| metformin / Generic mfg. |
ACTRN12612000864820: Investigation of whether metformin can be used safely and effectively in patients with type 2 diabetes on peritoneal dialysis |
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| Not yet recruiting | 2 | 6 | | | Tilenka Thynne, Department Clinical Pharmacology ,Flinders Medical Centre | Type 2 Diabetes, Chronic kidney Disease- on peritoneal dialysis | | | | |
ACTRN12611000495921: Multi-Parametric Cardiovascular Magnetic Resonance Assessment of Hypertrophic Cardiomyopathy - Therapeutic Metformin sub-study |
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| Not yet recruiting | 2 | 120 | | | Professor Joseph Selvanayagam, National Heart Foundation | Hypertrophic Cardiomopathy | | | | |
ACTRN12612000352808: Investigation of whether metformin can be used safely and effectively in patients with type 2 diabetes on haemodialysis |
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| Recruiting | 2 | 6 | | | Dr Tilenka Thynne, Department Clinical Pharmacology ,Flinders Medical Centre | Type 2 Diabetes, Chronic Renal failure on haemodialysis | | | | |
ACTRN12614001054606: Pilot study to evaluate the prognostic and metabolic effects of metformin during treatment of metastatic prostate cancer with androgen deprivation therapy |
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| Recruiting | 2 | 80 | | | Queensland University of Technology, 2014 Princess Alexandra Hospital Research Support Scheme Grants, Tolmar Australia Pty Ltd | Metastatic prostate cancer | | | | |
2011-003335-63: Effects of liraglutide on pancreatic function in type 2 diabetic patients with secondary failure to oral hypoglycemic agents. Effetti di liraglutide sulla funzione pancreatica nei pazienti con diabete tipo 2 in fallimento secondario agli ipoglicemizzanti orali. |
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| Ongoing | 2 | 80 | Europe | Solution for injection, Tablet, Coated tablet, VICTOZA*SC 2PEN 3ML 6MG/ML, GLIMEPIRIDE TEVA*20CPR 4MG, LEVEMIR*FLEX 5PEN 3ML 100UI/ML, METFORMINA TEVA IT*60CPR RIV1G | AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA, UNIVERSITA' DI PISA, NOVO NORDISK | Type 2 Diabetes mellitus Diabete mellito tipo 2, Type 2 Diabetes Diabete tipo 2, Diseases [C] - Hormonal diseases [C19] | | | | |
2014-000349-59: METAL trial: metformin plus erlotinib in patients with metastatic lung cancer in second line therapy Metal trial: combinazione di metformina più erltoinib in seconda linea di trattamento in pazienti con tumore del polmone avanzato |
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| Ongoing | 2 | 60 | Europe | erlotinib, L01XE03, Capsule, tarceva | department of experimental and clinical medicine "F. Magrassi", department of experimental and clinical medicine "F. Magrassi" | Patients with metastatic non small cell lung cancer in second line therapy pazienti con NSCLC in fase metastatica in seconda line adi trattamento, Patinets with advanced lung cancer pazienti con tumore del polmone in stadio avanzato, Diseases [C] - Cancer [C04] | | | | |
2014-000888-41: Activity and safety of Everolimus in combination with octreotide LAR and Metformin in patients with advanced pancreatic well-differentiated Neuroendocrine Tumors (pWDNETs): a Phase II, open, monocentric, prospective study. VALUTAZIONE DELL’ATTIVITÀ E DELLA SICUREZZA DELLA COMBINAZIONE EVEROLIMUS, OCTREOTIDE LAR E METFORMINA IN PAZIENTI AFFETTI DA TUMORI NEUROENDOCRINI DEL PANCREAS BEN DIFFERENZIATI IN STADIO AVANZATO E/O NON RESECABILI. STUDIO CLINICO-BIOLOGICO DI FASE II, MetNET 1 Trial. |
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| Not yet recruiting | 2 | 43 | Europe | Afinitor, Sandostatina lar 30, Metformina teva, 039398045, Tablet, Injection, Afinitor, Sandostatina lar 30, Metformina teva | Fondazione IRCCS Istituto Nazionale dei tumori, Not applicable | advanced/ or not resectable well differnciated pancreatic neuroendocrin tumor Tumore neuroendocrino del pancreas ben differenziato avanzato e/o non resecabile, advanced/ or not resectable well differnciated pancreatic neuroendocrin tumor Tumore neuroendocrino del pancreas ben differenziato avanzato e/o non resecabile, Diseases [C] - Cancer [C04] | | | | |
ChiCTR-IPR-14005374: A multicentre, randomized, blind, positive drug-controlled clinical trial of evaluating the efficacy and safety of using Compound Bismuth Potassium Citrate Capsules combine with Omeprazole Magnesium Enteric-coated Tablets to eradicate Helicobacter Pylori infection with duodenal ulcer. |
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| Recruiting | 2 | 400 | | Compound Bismuth Potassium Citrate Capsules, Omeprazole Magnesium Enteric-coated Tablets ;Bismuth potassium citrate, amoxicillin and clarithromycin combined omeprazole magnesium enteric-coated metformin hydrochloride | First affiliated hospital of Nanchang University; Guangzhou Boji medical biotechnology Limited by Share Ltd, Jingjiang reach source in hubei pharmaceutical co., LTD | Helicobacter pylori infection | | | | |
2015-001001-14: Effect of metformin in overweight breast cancer survivors at increased risk of recurrence Effetto della metformina in pazienti in sovrappeso a rischio di recidiva di tumore mammario |
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| Ongoing | 2 | 236 | Europe | Coated tablet, METFORAL - 850 MG COMPRESSE RIVESTITE CON FILM 30 COMPRESSE | ISTITUTO EUROPEO DI ONCOLOGIA, Ministero della salute - Ricerca corrente 2014 | Metabolic-unbalanced breast cancer survivors at higher risk for recurrence (triple negative breast cancer, luminal B Her2 positive, non luminal HER2 positive) Pregresso tumore della mammella ad alto rischio di recidiva (tumore triplo negativo, tumore ormono responsivo con HER2 sovraespresso, tumore non ormono responsivo con HER2 sovraespresso) in soggetti con squilibrio metabolico, Overweight breast cancer survivors at increased risk of recurrence Pazienti in sovrappeso a rischio di recidiva di tumore mammario, Diseases [C] - Cancer [C04] | | | | |
2006-004447-35: Biological Variation of Insulin Resistance, Testosterone and Cardiovascular Risk Factors In Women with Polycystic Ovarian Syndrome: modification with Rimonabant compared to Metformin. |
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| Ongoing | 2 | 56 | Europe | Metformin, rimonabant, Glucophage, Acomplia, Glucophage, Acomplia | Hull and East Yorkshire Hospital Trust | Patients with Polycystic Ovary Syndrome and body mass index above 30 kg/m2 | | | | |
2006-005772-41: LIMIT: Lowering the Incidence of vascular complications with Metformin in patients with Impaired glucose tolerance and a recent TIA or minor ischemic stroke: a phase 2, randomized, controlled trial |
