| metformin / Generic mfg. |
NCT02946996: Study of Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients Receiving Androgen Deprivation Therapy |
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| Active, not recruiting | 2 | 41 | US | Metformin, OPC | Medical University of South Carolina | Prostate Cancer | 12/23 | 07/24 | | |
METALLICA, NCT04300790: Study to Evaluate the Effect of Metformin in the Prevention of HG in HR[+]/HER2[-] PIK3CA-mut Advanced BC Patients |
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| Active, not recruiting | 2 | 69 | Europe | Alpelisib, BYL719, Metformin, Fulvestrant, Letrozole, Exemestane, Vildagliptin, Tamoxifen | MedSIR, Novartis | Breast Cancer | 03/25 | 06/26 | | |
NCT05952349: Effect of Metformin and Combination of Olive Oil Plus Nutritional Supplements on Inflammatory Markers IL-6 and IL-8 in PCOS. |
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| Completed | 2 | 88 | RoW | OLIVE OIL 5ML/5MG (BD) NUTRITIONAL SACHET 2100MG (BD), Metformin (1000 mg Twice a day) | Khyber Medical University Peshawar | PCO | 12/23 | 04/24 | | |
NCT03800602: Nivolumab and Metformin in Patients With Treatment Refractory MSS Colorectal Cancer |
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| Active, not recruiting | 2 | 24 | US | Metformin, Glucophage, Glumetza, Fortamet, Nivolumab, BMS-936558, MDX-1106, NIVO, ONO-4538, Opdivo | Emory University, Bristol-Myers Squibb, National Cancer Institute (NCI), National Institutes of Health (NIH) | Colorectal Adenocarcinoma, Metastatic Microsatellite Stable Colorectal Carcinoma, Refractory Colorectal Carcinoma, Stage IV Colorectal Cancer, Stage IVA Colorectal Cancer, Stage IVB Colorectal Cancer, Stage IVC Colorectal Cancer, Colorectal Cancer Metastatic | 01/24 | 01/25 | | |
NCT04220021: Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD |
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| Active, not recruiting | 2 | 18 | US | Metformin, Metformin hydrochloride sustained-release (SR) | University of Florida, ALS Association | C9orf72 Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia | 08/24 | 08/24 | | |
NCT05781711: Clinical Study to Evaluate the Possible Efficacy of Metformin in Patients With Parkinson's Disease |
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| Recruiting | 2 | 60 | RoW | levodopa-carbidopa, Metformin | Tanta University, Eman Ibrahim Elberri, Faculty of Pharmacy, Tanta University, Fedaa Abd El-monem Kamal El-deen Kotkata Faculty of Pharmacy, Tanta University, Manal Ali Mahrous Hamouda Faculty of Pharmacy, Menufia University | Parkinson Disease | 09/24 | 11/25 | | |
NCT05333835: A Trial Comparing the Efficacy and Safety of HR17031 Injection to INS068 Injection and to SHR20004 Injection in Patients With Type 2 Diabetes |
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| Active, not recruiting | 2 | 455 | RoW | HR17031 injection, INS068 injection, SHR20004 injection | Jiangsu HengRui Medicine Co., Ltd. | Type 2 Diabetes | 03/24 | 03/24 | | |
NCT03710343: Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study |
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| Active, not recruiting | 2 | 3 | Canada | Metformin, Sandoz Metformin FC | Holland Bloorview Kids Rehabilitation Hospital, The Hospital for Sick Children | Cerebral Palsy | 01/25 | 03/25 | | |
NCT02035787: Metformin With the Levonorgestrel-Releasing Intrauterine Device for the Treatment of Complex Atypical Hyperplasia (CAH) and Endometrial Cancer (EC) in Non-surgical Patients |
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| Completed | 2 | 21 | US | Metformin, glucophage | UNC Lineberger Comprehensive Cancer Center, Golfers Against Cancer Grant | Complex Atypical Hyperplasia, Endometrial Cancer | 10/23 | 04/24 | | |
