carvedilol / Generic mfg.  >>  Phase 4
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24 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
carvedilol / Generic mfg.
ChiCTR-TRC-10001091: 7-day hemodynamic response to carvedilol combined with isosorbide mononitrate (ISMN) versus carvedilol alone in cirrhotic patients: a randomized controlled trial

Completed
4
100
 
Carvedilol, orally taken for 7 days. The initial dosage is 12.5mg once daily, and the dosage is modulated for the target that the heart rate reduces below 55 per minute or the reduction > 20% of the baseline heart rate. Keep the systolic blood pressure ≥90mmHg. Once hypotension occurs, reduce the dosage at once and drug withdrawl is required if necessary. ;Carvedilol+Isosorbide Mononitrate Sustained Release Tablets, orally taken for 7days. The initial dosage of carvedilol is 12.5mg once daily, and ISMN 30mg daily. The dosage is modulated for the target that the heart rate reduces below 55 per minute or the reduction > 20% of the baseline heart rate. once hypotension occurs, reduce the dosage at once and drug withdrawl is required if necessary.
Shandong Provincial Hospital; Level of the institution：, Self-fianace
portal hypertension
 
 
2007-001994-27: The effect of beta-adrenergic receptor blockade on sympathetic activity and coagulation in patients with heart failure (BACH-F study)

Ongoing
4
80
Europe
Carvedilol, Metoprolol succinate, Carvedilol, Metoprolol retard, Carvedilol, Metoprolol retard
Netherlands Heart Foundation
Congestive heart failure
 
 
2009-010280-17: TS HYPE - Turner syndrome and Hypertension; a double-blinded randomised interventional trial.

Ongoing
4
40
Europe
Cozaar, Carvedilol PCD, Cozaar, Carvedilol PCD
Organisation name was not entered
Turner syndrome, hypertension and aortopathy
 
 
2009-011163-36: Ablación de sustrato de las taquicardias ventriculares monomórficas versus fármacos antiarrítmicos en pacientes con descargas apropiadas de desfibrilador automático implantable

Ongoing
4
180
Europe
TRANGOREX 200 mg comprimidos, CARVEDILOL SANDOZ 25 mg comprimidos, SOTALOL TEVA 80 mg Comprimidos, TRANGOREX 200 mg comprimidos, CARVEDILOL SANDOZ 25 mg comprimidos, SOTALOL TEVA 80 mg Comprimidos
FUNDACION PARA LA INVESTIGACION BIOMEDICA HOSPITAL GREGORIO MARAÑON
PREVENCION DE ARRITMIAS EN CARDIOPATIA ISQUEMICA
 
 
ChiCTR-IPR-17012836: Randomized controlled trial of carvedilol and propranolol in the treatment of HVPG patients with cirrhosis and portal hypertension

Not yet recruiting
4
170
 
carvedilol 10mg bid ;propranolol 60mg bid
Drum Tower Hospital affiliated to Nanjing University Medicine School; Drum Tower Hospital affiliated to Nanjing University Medicine School, Self financing
portal hypertension and cirrhosis
 
 
2018-002509-78: Comparing Carvedilol versus Placebo on the rate of variceal haemorrhage in patients with cirrhosis of the liver and small oesophageal varices

Not yet recruiting
4
1200
Europe
Carvedilol EG 6.25mg tablets, Tablet, Carvedilol EG 6.25mg tablets
Kings College Hospital NHS Foundation Trust, National Institute for Health Research Health Technology Assessment Board
Liver cirrhosis with small oesophageal varices, Liver disease with scarring of the liver tissue; and swelling of the veins within the gullet due to raised blood pressure of the main blood vessels carrying blood to the liver., Body processes [G] - Digestive System and Oral Physiological Phenomena [G10]
 
 
NCT05179070: Effect of Carvedilol Rapid Up-Titration in Patients With Heart Failure With Reduced Ejection Fraction

Recruiting
4
26
RoW
Carvedilol, Vblock
Universitas Sebelas Maret
Heart Failure With Reduced Ejection Fraction HFrEF
02/22
03/22
NCT04767061: Impact of Beta-blockers on Physical Function in HFpEF

Completed
4
9
US
Beta blockers, atenolol, betaxolol, bisoprolol, metoprolol, nebivolol, nadolol, propranolol, acebutolol, penbutolol, pindolol, carvedilol, labetalol, sotalol, metoprolol succinate, metoprolol tartrate
Weill Medical College of Cornell University, The New York Community Trust
Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure, Heart Disease
04/22
04/23
NCT04049786: Impact of Bariatric Surgery on Pharmacokinetic Study of Simvastatin and Carvedilol