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| Ongoing | 2 | 40 | Europe | metformin, metformin | investigator-driven research: Erasmus MC, Neurovascular Section | Patients with impaired glucose tolerance and a recent TIA or minor ischemic stroke | | | | |
2006-006236-22: Use of Metformin to reduce serum level of Testosterone and improve the metabolic picture in women treated for breast cancer |
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| Ongoing | 2 | 250 | Europe | METFORMINA MERCK, METFORMINA MERCK | AZIENDA SANITARIA OSPEDALIERA O.I.R.M. - S. ANNA | Menopausal women on treatment for BC, with higher risk of recurrence due to augmented level of T | | | | |
2006-004695-12: A Dose-Ranging Study of GSK189075 versus Placebo in the treatment of Type 2 Diabetes Mellitus in Subjects taking Metformin. |
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| Ongoing | 2 | 30 | Europe | GSK189075, GSK189075, | GlaxoSmithKline Research & Development | Type 2 Diabetes Mellitus | | | | |
2006-001911-31: Metformin-Wirkung am Ovar bei PCOS (MAO-Studie) - eine Pilotstudie |
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| Ongoing | 2 | 20 | Europe | Glucophage, Glucophage | Universitätsfrauenklinik Innsbruck | Polycystic ovary syndrome is one of the most common endocrine disorders, affecting approximately 10% of women of reproductive age, associated with hyperandrogenaemia and menstrual dysfunction. The aim of the study is to examine the effects of the insulin sensitizing drug metformin on ovarian function and ovulation rate in women with PCOS. | | | | |
2007-002815-20: A Prospective Randomised Pilot Study of Metformin and Lifestyle Intervention in the Prevention of Metabolic Syndrome due to Androgen Deprivation Therapy in Prostate Cancer |
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| Ongoing | 2 | 40 | Europe | Metformin, Metformin, Glucophage, Glucophage | Royal Surrey County Hospital | Patients with prostate cancer on androgen deprivation therapy (ADT). Randomisation between standard treatment with ADT only, and the additional use of metformin with dietary and exercise advice.Aim is to reduce the prevalence of metabolic syndrome in the intervention arm - this is a condition linked to ADT in prostate cancer patients | | | | |
2007-007118-12: TRATAMIENTO CON METFORMINA EN NIÑOS OBESOS NO DIABÉTICOS CON HIPERINSULINEMIA |
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| Ongoing | 2 | 60 | Europe | metformina, | Emilio Garcia Garcia | Estudiar la eficacia, seguridad y tolerancia de la metformina en el tratamiento de la obesidad en niños no diabéticos con resistencia insulínica. | | | | |
2009-010292-24: Evaluation of Metformin effect on left ventricular function and on energetic metabolism, in patients affected by heart failure and glucidic intolerance. |
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| Ongoing | 2 | 25 | Europe | METFORMINA TEVA, METFORMINA TEVA | OSPEDALE S. RAFFAELE | patients affected by heart failure and glucidic intolerance. | | | | |
2009-009517-18: Ensayo clínico de fase IIa, multicéntrico, aleatorizado, controlado con placebo y con tratamiento activo, cruzado para estudiar la seguridad y la eficacia de MK-3577 en pacientes con diabetes mellitus de tipo 2 con control insuficiente de la glucemia.A Phase IIa, Multicenter, Randomized, Placebo- and Active-Comparator Controlled,Cross-Over Clinical Trial to Study the Safety and Efficacy of MK-3577 in Patients withType 2 Diabetes Mellitus Who Have Inadequate Glycemic Control |
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| | 2 | 40 | Europe | MK-3577, MK-3577, Metformin Hydrochloride Tablets, Metformin Hydrochloride Tablets | Merck & Co., Inc., MERCK & CO., INC., Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Merck and Co. Inc., Merck & co.Inc | Diabetes Mellitus Tipo 2Type 2 Diabetes Mellitus | | 07/10 | | |
2009-009944-21: EFECTOS ENDOCRINO-METABÓLICOS Y SOBRE LA ADIPOSIDAD VISCERAL DE LA ADMINISTRACIÓN DE METFORMINA EN NIÑOS PREPUBERALES CON BAJO PESO AL NACER PARA LA EDAD GESTACIONAL, RECUPERACIÓN POSTNATAL ESPONTÁNEA DE PESO Y TALLA, Y MARCADORES DE RIESGO PARA EL SÍNDROME METABÓLICO |
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| Ongoing | 2 | 64 | Europe | METFORMINA SANDOZ 850 mg comprimidos recubiertos con película, METFORMINA SANDOZ 850 mg comprimidos recubiertos con película | HOSPITAL SANT JOAN DE DÉU | PRENATAL GROWTH RESTRAINT FOLLOWED BY EXCESSIVE CATCH-UP IN WEIGHT AND ASSOCIATED METABOLIC SYNDROMERETRASO DEL CRECIMIENTO INTRAUTERINO ASOICADO A CRECIMIENTO RECUPERADOR EXCESIVO Y SINDROME METABÓLICO | | | | |
2009-012226-37: Ensayo clínico piloto de tratamiento con Pioglitazona+Flutamida+Metformina a Dosis Bajas versus Etinil-Estradiol + Acetato de Ciproterona como control, en Adolescentes con Hiperandrogenismo Ovárico e Hiperinsulinismo: Efectos sobre Parámetros de Inflamación Crónica, Diabetes Tipo 2 y Riesgo Cardiovacular |
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| Ongoing | 2 | 48 | Europe | DIANE 35, METFORMINA SANDOZ 850 mg comprimidos recubiertos con película, FLUTAMIDA CINFA 250 mg comprimidos, ACTOS 15 mg comprimdos, DIANE 35, METFORMINA SANDOZ 850 mg comprimidos recubiertos con película, FLUTAMIDA CINFA 250 mg comprimidos, ACTOS 15 mg comprimdos | HOSPITAL SANT JOAN DE DÉU | Hiperandrogenismo ovárico asociado a hiperinsulinismo. | | | | |
2009-016246-12: Efectos Sobre Marcadores de Riesgo Cardiovascular de la Adición de Metformina al Tratamiento con Hormona de Crecimiento en Pacientes Prepuberales con Antecedentes de Peso Bajo al Nacer para la Edad Gestacional y sin Recuperación de Talla Postnatal |
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| Ongoing | 2 | 64 | Europe | METFORMINA SANDOZ 850 mg comprimidos recubiertos con película, METFORMINA SANDOZ 850 mg comprimidos recubiertos con película | HOSPITAL SANT JOAN DE DÉU | cambios endocrinometabólicos y de composición corporal en pacientes con bajo peso al nacimiento sin recuperación de peso/ talla en tratamiento con hormona de crecimiento | | | | |
2008-005708-18: Prevention of metabolic complications of glucocorticoid excess |
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| Ongoing | 2 | 100 | Europe | Metformin, Glucophage (metformin), Glucophage (metformin) | Queen Mary University of London | Rheumatoid arthritis, SLE, Polymyalgia rheumatica, Disthyroid eye disease, Cushing\'s syndrome | | | | |
2009-017716-32: A phase II, randomized, placebo controlled study to evaluate the efficacy of the combination of gemcitabine, erlotinib and metformin in patients with locally advanced and metastastatic pancreatic cancer |
