| metformin / Generic mfg. |
UMIN000028405: Phase 1b investigator initiated trial of combination therapy of Metformin and Nivolumab in participants with advanced or recurrent solid cancer |
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| Active, not recruiting | 1b | 39 | Japan | Opdivo (nivolumab) - Ono Pharma, BMS, metformin - Generic mfg. | Okayama University Hospital Center for Innovative Clinical Medicine, Ono Pharmaceutical Co.Ltd. | Advanced or recurrent solid cancer;Advanced or recurrent non-small cell lung cancer, advanced or recurrent thymic epithelial tumor and advanced or recurrent pancreatic cancer | | | | |
| Not yet recruiting | 1 | 12 | | | Flinders University, The Repat Foundation: Road Home Grant | Prostate cancer | | | | |
| Not yet recruiting | 1 | 12 | | | Flinders Centre for Innovation in Cancer, Flinders University/Flinders Medical centre, Flinders Centre for Innovation in Cancer, Flinders University/Flinders Medical centre | Brain tumours - Glioblastoma multiforme (GBM) | | | | |
| Completed | 1 | 36 | | Given pramipexole only ;Given pramipexole and metformin simultaneously | Institute of Clinical Pharmacology, Central South University; Institute of Clinical Pharmacology, Central South University, National Natural Science Foundation of China | Parkinson's disease | | | | |
ChiCTR-OCS-12002381: Actually acanthosis nigricans and youth obesity intervention before and after treatment clinical research |
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| Completed | 1 | 115 | | metformin Thyroid element berberine | Shanghai 10th People's Hospital; Shanghai 10th People's Hospital, Self funded | acanthosis nigricans | | | | |
ChiCTR-OCH-12002652: Height, weight, and motor-social development of children exposed to metformin in utero because their mothers with polycystic ovary syndrome or Gestational Diabetes |
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| Completed | 1 | 130 | | taken metformin during pregnancy | Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University; Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Self-supporting | Gestational Diabetes，polycystic ovary syndrome， | | | | |
ChiCTR-TRC-12002625: Study for regulation mechanism of IGF1R in the proliferation and metastasis of nasopharyngeal carcinoma |
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| Completed | 1 | 60 | | metformin ;No intervention | Sun Yat-Sen University Cancer Center; Sun Yat-Sen University Cancer Center, self-fund | nasopharyngeal carcinoma | | | | |
ChiCTR-IPN-15005783: Effect of multiple doses of rifampicin on the pharmacodynamics of metformin in healthy subjects |
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| Recruiting | 1 | 12 | | rifampicin+Metformin | the Third Xiangya Hospital, Central South University; Level of the institution：, National Scientific Foundation of China (No. 81301924), Scientific Foundation of Hunan (No.14JJ7016), | Endocrine disease | | | | |
| Not yet recruiting | 1 | 20 | | metformin | Pharmacogenetics Research Institute, Xiangya Hospital, Central South University; Pharmacogenetics Research Institute, Xiangya Hospital, Central South University, The National Scientific Foundation of China (No. 81273595, 81001476, 30901834) | diabetes | | | | |
| Not yet recruiting | 1 | 48 | | Subjects will be given Glucophage or domestic metformin tablets by 0.5g ;Subjects will be given domestic metformin tablets or Glucophage by 0.5g (crossover) | Shandong Provincial Qianfoshan Hospital; Level of the institution：, Merck Serono Diabetes Research Foundation | Type 2 diabetes mellitus | | | | |
ChiCTR-IIR-16009402: Bioequivalence study of Metformin Hydrochloride Sustained-release Tablets to Chinese volunteers in in a fasting and after meal, randomised, two-way crossover study |