Enrolling by invitation
4
120
US
Digestive biopsy, Carvedilol 25mg, Serial blood sampling for PK analysis, Metoprolol 100 mg for CYP2D6 phenotyping, Simvastatin 40mg, SVA, Midazolam 2 mg for CYP3A4 phenotyping, MDZ, Genotyping
Natalia Valadares de Moraes, Fundação de Amparo à Pesquisa do Estado de São Paulo, University of Sao Paulo
Obesity, Bariatric Surgery, Roux-en Y Gastric Bypass
08/22
08/23
ChiCTR1900026206: Experimental study of carvedilol in preventing the transition from subclinical portal hypertension to clinical portal hypertension

Not yet recruiting
4
400
 
Carvedilol ;placebo
Shandong Provincial Hospital; Shandong Provincial Hospital, Self-financing
portal hypertension
 
 
NCT04757584: Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF

Completed
4
9
US
Beta blockers, atenolol, betaxolol, bisoprolol, metoprolol, nebivolol, nadolol, propranolol, acebutolol, penbutolol, pindolol, carvedilol, labetalol, sotalol, metoprolol succinate, metoprolol tartrate
Weill Medical College of Cornell University, National Institute on Aging (NIA)
Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure, Heart Disease
04/23
04/23
DANBLOCK, NCT03778554 / 2018-002699-42: Danish Trial of Beta Blocker Treatment After Myocardial Infarction Without Reduced Ejection Fraction

Recruiting
4
2760
Europe
Metoprolol Succinate, Bisoprolol, Carvedilol, Nebivolol
Bispebjerg Hospital, Amager Hospital, Bispebjerg Frederiksberg Hospital, Bornholm Hospital, Gentofte Hospital, Glostrup University Hospital, Copenhagen, Herlev Hospital, Hvidovre University Hospital, Nordsjaelland Hospital, Holbaek Hospital, Nykoebing Hospital, Naestved Hospital, Nordsjaellands Hospital, Zealand University Hospital, Slagelse Hospital, Odense University Hospital, Svendborg Hospital, Sydvestjysk Sygehus, Hospital of Southern Jutland, Sygehus Lillebaelt (Vejle and Kolding), Aarhus Universitetshospital, Hospitalsenheden Midt, Hospitalsenheden Vest, Regionshospitalet Horsens, Silkeborg Sygehus, Aalborg University Hospital
Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction (nSTEMI), ST Elevation Myocardial Infarction
12/24
12/24
NCT03596385 / 2017-002485-40: TREatment With Beta-blockers After myOcardial Infarction withOut Reduced Ejection fracTion"

Active, not recruiting
4
8507
Europe
Beta blocker, atenolol, bisoprolol, carvedilol, metoprolol, nevibolol.
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Myocardial Infarction
04/25
04/25
BB_cACLD, NCT06449339: Non-selective Beta-blocker in Compensated Advanced Chronic Liver Disease

Recruiting
4
474
RoW
Carvedilol
Chinese University of Hong Kong, Singapore General Hospital, University of Palermo, University of Malaya, University Hospital, Bordeaux, Shanghai Jiao Tong University School of Medicine
Portal Hypertension, Hepatic Decompensation, Advanced Chronic Liver Disease
07/31
07/31
NCT05553314: Carvedilol in HF With Preserved EF

Recruiting
4
100
RoW
Carvedilol, carvedilol slow-release (SR), Placebo
Seoul National University Bundang Hospital, Samsung Medical Center, Wonju Severance Christian Hospital
Heart Failure With Preserved Ejection Fraction, Beta Blocker, Myocardial Strain
08/24
12/24
BOPPP, NCT03776955: Beta-blockers for Oesophageal Varices

Recruiting
4
1200
Europe
Carvedilol
King's College Hospital NHS Trust, King's College London, Guy's and St Thomas' NHS Foundation Trust, St George's University Hospitals NHS Foundation Trust, Cardiff University, Brighton and Sussex University Hospitals NHS Trust
Cirrhoses, Liver, Oesophageal Varices
09/24
12/24
CVL NR, NCT06594783: Carvedilol Plus EVL or Not for the Primary Prevention of Esophageal Variceal Bleeding in Carvedilol Non-responders