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| Ongoing | 2 | 120 | Europe | erlotinib, gemcitabine, metformin, CHMP/511166/2006, CHMP/512295/08, CPMP/4082/00, | Academic Medical Center | locally advanced and metastatic pancreatic cancer | | | | |
2011-000490-30: Phase II randomised, open-label, unicentric clinical trial of neoadjuvant treatment comprising chemotherapy and trastuzumab with or without metformin, in women with HER2/ErbB2 positive primary breast cancer. Ensayo fase II, aleatorizado, abierto, unicéntrico, de tratamiento neoadyuvante con quimioterapia y trastuzumab con o sin la adición de metformina en mujeres diagnosticadas de cáncer de mama primario HER2/ErbB2 positivo. |
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| Ongoing | 2 | 178 | Europe | METFORMINA TEVA 850 mg comprimidos recubiertos con película, HERCEPTIN 150 mg polvo para concentrado para solución para perfusión, PACLITAXEL HOSPIRA 6 mg/ml concentrado para solución para perfusión, METFORMINA TEVA 850 mg comprimidos recubiertos con película, HERCEPTIN 150 mg polvo para concentrado para solución para perfusión, PACLITAXEL HOSPIRA 6 mg/ml concentrado para solución para perfusión | Consorcio de Apoyo a la Investigación Biomédica en Red (CAIBER), Ministerio de Sanidad, Politica Social e Igualdad, Caiber (Consorcio de Apoyo a la Investigacion Biomédica en Red) | Women with stage II-III, HER2/ErbB2-positive primary breast cancer elegible for neoadjuvant treatment. Cáncer de mama primario que sobreexpresa o amplifica HER2. | | | | |
| Ongoing | 2 | 30 | Europe | Metformin hydrochloride, N/A, Metformin hydrochloride, Metformin hydrochloride | Central Manchester University Hospitals NHS Foundation Trust, University of Manchester | Endometrial carcinoma or hyperplasia | | | | |
2013-001732-21: A phase II study of metformin in myotonic dystrophy type 1 patients |
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| Ongoing | 2 | 30 | Europe | metformin 500mg, metformin 500mg | Centre d\'Etude des Cellules Souches (CECS), CECS | Myotonic dystrophy type 1 (DM1) also known as Steinert disease | | | | |
| Ongoing | 2 | 20 | Europe | Metformina TEVA, IPSTYL, [Metformina], [IPSTYL], Tablet, Powder and solvent for solution for injection, METFORMINA TEVA - 30 CPR RIVESTITE IN BLISTER BIANCO OPACO PVC/PVDC/AL DA 850 MG, IPSTYL - 30 MG/2 ML POLVERE E SOLVENTE PER SOSPENSIONE INIETTABILE A RILASCIO PROLUNGATO PER USO INTRAMUSCOLARE1 FLACONE POLVERE + 1 FIALA SOLVENTE 2 ML | FONDAZIONE IRCCS "ISTITUTO NAZIONALE DEI TUMORI", IPSEN S.P.A. | Patients with progressive advanced Well-differentiated gastro-intestinal (GI) or lung carcinoids. Tumore neuroendocrino gastro-intestinale (GI) o carcinoide polmonare ben differenziato in stadio avanzato e/o non resecabile, Advanced neuroendocrine tumor Tumore neuroendocrino in stadio avanzato, Diseases [C] - Hormonal diseases [C19] | | | | |
2011-004683-30: A phase II study of sorafenib and metformin in patients with locally advanced and/or metastatic non-smal cell lung cancer (NSCLC) with a K-Ras mutation |
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| Ongoing | 2 | 64 | Europe | nexavar, LO1XE05, Nexavar, Nexavar | VU University Medical, Bayer Healthcare AG | Patients with advanced non small cell lung cancer that harbours a K-Ras mutation | | | | |
2011-004245-41`ACTRN12614001040651: Study of effects of Glucophage SR (a slow relaese metformin) tablet in patients with type-2 (adult onset) Diabetes and mild kidney dysfunction. |
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| Ongoing | 2 | 50 | Europe | Glucophage® SR, Not Applicable, Glucophage® SR (Merck Serono), Glucophage® SR (Merck Serono) | Hywel Dda Health Board, NewZealand College of chiropractic | subclinical spinal pain | | | | |
2016-001455-42: the influence of metformin and a low caloric diet on thyroid iodide uptake. De effecten van metformine en een laag-calorisch dieet op de schildklier jodium opname. |
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| Ongoing | 2 | 17 | Europe | Metformin, Tablet, Metformin | Radboud Universitair Medisch Centrum, Radboud Universitair Medisch Centrum | physiological thyroid function in terms of thyroid iodide uptake and thyroid hormone production knowledge can be extrapolated for treatment of thyroid diseases such as hyperthyroidism and thyroid carcinoma fysiologische schildklierfunctie in termen van schildklierjodiumopname en schildklierhormoon productie. kennis kan geëxtrapoleerd worden ter verbetering van de behandeling van schildklieraandoeningen zoals hyperthyreoïdie en schildkliercarcinoom, thyroid function schildklierfunctie, Body processes [G] - Physiological processes [G07] | | | | |
2011-001793-26: A Phase II Trial of Metformin and Axitinib in BRAF Mutated Advanced Melanoma (MAXIM) |
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| Ongoing | 2 | 48 | Europe | Axitinib, Metformin, (AG-013736), Metformin, Metformin | Royal Marsden Hospital, Pfizer | Advanced BRAF mutant melanoma | | | | |
NCT02254512: METformin With a Cargohydrate Restricted Diet in Combination With Platinum Based Chemotherapy in Stage IIIB/IV Non-squamous Non-small Cell Lung Cancer |
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| Recruiting | 2 | 60 | US | Metformin, Glucophage, Carboplatin, Pemetrexed, Alimta | Beth Israel Medical Center | Carcinoma, Non-squamous Non-small-cell Lung | 06/17 | 09/17 | | |
ChiCTR-OIN-17012130: A single-arm prospective Phase II clinical trial of metformin in the maintenance of non-Hodgkin's lymphoma patients |
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| Completed | 2 | 222 | | Metformin involved in maintenance therapy ;Metformin not involved in maintenance therapy | Shanghai Jiaotong University School of Medicine, Ruijin Hospital, Hematology department; Ruijin Hospital, Shanghai Jiaotong University School of Medcine, self-financing | non-Hodgkin's lymphoma | | | | |
2016-003575-21: MAVMET: A research study exploring whether MAraViroc, a licensed treatment for HIV infection and METformin, a licensed treatment for diabetes, are effective and safe at reducing the amount of fat in the liver. |
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| Ongoing | 2 | 88 | Europe | Metformin, Celsentri, metformin, metformin, maraviroc, Film-coated tablet, Metformin, Celsentri, metformin | MRC Clinical Trials Unit at UCL, Viiv Healthcare | Hepatic steatosis in adults with chronic HIV-1 infection, HIV-1- infected patients with non-alcoholic fatty liver disease, Diseases [C] - Nutritional and Metabolic Diseases [C18] | | | | |