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| Not yet recruiting | 1 | 64 | | Phase I: Metformin Hydrochloride Sustained-release Tablets (500 mg); Phase II: Clucophage XR 500mg ;Phase I: Clucophage XR 500mg; Phase II: Metformin Hydrochloride Sustained-release Tablets (500 mg) ;Phase I: Metformin Hydrochloride Sustained-release Tablets (500 mg); Phase II: Clucophage XR 500mg ;Phase I: Clucophage XR 500mg; Phase II: Metformin Hydrochloride Sustained-release Tablets (500 mg) | Beijing Shijitan Hospital Capital Medical University; Youcare pharmaceutical group co., LTD., Youcare pharmaceutical group co.,LTD. | diabetes | | | | |
ChiCTR-IPC-15006135: The optimal dose of metformin and its influence on intestinal microflora in Chinese patients with type 2 diabetes |
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| Not yet recruiting | 1 | 380 | | metformin 500mg qd (8a) ;Metformin 500mg bid (8a, 5p) ;Metformin 500mg tid (8a, 12n, 5p) ;Metformin 500mg (8a), 1000mg (12n), 500mg (5p) ;Metformin 500mg (8a) 1000mg (12n), 1000mg (5p) | Qilu Hospital of Shandong University; Qilu Hospital of Shandong University, Merck Serono Diabetes Research Fundation | diabetes mellitus | | | | |
SUGAR-MGH, NCT01762046: Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans |
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| Active, not recruiting | 1 | 1033 | US | Glipizide, Metformin, Oral Glucose Tolerance Test | Massachusetts General Hospital, Brigham and Women's Hospital, Joslin Diabetes Center, Broad Institute | Diabetes Mellitus, Type 2 | 12/15 | 12/25 | | |
ChiCTR-IIR-17011337: Bioequivalence study of Metformin Hydrochloride osmotic pump control-released Tablets to Chinese volunteers fasting and Fed, randomised, two-way crossover study |
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| Not yet recruiting | 1 | 56 | | Fasting, Phase 1 for T, Phase 2 for R ;Fasting, Phase 1 for R, Phase 2 for T ;Fed, Phase 1 for T, Phase 2 for R ;Fed, Phase 1 for R, Phase 2 for T | Beijing Shijitan Hospital Capital Medical University; Qingdao BAHEAL pharmaceutical Co., LTD, Qingdao BAHEAL pharmaceutical Co., LTD | diabetes | | | | |
ChiCTR-IIR-17011505: Deciphering the effects of metformin on heathy people through a metabolomics approach |
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| Completed | 1 | 36 | | placebo ;metformin,1500mg,qd | the First Affiliated Hospital of Chongqing Medical University; the First Affiliated Hospital of Chongqing Medical University, the Foundation for Sci & Tech Research Project of Chongqing | Healthy people | | | | |
ChiCTR1800015083: Bioequivalence study of Metformin Hydrochloride Tablets to Chinese healthy volunteers fasting and Fed, randomised,open, two-way crossover study |
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| Recruiting | 1 | 72 | | Fasting T-R (850mg) ;Fasting R-T (850mg) ;Fed T-R (850mg) ;Fed R-T (850mg) | Beijing Shijitan Hospital Capital Medical University; Guangdong Sinocorp Pharmaceutical Co., Ltd, Guangdong Sinocorp Pharmaceutical Co., Ltd | diabetes | | | | |
ChiCTR2000032538: Study for the bioequivalence of Pioglitazone Hydrochloride and Metformin hydrochloride (15mg/500mg) tablets |
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| Completed | 1 | 59 | | After fasting overnight for at least 10 hours, oral one tablet of the test preparation or reference preparation with 200mL 20% glucose solution on an empty stomach in the morning of the test day, once every cycle, then subjects were gargled with 40mL water. Cross-administration after ten days ;After fasting overnight for at least 10 hours, eat a high-fat and high-calorie standard meal 30 minutes before taking 1 test preparation or the reference preparation with 200mL 20% glucose solution in the morning of the test day, once every cycle, then subjects were gargled with 40mL water. Cross-administra | Nanjing First Hospital; Jiangsu Deyuan Pharmaceutical Co., Ltd., fully self-financing | Type 2 diabetes | | | | |
ChiCTR1900020788: Bioequivalence study of Metformin Hydrochloride Tablets to Chinese healthy volunteers fasting and Fed, randomised,open, two-way crossover study |