| Not yet recruiting | 2 | 51 | NA | Metformin, Radiotherapy, Chemotherapy, PET/CT | Peking Union Medical College Hospital | Cervical Cancer, Radiotherapy, Metformin, Hypoxia, PET/CT | 08/25 | 02/26 | | |
NCT01750567: A Pilot Study of Metformin Therapy in Patients With Relapsed Chronic Lymphocytic Leukemia (CLL) and Untreated CLL |
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| Active, not recruiting | 2 | 37 | US | Metformin, Glucophage | University of Michigan Rogel Cancer Center | Relapsed Chronic Lymphocytic Leukemia | 05/24 | 05/24 | | |
NCT03675893: RESOLVE: Abemaciclib + Letrozole +/- Metformin or Zotatifin in Endometrial or Low-Grade Serous Ovarian Cancer |
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| Recruiting | 2 | 130 | US | Letrozole, Femara, Abemaciclib, Verzenio, LY3023414, Metformin, Glucophage, Zotatifin, eFT226 | Dana-Farber Cancer Institute, Eli Lilly and Company, Effector Therapeutics | Endometrial Cancer, Ovarian Cancer | 08/26 | 08/29 | | |
| Active, not recruiting | 2 | 30 | Europe | Fasting-mimicking diet, Metformin, Metforal, Preoperative chemotherapy, doxorubicin+cyclophosphamide and paclitaxel | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, IFOM, The FIRC Institute of Molecular Oncology, European Institute of Oncology, University of Milan | Triple-negative Breast Cancer | 05/24 | 05/24 | | |
NCT05906563: Evaluation of Melatonin and Metformin Loaded Nanoparticles in the Treatment of Periodontal Intra-bony Defects |
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| Enrolling by invitation | 2 | 52 | RoW | Melatonin gel, Metformin and melatonin gel, placebo gel, scaling and root planning | Amira ragab | Bone Loss in Jaw | 05/24 | 06/24 | | |
NCT06125873: Effect of Moringa Leaf Capsules on Glycemic Control of Type 2 Diabetic Patients |
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| Enrolling by invitation | 2 | 50 | RoW | Metformin, Metformin is a glucose-lowering drug by inhibiting hepatic gluconeogenesis and opposing the action of glucagon. | Islamabad Medical and Dental College | Diabetes Mellitus Type 2 | 05/24 | 08/24 | | |
NCT06377696: Remote Cognitive Assessment and Wearable Device While Assessing the Impact of Metformin in Patients With History of Cranial Radiation Therapy |
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| Recruiting | 2 | 100 | US | Best Practice, standard of care, standard therapy, Medical Device Usage and Evaluation, Metformin, N,N-dimethylbiguanide, Neurocognitive Assessment, Questionnaire Administration | Mayo Clinic | Malignant Brain Neoplasm | 05/27 | 05/27 | | |
ChiCTR2200055624: Levonorgestrel-releasing intrauterine device and megestrol acetate plus metformin for fertility-sparing treatment of atypical endometrial hyperplasia and endometrial carcinoma: a prospective, randomised, blinded-endpoint design trial protocol |
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| Recruiting | 2 | 80 | | LNG-IUD plus metformin ;megestrol acetate plus metformin | Shenyang Women's and Children's Hospital; Level of the institution：, Shenyang Young and Middle-Aged Scientific and Technological Innovation Talents Support Program | atypical endometrial hyperplasia and endometrial carcinoma | | | | |
| Not yet recruiting | 2 | 150 | NA | HRS-7535, Placebo | Shandong Suncadia Medicine Co., Ltd. | Type 2 Diabetes | 11/25 | 11/25 | | |
LEPTOB, NCT03974139: Impact of Metformin on Leptin Transport in Cerebrospinal Fluid of Obese Patients |
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| Recruiting | 2 | 31 | Europe | Metformin Oral Tablet | Lille Catholic University, Centre Hospitalier Arras | Obesity Without Type 2 Diabetes, With BMI>30 | 06/24 | 09/24 | | |