2017-000722-35: Trial to investigate the effect of metformin treatment before and after surgery in patients with colon cancer |
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| Ongoing | 2 | 48 | Europe | Capsule, metformin | Ismail Gögenur, Department of surgery, Slagelse Hospital | Colon cancer, Bowel cancer, Diseases [C] - Cancer [C04] | | | | |
2017-003864-10: Medication for excessive urine production in patients treated with tolvaptan Medicijnen tegen verhoogde urineproductie bij tolvaptan |
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| Ongoing | 2 | 12 | Europe | Hydrochlorothiazide, Metformin, HCT, Tablet | University Medical Center Groningen, University Medical Center Groningen | Autosomal dominant polycystic kidney disease Autosomaal dominante polycysteuze nierziekte, Polycystic kidney disease Familiaire cystenieren, Diseases [C] - Symptoms and general pathology [C23] | | | | |
2018-000788-95: Exploiting metformin plus/minus cyclic FAsting Mimicking diet (FMD) to improve the Efficacy of platinum-pemetrexed chemotherapy in advanced LKB1-mutated lung adenocarcinoma: the FAME trial Combinazione di metformina e cicli di Dieta Mima Digiuno (DMD), o sola metformina, al fine di incrementare l¿efficacia della chemioterapia con platino e pemetrexed nel trattamento dell¿adenocarcinoma polmonare con mutazione di LKB1: lo studio FAME |
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| Not yet recruiting | 2 | 88 | Europe | METFORMINA, IMP1, Film-coated tablet, METFORMINA - 500 30 COMPRESSE 500 MG | FONDAZIONE IRCCS "ISTITUTO NAZIONALE DEI TUMORI", AIRC 5x1000 | Patients with LKB1-mutated advanced lung adenocarcinomas Adenocarcinoma polmonare avanzato in pazienti con mutazione gene LKB1, Patients with advanced lung adenocarcinoma Adenocarcinoma polmonare avanzato, Diseases [C] - Cancer [C04] | | | | |
2017-004149-26: Effect of Metformin in insulin resistant patients with heart failure with reduced ejection fraction Effekt von Metformin bei insulinresistenten Patienten mit Herzinsuffizienz bei reduzierter Pumpleistung des Herzens |
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| Ongoing | 2 | 88 | Europe | Metformin, Film-coated tablet, Sifor 1000 | Charité Universitätsmedizin Berlin, DZHK | patients with Heart Failure with reduced Ejection Fraction, patients with Heart Failure with reduced Ejection Fraction, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2017-004959-23: A blind study to Evaluate the Efficacy and Safety of 5 Aminolevulinic Acid Co-administered during 24 weeks with Sodium Ferrous Citrate (study drugs) Compared with Placebo in the Treatment of Type 2 Diabetes Mellitus Patients |
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| Ongoing | 2 | 100 | Europe | 5- Aminolevulinic acid hydrochloride 50mg Capsules, Sodium Ferrous Citrate 39mg Capsules, Capsule | neopharma Japan Co., Ltd, neopharma Japan Co., Ltd. | Type 2 Diabetes Mellitus in Patients who have not Achieved Adequate Glycemic Control with Maximum Tolerated Dose of Metformin Daily or Sulfonylurea, Type 2 Diabetes Mellitus, Body processes [G] - Metabolic Phenomena [G03] | | | | |
2017-004880-11: The POWERED Study: Prophylaxis with metformin to prevent post transplant diabetes |
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| Not yet recruiting | 2 | 57 | Europe | Metformin, Film-coated tablet, Metformin | Barts Health NHS Trust, Diabetic Kidney Disease Centre (Barts Health NHS Trust) | post transplant diabetes, diabetes, Diseases [C] - Hormonal diseases [C19] | | | | |
2017-001788-19: Metformin Therapy to Inhibit Progression inPatients with Abdominal Aortic Aneurysm |
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| Ongoing | 2 | 170 | Europe | SmPC Glucophage 500 mg - clean, Glucophage IR 500, SKU no FR2PM90 AUT, Tablet, SmPC Glucophage 500 mg - clean | Medical University Vienna, Medcial University Vienna | Abdominal Aortic Anuerysm, widening of the infrarenal aorta over time, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
NCT06473662: Study to Evaluate the Safety and Efficacy of Oral Insulin Formulation in Type 2 Diabetes Mellitus Subjects |
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| Completed | 2 | 100 | Europe | Oral insulin | Roger New | Type 2 Diabetes Treated With Insulin | 07/20 | 07/20 | | |
2018-000584-85: Treatment with Metformin and growth hormone in children with a low birth weight Behandling med Metformin og væksthormon af børn med lav fødselsvægt |
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| Ongoing | 2 | 24 | Europe | Metformin, Oral solution, Metformin | Rigshospitalet, Rigshospitalet | Growth disorder in children born small for gestational age Vækstforstyrrelser hos børn med lav fødselsvægt, Growth disorder in children with low birth weight Vækstforstyrrelser hos børn med lav fødselsvægt, Diseases [C] - Hormonal diseases [C19] | | | | |
NCT03076281: Metformin Hydrochloride and Doxycycline in Treating Patients With Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery |
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| Active, not recruiting | 2 | 7 | US | Metformin Hydrochloride, 1,1-Dimethylbiguanide Hydrochloride, 1115-70-4, 91485, Cidophage, Dimefor, Glucoformin, Glucophage, Glifage, Doxycycline, 17086-28-1, Doxycycline Monohydrate, Metformin +Doxycycline | Sidney Kimmel Cancer Center at Thomas Jefferson University | Larynx, LIP, Oral Cavity, Pharynx | 12/18 | 08/20 | | |
2017-000082-72: Impact of metformin on leptin in the cerebrospinal fluid of obese patients Impact de la Metformine sur la leptine dans le liquide cérébrospinal de patients obèses |
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| Not yet recruiting | 2 | 31 | Europe | Metformine chlorhydrate, Tablet, Metformine Sandoz 500 mg, METFORMINE ARROW 850 | Groupement des Hôpitaux de l'Institut Catholique de Lille (GHICL), Centre hospitalier d'Arras, Santélys, INSERM, Fondation de l'Avenir, European Research Council | OBESITY (BMI > 30) Obésité (IMC > 30), Obesity Obésité, Body processes [G] - Metabolic Phenomena [G03] | | | | |
NRG-LU001, NCT02186847: Chemotherapy and Radiation Therapy With or Without Metformin Hydrochloride in Treating Patients With Stage III Non-small Cell Lung Cancer |
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| Active, not recruiting | 2 | 170 | Canada, US, RoW | Radiation Therapy, 3-dimensional conformal radiation therapy, 3D-CRT, Intensity-modulated radiation therapy, IMRT, Carboplatin, Metformin, Metformin HCL, Metformin Hydrochloride, Paclitaxel | NRG Oncology, National Cancer Institute (NCI) | Adenosquamous Lung Carcinoma, Bronchioloalveolar Carcinoma, Large Cell Lung Carcinoma, Lung Adenocarcinoma, Non-Small Cell Lung Carcinoma, Recurrent Non-Small Cell Lung Carcinoma, Squamous Cell Lung Carcinoma, Stage IIIA Non-Small Cell Lung Cancer, Stage IIIB Non-Small Cell Lung Cancer | 04/19 | 04/25 | | |