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| Not yet recruiting | 1 | 72 | | Fasting T-R ;Fasting R-T ;Fed T-R ;Fed R-T | Beijing Shijitan Hospital Capital Medical University; Level of the institution：, Beijing guorentang pharmaceutical technology development co. LTD | diabetes | | | | |
NCT06084156: A Study to Evaluate the DDI of HSK7653 With Metformin |
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| Completed | 1 | 22 | RoW | HSK7653, Metformin | Haisco Pharmaceutical Group Co., Ltd. | Type 2 Diabetes Mellitus | 12/19 | 12/19 | | |
ChiCTR1900022104: Pharmacokinetics Evaluation of Fotagliptin Benzoate Tablets and Metformin Hydrochloride Tablets in Single-ues and Combination Therapy in Healthy Subjects |
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| Recruiting | 1 | 18 | | Phase I: Metformin Hydrochloride Tablets; Phase II: Metformin Hydrochloride Tablets and Fotagliptin Benzoate Tablets; Phase III: Fotagliptin Benzoate Tablets | The First Hospital of Jilin University; Shenzhen Salubris Pharmaceuticals Co., Ltd, Sponsor | Type 2 Diabetes | | | | |
NCT02336087: Gemcitabine Hydrochloride, Paclitaxel Albumin-Stabilized Nanoparticle Formulation, Metformin Hydrochloride, and a Standardized Dietary Supplement in Treating Patients With Pancreatic Cancer That Cannot be Removed by Surgery |
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| Active, not recruiting | 1 | 21 | US | Gemcitabine Hydrochloride, dFdC, dFdCyd, Paclitaxel Albumin-Stabilized Nanoparticle Formulation, ABI 007, ABI-007, Abraxane, Metformin Hydrochloride, Glucophage, Metformin HCl, Therapeutic Dietary Intervention, Laboratory Biomarker Analysis, Quality-of-Life Assessment, Quality of Life Assessment | City of Hope Medical Center, National Cancer Institute (NCI) | Pancreatic Adenocarcinoma, Unresectable Pancreatic Carcinoma, Stage III Pancreatic Cancer AJCC v6 and v7, Stage IV Pancreatic Cancer AJCC v6 and v7 | 10/20 | 12/24 | | |
NCT04621669: Drug-durg Interaction of SHR3680 With Digoxin, Rosuvastatin Calcium and Metformin Hydrochloride |
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| Not yet recruiting | 1 | 18 | RoW | SHR3680, digoxin, Rosuvastatin calcium, metformin hydrochloride | Jiangsu HengRui Medicine Co., Ltd. | Drug-drug Interaction,SHR3680 | 05/21 | 07/21 | | |
| Not yet recruiting | 1 | 126 | RoW | Metformin Hydrochloride, Folic acid, Myo-inositol, Folic Acid | Rashid Latif Medical College | PCOS | 05/21 | 07/21 | | |
U-C OC IN PCOS, NCT02244567: Effect of Metformin Therapy on Serum Under-carboxylated Osteocalcin Levels in Hyperandrogenic Lean Polycystic Ovarian Syndrome Women |
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| Recruiting | 1 | 100 | RoW | Metformin 850 mg twice daily for 3 months, Cidophage, Serum uc-oc, Serum undercarboxylated-osteocalcin, drug, vitamin | Beni-Suef University, Cairo University | Polycystic Ovarian Syndrome | 06/21 | 06/21 | | |
NCT04841720: A Study Evaluating Drug-Drug Interaction (DDI) Between HSK16149 Capsules and Metformin Hydrochloride Tablets |
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| Recruiting | 1 | 22 | RoW | HSK16149, HSK16149（phase 1）, Metformin Hydrochloride tablet, Metformin hydrochloride tablets（phase 2）, HSK16149+Metformin（phase 3）, HSK16149 capsules and Metformin hydrochloride tablets | Haisco Pharmaceutical Group Co., Ltd., The Fourth Hospital of Hebei Medical University | Diabetic Neuropathies, Diabetic Neuropathy Peripheral | 06/21 | 08/21 | | |
18P.389, NCT03618654: Durvalumab With or Without Metformin in Treating Participants With Head and Neck Squamous Cell Carcinoma |
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| Completed | 1 | 38 | US | Metformin, 1,1-Dimethylbiguanide, 657-24-9, N,N-Dimethylimidodicarbonimidic Diamide, Durvalumab, Imfinzi, Kappa-chain, Human Monoclonal MEDI4736 Heavy Chain, MEDI4736, Immunoglobulin G1 | Sidney Kimmel Cancer Center at Thomas Jefferson University | Head and Neck Squamous Cell Carcinoma, Oral Cavity Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma | 11/21 | 12/22 | | |