NCT03989778: Vitamin D and Polycystic Ovarian Syndrome (PCOS) |
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| Recruiting | 2 | 300 | RoW | Vitamin D | Aga Khan University | Infertility, Female, Infertility, Vitamin D Deficiency | 06/24 | 06/25 | | |
| Not yet recruiting | 2 | 120 | RoW | Metformin Hydrochloride tablet, Metformin, Placebo | Xuanwu Hospital, Beijing, Institute of Zoology, Chinese Academy of Sciences, Beijing Institute of Genomics, Chinese Academy of Sciences, Merck Serono Co., Ltd., China | Metformin, Aging | 09/26 | 07/28 | | |
NCT06481085: To Evaluate Efficacy and Safety of HDM1002 Tablets in Adults With Type 2 Diabetes Mellitus |
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| Not yet recruiting | 2 | 318 | RoW | HDM1002 50 mg, HDM1002, HDM1002 100 mg, HDM1002 200 mg, HDM1002 400 mg, HDM1002 200 mg BID, Placebo, Matching placebo for group A to group E | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | Type 2 Diabetes | 04/25 | 04/25 | | |
TROJAN, NCT03379909: Phase II Study of Oral Metformin for Intravesical Treatment of Non-muscle-invasive Bladder Cancer |
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| Recruiting | 2 | 49 | Europe | Metformin | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Radboud University Medical Center | Superficial Bladder Cancer, Bladder Cancer | 07/24 | 10/29 | | |
| Not yet recruiting | 2 | 40 | NA | Metformin, glyburide, Cellulose, cellulose powder | University of Maryland, Baltimore | Sarcoidosis, Pulmonary | 01/25 | 03/25 | | |
NCT05854966: CPI-613 Given With Metformin in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) |
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| Not yet recruiting | 2 | 17 | US | CPI 613, Devimistat, Metformin, Metformin pill, Blood draws, Bone marrow biopsy | Wake Forest University Health Sciences, National Cancer Institute (NCI), Cornerstone Pharmaceuticals | Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia Refractory, Granulocytic Sarcoma | 04/25 | 09/25 | | |
NCT06463743: Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS) |
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| Not yet recruiting | 2 | 30 | NA | metformin, Placebo | State University of New York at Buffalo | Multiple Sclerosis | 11/25 | 05/26 | | |
NCT06429007: A Safety and Feasibility Trial Protocol of Metformin in Infants After Perinatal Brain Injury |
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| Not yet recruiting | 2 | 30 | NA | Metformin | Boston Children's Hospital | Hypoxic-Ischemic Encephalopathy, HIE, Neurodevelopment, Infant Development | 10/26 | 10/27 | | |
NCT05847244: The Effect of Addition of Metformin In Obese Non- Diabetic Patients With Heart Failure With Preserved Ejection Fraction |
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| Recruiting | 2 | 80 | RoW | Metformin | Sara ElAdawy, Cairo University | Diastolic Dysfunction, Obesity | 10/24 | 12/24 | | |
AUR1-1-199, NCT04930744: Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) |
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| Recruiting | 2 | 112 | RoW | Isoniazid, Rifampicin, Ethambutol, Myambutol, Pyrazinamide, Metformin hydrochoride, Glucophage | University of Massachusetts, Worcester, National Institute of Allergy and Infectious Diseases (NIAID), Aurum Institute, A*STAR Infectious Diseases Labs, University of Cape Town, Wits Health Consortium (Pty) Ltd | Tuberculosis, Pulmonary Tuberculosis, HIV Coinfection | 11/25 | 11/25 | | |
| Recruiting | 2 | 303 | Europe, RoW | Lifestyle management, Acupuncture, Metformin | Karolinska Institutet, Karolinska University Hospital, Peking University | Polycystic Ovary Syndrome, Insulin Resistance, Hyperandrogenism | 12/24 | 12/25 | | |
NCT04691960: A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging |
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| Recruiting | 2 | 36 | US | Ketogenic Diet, Metformin | Weill Medical College of Cornell University | Glioblastoma | 12/24 | 12/24 | | |
NCT04033107: High Dose Vitamin C Combined With Metformin in the Treatment of Malignant Tumors |
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| Recruiting | 2 | 30 | RoW | Vitamin C, Ascorbic acid, Metformin | Zhongnan Hospital | Hepatocellular Cancer, Pancreatic Cancer, Gastric Cancer, Colorectal Cancer | 12/24 | 12/24 | | |
NCT05183204: Paxalisib With a High Fat, Low Carb Diet and Metformin for Glioblastoma |
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| Recruiting | 2 | 33 | US | Paxalisib, Metformin, Ketogenic Diet | Weill Medical College of Cornell University, Kazia Therapeutics Limited | Glioblastoma | 12/24 | 12/25 | | |
| Not yet recruiting | 2 | 770 | RoW | Metformin, Glucophage, Glumetza, and Riomet., Placebo | Arab Contractors Medical Centre | Atrial Fibrillation | 01/25 | 04/25 | | |
METOXY-LACC, NCT04275713: Altered Tumor Oxygenation by Metformin, a Potential Step in Overcoming Radiotherapy Resistance in LACC |
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| Recruiting | 2 | 90 | Europe | Metformin, Cisplatin | Oslo University Hospital | Cervical Cancer | 05/25 | 09/25 | | |
NCT04530383: Effects of Metformin on Airway Ion Channel Dysfunction in Cystic Fibrosis-related Diabetes |
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| Recruiting | 2 | 36 | US | Metformin Hydrochloride, Glucophage | University of Kansas Medical Center | Cystic Fibrosis-related Diabetes, Cystic Fibrosis | 05/25 | 10/25 | | |
NCT04741945: Repurposing Metformin as a Leukemia-preventive Drug in CCUS and LR-MDS |
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| Recruiting | 2 | 40 | Europe | Metformin | Kirsten Grønbæk, Steno Diabetes Center Copenhagen, Zealand University Hospital, Van Andel Research Institute, Herlev Hospital, Technical University of Denmark, Region Hovedstadens Apotek, University of Copenhagen | Preleukemia, Myelodysplastic Neoplasm, Cytopenia, Preleukemic Anemia | 07/25 | 06/26 | | |
NCT05414409: The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action |
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| Recruiting | 2 | 114 | US | Metformin | Heba M. Ismail | Type 1 Diabetes, Obesity | 08/26 | 08/26 | | |
TRUTH-DKD, NCT05469659: Effect of Tofogliflozin on UACR Compared to Metformin Hydrochloride in Diabetic Kidney Disease |
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| Recruiting | 2 | 120 | Japan | Tofogliflozin, Metformin | Shinshu University, Kowa Company, Ltd. | T2DM (Type 2 Diabetes Mellitus), Metformin, SGLT2-Inhibitors | 10/25 | 10/26 | | |
NCT01797523: A Phase II, Single-Arm Study of RAD001 (Everolimus), Letrozole, and Metformin in Patients With Advanced or Recurrent Endometrial Carcinoma |
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| Active, not recruiting | 2 | 62 | US | Metformin, Letrozole, Femara, Everolimus, Afinitor, Zortress, RAD001 | M.D. Anderson Cancer Center, Novartis, National Cancer Institute (NCI) | Endometrial Cancer | 10/25 | 10/25 | | |
NCT05553704: Metformin in Patients With Ulcerative Colitis Treated With Mesalamine |
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| Recruiting | 2 | 60 | RoW | Metformin | Tanta University, Sahar Mohamed El-Haggar clinical pharmacy department, Tanta University, Sahar Kamal Hegazi clinical pharmacy department, Tanta University, Mounir Hussein Bahgat Internal Medicine Department Mansoura University, Maha Mohamed Maher Internal Medicine Department Mansoura University | Inflammatory Bowel Diseases | 11/25 | 12/25 | | |