| Active, not recruiting | 2 | 160 | Europe | ASA, Cardioaspirin, MET, Metformin, Placebo | Ente Ospedaliero Ospedali Galliera | Tertiary Prevention in Colon Cancer | 03/24 | 03/24 | | |
2018-004119-36: Altered tumor oxygenation by Metformin, a potential step in overcoming radiotherapy resistance in locally advanced cervical cancer |
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| Not yet recruiting | 2 | 90 | Europe | Glucophage, Cisplatin Accord, Tablet, Concentrate for solution for infusion, Glucophage, Cisplatin Accord | Oslo University Hospital, Oslo University Hospital | Locally advanced cervical cancer, Locally advanced cervical cancer, Diseases [C] - Cancer [C04] | | | | |
2018-001755-12: A pilot study of the use of metformin to reduce airway glucose in COPD |
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| Not yet recruiting | 2 | 40 | Europe | Metformin, 657-24-9, Capsule, Metformin | Imperial College, NIHR Imperial Biomedical Research Centre | Chronic obstructive pulmonary disease, Chronic obstructive pulmonary disease, Diseases [C] - Respiratory Tract Diseases [C08] | | | | |
2018-004287-56: Methotrexate and Metformin in rheumatoid arthritis patients Efficacité de l’association Méthotrexate/Metformine chez les patients atteints de polyarthrite rhumatoïde |
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| Ongoing | 2 | 128 | Europe | Metformin, Methotrexate, Acide folique, Prednisone, B03BB01, H02AB07, Cachet, Injection, METFORMINE ARROW 500mg, Methotrexate, Acide folique, Prednisone | CHU de Bordeaux, Ministère de la Santé, NORDIC PHARMA SAS | rheumatoid arthritis (RA) polyarthrite rhumatoïde (PR), rheumatoid arthritis (RA) polyarthrite rhumatoïde (PR), Body processes [G] - Immune system processes [G12] | | | | |
2019-003093-13: Targeting triple negative BREAst cancer metabolism with a combination of chemotherapy and a diet mimicking FASTing plus/minus metformin in the preoperative setting: the BREAKFAST trial Dieta Mima Digiuno (DMD) ciclica, da sola o in combinazione con metformina, al fine di incrementare l’efficacia della chemioterapia nel trattamento preoperatorio del carcinoma mammario triplo negativo: lo studio BREAKFAST |
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| Not yet recruiting | 2 | 90 | Europe | Metformina, [Metformina], Film-coated tablet, METFORAL - 850 MG COMPRESSE RIVESTITE CON FILM 30 COMPRESSE | FONDAZIONE IRCCS "ISTITUTO NAZIONALE DEI TUMORI", Ministero della Salute - Fondo 5 x mille | Targeting triple negative BREAst cancer Carcinoma mammario triplo negativo, Targeting triple negative BREAst cancer Carcinoma mammario triplo negativo, Diseases [C] - Cancer [C04] | | | | |
2019-004916-76: Combination study between nivolumab and metformin in advanced kidney cancer. Studio di combinazione tra nivolumab e metformina nel tumore del rene avanzato. |
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| Ongoing | 2 | 21 | Europe | Nivolumab, Metformina, [Nivolumab], [Metformina], Concentrate for solution for infusion, Tablet, Opdivo | FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS UNIVERSITA' CATTOLICA DEL SACRO CUORE | Patients with advanced renal cell carcinoma pre-treated with VEGFR inhibitors. Pazienti con carcinoma renale avanzato pre-trattati con farmaci inibitori del VEGFR., Patients with advanced renal cell carcinoma pre-treated with VEGFR inhibitors. Pazienti con carcinoma renale avanzato pre-trattati con farmaci inibitori del VEGFR., Diseases [C] - Cancer [C04] | | | | |
2018-004385-34: Randomized phase II trial in patients with locally advanced rectal carcinoma studio di fase II in pazienti con carcinoma del retto localmente avanzato |
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| Ongoing | 2 | 340 | Europe | METFORMINA, XELODA, OXALIPLATINO, aspirina, [657-24-9], [154361-50-9], [63121-00-6], [58-78-2], Tablet, Concentrate for solution for infusion, xeloda, OXALIPLATINO | ISTITUTO NAZIONALE TUMORI - IRCCS FONDAZIONE PASCALE, Istituto Nazionale Tumori - Fondazione G.Pascale, IRCCS Napoli | LOCALLY ADVANCED RECTAL CANCER PATIENTS IN STAGE II/III Pazienti con cancro del retto localmente avanzato in stadio II/III., LOCALLY ADVANCED RECTAL CANCER PATIENTS IN STAGE II/III Pazienti con cancro del retto localmente avanzato in stadio II/III., Diseases [C] - Cancer [C04] | | | | |
NCT04559308: The Effect of Metformin on Breast Cancer Patients |
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| Recruiting | 2 | 80 | RoW | Metformin, Glucophage, Chemotherapy, Doxorubicin, Cyclophosphamide, Paclitaxel | Beni-Suef University, Ahram Canadian University | Breast Cancer | 09/20 | 10/20 | | |
NCT03308695: CS02 vs Placebo With Metformin in Type 2 Diabetic Subjects |
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| Recruiting | 2 | 208 | US, RoW | CS02 Tablet, CS02 PTM (placebo), Metformin | Center Laboratories, Inc. | T2DM With Inadequate Glycemic Control | 10/20 | 05/21 | | |
NCT02874430: Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer |
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| Active, not recruiting | 2 | 27 | US | Metformin Hydrochloride, 1,1-Dimethylbiguanide Hydrochloride, 1115-70-4, 91485, Cidophage, Dimefor, Glifage, Glucoformin, Glucophage, N,N-Dimethylimidodicarbonimidic Diamide Monohydrochloride, Riomet, Siofor, Doxycycline, 17086-28-1, Doxycycline Monohydrate | Sidney Kimmel Cancer Center at Thomas Jefferson University | Breast Carcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Serous Adenocarcinoma, Uterine Corpus Cancer, Uterine Corpus Carcinosarcoma | 12/20 | 06/23 | | |
2020-002468-30: Effect of Metformin in patients with thyroid cancer metastasis Effetto della Metformina nei pazienti affetti da metastasi da carcinoma differenziato della tiroide |
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| Not yet recruiting | 2 | 20 | Europe | Glucophage unidie 1000 MG, [nd], Tablet, GLUCOPHAGE | ENTE OSPEDALIERO OSPEDALI GALLIERA | patients with differentiated thyroid cancer metastasis with minimally progressive development pazienti affetti da metastasi da carcinoma differenziato della tiroide ad andamento minimamente progressivo, patients with metastatic thyroid carcinoma pazienti con tumore alla tiroide in fase metastatica, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Diagnosis [E01] | | | | |
2020-005088-30: STOP-LEUKEMIA: A pilot study of metformin as a leukemia-preventive drug in patients with CCUS or LR-MDS STOP-LEUKEMIA: Et pilotstudie af metformin som et leukæmi-forebyggende lægemiddel hos patienter med CCUS eller lav-risiko MDS |
