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2012-003412-31: Fertility preservation in breast cancer patients: oocytes or embryos vitrification. Préservation de la fertilité chez les patientes atteintes de cancer du sein : vitrification des ovocytes ou des embryons. |
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| Ongoing | 4 | 54 | Europe | Letrozole, hormone folliculo–stimulante humaine recombinante, cetrorelix acetate, menotrophine, follitropine alfa, Film-coated tablet, Solution for injection in pre-filled pen, Powder and solvent for solution for injection, Concentrate and solvent for suspension for injection, Femara, Gonal-f 300IU, Gonal-f 900IU, Cétrotide, Menopur 75IU, Decapeptyl 0,1mg, Bemfola 150UI/0,25 ml, Bemfola 225 UI/0,375ml, Bemfola 300 UI/0,375ml | CUB - Hôpital Erasme, CUB - Hôpital Erasme | The aim of this trial is to offer a safe and efficient alternative protocol to preserve fertility by storing oocytes in breast cancer patients before chemotherapy. Letrozole, an inhibitor of aromatase, is administered during standard gonadotropins ovarian stimulation to maintain a low estradiol level during ovarian stimulation in patients with hormono-sensitive tumour., Letrozole is associated with standard ovarian stimulation in order preserve fertility by storing oocytes/embryos in breast cancer patients before chemotherapy by maintaining low estradiol level., Diseases [C] - Cancer [C04] | | | | |
2007-000212-89: Uso de antagonistas de la GnRH en la preparación endometrial de las receptoras de ovocitos. |
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| Ongoing | 4 | 480 | Europe | DECAPEPTYL MENSUAL, CETRORELIX, DECAPEPTYL MENSUAL, CETRORELIX | Instituto Universitario IVI Valencia | Comparar los resultados obtenidos con el empleo de antagonistas de la GnRH en la sincronización receptora de ovocitos–donante frente a los resultados obtenidos con el tradicional empleo de supresión hipofisaria con análogos de la GnRHa.To compare outcomes using gNRH antagonists versus GnRH analogues in endometrial syncronization bettwenn ovum donors and recipients in a egg donation programme. | | | | |
2009-012847-40: A Randomised Study Comparing Two Different Regimens of Ovarian Stimulation Using Pergoveris and Cetrorelix for Controlled Ovarian Superovulation in Assisted Conception Treatment. |
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| Ongoing | 4 | 80 | Europe | Pergoveris, Cetrotide, Pergoveris, Cetrotide, Pergoveris, Cetrotide | NHS Lothian, The University of Edinburgh | Subfertility | | | | |
2012-004824-39: Comparison of two different drug protocols for ovarian stimulation in women with low egg reserve undergoing first attempt of in vitro fertilization |
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| Not yet recruiting | 4 | 60 | Europe | cetrotide®, Suprecur®, Powder for solution for injection, Solution for injection, Cetrotide, buserelin | UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST, Merck Serono | response to ovarian stimulation in women with reduced ovarian reserve undergoing first cycle of in vitro fertilisaion., response to in vitro fertilisation treatment in women with predicted reduced number of eggs., Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13] | | | | |
NCT04727671: Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes in Polycystic Ovary Syndrome Patients. |
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| Completed | 4 | 50 | RoW | Triptorelin acetate, Cetrorelix, recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin, Human Chorionic Gonadotropin (hCG) | Damascus University | In Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility, Polycystic Ovary Syndrome | 08/21 | 12/21 | | |
NCT04724343: Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes. |
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| Completed | 4 | 50 | RoW | Triptorelin acetate, Cetrorelix, recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin, Human Chorionic Gonadotropin (hCG) | Damascus University | In Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility | 01/22 | 07/22 | | |
NCT04727684: Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology in Polycystic Ovary Syndrome Patients During IVF/ICSI |