| Active, not recruiting | 2 | 128 | Europe | Metformin treatment, Placebo, Methotrexate treatment | University Hospital, Bordeaux, Ministry for Health and Solidarity, France | Arthritis, Rheumatoid | 06/26 | 06/26 | | |
| Enrolling by invitation | 2 | 500 | Europe | Metformin, Standard care | Uppsala University Hospital | Abdominal Aortic Aneurysm | 01/26 | 01/26 | | |
NCT05929495: Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma |
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| Not yet recruiting | 2 | 25 | Europe | Metformin | University of Milano Bicocca | Glioblastoma, IDH-wildtype, Metformin, Malignancies | 01/26 | 01/26 | | |
NCT03862950: A Trial of Metformin in Individuals With Fragile X Syndrome (Met) |
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| Recruiting | 2 | 120 | Canada | Placebo Medication, Placebo, Metformin, Glumetza, Glucophage, Fortamet | University of Alberta, St. Justine's Hospital | Fragile X Syndrome, Fragile X Mental Retardation Syndrome, Mental Retardation, X-Linked, Genetic Diseases, X-Linked, Trinucleotide Repeat Expansion, Fra(X) Syndrome, Intellectual Disability, FXS, Neurobehavioral Manifestations, Sex Chromosome Disorders | 06/26 | 06/26 | | |
NCT05900284: Safety and Feasibility of Metformin for Sepsis Induced AKI |
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| Enrolling by invitation | 2 | 80 | US | Metformin low dose, Glumetza low dose, Metformin high dose, Glutzema high dose, Placebo, Placebo dose | Hernando Gomez, National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Sepsis, Septic Shock, Acute Kidney Injury, Metformin | 11/26 | 12/26 | | |
NCT05893225: Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration |
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| Recruiting | 2 | 120 | Europe | Metformin Hydrochloride 850 mg Oral Tablet, Placebo | University Hospital, Antwerp, University Hospital, Ghent, Hasselt University, AZ Sint-Jan AV, Noorderhart Pelt, National MS Center Melsbroek | Multiple Sclerosis, Primary Progressive Multiple Sclerosis, Secondary-progressive Multiple Sclerosis | 12/26 | 12/26 | | |
MET-FINGER, NCT05109169: METformin and FINGER Intervention to Prevent Cognitive Impairment and Disability in Older Adults at Risk for Dementia |
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| Recruiting | 2 | 600 | Europe | FINGER 2.0 multidomain lifestyle-based intervention, Self-guided multidomain lifestyle intervention | Imperial College London, Alzheimer's Association, Alzheimer's Drug Discovery Foundation, Alzheimerfonden, Region Stockholm, Merck KGaA, Darmstadt, Germany, Finnish Institute for Health and Welfare, Fingers Brain Health Institute, Karolinska University Hospital, Karolinska Institutet | Cognitive Decline, Cognitive Impairment, Dementia | 02/27 | 06/27 | | |
OPTIMUM, NCT04945148: Oxidative Phosphorylation Targeting In Malignant Glioma Using Metformin Plus Radiotherapy Temozolomide |
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| Not yet recruiting | 2 | 640 | Europe | Metformin, Radiation IMRT, Radiation, Temozolomide | Hopital Foch, National Cancer Institute, France | Glioblastoma, IDH-wildtype | 10/26 | 10/26 | | |
NCT05574387: Metformin as Added on Therapy in Patients With Ulcerative Colitis |
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| Recruiting | 2 | 46 | RoW | Metformin | Tanta University, Principal Investigator Sahar El-Haggar, Prof Clinical pharmacy Department- Tanta University, Principal Investigator Sahar Hegazy, Prof Clinical pharmacy Department- Tanta University, Principal Investigator Mostafa Mahmoud Bahaa El-Dien Pharmacy Practice Department- Horus University | Inflammatory Bowel Diseases | 12/26 | 04/27 | | |