| Active, not recruiting | 1 | 20 | Europe | Lanreotide and Metformin, Ipstyl and Metformin | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | Neuroendocrine Tumors | 12/21 | 12/21 | | |
ACTRN12621000878875: Is metformin better taken before or with meals? An acute evaluation of the impact of timing of metformin administration on intestinal glucose absorption, gut hormone secretion and the blood glucose response to an intraduodenal glucose infusion in type 2 diabetes |
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| Completed | 1 | 20 | | | The University of Adelaide, The Hospital Research Foundation | Type 2 diabetes | | | | |
NCT06170463: Insulin Sensitizers Role in Control of PCOS Vicious Cycle. |
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| Completed | 1 | 210 | RoW | Metformin Hydrochloride, MI/DCI combination in 40:1 ratio, Combination of Metformin hydrochloride and MI/DCI | Zagazig University | PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries | 03/23 | 04/23 | | |
NCT06199544: Effect of Unani Medicine for the Management of Anomalies Associated With Polycystic Ovarian Syndrome |
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| Recruiting | 1 | 150 | RoW | Metformin, Picolin, Rasoline | Hamdard University | Comparative Study | 06/24 | 12/24 | | |
NCT03916263: Low Starch Dietary Education Program vs. Traditional Treatment for PCOS |
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| Completed | 1 | 71 | US | Metformin, Traditional care, One-On-One Dietary Instruction, Video Dietary Instruction | Texas Tech University Health Sciences Center | PCOS, Diet Modification, Metabolism, Nutrition Disorders | 10/22 | 12/22 | | |
ChiCTR2100050345: Risk investigation and intervention study of metabolic syndrome in patients with bipolar disorder |
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| Not yet recruiting | 1 | 60 | | Tai Ji Chuan, Wuqinxi, healthy and balanced diet ;Metformin and statins as lipid regulators | Suzhou Second People's Hospital; Suzhou Second People's Hospital, Provincial government funding | Bipolar Disorder | | | | |
IMPACT, NCT03378297: A Randomized WOO Study of Novel Therapeutic Agents in Women Triaged to Primary Surgery for EOC |
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| Completed | 1 | 26 | Europe | Metformin, Acetylsalicylic acid, Olaparib, Letrozole | Haukeland University Hospital | Ovarian Cancer | 01/23 | 01/23 | | |
NCT05081583: Clinical Evaluation of the Pharmacokinetic Goldenseal-Metformin Interaction in Diabetic Patients |
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| Active, not recruiting | 1 | 22 | US | Midazolam Hcl 1Mg/Ml Inj, Versed, Goldenseal (Hydrastis canadensis) | Washington State University, National Center for Complementary and Integrative Health (NCCIH) | Interaction, Adverse Herb-Drug, Diabetes Mellitus, Type 2 | 01/23 | 08/23 | | |
NCT05729386: A Study to Evaluate the Safety, PK of GC2129A in Healthy Volunteers Under Fed Conditions |
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| Recruiting | 1 | 34 | RoW | GC2129A(Period 1), Linaglptin 5mg and Metformin Hydrocholoride 1000mg(Period 1), GC2129A(Period 2), Linaglptin 5mg and Metformin Hydrochloride 1000mg(Period 2) | GC Biopharma Corp | Healthy Volunteers | 04/23 | 04/23 | | |
NCT05703984: A Study to Evaluate the Safety, PK of GC2129A in Healthy Volunteers Under Fasting Conditions |
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| Recruiting | 1 | 50 | RoW | GC2129A(Period 1), Linaglptin 5mg and Metformin Hydrocholoride 1000mg(Period 1), GC2129A(Period 2), Linaglptin 5mg and Metformin Hydrochloride 1000mg(Period 2) | GC Biopharma Corp | Healthy Volunteers | 04/23 | 04/23 | | |
NCT05768360: A Study to Assess the Effects of Savolitinib on the Pharmacokinetics of Digoxin, Rosuvastatin, Metformin, and Furosemide in Healthy Male Subjects |
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| Completed | 1 | 6 | Europe | Savolitinib, Digoxin, Metformin Hydrochloride, Rosuvastatin, Furosemide | AstraZeneca, Parexel | Healthy Male Subjects | 06/23 | 06/23 | | |
