré | Total hip arthroplasty Prothèse de hanche, Hip surgery Chirurgie de la hanche, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
| Completed | 3 | 80 | Europe | Sufentanil, Dexmedetomidine | CMC Ambroise Paré | Primary Total Hip Arthroplasty | 02/23 | 02/23 | | |
NCT05233683: Caudal Block Versus Dorsal Penile Nerve Block Plus Ring Block for Pain Management of Different Surgical Techniques of Circumcision in Infants and Children |
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| Not yet recruiting | 3 | 120 | RoW | Caudal block, Dorsal penile nerve block plus ring block, Circumcision with Plastibell, Conventional Dissection Method | King Saud University | Anesthesia, Anesthesia, Local, Analgesia, Pediatric ALL, Pain, Postoperative, Pain, Acute | 03/23 | 03/23 | | |
NCT04081545: Effect of Opioid Free Anesthetic on Post-Operative Opioid Consumption After Laparoscopic Bariatric Surgery |
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| Active, not recruiting | 3 | 184 | US | Opioid Anesthetics, Opioid-based regimen, Non Opioid Analgesics, Opioid-free regimen | Christine Oryhan, Virginia Mason Hospital/Medical Center | Opioid Use, Unspecified, Bariatric Surgery Candidate, Anesthesia | 03/23 | 06/23 | | |
NCT05634148: Dexmedetomidine in Reducing Incidence of Emergence Agitation After Nasal Surgery |
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| Completed | 3 | 42 | RoW | Dexmedetomidine, Control | Security Forces Hospital | Postoperative Delirium | 04/23 | 04/23 | | |
NCT05493228: Dexmedetomidine Infusion on Intraoperative Propofol,Fentanyl Requirements in Spine Surgery for Pediatric Cancer Patients |
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| Recruiting | 3 | 38 | RoW | Precedex Injectable Product, dexmedetomidine, Saline, Salt water | Children's Cancer Hospital Egypt 57357 | Spine Cancer, Anesthesia | 04/23 | 10/23 | | |
NCT03089905: A Study to Compare the Long-term Outcomes After Two Different Anaesthetics |
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| Active, not recruiting | 3 | 450 | Europe, US, RoW | Sevoflurane, Sevorane, Remifentanil, Ultiva, Dexmedetomidine, Precedex, Dexmedetomidine Ever Pharma | Murdoch Childrens Research Institute, Sydney Children's Hospitals Network, Baylor College of Medicine, Boston Children's Hospital, The Cleveland Clinic, University of Texas, Southwestern Medical Center at Dallas, Royal Children's Hospital, Children's Hospital of Philadelphia, Queensland Children's Hospital, Perth Children's Hospital, Women and Children's Hospital, Istituto Giannina Gaslini, Flinders Medical Centre | Anesthesia, Neurotoxicity, Child Development | 04/23 | 06/26 | | |
NCT05191745: Long-acting Parasternal Blocks for Analgesia After Cardiac Surgery |
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| Completed | 3 | 60 | Canada | Parasternal blocks, pecto-intercostal fascial blocks, Standard of care | Jewish General Hospital | Coronary Artery Bypass Graft Surgery | 04/23 | 06/24 | | |
NCT05624151: Dexmedetomidine Versus Magnesium Sulphate Added to Bupivacaine in Infraorbital Nerve Block for Perioperative Analgesia in Paediatric Patients for Cleft Lip Surgery |
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| Completed | 3 | 75 | RoW | Dexmedetomidine +Bupivacaine, Magnesium Sulfate + Bupivacaine, Bupivacaine | Ain Shams University | Analgesia | 05/23 | 05/23 | | |
NCT05674877: Opioid Sparing Anesthesia in Patients With Liver Cirrhosis Undergoing Liver Resection |
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| Completed | 3 | 100 | RoW | Opioid-based group (OB) (placebo/saline), OB, Opioid sparing group (OS) (dexmedetomidine (PRECEDEX™ "dexmedetomidine hydrochloride" - Pfizer) and ketamine), OS | Cairo University | Liver Cirrhosis | 06/23 | 07/23 | | |
NCT06386783: Fentanyl Versus Dexmedetomidine as an Adjuvant to Bupivacaine in Spinal Anesthesia ; Peritoneal Symptomatic Effects |
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| Recruiting | 3 | 148 | RoW | Dexmedetomidine Injection [Precedex], Fentanyl HCl | Aswan University | Dexmedetomidine, Fentanyl | 07/24 | 08/24 | | |
RUMBLE, NCT04144933: Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery |