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| Not yet recruiting | 2 | 60 | Europe | Tablet, Metformin "Medical Valley" | Kirsten Grønbæk, Rigshospitalet | Clonal cytopenia of undetermined significance (CCUS) and lower-risk myelodysplastic syndrome (LR-MDS). Klonal cytopeni af ubestemt signifikans (CCUS) og lavere-risiko myelodysplastisk syndrom (MDS), Predispositions to leukemia Forstadier til leukæmi, Diseases [C] - Blood and lymphatic diseases [C15] | | | | |
2021-000134-34: Metformin and Nightly Fasting in Women with Early Breast Cancer Metformina e digiuno intermittente nelle donne con tumore al seno |
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| Not yet recruiting | 2 | 120 | Europe | Metformina a lento rilascio, [nd], Tablet | ENTE OSPEDALIERO OSPEDALI GALLIERA, Ministero della Salute, Bando RICERCA FINALIZZATA 2019, - National Institutes of Health (NIH), RFA-CA-19-031 Cancer Prevention Clinical Trials Network (CP-CTNet): CP-CTNet Site | Luminal (ER+ve and/or PgR+ve >=1%) invasive breast cancer not candidate to neo - adjuvant chemotherapy Tumore della mammella con recettori degli estrogeni e/o progesterone positivi non candidate a chemioterapia neoadiuvante, Breast cancer Tumore al seno, Diseases [C] - Cancer [C04] | | | | |
MetNET1, NCT02294006: Activity and Safety of Everolimus+Octreotide LAR+Metformin in Advanced Pancreatic Well-differentiated NETs |
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| Active, not recruiting | 2 | 26 | Europe | Everolimus plus Octreotide LAR plus Metformin | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | Well Differentiated Pancreatic Endocrine Tumor | 06/21 | 10/21 | | |
NCT04750135: Assessment of Metformin as Adjuvant Therapy in Patients With Ulcerative Colitis |
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| Not yet recruiting | 2 | 40 | RoW | metformin 500 mg TID Oral Tablet, Glucophage XR, Placebo | National Hepatology & Tropical Medicine Research Institute | Ulcerative Colitis, Inflammatory Bowel Diseases | 06/21 | 06/21 | | |
2019-000218-12: A 16-Week Study to Evaluate the Efficacy and Safety of PF-06882961 in Adults with Type 2 Diabetes Mellitus 16-týždňové klinické skúšanie na vyhodnotenie účinnosti a bezpečnosti produktu PF-06882961 u dospelých účastníkov s diabetes mellitus 2. typu |
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| Not yet recruiting | 2 | 400 | Europe, RoW | PF-06882961 2,5 mg, PF-06882961 10 mg, PF-06882961 40 mg, PF-06882961 100 mg, PF-06882961, Tablet | Pfizer Inc., Pfizer Inc. | TYPE 2 DIABETES MELLITUS INADEQUATELY CONTROLLED ON METFORMIN OR DIET AND EXERCISE, Type 2 diabetes mellitus, Diseases [C] - Nutritional and Metabolic Diseases [C18] | | | | |
| Recruiting | 2 | 50 | US | Metformin hydrochloride, Placebo | Columbia University | Heart Failure | 08/21 | 02/22 | | |
2021-000192-37: Oxidative Phosphorylation Targeting In Malignant glioma Using Metformin plus radiotherapy temozolomide La metformine en association avec radiothérapie-témozolomide comme thérapie ciblée métabolique pour le sous-groupe de patients atteints d’un glioblastome dépendant de la phosphorylation oxydative |
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| Not yet recruiting | 2 | 64 | Europe | Metformine, Coated tablet, METFORMINE | Hôpital Foch, Delegation of Clinical Research and Innovation (DRCI), Hôpital Foch | Patients with a diagnosis of Glioblastoma Patients atteints d'un Glioblastome, Patients with a diagnosis of Glioblastoma Patients atteints d'un Glioblastome, Diseases [C] - Cancer [C04] | | | | |
2021-003299-15: Metformin vs placebo for reversal of accelerated biological aging in persons living with HIV 50 years or older and with suppressed virologic replication Metformina frente a placebo para la reversión del envejecimiento biológico acelerado en personas que viven con el VIH de 50 años o más y con replicación virológica suprimida |
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| Not yet recruiting | 2 | 60 | Europe | Metformina, Film-coated tablet, Metformina | Fundación para la Investigación Biomédica del Hospital La Paz, Fundación para la Investigación Biomédica del Hospital La Paz | Patients with HIV and accelerated biological aging Pacientes con VIH y envejecimiento acelerado, Patients with HIV Pacientes con VIH, Diseases [C] - Virus Diseases [C02] | | | | |
M-HARTT, NCT02780024: Metformin, Neo-adjuvant Temozolomide and Hypo- Accelerated Radiotherapy Followed by Adjuvant TMZ in Patients With GBM |
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| Active, not recruiting | 2 | 50 | Canada | Metformin, Glucophage | McGill University Health Centre/Research Institute of the McGill University Health Centre | Glioblastoma Multiforme | 10/21 | 02/26 | | |
ChiCTR2000028833: Superiority of a metformin hydrochloride combination regimen for aplastic anemia in a phase II clinical trial |
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| Not yet recruiting | 2 | 94 | | Combined regimen with metformin hydrochloride ;HSCT/ATG | Department of Hematology, Second Medical Center, Chinese PLA General Hospital; Department of Hematology, Second Medical Center, Chinese PLA General Hospital, Hospital research projects | Acquired aplastic anemia | | | | |
NCT02684578: Metformin for the Minimization of Geographic Atrophy Progression in Patients With AMD |
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| Completed | 2 | 66 | US | Metformin, Glucophage | University of California, San Francisco, San Francisco Veterans Affairs Medical Center, VA Palo Alto Health Care System, University of California, Davis, University of California, San Diego, Northwestern University, University of Illinois at Chicago, Retinal Consultants Medical Group, Retina Health Center, California Retina Consultants, Oregon Health and Science University | Age-Related Macular Degeneration, Macular Degeneration, Age-Related, Dry Macular Degeneration, Geographic Atrophy | 04/22 | 10/22 | | |
NCT04780854: Drug Repurposing for the Prevention of Chemotherapy-induced Peripheral Neuropathy (CIPN) |
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| Recruiting | 2 | 68 | RoW | Metformin, N,N-dimethylbiguanide, Cidophage, Placebo, inactive pill | Cairo University, German University in Cairo | Chemotherapy-induced Peripheral Neuropathy | 05/22 | 07/22 | | |
2018-004289-33: Does metformin reduce growth rate of small abdominal aortic aneurysms? |