NCT06335134: A Drug-Drug Interaction Study Between XW003 and Metformin, Warfarin, Rosuvastatin or Digoxin |
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| Recruiting | 1 | 56 | RoW | XW003 injection, ecnoglutide, Metformin, Warfarin, Rosuvastatin, Digoxin | Hangzhou Sciwind Biosciences Co., Ltd. | Healthy Volunteers | 01/24 | 03/24 | | |
NCT05365451: Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters |
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| Completed | 1 | 32 | US | MetFORMIN Oral Solution, Riomet, Cimetidine 400 MG, Tagamet, Furosemide Oral Liquid Product, Lasix, Probenecid 500 MG, Probalan | Washington State University, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH) | Interaction, Endogenous Biomarkers | 07/23 | 07/23 | | |
NCT05694221: Drug Drug Interaction (DDI) Between Supaglutide and Digoxin or Metformin |
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| Not yet recruiting | 1 | 32 | NA | Supaglutide injection, Diabegone, Digoxin, Metformin | Shanghai Yinnuo Pharmaceutical Technology Co., Ltd., Huashan Hospital | Healthy Volunteers | 07/23 | 12/23 | | |
NCT05760677: Study on the Efficacy and Safety of Chiglitazar Sodium in PCOS With T2DM |
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| Enrolling by invitation | 1 | 142 | RoW | pioglitazone group: lifestyle intervention+ metformin+ orlistat (obese patients)+ pioglitazone, the Chiglitazar group: lifestyle intervention+ metformin+ orlistat (obese patients)+ Chiglitazar | Affiliated Hospital of Nantong University | PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, T2D | 09/23 | 09/24 | | |
NCT05981365: Voxelotor CYP and Transporter Cocktail Interaction Study |
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| Completed | 1 | 44 | US | Voxelotor, Oxbryta, Bupropion, Wellbutrin, Repaglinide, Prandin, Flurbiprofen, Ansaid, Omeprazole, Prilosec, Midazolam, Dormicum, Metformin, Glucophage, Furosemide, Lasix, Rosuvastatin, Crestor | Pfizer | Sickle Cell Disease | 10/23 | 10/23 | | |
NCT06247748: Influence of JY09 on Pharmacokinetics of Metformin , Rosuvastatin , and Digoxin and the QT Interval Study in Overweight Chinese Subjects |
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| Active, not recruiting | 1 | 28 | RoW | Exendin-4 Fc fusion protein (JY09) injection, JY09, Metformin Hydrochloride tablet, Metformin, Rosuvastatin calcium tablets, Rosuvastatin, Digoxin tablet, digoxin | Beijing Dongfang Biotech Co., Ltd. | Diabetes Mellitus, Type 2, Overweight | 04/24 | 04/24 | | |
NCT06066060: A DDI Study of JMKX000623 and Metformin Hydrochloride |
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| Completed | 1 | 24 | RoW | JMKX000623, Metformin | Jemincare | Healthy, Drug-Drug Interaction | 11/23 | 11/23 | | |
NCT05615012: A Study Investigating Interactions Between BMS-986322 and Rosuvastatin, Metformin and Methotrexate in Healthy Participants |
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| Completed | 1 | 76 | US | BMS-986322, Rosuvastatin, Metformin, Glucose, Methotrexate, Leucovorin | Bristol-Myers Squibb | Healthy Participants | 12/23 | 12/23 | | |
ChiCTR2200066320: To evaluate the single-center, randomized, open, three-cycle, three-crossover, drug-drug interaction phase I clinical study of HTD1801 capsule and metformin hydrochloride tablets in healthy subjects |
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| Not yet recruiting | 1 | 33 | | Metformin Hydrochloride Tablets - HTD1801 Capsules - HTD1801 Capsules Combined with Metformin ;HTD1801 Capsules - HTD1801 Capsules Combined with Metformin - Metformin Hydrochloride Tablets ;HTD1801 Capsules Combined with Metformin - Metformin Hydrochloride Tablets - HTD1801 Capsules | The Second Affiliated Hospital of Anhui Medical University; Shenzhen Junshengtai Biotechnology Co., LTD, Shenzhen Junshengtai Biotechnology Co., LTD | hyperglycemia | | | | |
NCT06160414: A Study to Investigate the Potential Drug Interactions Between ALXN2080 and Rosuvastatin and Metformin in Healthy Adult Participants |