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| Recruiting | 3 | 60 | Canada | Acetaminophen, Gabapentin, Opioid-free preoperative medications, Opioid-containing preoperative medications, Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine, Opioid-free pre-intubation medications, Dexamethasone, Ondansetron, Postoperative nausea and vomiting prophylaxis, Sevoflurane, Lidocaine 2% Injectable Solution, Ketamine, Dexmedetomidine, Magnesium Sulfate, Opioid-free maintenance medications, Lidocaine 1% Injectable Solution, Sufentanil, Opioid-containing pre-intubation medications, Sevoflurane, Sufentanil, Opioid-containing maintenance medications | University of Saskatchewan | Anesthesia, General Anesthesia, Analgesics, Opioid, Opioid Free Anesthesia, Postoperative Ileus, Colorectal Surgery, Laparoscopic Surgery, Analgesia, Dexmedetomidine, Lidocaine, Ketamine | 07/24 | 08/24 | | |
NCT05988671: Intraperitoneal Dexamethasone, Dexmedetomidine, and Dexamethasone-Dexmedetomidine Combination on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy |
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| Recruiting | 3 | 120 | RoW | normal Saline, Dexamethasone, Dexmedetomidine, Combination of dexamethasone + dexmedetomidine | Al-Azhar University, Benha University | Laparoscopic Cholecystectomy, Postoperative Nausea and Vomiting | 03/24 | 03/24 | | |
NCT03653832: Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial) |
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| Completed | 3 | 1437 | Europe | Dexmedetomidine, Dexdor, Clonidine, Catapres, Propofol, Diprivan | University of Edinburgh, West Hertfordshire Hospitals NHS Trust, Queen's University, Belfast, The University of Queensland, University Hospital of Wales, Edinburgh Napier University, King's College London, University of Warwick, University of Manchester, Royal Surrey County Hospital NHS Foundation Trust, University College, London, NHS Lothian, Imperial College London, University of Cambridge | Critical Illness | 10/23 | 12/23 | | |
NCT05671081: Dexmedetomidine Versus Magnesium Sulfate in Ultrasound Guided Bilateral Bi-level Erector Spinae Plane Block in Corrective Scoliosis Surgery |
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| Active, not recruiting | 3 | 60 | RoW | Dexmedetomidine, Magnesium sulfate, Narcotic Analgesics | Ain Shams University | Anesthesia , Analgesia | 03/24 | 03/24 | | |
ChiCTR2100049820: Efficacy and safety of olanzapine and dexmedetomidine in the treatment of ICU delirium |
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| Not yet recruiting | 3 | 166 | | Oral olanzapine ;Intravenous dexmedetomidine | Dalian Municipal Central Hospital; Dalian Municipal Central Hospital, Open Project Program of Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education | Delirium | | | | |
ChiCTR2200062799: Efficacy and safety of ciprofol and dexmedetomidine for agitation and delirium in ICU |
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| Not yet recruiting | 3 | 102 | | Intravenous ciprofol ;Intravenous dexmedetomidine | Dalian Municipal Central Hospital; Dalian Municipal Central Hospital, Open Project Program of Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education | Delirium | | | | |
NCT05641064: Evaluation of Intraoperative Dexmedetomidine Use in Patients Undergoing Surgical Aortic Valve Replacement |
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| Recruiting | 3 | 60 | RoW | Placebo, saline, Dexmedetomidine 0.5mcg/kg/h, dexmedetomidine in 0.5mcg/kg/h dose, Dexmedetomidine 1 mcg/kg/h, dexmedetomidine in 1 mcg/kg/h dose | University Hospital Dubrava | Systemic Inflammatory Response, Aortic Valve Stenosis | 12/23 | 12/25 | | |
NCT06274333: Adding Dexmedetomidine or Tramadol to Paracetamol- An Effort to Attenuate Catheter Related Bladder Discomfort |
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| Recruiting | 3 | 60 | RoW | Dexmedetomidine 0.5 mic/kg, Tramadol 1mg/kg, Paracetamol 10mg/kg | Al-Azhar University, Benha University | Percutaneous Nephrolithotripsy (PCNL) | 05/24 | 05/24 | | |
ACTRN12622000754741: ConsCIOUS-3: Will noradrenergic suppression reduce connected consciousness after intubation? A randomised, placebo controlled trial. |