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| Completed | 4 | 50 | RoW | Triptorelin acetate, Cetrorelix, recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin, Human Chorionic Gonadotropin (hCG) | Damascus University | In Vitro Fertilization, Infertility, Intracytoplasmic Sperm Injection, Polycystic Ovary Syndrome | 02/22 | 05/22 | | |
NCT04993924: GnRH Antagonist Pre-treatment in the Early Follicular Phase for Resolution of a Baseline Functional Ovarian Cyst |
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| Recruiting | 4 | 15 | RoW | Cetrorelix Acetate, Ganerelix Acetate | Assaf-Harofeh Medical Center | IVF, Ovarian Cysts | 03/22 | 03/23 | | |
NCT04724486: Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology During IVF/ICSI |
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| Completed | 4 | 50 | RoW | Triptorelin acetate, Cetrorelix, recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin, Human Chorionic Gonadotropin (hCG) | Damascus University | In Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility | 03/22 | 07/22 | | |
ChiCTR2000034834: The randomized controlled study for the effectiveness of flexible low-does cetrotide in GnRH antagonist in IVF |
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| Not yet recruiting | 4 | 160 | | Antagonist halved ;Routine medication | Affiliated Hospital of Weifang Medical University; Reproductive Hospital of Weifang Medical University, Optional | Female infertility | | | | |
2021-005005-28: Assisted reproductive technology (ART) and pregnancy outcomes in women with adenomyosis (internal endometriosis) according to stimulation protocol in relation to immunological and endometrial features: a prospective, randomized study. Esito della riproduzione assistita (ART) e della successiva gravidanza nelle donne con adenomiosi (endometriosi interna) secondo il diverso protocollo di stimolazione ovarica in relazione alle caratteristiche immunologiche ed endometriali: uno studio prospettico, randomizzato. |
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| Not yet recruiting | 4 | 500 | Europe | Enantone, Cetrotide, Orgalutran, Visanne, Pregnyl, [-], Solution for injection, Powder and solvent for solution for injection/infusion, Tablet, Powder and solvent for solution for injection | AZIENDA OSPEDALIERO-UNIVERSITARIA DI MODENA, Ministero della Salute | Women with transvaginal ultrasound (TV-US)-based diagnosis of adenomyosis and women without adenomyosis but with similar baseline reproductive risks Donne con diagnosi di adenomiosi basata sull'ecografia transvaginale (TV-US) e donne senza adenomiosi ma con rischi riproduttivi di base simili, Women with and without a diagnosis of adenomyosis with reproductive risks Donne con e senza diagnosi di adenomiosi con rischi riproduttivi, Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13] | | | | |
NCT05071339: GnRH Antagonist Pre-treatment for the Prevention of Asynchronous Follicular Growth |
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| Recruiting | 4 | 15 | RoW | Ganirelix Acetate, Cetrolix Acetate | Assaf-Harofeh Medical Center | IVF | 03/23 | 03/23 | | |
NCT04671966: Sex Differences in Myocardial Steatosis Induced Left Ventricular Dysfunction |
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| Recruiting | 4 | 100 | US | Estradiol patch, Cetrotide, Fasting, Lower Body Negative Pressure, LBNP | The University of Texas at Arlington, University of Texas Southwestern Medical Center | Heart Diseases, Left Ventricular Dysfunction | 12/24 | 12/24 | | |
NCT06199960: Dual Ovarian Stimulation (Duostim) and Shanghai Protocols in Poor Ovarian Responders |
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| Completed | 3 | 116 | RoW | Doustim protocol, Double GnRH-antagonist stimulation | Royan Institute | Assisted Reproductive Techniques | 05/22 | 11/23 | | |
ChiCTR1900021024: The effect of flexibly reducing the dose of GnRH antagonist and adding low dose prednisone on clinical pregnancy rate in IVF antagonist cycles: a multicenter randomized controlled trial |
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| Not yet recruiting | 3 | 2052 | | Centrotide, 0.125mg/d ;0.25mg/d Cetrotide，and 10mg qd Prednisone is administered orally ;0.25mg/d Centrotide | Ruijin Hospital of Shanghai; Ruijin Hospital of Shanghai, The Summit Project | Infertility | | | | |
| Completed | 3 | 900 | RoW | Letrozole, Letrozole-Teva | The University of Hong Kong, Peking University Third Hospital | Subfertility | 04/22 | 04/23 | | |