| Recruiting | 2 | 480 | US | Metformin, AAA, Placebo | Stanford University, Kaiser Permanente, VA Palo Alto Health Care System, National Heart, Lung, and Blood Institute (NHLBI) | Abdominal Aortic Aneurysm | 03/27 | 03/27 | | |
| Recruiting | 2 | 67 | Europe | Metformin Hydrochloride | Istituto Ortopedico Rizzoli | Osteosarcoma, Ewing Sarcoma | 07/27 | 07/27 | | |
NCT05607316: Evaluating the Efficacy and Safety of Metformin in Vitiligo |
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| Recruiting | 2 | 30 | US | Metformin Hydrochloride, Glucophage, Glumetza, Riomet | University of Massachusetts, Worcester | Vitiligo | 07/27 | 11/27 | | |
| Not yet recruiting | 2 | 250 | Canada | Metformin, Placebos | Hamilton Health Sciences Corporation | Burns | 03/28 | 03/29 | | |
METIN, NCT06012682: Clinical Trials Evaluating the Effect of Metformin Treatment on Function Endometrium in Women Diagnosed With Idiopathic Infertility |
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| Not yet recruiting | 2 | 200 | NA | Metformin Hydrochloride, Placebo | Medical University of Bialystok, Medical Research Agency, Poland | Infertility, Female | 09/27 | 09/27 | | |
| Recruiting | 2 | 512 | US | Metformin, Glumetza, Fortamet, Glucophage extended release (XR), Placebo | Brigham and Women's Hospital, Arthritis Foundation | Osteoarthritis, Knee, Post-traumatic Osteoarthritis, ACL Tear | 12/28 | 12/29 | | |
I-SPY 2, NCT01042379: I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer |
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| Recruiting | 2 | 5000 | US | Standard Therapy, Paclitaxel (Taxol); Doxorubicin (Adriamycin), AMG 386 with or without Trastuzumab, AMG 386 (Trebananib); (Trastuzumab) Herceptin, AMG 479 (Ganitumab) plus Metformin, Ganitumab, MK-2206 with or without Trastuzumab, (Trastuzumab) Herceptin, AMG 386 and Trastuzumab, AMG 386 (Trebananib); Trastuzumab (Herceptin), T-DM1 and Pertuzumab, T-DM1 (Trastuzumab emtansine); Pertuzumab (Perjeta), Pertuzumab and Trastuzumab, Pertuzumab (Perjeta); Trastuzumab (Herceptin), Ganetespib, ABT-888, Veliparib, Neratinib, PLX3397, Pembrolizumab - 4 cycle, Talazoparib plus Irinotecan, Patritumab and Trastuzumab, Pembrolizumab - 8 cycle, SGN-LIV1A, Durvalumab plus Olaparib, SD-101 + Pembrolizumab, Tucatinib plus trastuzumab and pertuzumab, Cemiplimab, Cemiplimab plus REGN3767, Trilaciclib with or without trastuzumab + pertuzumab, Trilaciclib (G1T28); Pertuzumab (Perjeta); Trastuzumab (Herceptin), SYD985 ([vic-]trastuzumab duocarmazine), Oral Paclitaxel + Encequidar + Dostarlimab (TSR-042) + Carboplatin with or without trastuzumab, Oral Paclitaxel + Encequidar (Oraxol); Dostarlimab (TSR-042); Trastuzumab (Herceptin), Oral Paclitaxel + Encequidar + Dostarlimab (TSR-042) with or without trastuzumab, Amcenestrant, SAR439859, Amcenestrant + Abemaciclib, Amcenestrant (SAR439859), Abemaciclib (Verzenio), Amcenestrant + Letrozole, Amcenestrant (SAR439859), Letrozole (Femara), ARX788, ARX788 + Cemiplimab, VV1 + Cemiplimab, VOYAGER V1™, VSV-IFNβ-NIS, Datopotamab deruxtecan, Dato-DXd, Datopotamab deruxtecan + Durvalumab, Zanidatamab, Lasofoxifene, Z-endoxifen, ARV-471, ARV-471 + Letrozole | QuantumLeap Healthcare Collaborative | Breast Neoplasms, Breast Cancer, Breast Tumors, Angiosarcoma, TNBC - Triple-Negative Breast Cancer, HER2-positive Breast Cancer, HER2-negative Breast Cancer, Hormone Receptor Positive Tumor, Hormone Receptor Negative Tumor, Early-stage Breast Cancer, Locally Advanced Breast Cancer | 12/30 | 12/31 | | |
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NCT04114136: Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies |