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| Completed | 3 | 52 | | | Royal Prince Alfred Hospital , Royal Prince Alfred Hospital | Intubation for General Anaesthesia | | | | |
NCT05849597: Dexmedetomidinine in the Prevention of Postoperative Delirium in the Intensive Care Unit After Cardiac Surgery |
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| Recruiting | 3 | 200 | RoW | Dexmedetomidine, Propofol | University of Novi Sad | Intensive Care Unit Delirium | 04/24 | 12/24 | | |
PROMISE, NCT05485519: Prospective, Randomized, Open Label Controlled Trial To Evaluate The Safety And Efficacy Of Dexmedetomidine Use Beyond 24 Hours Compared With Midazolam In Children Admitted To Pediatric Intensive Care Unit at King Abdullah Specialist Children Hospital- Ministry of National Guard Health Affairs. |
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| Recruiting | 3 | 430 | RoW | Dexmedetomidine, Midazolam | King Abdullah International Medical Research Center | Dexmedetomidine, Midazolam, Withdrawal Symptoms, Failure of Extubation | 05/24 | 05/24 | | |
NCT04928391: A Single Bolus of Dexmedetomidine Versus Nalbuphine in Postoperative Agitation |
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| Recruiting | 3 | 90 | RoW | Dexmedetomidine, Precedex, Nalbuphine, nalufin, 0.9% saline, Normal saline | Assiut University | Cleft Palate | 05/25 | 05/25 | | |
NCT06235606: Liposomal Bupivacaine With Standard Bupivacaine Versus Dexmedetomidine With Standard Bupivacaine |
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| Recruiting | 3 | 96 | RoW | Bupivacaine Liposome 13.3 Milligrams/Milliliter [Exparel], Dexmedetomidine 0.5milligram (50micrograms) | The University of Hong Kong | Acute Pain | 01/26 | 07/26 | | |
| Recruiting | 3 | 192 | Canada | Dexmedetomidine, Precedex, Normal saline | Ottawa Heart Institute Research Corporation | Ventricular Tachycardia, Ventricular Arrhythmias, Ventricular Fibrillation, Recurrent Ventricular Tachycardia | 05/27 | 08/27 | | |
| Recruiting | 3 | 120 | Europe | Opioid free anesthesia, OFA | Unai Ortega Mera, Osakidetza | Colorectal Surgery | 05/24 | 06/24 | | |
NCT04928300: Low Dose Dexmedetomidine Versus Ketamine in Multiple Fracture Ribs |
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| Recruiting | 3 | 90 | RoW | Dexmedetomidine, Precedex, Ketamine, ketalar, 0.9% saline, Normal saline | Assiut University | Rib Fractures | 07/24 | 07/24 | | |
| Recruiting | 3 | 268 | Europe | Dexmédétomidine 0.5 g/kg + lidocaine 1.5 mg/kg, experimental, Remifentanil, Control | University Hospital, Rouen | Anesthesia | 11/24 | 11/24 | | |
| Not yet recruiting | 3 | 826 | NA | Dexmedetomidine, Placebo Control | St. Joseph's Healthcare Hamilton | Non-Invasive Ventilation | 01/25 | 01/25 | | |
| Recruiting | 3 | 230 | RoW | Opioid-free anesthesia, Dexmedetomidine and lidocaine-based anesthesia, Conventional opioid-based anesthesia, Remi-fentanyl | Gangnam Severance Hospital | Breast Cancer, Mastectomy, Pain, Chronic, Pain, Post Operative | 10/24 | 10/25 | | |
NCT05340803: Sedation of Ventilated Traumatic Brain Injury Patients With Midazolam Alone Versus Combination With Dexmedetomidine or Magnesium Sulfate; Monitored by Ultrasonograghic Optic Nerve Sheath Diameter |
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| Not yet recruiting | 3 | 108 | NA | Ultrasonograghic optic nerve sheath diameter US-ONSD, midazolam, dexmedetomidine, magnesium sulfate | Assiut University | TBI (Traumatic Brain Injury) | 01/25 | 12/25 | | |
| Recruiting | 3 | 80 | Europe | Inhaled sedation with sevoflurane, Experimental, Intravenous sedation (current practice), Control | University Hospital, Clermont-Ferrand | Acute Respiratory Distress Syndrome | 05/25 | 07/25 | | |
| Recruiting | 3 | 372 | US | Dexmedetomidine, Precedex, Dexdor, Midazolam, Versed, Hypnovel, Dormicum | Vanderbilt University Medical Center, Pfizer, National Heart, Lung, and Blood Institute (NHLBI) | Delirium, Critical Illness, Sedation Complication, Executive Dysfunction, Post Traumatic Stress Disorder | 04/26 | 01/27 | | |
pediaPREM, NCT05681572: Effect of Sedative and Anxiolytic Premedication on Children Experience After General Anesthesia |
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| Recruiting | 3 | 1000 | Europe | Midazolam, Dexmedetomidine, Placebo | University Hospital, Montpellier | Anesthesia | 02/26 | 03/26 | | |