NCT04414761: Live Birth Rate Between PPOS and GnRH Antagonist Protocol in Patients With Anticipated High Ovarian Response |
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| Completed | 3 | 784 | RoW | Progesterone, medroxyprogesterone, duphaston, GnRH Antagonist, Cetrorelix, Ganirelix | ShangHai Ji Ai Genetics & IVF Institute | IVF, GnRH Antagonist, PPOS | 10/22 | 10/22 | | |
NCT04842825: Sequential Therapy of TCM Herbs to Improve the Success Rate of IVF-ET in Diminished Ovarian Reserve Patients |
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| Recruiting | 3 | 200 | RoW | Er Zhi Wan combined with Si Wu Tang, conventional western medicine(Recombinant Human Follitropin Alfa for Injectionã€Fructose Injectionã€Tetyacycline Hydrochloride Capsulesã€Cetrorelix Acetate Powder for Injection ), Recombinant Human Follitropin Alfa ã€Fructose ã€Tetyacycline Hydrochloride Capsulesã€Cetrorelix Acetate Powder, (Recombinant Human Follitropin Alfa for Injectionã€Fructose Injectionã€Tetyacycline Hydrochloride Capsulesã€Cetrorelix Acetate Powder for Injection ) | Peking University Third Hospital | Infertility, Female | 12/22 | 12/22 | | |
NCT04935073: Traditional Chinese Medicine Herbs in the Freeze-all IVF Cycle |
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| Not yet recruiting | 3 | 90 | NA | Prescription of traditional Chinese Medicine named Er Zhi Wan combined with Si Wu Tang, conventional western medicine(Recombinant Human Follitropin Alfa for Injectionã€Fructose Injectionã€Tetyacycline Hydrochloride Capsulesã€Cetrorelix Acetate Powder for Injection ), Recombinant Human Follitropin Alfa for Injectionã€Fructose Injectionã€Tetyacycline Hydrochloride Capsulesã€Cetrorelix Acetate Powder for Injection | Peking University Third Hospital | Infertility, Female | 12/22 | 12/22 | | |
NCT04414748: Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Patients Undergoing PGT-A |
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| Recruiting | 3 | 400 | RoW | GnRH antagonist, Cetrorelix, oral Duphaston, Duphaston | ShangHai Ji Ai Genetics & IVF Institute | Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation, Euploid Rate, GnRH Antagonist | 12/24 | 12/25 | | |
NCT05972902: Dydrogesterone, Cetrorelix Acetate and Triptorelin in Intra Cytoplasmic Sperm Injection Outcomes |
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| Recruiting | 3 | 387 | RoW | Dydrogesterone, Duphaston, Cetrorelix acetate, cetrotide, Triptorelin, Decapeptyl, sc 0.1 mg/day | Beni-Suef University | IVF | 12/23 | 12/23 | | |
NCT05326087: Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Women With PCOS Undergoing PGT-A |
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| Not yet recruiting | 3 | 204 | NA | GnRH antagonist, Cetrorelix, MPA | ShangHai Ji Ai Genetics & IVF Institute | Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation, Polycystic Ovarian Syndrome, GnRH Antagonist | 12/25 | 12/26 | | |
NCT05951400: Progesterone Primed Ovarian Stimulation Versus GnRH Antagonist in With Expected High Ovarian Response Undergoing in Vitro Fertilization |
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| Not yet recruiting | 2/3 | 200 | RoW | Dydrogesterone Tablets, Duphaston, Cetrorelix, cetrotide | Beni-Suef University | IVF, PCO | 09/23 | 09/23 | | |
NCT06212102: Dydrogesterone Versus GnRH Antagonist in Poor Responders Undergoing Double Ovarian Stimulation |
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| Not yet recruiting | 2 | 120 | RoW | Progestin primed ovarian stimulation, GnRH antagonist | Bedaya Hospital | Infertility | 03/26 | 12/26 | | |
NCT05738382: Efficacy and Safety of BG2109 During Controlled Ovarian Hyperstimulation in Female Subjects Undergoing ART Procedures |
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| Not yet recruiting | 2 | 240 | RoW | BG2109, Cetrorelix, Cetrorelix Acetate | Bio Genuine (Shanghai) Biotech Co., Ltd. | Assisted Reproductive Technology, Controlled Ovarian Hyperstimulation | 06/24 | 12/24 | | |
CS-EOSP-ICSI, NCT04071574: Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility |
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| Completed | 1/2 | 200 | RoW | Human Chorionic Gonadotropin (hCG), OVITRELLE / PREGNYL, Gonadotropins, MENOPUR, GNRH-A Triptorelin, DECAPEPTYL, GnRH antagonist, CETROTIDE / ORGULATRON | Lebanese University | Female Infertility, Female Infertility Due to Ovulatory Disorder, Premature Ovarian Failure, Polycystic Ovary Syndrome, Female Infertility of Tubal Origin, Ectopic Pregnancy, Salpingitis, Female Infertility Due to Tubal Block, Female Infertility Due to Tubal Occlusion, Hydrosalpinx, Female Infertility - Cervical/Vaginal, Female Infertility Endocrine, Endometriosis, Fibroids, Congenital Uterine Anomaly, Infections Uterine, Female Infertility of Other Origin | 08/19 | 05/23 | | |
| Recruiting | 1/2 | 30 | Europe | Triptorelin 3.75 MG Injection, Gonapeptyl, Decapeptyl, Transvaginal oocyte retrieval, Triptorelin Injection | Universitair Ziekenhuis Brussel, Universitaire Ziekenhuizen KU Leuven | Breast Cancer Female | 11/25 | 12/25 | | |
ChiCTR1900027870: Suspended Preliminary clinical trial of cetrorelix acetate for bioequivalence |
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| Suspended | 1 | 12 | | Cycle I: Test preparation; Cycle II: Reference preparation ;Cycle I: Reference preparation; Cycle II: Test preparation | Wuhan Xiangfang Specialty Clinical Pharmacology Research Center; Shenzhen Hanyu Pharmaceutical Co., Ltd., Shenzhen Hanyu Pharmaceutical Co., Ltd. | Pharmacokinetics and Bioequivalence Study in human | | | | |
ChiCTR2200063799: A prospective randomized controlled study on the necessity of GnRH-a addition in patients with LH < 6 IU/L during controlled ovarian hyperstimulation |
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| Not yet recruiting | 1 | 870 | | Add Cetrorelix ;Without cetrorelix | Peking University Shenzhen Hospital; Peking University Shenzhen Hospital, High level hospital research funds | infertility | | | | |
ChiCTR-ICR-15006210: The application of Cetrorelix in prevention of early onset ovarian hyperstimulation syndrome in high response patients: a randomized controlled trial |
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| Completed | N/A | 200 | | gonadotrophin-releasing hormone antagonist ;observation | Peking University Third Hospital; Peking University Third Hospital, OBGYN department, Peking University Third Hospital | ovarian hyperstimulation syndrome | | | | |
ChiCTR1900021293: Study for preventive effect and mechanism of gonadotropin-releasing hormone antagonist and aromatase inhibition on early-onset ovarian hyperstimulation syndrome after oocyte extraction |
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| Completed | N/A | 151 | | taking letrozole ;Cetrotide ;taking placebo | Shenyang Women's and Children's Hospital; shenyang women's and children's hospital, Shenyang Science and Technology Bureau | ovarian hyperstimulation syndrome | | | | |
Prog_STIM, NCT04108039: Micronized Progesterone vs Gonadotropin-releasing Hormone (GnRH) Antagonist in Freeze-all IVF Cycles. |
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| Completed | N/A | 44 | Europe | GnRh antagonist, Cetrorelix or Ganirelix, Micronized progesterone, Utrogestan | Institut Universitari Dexeus | Infertility, IVF, Preimplantation Diagnosis | 01/22 | 05/22 | | |
NCT04308343: The Aromatase Inhibitor and Gnrh Antagonist Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy |
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| Not yet recruiting | N/A | 120 | NA | Methotrexate, Letrozole, cetrotide | Assiut University | Ectopic Pregnancy | 03/22 | 09/22 | | |
ChiCTR2000034025: Comparison of GnRH agonist versus GnRH antagonist protocol on the cumulative live birth rate in POSEIDON subgroup 3 patients: a randomized controlled trial |
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| Not yet recruiting | N/A | 266 | | Triptorelin (Dabipramine 0.1mg/ day) will be routinely administered subcutaneously for 14 days after ovulation ;Give Cetrotide 0.25mg/day when about 12 mm of the follicle diameter until HCG trigger day | Reproductive medicine center of Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of science and technology; Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of science and technology, China Foundation for Health Promotion project for young and middle-age doctors of reproductive field. | Female infertility | | | | |
NCT06297564: Progesterone Primed Endometrial Protocol Versus Gonadotropin-releasing Hormone Antagonist Protocol in Assisted Reproductive Treatments |
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| Completed | N/A | 40 | RoW | Progesterone primed endometrial protocol, Gonadotropin-releasing hormone antagonist protocol | New Valley University | Progesterone Primed Endometrial Protocol, Gonadotropin Releasing Hormone Antagonist Protocol, Assisted Reproductive Treatments | 01/24 | 01/24 | | |