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| Completed | 1 | 20 | Europe | Metformin, Rosuvastatin, ALXN2080 | Alexion Pharmaceuticals, Inc. | Healthy | 02/24 | 02/24 | | |
NCT06227832: A Study to Determine the Effect of KP-001 on Metformin and Midazolam Pharmacokinetics and the Effect of Clarithromycin on KP-001 Pharmacokinetics in Healthy Adult Participants |
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| Active, not recruiting | 1 | 38 | US | KP-001, Metformin, Midazolam, Clarithromycin | Kaken Pharmaceutical | Healthy Adults | 03/24 | 07/24 | | |
| Not yet recruiting | 1 | 60 | | In the fasting state, one tablet of test preparation was taken orally in the first period and one tablet of reference preparation was taken orally in the second period ;In the fasting state, one tablet of reference preparation was taken orally in the first period and one tablet of test preparation was taken orally in the second period ;In the postprandial state, one tablet of test preparation was taken orally in the first period and one tablet of reference preparation was taken orally in the second period ;In the postprandial state, one tablet of reference preparation was taken orally in the first period and one tablet of test preparation was taken orally in the second period | Huzhou Central Hospital; Huzhou Central Hospital, sponsor | healthy subjects | | | | |
NCT05680662: The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism |
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| Not yet recruiting | 1 | 200 | NA | quercetin, EGCG, metformin , zinc | Ministry of Health, Saudi Arabia | Breast Cancer Female, Triple Negative Breast Cancer | 12/23 | 01/24 | | |
NCT05536037: Metformin for the Prevention of Oral Cancer in Patients With Oral Premalignant Lesions |
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| Terminated | 1 | 4 | US | Metformin, 1-Dimethylbiguanide, 657-24-9, N-dimethylbiguanide, N-Dimethylimidodicarbonimidic Diamide, Biopsy, BIOPSY_TYPE, Bx | Thomas Jefferson University, National Cancer Institute (NCI) | Erythroplakia, Leukoplakia, Oral Cavity Carcinoma, Proliferative Verrucous Leukoplakia | 03/24 | 03/24 | | |
NCT02339168: Enzalutamide and Metformin Hydrochloride in Treating Patients With Hormone-Resistant Prostate Cancer |
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| Active, not recruiting | 1 | 24 | US | Enzalutamide, MDV3100, Xtandi, Metformin Hydrochloride, Glucophage, Metformin HCl | University of California, Davis, National Cancer Institute (NCI), Medivation, Inc., Astellas Pharma Inc | Prostate Cancer | 04/25 | 12/25 | | |
NCT06071442: Potential Drug Interaction Study Between Vemircopan and Rosuvastatin, Metformin, Levonorgestrel/Ethinyl Estradiol-containing Oral Contraceptives, and Carbamazepine |
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| Completed | 1 | 60 | US | Vemircopan, ALXN2050, Rosuvastatin, Metformin, Levonorgestrel / Ethinyl Estradiol, SIMPESSE, Carbamazepine | Alexion Pharmaceuticals, Inc. | Healthy Participants | 04/24 | 04/24 | | |
NCT03107884: Role of Metformin on Muscle Health of Older Adults |
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| Active, not recruiting | 1 | 64 | US | Metformin (Bed Rest), Metformin hydrochloride, Fortamet, glucophage, Glumetza, Riomet, Placebo (Bed Rest), Metformin (2 week run-in only), Glucophage, Placebo (2 week run-in only) | University of Utah | Muscle Atrophy, Insulin Resistance | 04/24 | 04/25 | | |
NCT01529593: Temsirolimus in Combination With Metformin in Patients With Advanced Cancers |
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| Active, not recruiting | 1 | 87 | US | Temsirolimus, CCI-779, Torisel, Metformin | M.D. Anderson Cancer Center | Advanced Cancers | 06/24 | 06/24 | | |
NCT06416800: A Study to Assess the Effect of Povorcitinib on Digoxin, Rosuvastatin, and Metformin Pharmacokinetics When Administered Orally to Healthy Adult Participants |