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| Recruiting | 2 | 72 | US | Nivolumab or Pembrolizumab (dependent upon approved indication), Opdivo (nivolumab) or Keytruda (pembrolizumab), Metformin, Glucophage, Glucophage XR, Fortamet, and Glumetza, Rosiglitazone, Avandia | Dan Zandberg | Melanoma, NSCLC, Hepatocellular Carcinoma, Urothelial Cancer, Gastric Adenocarcinoma, HNSCC, Esophageal Adenocarcinoma, Microsatellite Instability-High Solid Malignant Tumor | 04/32 | 04/32 | | |
2020-001685-11: RElapse in previously irradiated Prostate bed : a phase I/II study of stereotactic Ablative reIRradiation potentiated by Metformine Récidive en loge prostatique déjà irradiée : une étude phase I/II de ré-irradiation en conditions stéréotaxiques potentialisée par la Metformine |
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| Not yet recruiting | 1/2 | 44 | Europe | METFORMINE, SBRT (Stereotactic Body Radiation Therapy), 397 059-0, Coated tablet, , METFORMINE | INSTITUT DE CANCEROLOGIE DE L'OUEST, DGOS-Inca PHRC-I 2019 (GIRCI GO) | RElapse in previously irradiated Prostate bed Récidive en loge prostatique déjà irradiée, Relapse of a prostate cancer rechute d'un cancer de prostate, Diseases [C] - Cancer [C04] | | | | |
NCT02960659: Title: Therapeutic Targets in African-American Youth With Type 2 Diabetes |
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| Completed | 1/2 | 24 | US | Liraglutide, Metformin | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Children's National Research Institute | Type 2 Diabetes | 05/22 | 05/22 | | |
NCT04662164: A Study to Access the Efficacy in Type 2 Diabetes Mellitus on Stable Metformin |
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| Withdrawn | 1/2 | 36 | NA | hepalatide, L47 | Shanghai HEP Pharmaceutical Co., Ltd. | Type 2 Diabetes Patients | 12/25 | 12/25 | | |
NCT05215990: Efficacy of Metformin for Sputum Conversion in Patients With Active Pulmonary Tuberculosis |
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| Recruiting | 1/2 | 80 | RoW | MetFORMIN 500 Mg Oral Tablet, Placebo | Mahidol University, Ministry of Health, Thailand | Tuberculosis, Pulmonary | 12/22 | 03/23 | | |
| Completed | 1/2 | 120 | RoW | Metformin | Oxford University Clinical Research Unit, Vietnam, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam | Dengue, Viral Infection, Metformin, Anti-inflammatory Agents, Obesity, Overweight | 06/23 | 08/23 | | |
NCT04121468: A Phase I Double Blind Study of Metformin Acting on Endogenous Neural Progenitor Cells in Children With Multiple Sclerosis |
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| Recruiting | 1/2 | 30 | Canada | Metformin, Glucophage, Placebo | The Hospital for Sick Children, Queen's University, Ontario Institute for Regenerative Medicine, Unity Health Toronto, Stem Cell Network, Multiple Sclerosis Society of Canada | Multiple Sclerosis (MS) | 12/23 | 12/23 | | |
NCT05762471: Phase 1b/2a Study of GSBR-1290 in Adult Overweight or Obese Healthy Subjects and Subjects With Type 2 Diabetes Mellitus |
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| Completed | 1/2 | 142 | US | GSBR-1290, Placebo | Gasherbrum Bio, Inc | Overweight or Obesity, Type2 Diabetes Mellitus | 04/24 | 04/24 | | |
NCT04623567: Efficacy Assessment of Chinese Herbal Medicine Jiangtang Tiaozhi Recipe Treating Participants With Glucose and Lipid Metabolism Disturbances |
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| Recruiting | 1/2 | 96 | RoW | Jiangtang Tiaozhi recipe, Metformin, Glucophage | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | Type2 Diabetes, Dyslipidemias | 12/23 | 06/24 | | |
MROSF, NCT06332612: Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial |
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| Not yet recruiting | 1/2 | 30 | RoW | Metformin Hydrochloride, Glucophage, betamethasone dipropionate, Betnovate, Pentoxifylline, Trental | Ziauddin University | Oral Submucous Fibrosis | 09/24 | 12/24 | | |