OFOBA, NCT05439005 / 2022-001139-98: Opioid Free Versus Opioid Based Anaesthesia for Free Flap Reconstruction Surgery of the Breast: A Phase III Multicentric Randomized Controlled Study. |
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| Recruiting | 3 | 158 | Europe | Dexmedetomidine | Institut Curie | Breast Cancer | 03/26 | 03/26 | | |
| Recruiting | 3 | 1000 | Europe | Dexamethasone, Dexavit, Backrest elevation, Early wakeup call, Olanzapine | Christian Hassager | Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome | 09/27 | 12/27 | | |
NCT05304598: Using Dexmedetomidine Prior to Intubation in Neonates |
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| Recruiting | 3 | 30 | US | Dexmedetomidine, Usual Care | Maimonides Medical Center | Effect Neonatal | 12/27 | 12/27 | | |
ACTRN12623000153617: Dexmedetomidine as an adjuvant to levobupivacaine for spinal anaesthesia in elderly patients undergoing hip replacement surgery: Prospective, randomised, double-blinded study. |
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| Not yet recruiting | 2/3 | 60 | | | University Hospital Centre Sestre Milosrdnice, University Hospital Centre Sestre Milosrdnice | hip replacement surgery | | | | |
ACTRN12611000166976: Sedation Practice in Intensive Care in Australia and New Zealand- A Pilot Study |
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| Not yet recruiting | 2/3 | 60 | | | ANZIC-research centre, Monash University, Hospira Inc | Sedation in intensive care patients | | | | |
| Enrolling by invitation | 2/3 | 60 | RoW | ultrasound guided erector spinae plan block using bupivacaine for modified radical mastectomy, ultrasound guided erector spinae plan block with bupivacaine and Dexmetonidine for modified radical mastectomy, ultrasound guided erector spinae plan block with bupivacaine and magnesium slphate for modified radical mastectomy | South Egypt Cancer Institute | Pain, Postoperative | 02/21 | 02/21 | | |
NCT04115449: Effect of Intravenous Dexmedetomidine on Patient Discomfort in Laparoscopic Cholecystectomy Under Spinal Anesthesia. |
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| Recruiting | 2/3 | 40 | RoW | Dexmedetomidine, normal saline | Theodor Bilharz Research Institute | Shoulder Pain | 05/21 | 07/21 | | |
ChiCTR2100051804: PINK1/Parkin pathway mediated mitochondrial autophagy in the effect and mechanism of dexmedetomidine on renal ischemia-reperfusion injury |
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| Completed | 2/3 | 90 | | received intravenous infusion of Dexmedetomidine 1 Ug/kg 10 min after anesthesia induction, and then continued intravenous infusion at the rate of 0.4 ug/(kg h) until the end of operation ;0.9 % NS | The First Affiliated Hospital of Bengbu Medical College in Anhui Province; None, Department of Education, Anhui Province | Renal injury | | | | |
peter 3 SECI, NCT04732377: Analgesic Efficacy of Dexmedetomidine as Adjuvant to Levobupivacaine in Ultrasound-guided Erector Spinae Plan Block for Modified Radical Mastectomy |
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| Recruiting | 2/3 | 40 | RoW | erector spinae block with bupivacaine, erector spinae block with bupivacaine and dexmedetomidine | South Egypt Cancer Institute | Acute Pain | 11/21 | 12/21 | | |
NCT04656470: Neuroimaging Study of Dexmedetomidine-Induced Analgesia |
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| Recruiting | 2/3 | 20 | US | Dexmedetomidine, Precedex | Massachusetts General Hospital | Analgesia, Anesthesia | 03/23 | 03/24 | | |
NCT05579964: The Role of Dexmedetomidine as Myocardial Protector in Pediatric Cardiac Surgery Total Correction of Tetralogy of Fallot |
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| Completed | 2/3 | 66 | RoW | Dexmedetomidine Hcl 100 Mcg/mL Inj, Precedex, Kabimidine, Placebo, NaCl 0.9% | National Cardiovascular Center Harapan Kita Hospital Indonesia | Congenital Heart Disease in Children, Cardiopulmonary Bypass, Tetralogy of Fallot | 04/23 | 06/23 | | |
NCT05727098: Dexmedetomedine and Ketamine in Erector Spinae Block for Postoperative Analgesia Following Mastectomy. |