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| Recruiting | 1 | 54 | US | Digoxin, Rosuvastatin, Metformin, Povorcitinib | Incyte Corporation | Healthy Participants | 08/24 | 08/24 | | |
NCT06452511: Comparing the Effect of Metformin vs. Pep2dia as an Adjunct to Letrozole on Ovulation Induction and Pregnancy Outcomes in Overweight Women With PCOS |
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| Not yet recruiting | 1 | 100 | RoW | Metformin, pep2dia | Muhamed Ahmed Abdelmoaty Muhamed Alhagrasy | PCOS | 06/25 | 07/25 | | |
| Not yet recruiting | 1 | 146 | NA | Fish oil, Metformin, Fish Oil and Metformin | University of Alberta, Heart and Stroke Foundation of Canada | PCOS, Cardiovascular Disease, Atherosclerotic Cardiovascular Disease, Atherosclerotic Plaque, Cardiac Hypertrophy | 06/26 | 12/27 | | |
NCT06087796: Topical Pentoxifylline; Metformin Versus Betamethasone in the Treatment of Alopecia Areata. |
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| Not yet recruiting | 1 | 60 | RoW | Betamethasone Valerate 0.1% Cream, Topical betamethasone, Pentoxifylline, topical pentoxifylline, Metformin, Topical metformin | Assiut University | Alopecia Areata | 09/24 | 10/24 | | |
| Not yet recruiting | 1 | 50 | NA | Metformin, Glucophage, Fortamet, Glumetza, Riomet, Placebo | University of Utah | Muscle Atrophy or Weakness | 07/29 | 07/30 | | |
GO39374, NCT03006172: To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer |
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| Active, not recruiting | 1 | 256 | Europe, Canada, US | Inavolisib, RO7113755, GDC-0077, Fulvestrant, Letrozole, Palbociclib, Metformin, Trastuzumab, Pertuzumab | Genentech, Inc. | Breast Cancer, Solid Tumor | 11/24 | 11/24 | | |
NCT01422746: Effect of Metformin on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess |
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| Recruiting | 1 | 20 | US | Metformin, Glucophage | University of Virginia | Obesity, Hyperandrogenemia, Polycystic Ovary Syndrome | 12/24 | 12/24 | | |
ChiCTR2200057842: Metformin and omeprazole induce enhanced high-dose vitamin C in the treatment of advanced malignant tumors |
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| Recruiting | 1 | 108 | | Vitamin C injection ;Omeprazole injection ;metformin | The First Affiliated Hospital of Sun Yat-Sen University; The First Affiliated Hospital of Sun Yat-Sen University, National Key Research and Development Program | Advanced malignant tumors | | | | |
NCT03889795: Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors |
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| Recruiting | 1 | 15 | US | Metformin, Glucophage, Simvastatin, Zocor, Digoxin, Digitalis | Danae Hamouda, MD | Advanced Pancreatic Cancer, Advanced Solid Tumor | 12/25 | 12/26 | | |
NCT05232994: Metformin and Esomeprazole For Preterm Pre-eclampsia |
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| Not yet recruiting | 1 | 38 | US | Esomeprazole 20mg, Metformin | Christiana Care Health Services | Preeclampsia Severe, Preeclampsia Second Trimester, Preterm Birth Complication | 12/24 | 12/25 | | |
NCT05590676: Metformin Treatment in Infants After Perinatal Brain Injury |
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| Terminated | 1 | 1 | Canada | Metformin Hydrochloride | The Hospital for Sick Children, University of Waterloo, University of Alberta | Hypoxic Ischemic Encephalopathy of Newborn, Premature Birth | 02/24 | 02/24 | | |
NCT06457139: Preventing T2DM After GDM With Immediate Postpartum Screening and Treatment |
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| Not yet recruiting | 1 | 80 | US | Metformin Hydrochloride, metformin, glucophage, Active Comparator | University of Massachusetts, Worcester | Gestational Diabetes, Type 2 Diabetes | 04/28 | 12/28 | | |
ChiCTR2200063873: Canceled by the investigator. A prospective clinical study of oral metformin in the treatment of secondary lymphedema |