Not yet recruiting
4
80
RoW
Carvedilol plus endoscopic variceal ligation, Carvedilol alone
Taipei Veterans General Hospital, Taiwan
Cirrhosis, Esophageal Varices
10/30
10/30
P-HCC-CVL, NCT06594744: Endoscopic Variceal Ligation vs Carvedilol for the Prevention of First Esophageal Variceal Bleeding in Patients With HCC

Not yet recruiting
4
120
RoW
Endoscopic variceal ligation, Carvedilol
Taipei Veterans General Hospital, Taiwan
Hepatocellular Carcinoma (HCC), Esophageal Varices
10/30
10/30
NCT02817360: NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients

Recruiting
4
2400
Europe, RoW
RAS-antagonist and beta-blocker up-to maximal dosages, Enalapril 40mg/d, Ramipril 10mg/d, Lisinopril 40mg/d, Cilazapril 5mg/d, Perindopril 8mg/d, Captopril 150mg/d, Spirapril 24mg/d, Quinapril 40mg/d, Trandolapril 4mg/d, Zofenopril 60mg/d, Fosinopril 40mg/d, Candesartan 32mg/d, Valsartan 320mg/d, Irbesartan 300mg/d, Losartan 150mg/d, Eprosartan 800mg/d, Bisoprolol 10mg/d, Metoprololsuccinat 200mg/d, Carvedilol 50mg/d (100mg/d if weight is > 85kg), Nebivolol 10mg/d, RAS-antagonist and beta-blocker none or at stable dose
Martin Huelsmann
Heart Diseases, Diabetes Mellitus, Type 2
12/25
12/26
CardioTox, NCT04939883: Effects of Carvedilol on Cardiotoxicity in Cancer Patients Submitted to Anthracycline Therapy

Recruiting
4
1018
RoW
Carvedilol, Placebo
Hospital Sirio-Libanes, Ministry of Health, Brazil
Cancer
12/25
12/25
NCT06035978: Determination of Drug Levels for Pharmacotherapy of Heart Failure

Not yet recruiting
4
100
RoW
Nebivolol, Nebilet, anatomical-therapeutic-chemical code (ATC) C07AB12, Valsartan and Sacubitril, Entresto, ATC C09DX04, Carvedilol, Dilatrend, ATC C07AG02, Bisoprolol, Concor, ATC C07AB07, Metoprolol, Betaloc ZOK, ATC C07AB02, Spironolactone, Verospiron, ATC C03DA01
University Hospital Ostrava
Cardiovascular Diseases, Heart Failure With Reduced Ejection Fraction
04/26
04/26
Carvedilol for cirrhotic portal hypertension, ChiCTR2300073864: Carvedilol to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension stratified by liver stiffness: a randomized, double-blind, placebo-controlled, multicenter trial

Not yet recruiting
4
446
 
carvedilol; placebo
The Sixth People's Hospital of Shenyang; The Sixth People's Hospital of Shenyang, NA
cirrhosis and portal hypertension
 
 
BOPPP, NCT05872698: Beta-blockers or Placebo for Primary Prophylaxis () of Oesophageal Varices Trial.

Recruiting
4
1200
Europe
Carvedilol, Placebo
King's College Hospital NHS Trust, King's College London, Cardiff University, Brighton and Sussex University Hospitals NHS Trust
Cirrhosis, Liver, Portal Hypertension, Variceal Hemorrhage, Varices, Esophageal
12/26
12/26
2015-000239-34: A clinical study to investigate the use of commonly used heart failure medicines in the prevention of heart related illnesses in patients with diabetes mellitus but without heart disease.

Ongoing
3/4
2400
Europe, RoW
Enalapril maleate, Ramipril, Lisinopril dihydrate, Perindopril arginine, Perindopril erbumine, Perindopril tert-butylamine, Captopril, Quinapril hydrochloride, Trandolapril, Fosinopril sodium, Candesartan cilextil, Valsartan, Irbesartan, Losartan potassium, Eprosartan mesilate, Bisoprolol fumerate, Carvedilol, Nebivilol hydrochloride, Not applicable, Tablet, , Capsule
Medizinische Universität Wien, Medical University of Vienna, Medizinische Universität Wien,
Type 2 diabetes mellitus, Type 2 diabetes, Diseases [C] - Hormonal diseases [C19]
 
 

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