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| Completed | 2/3 | 75 | RoW | Bupivacaine Hydrochloride, local anesthetic, Bupivacaine Hydrochloride and dexmedetomedine, local anesthetic and dexmedetomedine, Bupivacaine Hydrochloride and ketamine, local anesthetic and ketamine | National Cancer Institute, Egypt | Breast Cancer | 04/23 | 04/23 | | |
NCT05194904: Intravenous Dexmedetomidin on Postoperative Pain After Hypospadias Repair in Children |
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| Not yet recruiting | 2/3 | 60 | NA | Dexmedetomidine, ketorolac | Assiut University | Postoperative Pain | 07/23 | 11/23 | | |
NCT06394375: Opioid Free Anesthesia in Abdominal Laparoscopic Surgery |
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| Completed | 2/3 | 74 | RoW | Dexmedetomidine, Fentanyl | Indonesia University | Laparoscopic Surgery, Abdominal Surgery | 10/23 | 12/23 | | |
| Recruiting | 2/3 | 120 | Europe | Dexmedetomidine, DEXDOR, Sufentanil, Sufenta | Centre Hospitalier de Montauban | Hip Arthropathy, Hip Disease | 10/23 | 01/24 | | |
NCT02819141: Self-management of Sedative Therapy by Ventilated Patients |
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| Active, not recruiting | 2/3 | 190 | US | Dexmedetomidine, Precedex | Mayo Clinic, University of Minnesota, National Heart, Lung, and Blood Institute (NHLBI) | Critical Illness, Anxiety, Respiratory Failure | 04/24 | 12/24 | | |
DEX-NANO, NCT05340725: Rectal Dexmedetomidine Niosomes for Postoperative Analgesia in Pediatric Cancer Patients. |
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| Recruiting | 2/3 | 45 | RoW | DEX-IV, Precedex, DEX-Rectal, DEX-Nano-Rectal | Assiut University | Postoperative Pain | 12/23 | 12/23 | | |
| Recruiting | 2/3 | 100 | RoW | Dexmedetomidine | New Valley University | Pain Management | 06/24 | 08/24 | | |
NCT06046105: Efficacy of Adding Dexmedetomidine Versus Ibuprofen as an Adjuvant to Intraperitoneal Bupivacaine for Pain Control After Laparoscopic Gynecological Procedures |
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| Not yet recruiting | 2/3 | 180 | NA | Administering intraperitoneal bupivacaine for pain control after laparoscopic gynecological procedures, Administering intraperitoneal bupivacaine plus Dexmedetomidine for pain control after laparoscopic gynecological procedures, Administering intraperitoneal bupivacaine plus Ibuprofen for pain control after laparoscopic gynecological procedures | Ain Shams University | Postoperative Pain, Acute | 03/24 | 03/24 | | |
NCT06378827: Intraoperative Dexmedetomidine and Coronary Artery Bypass Graft Surgery |
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| Recruiting | 2/3 | 100 | RoW | Dexmedetomidine | University of Novi Sad | Acute Kidney Injury | 07/24 | 10/24 | | |
| Not yet recruiting | 2/3 | 20 | Canada | Dexmedetomidine, Placebos | University of British Columbia | Inflammation, Cancer | 06/24 | 12/24 | | |
NCT06382831: Opioid Free Versus Opioid Balanced Anesthesia in Ophthalmic Surgery |
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| Not yet recruiting | 2/3 | 104 | NA | Dexmedetomidine, Fentanyl | Indonesia University | Anesthesia and Analgesia, Anesthesia, Endotracheal | 08/24 | 10/24 | | |
NCT06427707: The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries. |
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| Not yet recruiting | 2/3 | 90 | RoW | Intravenous Infusion of propofol, lidocaine, Magnesium sulfate, Intravenous infusion of ketamine, lidocaine, Magnesium sulfate, Intravenous infusion of dexmedetomidine, lidocaine, Magnesium sulfate, Precedex | Ain Shams University | Intraoperative Bleeding | 10/24 | 10/24 | | |
NCT06082076: Prevention of Shivering Associated With Spinal Anesthesia |
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| Not yet recruiting | 2/3 | 90 | NA | Dexmedetomidine, Ketamine, Meperidine | Assiut University | Shivering, Spinal Anesthesia | 11/24 | 12/24 | | |
NCT05781854: Dexmedetomidine for Intermittent Epidural Boluses Versus Continuous Epidural Infusion for Labour Epidural Analgesia |
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| Recruiting | 2/3 | 60 | RoW | Epidural analgesia with bupivacaine and dexmedetomidine | Assiut University | Labor Pain | 03/25 | 10/25 | | |