NCT05939284: Progesterone-Primed Ovarian Simulation in Controlled-ovarian Simulation of Infertile PCOS Patients |
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| Completed | N/A | 238 | RoW | Injection of Cetrorelix, Oral insertion of dydrogeserone | Zagazig University | PCOS | 09/22 | 01/23 | | |
NCT04989348: Euploid Rate of Blastocyst Derived From PPOS VS Antagonist Protocol |
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| Completed | N/A | 240 | RoW | Gonadotrophin releasing hormone antagonist protocol, Progestin-primed ovarian stimulation protocol | Shanghai First Maternity and Infant Hospital, The University of Hong Kong | IVF | 03/23 | 02/24 | | |
NCT05112692: Progestin-primed Ovarian Stimulation Protocol Versus GnRH Antagonist Protocol in Polycystic Ovary Syndrome Patients Undergoing IVF/ICSI Cycles |
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| Not yet recruiting | N/A | 200 | NA | Dydrogesterone Tablets, cetrorelix 0.25mg, human menopausal gonadotropin, triptorelin 0.1 mg, human chorionic gonadotropin, cryopreservation, Estradiol Valerate and progesterone | Mansoura University | PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries | 11/23 | 12/23 | | |
NCT04819204: Testosterone and Neurovascular Control in Humans |
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| Not yet recruiting | N/A | 20 | Canada | Cetrorelix Acetate, Cetrotide, Testosterone gel, Androgel 1% | Western University, Canada | Healthy | 12/23 | 12/23 | | |
NCT05767086: Comparison of 3 Different Protocols for Preventing Premature Ovulation in Ovarian Stimulation Cycles |
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| Recruiting | N/A | 297 | RoW | Gonadotropin releasing hormone antagonist (Cetrotide), Cetrotide, Medroxyprogesterone Acetate (Tarlusal), Tarlusal, Dydrogesterone, Duphaston (Duphaston) | Bezmialem Vakif University | Infertility | 03/24 | 03/24 | | |
NCT05751681: Dydrogesterone-Primed Ovarian Stimulation Protocol Versus Gonadotropin Releasing Hormone Antagonist Protocol in ICSI |
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| Recruiting | N/A | 79 | RoW | progestin primed ovarian stimulation protocol, dydrogesterone (Duphaston, Abbott), Cetrotide, cetrorelix | Zagazig University | Ovary Cyst, Fertility Issues | 04/24 | 03/25 | | |
| Recruiting | N/A | 626 | RoW | Dydrogesterone 10 mg, Duphaston, Cetrorelix 0.25 mg, Cetrotide | Mỹ Đức Hospital | Progestins Primed Ovarian Stimulation | 12/25 | 09/26 | | |
NCT05847660: Progesterone Primed Ovarian Stimulation Protocol Versus Antagonist Protocol for PCO Patient |
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| Not yet recruiting | N/A | 210 | NA | Progesterone antagonist, duphaston, conventional antagonist protocol, 0.25 mg of cetrotide | Fayoum University | Polycystic Ovary Syndrome, Infertility, IVF | 06/24 | 07/24 | | |
NCT03680053: Comparison of the Live Birth Rate Between the PPOS and the GnRH Antagonist Protocol in Patients Undergoing IVF |
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| Recruiting | N/A | 784 | RoW | Duphaston, Cetrorelix | ShangHai Ji Ai Genetics & IVF Institute | Infertility, ART | 09/24 | 12/25 | | |
NCT06023602: Effectiveness of Generic Versus Reference Cetrorelix Acetate for Ovarian Stimulation Using a Gonadotropin-releasing Hormone（GnRH）Antagonist Protocol in Women Undergoing IVF |
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| Not yet recruiting | N/A | 1338 | RoW | Generic cetrorelix acetate, Reference cetrorelix acetate | Northwest Women's and Children's Hospital, Xi'an, Shaanxi | Infertility | 12/24 | 12/25 | | |
| Recruiting | N/A | 90 | RoW | Acupuncture, conventional western medicine(Recombinant Human Follitropin Alfa for Injection、Fructose Injection、Tetyacycline Hydrochloride Capsules、Cetrorelix Acetate Powder for Injection ), Western medicine | Peking University Third Hospital | Acupuncture, Female Infertility | 12/24 | 12/24 | | |
NCT04447872: The LUTEAL Trial: Luteal Stimulation vs. Estrogen Priming Protocol |
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| Recruiting | N/A | 142 | US | Timing of injectable gonadotropins | Northwell Health | Infertility, Diminished Ovarian Reserve, IVF | 06/25 | 06/25 | | |