NCT02143050: Study of Dabrafenib, Trametinib and Metformin for Melanoma Patients |
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| Withdrawn | 1/2 | 53 | US | Dabrafenib, Tafinlar, Trametinib, Mekinist, Metformin, Glucophage | University of Louisville, James Graham Brown Cancer Center | Melanoma | 11/17 | 11/17 | | |
NCT04767841: The AMPK Modulator Metformin as a Novel Adjunct to Conventional Therapy in Patients With Knee Osteoarthritis |
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| Recruiting | 1/2 | 120 | RoW | Metformin, Placebo | Sadat City University | Osteo Arthritis Knee | 06/24 | 12/24 | | |
C3, NCT06030622: Phase 2A Pilot Trial of Recurrent/Refractory Metastatic Advanced Pancreatic Cancer |
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| Recruiting | 1/2 | 25 | US | Gemcitabine and C3 (Metformin, Simvastatin, and Digoxin), Glucophage, Zocor, Digitalis, Gemzar, C3 (Metformin, Simvastatin, and Digoxin) only, Glucophage, Zocor, Digitalis | State University of New York - Downstate Medical Center | Pancreatic Cancer Metastatic | 12/24 | 12/24 | | |
| Recruiting | 1/2 | 76 | US | Hydroxychloroquine, Metformin, Sirolimus, Hydroxychloroquine, Metformin, Sirolimus, Dasatanib, Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir, Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir, Dasatinib | Medical University of South Carolina | Prostate Cancer Recurrent, Solid Tumor, Adult | 10/24 | 10/25 | | |
ChiCTR2000034140: Study on Metformin Plus Temozolomide in Patient With Recurrent Glioblastoma Multiforme |
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| Not yet recruiting | 1/2 | 67 | | Metformin Plus Temozolomide | Sun Yat-sen University Cancer Center; Sun Yat-sen University Cancer Center, Sun Yat-sen University Cancer Center 308 Plan | Glioblastoma Multiforme | | | | |
NCT05759312: Zimberelimab Plus Metformin for Recurrent Ovarian Clear Cell Carcinoma |
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| Not yet recruiting | 1/2 | 20 | NA | Zimberelimab, Anti PD-1, Metformin Hydrochloride, Metformin | Fudan University | Ovarian Clear Cell Carcinoma | 02/25 | 02/25 | | |
NCT01638676: A Phase I/II Trial of Vemurafenib and Metformin to Melanoma Patients |
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| Recruiting | 1/2 | 55 | US | Vemurafenib, Vemurafenib branded as Zelboraf, Metformin, Metformin hydrochloride branded as Glucophage | University of Louisville, James Graham Brown Cancer Center | Melanoma | 06/25 | 06/27 | | |
RESILIENCE, NCT03686657: Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients |
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| Not yet recruiting | 1/2 | 115 | US | Metformin, Glucophage, Glucophage XR, Val, Cel and Met XR Low, Diovan, Celebrex, RK-01, Val, Cel and Met XR High | ARKAY Therapeutics, Albany Medical College | Type 2 Diabetes, High Blood Pressure, Arthritis, Obesity | 11/25 | 01/26 | | |
| Recruiting | 1/2 | 44 | Europe | Metformin, Stereotactic Body Radiation Therapy (SBRT) 30 Gray (Gy), SBRT, Stereotactic Body Radiation Therapy (SBRT) 36 Gy, Stereotactic Body Radiation Therapy (SBRT) 25 Gy | Institut Cancerologie de l'Ouest | Prostate Cancer | 11/28 | 11/30 | | |
NCT04545736: Oral Metformin for Treatment of ABCA4 Retinopathy |
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| Recruiting | 1/2 | 45 | US | Metformin hydrochloride | National Eye Institute (NEI) | ABCA4 Retinopathy, Stargardt Disease, Retinal Dystrophy, Retinal Degeneration | 08/27 | 08/27 | | |
| Recruiting | 1/2 | 30 | US | Metformin + Standard of Care, Placebo + Standard of Care | Yale University, United States Department of Defense | Focal Segmental Glomerulosclerosis | 11/27 | 11/27 | | |
