NCT00260819: Effects of Bosentan (Tracleer) in the Course of Pulmonary Artery Hypertension Induced by Hypoxia |
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| Completed | 1 | 20 | Europe | Bosentan, TRACLEER, Bosentam TRACLEER | Assistance Publique - Hôpitaux de Paris | Hypoxia-Induced Pulmonary Artery Hypertension | 04/08 | 04/08 | | |
NCT01100736: Role of Endothelin-A (ETA) and Endothelin-B (ETB) Receptors in the Vasodilatory Response to Endothelin-3 (ET-3) |
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| Completed | 1 | 10 | Europe | Bosentan, Tracleer, Sitaxsentan, Thelin, Placebo, Endothelin-3 | University of Edinburgh, Encysive Pharmaceuticals | Pulmonary Arterial Hypertension, Vasodilation, Vasoconstriction | 09/09 | 01/10 | | |
NCT01864863: To Compare the Pharmacokinetics of Traclear 62.5 mg Tablets and HGP1206 125mg 1 Tablet in Healthy Male Volunteers |
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| Completed | 1 | 28 | RoW | HGP1206, Bosentan 125 mg, Traclear, Traclear 62.5 mg | Hanmi Pharmaceutical Company Limited | Pulmonary Arterial Hypertension | 05/13 | 05/13 | | |
ACTRN12615000281594: Comparative assessment of the absorption of a generic formulation of bosentan film-coated tablet against the innovator bosentan film-coated tablet conducted under fasting conditions in healthy male volunteers |
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| Completed | 1 | 56 | | | Zenith Technology Corp Ltd, Novotech (Australia) Pty Ltd | Bioequivalence study conducted in healthy volunteers comparing two formulations of bosentan with no health condition or problem studied.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, bosentan is an endothelin receptor antagonist that belongs to a class of highly substituted pyrimidine derivatives and is indicated for the treatment of idiopathic pulmonary arterial hypertension, familial pulmonary arterial hypertension, pulmonary arterial hypertension associated with schleroderma or pulmonary arterial hypertension assocated with congenital or systemic to pulmonary shunts including Eisenmenger's physiology.
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NCT00223717: Treatment of Supine Hypertension in Autonomic Failure |
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| Completed | 1 | 152 | US | Clonidine, Catapres, Nitroglycerin transdermal, Nitro-Dur, Dipyridamole/ Aspirin (Aggrenox), Aggrenox, Desmopressin (DDAVP), DDAVP, Sildenafil, Viagra, Nifedipine, Adalat, Hydralazine, Hydrochlorothiazide, Microzide, Placebo, Bosentan, Tracleer, Diltiazem, Cardizem, Eplerenone, Inspra, guanfacine, Tenex, L-arginine, captopril, capoten, carbidopa, Lodosyn, losartan, cozaar, metoprolol tartrate, lopressor, nebivolol hydrochloride, Bystolic, prazosin hydrochloride, Minipress, tamsulosin hydrochloride, Flomax, Head-up tilt., HUT, aliskiren, Tekturna, Local heat stress, heating pad | Vanderbilt University | Hypertension | 01/17 | 01/17 | | |