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| Ongoing | 2 | 500 | Europe | Metformin, Tablet, Metformin | Department of Surgical Sciences, Uppsala University, Department of Vascular Surgery, Rigshospitalet | Small abdominal aortic aneurysm (AAA) under active surveillance; 30-49 mm in diameter for men and 30-44 mm in diameter for women, Small abdominal aortic aneurysm under surveillance where the aneurysm diameter is below threshold for surgical repair and not expected to reach this threshold within 24 months of study start, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
HERMET, NCT03238495: Randomized Trial of Neo-adjuvant Chemotherapy With or Without Metformin for HER2 Positive Operable Breast Cancer |
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| Recruiting | 2 | 100 | US | Taxotere, Carboplatin, Herceptin + Pertuzumab, Metformin | Qamar Khan | HER2-positive Breast Cancer | 06/22 | 06/23 | | |
SAKK 08/14, NCT02640534: Investigation of Metformin in Patients With Castration Resistant Prostate Cancer in Combination With Enzalutamide vs. Enzalutamide Alone |
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| Terminated | 2 | 169 | Europe | Enzalutamide, Metformin | Swiss Group for Clinical Cancer Research | Cancer of the Prostate, Prostate Cancer | 07/22 | 03/23 | | |
| Active, not recruiting | 2 | 239 | Europe, US, RoW | Erdafitinib, JNJ-42756493, Midazolam, Metformin | Janssen Research & Development, LLC | Urothelial Cancer | 09/22 | 12/24 | | |
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| Active, not recruiting | 2 | 165 | RoW | Levonorgestrel, Mirena, Metformin | Queensland Centre for Gynaecological Cancer, The University of Queensland, Queensland University of Technology | Complex Endometrial Hyperplasia With Atypia, Grade 1 Endometrial Endometrioid Adenocarcinoma | 10/22 | 12/23 | | |
NCT05351021: Efficacy of Metformin as Preventive Treatment in Paclitaxel Induced Peripheral Neuropathy in Breast Cancer Patients |
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| Completed | 2 | 76 | RoW | Metformin, Placebo | Mansoura University | Peripheral Neuropathy, Breast Cancer | 10/22 | 10/22 | | |
NCT05306028: Metformin and Insulin to Pancreatic Cancer Related Diabetes (Type 3c) |
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| Recruiting | 2 | 20 | RoW | Metformin or insulin treatment | Fudan University | Pancretic Cancer, Diabete Mellitus | 10/24 | 12/25 | | |
ACTRN12621001539820: Clozapine Obesity and Semaglutide Treatment (COaST). A randomised controlled multi-centre trial of semaglutide versus placebo for people with schizophrenia on clozapine with obesity |
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| Suspended | 2 | 80 | | | The University of Queensland, Metro South Hospital and Health Service | Schizophrenia, Obesity, schizoaffective disorder, metabolic syndrome | | | | |
DIASA3, NCT04662866: Effects of Glucose Lowering Agents in South Asian Women With Impaired Glucose Tolerance or Impaired Fasting Glucose |
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| Recruiting | 2 | 64 | Europe | Metformin capsule 500 mg, Empagliflozin encapsulated tablet 10 mg, Pioglitazone encapsulated tablet 30 mg, Linagliptin encapsulated tablet 5 mg, biguanide, glitazone, sodium glucose transport inhibitor, dipeptidyl peptidase inhibitor | Oslo University Hospital, The Research Council of Norway, Norwegian Diabetes Association, South-Eastern Norway Regional Health Authority, University of Oslo, University Hospital, Akershus, Vestre Viken Hospital Trust, University of Glasgow | Impaired Glucose Tolerance, Insulin Sensitivity, Glucose Metabolism Disorders | 12/22 | 10/23 | | |
NCT03606694: Effect of Dihydromirycetin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes Mellitus |
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| Active, not recruiting | 2 | 24 | RoW | Dihydromyricetin, Ampelopsis grossedentata Extract, Metformin, Brad Predial | University of Guadalajara | Type 2 Diabetes Mellitus | 12/22 | 12/23 | | |
NCT05790577: Comparison of 30% Metformin and 2% Nicotinamide Lotion With Kligman Formula in the Treatment of Melasma |
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| Completed | 2 | 88 | RoW | Metformin and Nicotinamide vs Kligman Formula | Ishtiaq Ahmed | Melasma | 02/23 | 02/23 | | |
NCT05298670: Drug Repurposing Using Metformin for Improving the Therapeutic Outcome in Multiple Sclerosis Patients |
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| Recruiting | 2 | 80 | RoW | MetFORMIN 1000 Mg Oral Tablet, Cidophage ®1000 mg tablets, CID, Giza, Egypt) tablet and Rebiff ® 44mcg or Avonex®, Interferon beta-1a, Rebiff ® 44mcg or Avonex® | German University in Cairo | Multiple Sclerosis | 02/23 | 03/23 | | |
NCT06252194: Comparative Study of Metformin Versus Doxycycline in Moderate to Severe Adult Acne Vulgaris Patients. |
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| Recruiting | 2 | 120 | RoW | Metformin and doxycycline | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Acne Vulgaris | 03/24 | 03/24 | | |
NCT05297045: A Study of Oral GLP1RA RGT001-075 in Adults With Type 2 Diabetes |
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| Terminated | 2 | 17 | US | RGT001-075, Placebo | Regor Pharmaceuticals Inc. | Type 2 Diabetes Mellitus | 05/23 | 05/23 | | |
NCT05981742: Effects of Combined Metformin and Cabergoline in Comparison With Metformin Only Therapy on Ovarian and Hormonal Activities in Iraqi Patients With PCOS |
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| Completed | 2 | 75 | RoW | Metformin Hydrochloride 500 MG, Cabergoline 0.5 MG, Metformin Hydrochloride 500 MG + Cabergoline 0.5 MG | Al-Rasheed University College | Polycystic Ovary Syndrome | 03/23 | 03/23 | | |
NCT03733132: Metformin Effect on Brain Function in Insulin Resistant Elderly People |
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| Completed | 2 | 40 | US | Metformin Hydrochloride, Metformin, Placebo Oral Tablet, Placebo | Mayo Clinic, National Institute on Aging (NIA) | Insulin Resistance, Obesity, Obesity, Abdominal | 04/23 | 04/23 | | |
2022-003879-42: randomized, controlled, double-blind clinical trial evaluating the effect of METformin treatment on endometrial function in women diagnosed with Idiopathic Infertility Badanie efektywności metforminy w leczeniu idiopatycznej niepłodności |