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| Not yet recruiting | 1 | 60 | | Take metformin orally ;placebo ;placebo | Affiliated Hospital of Zunyi Medical University; Affiliated Hospital of Zunyi Medical University, National Natural Science（82260391） | lymphedema | | | | |
NCT05349474: Metformin Treatment in Progressive Multiple Sclerosis |
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| Recruiting | 1 | 44 | US | Metformin 500 Mg Oral Tablet, up to 4 tablets a day, Placebo oral tablet identical to metformin, up to 4 tablets a day | University of California, Los Angeles | Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis | 05/25 | 05/26 | | |
| Suspended | 1 | 18 | US | Metformin, Glucophage, Placebo, Placebo oral tablet | The University of Texas Health Science Center at San Antonio | Aging, Vaccine Response Impaired | 07/25 | 07/26 | | |
NCT05828303: A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in Patients With Advanced Solid Tumors |
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| Recruiting | 1 | 12 | US | TPX-0005, repotrectinib, Metformin Hydrochloride, Glucophage, Metabet, Glucient, Diagemet, Axpinet, Digoxin, Lanoxin, Rosuvastatin Calcium, Crestor | Turning Point Therapeutics, Inc. | Advanced Solid Tumor, Metastatic Solid Tumor | 07/25 | 11/25 | | |
NCT06044025: A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy |
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| Recruiting | 1 | 30 | US | Metformin, Turmeric | University of Arkansas | Castration Sensitive Prostate Cancer | 10/25 | 10/26 | | |
NCT03311308: A Trial of Pembrolizumab and Metformin Versus Pembrolizumab Alone in Advanced Melanoma |
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| Recruiting | 1 | 30 | US | Pembrolizumab Injection [Keytruda], Keytruda, Metformin | Yana Najjar, Merck Sharp & Dohme LLC | Advanced Melanoma | 01/27 | 12/28 | | |
MANATEE-T1D, NCT05065372: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes |
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| Recruiting | 1 | 60 | US | Metformin Hcl 1000Mg Tab, Fortamet, Glucophage, Glumetza, Riomet, Aminohippurate Sodium 20 % Injection, Sodium 4-amino hippurate (PAH) injection 20% (2g/10 mL), Para-aminohippurate, Aminohippuric acid, Iohexol 300 Mg/mL Injectable Solution, Omnipaque 300, Placebo | University of Colorado, Denver, National Heart, Lung, and Blood Institute (NHLBI) | Type 1 Diabetes, Diabetic Kidney Disease, Cardiovascular Diseases, Endothelial Dysfunction, Insulin Sensitivity | 01/26 | 07/26 | | |
ChiCTR2300072264: Oral metformin treatment for unilateral upper limb lymphedema after breast cancer multicenter prospective randomized controlled study |
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| Recruiting | 1 | 174 | | Take metformin plus elastic bandage compression therapy ;Placebo plus elastic bandage compression therapy | Affiliated Hospital of Zunyi Medical University; Affiliated Hospital of Zunyi Medical University, National Natural Science (82260391) | lymphedema | | | | |
| Recruiting | 1 | 20 | US | Metformin | University of California, San Francisco, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Type 2 Diabetes | 12/24 | 12/25 | | |
NCT03905941: Relative Desirability of Metformin vs. Birth Control Pill in Treating PCOS in Women of Later Reproductive Age |
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| Recruiting | 1 | 88 | US | Metformin, Oral combined hormonal contraceptives | University of Virginia | Polycystic Ovary Syndrome | 04/27 | 05/27 | | |
NCT05917587: Metformin for the Treatment of Microvascular Dysfunction After Gestational Diabetes |
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| Not yet recruiting | 1 | 30 | NA | Metformin Hydrochloride, placebo | Anna Stanhewicz, PhD | Gestational Diabetes | 07/28 | 07/29 | | |
NCT05515978: Pragmatic Trial of Metformin for Glucose Intolerance or Increased BMI in Prostate Cancer Patients |
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| Recruiting | 1 | 200 | US | Metformin, Lifestyle Modification | University of Colorado, Denver | Prostate Cancer | 10/35 | 11/36 | | |
