| Tracleer (bosentan) / J&J, Roche |
NCT00317486: Effects of Tracleer (Bosentan) on Pulmonary Arterial Hypertension Related to Eisenmenger Physiology |
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| Completed | 4 | 54 | US, Canada, Europe, RoW | bosentan | Actelion | Pulmonary Arterial Hypertension Related to Eisenmenger Physiology | 04/05 | 04/05 | | |
NCT00367770: BREATHE 5-OL: Tracleer (Bosentan) in Patients With Pulmonary Arterial Hypertension Related to Eisenmenger Physiology |
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| Completed | 4 | 37 | US, Canada, Europe, RoW | Tracleer® | Actelion | Pulmonary Arterial Hypertension | 12/05 | 12/05 | | |
NCT00120380: Combination Therapy of Bosentan and Aerosolized Iloprost in Idiopathic Pulmonary Arterial Hypertension (IPAH) |
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| Terminated | 4 | 40 | Europe | Aerosolized iloprost, Placebo | Hannover Medical School | Hypertension | 05/06 | 05/06 | | |
| Completed | 4 | 22 | US, Europe, RoW | bosentan, Tracleer (R) | Actelion | Hypertension, Pulmonary | 02/07 | 11/07 | | |
NCT00266162: Bosentan in Treatment of Pulmonary Arterial Hypertension |
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| Completed | 4 | 60 | Europe | Bosentan administration | Competence Network for Congenital Heart Defects, German Federal Ministry of Education and Research, Actelion | Eisenmenger Syndrome | 02/08 | 02/08 | | |
| Completed | 4 | 11 | RoW | bosentan, Tracleer | Actelion | Hypertension, Pulmonary | 12/08 | 06/10 | | |
NCT00625469: Pulmonary Arterial Hypertension Secondary to Idiopathic Pulmonary Fibrosis and Treatment With Bosentan |
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| Withdrawn | 4 | 0 | US | bosentan, tracleer | Rajan Saggar, Actelion | Pulmonary Arterial Hypertension, Idiopathic Pulmonary Fibrosis | 06/09 | 12/09 | | |
| Completed | 4 | 100 | US | Bosentan, Sildenafil | Actelion | Pulmonary Arterial Hypertension | 05/10 | 08/10 | | |
| Completed | 4 | 32 | US | ambrisentan, Letairis | University of Alabama at Birmingham | Pulmonary Arterial Hypertension | 06/12 | 06/12 | | |
| Completed | 4 | 334 | US, Europe, RoW | bosentan, placebo | Actelion | Pulmonary Arterial Hypertension | 12/13 | 12/13 | | |
NCT01508780: Combined Use of Angiography, Optical Coherence Tomography and Intravascular Ultrasound in Evaluation of Pulmonary Vascular Structure and Function in Patients With Pulmonary Arterial Hypertension Treated With Oral Bosentan |
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| Withdrawn | 4 | 0 | US | St Jude Medical C7 Dragonfly Optical Coherence Tomography (OCT), Boston Scientific Intravascular Ultrasound | Massachusetts General Hospital, Actelion | Pulmonary Arterial Hypertension | 02/14 | 02/14 | | |