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| Not yet recruiting | 2 | 200 | Europe | Tablet, Glucophage | Medical Univeristy of Bialystok, Medical University of Bialystok | Potential causes of idiopathic infertility include in particular: abnormal function of the endometrium, including implantation disorders and immunological abnormalities, genetic abnormalities and the functioning of reproductive cells and embryos, functional abnormalities of reproductive cells and embryos, dysfunctions and discreet anatomical anomalies of the fallopian tubes transport of reproductive cells and embryos. Potencjalne podłoże niepłodności idiopatycznej wymienia się w szczególności: nieprawidłową funkcję endometrium, w tym zaburzenia implantacji oraz nieprawidłowości immunologiczne, nieprawidłowości genetyczne i funkcjonowanie komórek rozrodczych i zarodków, nieprawidłowości funkcjonalne komórek rozrodczych i zarodków, zaburzenia funkcji oraz dyskretne anomalie anatomiczne jajowodów (pomimo zachowanej drożności) zaburzające transport komórek rozrodczych oraz zarodków., Idiopathic infertility is diagnosed after all other medically known symptoms of infertility are excluded. This category includes 5 - 10% of all infertile couples. Niepłodność diopatyczną rozpoznaje się po wykluczeniu wszystkich innych medycznie znanych objawów niepłodności. Ta kategoria obejmuje 5 - 10% wszystkich niepłodnych par., Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13] | | | | |
2022-003595-16: Clinical trial on the use of metformin in addition to standard therapy in patients with high-grade glioma Studio clinico sull'uso della metformina in aggiunta alla terapia standard in pazienti affetti da glioma di alto grado |
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| Not yet recruiting | 2 | 25 | Europe | metformina, metformina, Film-coated tablet | UNIVERSITÀ DEGLI STUDI MILANO BICOCCA, AIRC | IDH-wildtype glioblastoma glioblastoma IDH-wildtype (GBM), High-grade glioblastoma Glioblastoma di alto grado, Diseases [C] - Cancer [C04] | | | | |
NCT03651895: Metformin to Reduce Airway Glucose in COPD Patients |
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| Recruiting | 2 | 40 | Europe | Metformin, Placebo | Imperial College London | Chronic Obstructive Pulmonary Disease | 06/23 | 06/23 | | |
NCT04267809: Modulate Cellular Stress in the Immune Cells to Reduce Rate of Symptomatic Viral Infection |
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| Completed | 2 | 32 | RoW | Metformin Hydrochloride, Metformin, Calcium and Vitamin D | Singapore General Hospital, Duke-NUS Graduate Medical School | Endoplasmic Reticulum Stress, Viral Infection, Yellow Fever | 07/23 | 07/23 | | |
MET-RAS study, ChiCTR2000037943: Metformin combined with FOLFIRI+bevacizumab in the second-line treatment of non-diabetic RAS mutant metastatic colorectal cancer: a multi-center, single-arm phase II clinical study |
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| Recruiting | 2 | 116 | | Metformin | Sun Yat-Sen University Cancer Center; Sun Yat-Sen University Cancer Center, Sun Yat-sen University Cancer Center Clinical Research 308 Project | Colorecal cancer | | | | |
| Recruiting | 2 | 10 | US | Metformin, Placebo oral capsule | University of California, San Francisco, National Institute on Aging (NIA) | Pulmonary Hypertension, Heart Failure | 09/24 | 09/24 | | |
NCT03617458: Interventions Against Insulin Resistance in Pulmonary Arterial Hypertension |
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| Active, not recruiting | 2 | 82 | US | Metformin, Placebo, mHealth Intervention, Usual Care | Vanderbilt University Medical Center, Mayo Clinic, The Cleveland Clinic | Pulmonary Artery Hypertension | 09/23 | 07/25 | | |
FAME, NCT03709147: Metformin Plus/Minus Fasting Mimicking Diet to Target the Metabolic Vulnerabilities of LKB1-inactive Lung Adenocarcinoma |
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| Recruiting | 2 | 64 | Europe | Metformin Hydrochloride, Metformin, Cisplatin, CDDP, Carboplatin, CBDCA, Pemetrexed, Fasting-mimicking diet, FMD, Pembrolizumab | Marina Garassino | Advanced LKB1-inactive Lung Adenocarcinoma | 09/23 | 09/23 | | |
NCT05579977 / 2022-002834-15: Trial to Learn About the Study Medicine (PF-07081532) and Rybelsus in People With Type 2 Diabetes and Separately PF-07081532 in People With Obesity |
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| Terminated | 2 | 902 | Europe, Canada, Japan, US, RoW | PF-07081532, Placebo, Rybelsus | Pfizer, Pfizer Inc. | Diabetes Mellitus, Obesity | 07/23 | 09/23 | | |
2022-002834-15: Trial to Learn About the Study Medicine (PF-07081532) and Rybelsus in People With T2DM and Separately PF-07081532 in People With Obesity Klinické hodnocení zkoumající hodnocený léčivý přípravek (PF-07081532) a přípravek Rybelsus u osob s diabetem 2. typu a samostatně podávaný přípravek PF-07081532 u osob s obezitou. |
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| Not yet recruiting | 2 | 780 | RoW, Europe | 20mg PF-07081532-82, 60mg PF-07081532-82, 100mg PF-07081532-82, 3mg Rybelsus, 7mg Rybelsus, 14mg Rybelsus, PF-07081532-82, Tablet, Rybelsus | Pfizer Inc., Pfizer Inc. | Type 2 Diabetes Mellitus and Obesity, Type 2 Diabetes Mellitus and Obesity, Body processes [G] - Metabolic Phenomena [G03] | | | | |
NCT02570672: Metformin for Preventing Frailty in High-risk Older Adults |
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| Completed | 2 | 145 | US | Metformin, Placebo | The University of Texas Health Science Center at San Antonio, National Institute on Aging (NIA) | Frailty | 02/24 | 02/24 | | |
NCT05131828: CCMR Two: A Phase IIa, Randomised, Double-blind, Placebo-controlled Trial of the Ability of the Combination of Metformin and Clemastine to Promote Remyelination in People With Relapsing-remitting Multiple Sclerosis Already on Disease-modifying Therapy |
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| Recruiting | 2 | 70 | Europe | Metformin and clemastine in combination, Placebo | Cambridge University Hospitals NHS Foundation Trust, University of Cambridge | Multiple Sclerosis | 05/25 | 05/25 | | |
NCT04341571: Effect of Probiotics Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes. |
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| Active, not recruiting | 2 | 30 | RoW | Probiotics, Metformin | University of Guadalajara | PreDiabetes, Impaired Glucose Tolerance, Hyperglycemia, Resistance, Insulin | 08/24 | 12/24 | | |
PRED2, NCT05990205: Effect of the SCL16A11 Risk Haplotype on Treatments to Prevent Type 2 Diabetes |
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| Completed | 2 | 437 | RoW | Life Style Intervention + Metformin, LSI + MET, Life Style Intervention, LSI | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | PreDiabetes | 12/23 | 03/24 | | |
NCT05759897: A 16 Week Study of HRS-7535 in Adults With Type 2 Diabetes Mellitus |
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| Not yet recruiting | 2 | 180 | NA | HRS-7535, Placebo | Shandong Suncadia Medicine Co., Ltd. | Type 2 Diabetes | 12/23 | 01/24 | | |
