Renal Cancer  >>  Torisel (temsirolimus)  >>  Phase 1
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10 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Torisel (temsirolimus) / Pfizer
NCT00563147: A Phase 1b, Open-Label, Dose-Finding Study to Evaluate the Safety of Tivozanib (AV-951) in Combination With Temsirolimus in Subjects With Metastatic Renal Cell Carcinoma

Checkmark Data
Nov 2011 - Nov 2011: Data
Checkmark Data
Nov 2011 - Nov 2011: Data
Completed
1b
28
US
tivozanib (AV-951) plus temsirolimus, Torisel (temsirolimus)
AVEO Pharmaceuticals, Inc.
Renal Cell Carcinoma
11/10
02/11
NCT00045370: Chemotherapy and Biological Therapy in Treating Patients With Locally Advanced or Metastatic Kidney Cancer

Completed
1
US
recombinant interferon alfa, temsirolimus
Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI)
Kidney Cancer
11/03
11/03
NCT00659568: Metformin and Temsirolimus in Treating Patients With Metastatic or Unresectable Solid Tumor or Lymphoma

Completed
1
28
Canada
metformin hydrochloride, temsirolimus
London Health Sciences Centre
Breast Cancer, Endometrial Cancer, Kidney Cancer, Lung Cancer, Lymphoma, Unspecified Adult Solid Tumor, Protocol Specific
02/10
08/10
NCT00112476: Temsirolimus and Bryostatin 1 in Treating Patients With Unresectable or Metastatic Solid Tumors

Checkmark In pts with mRCC & soft tissue sarcoma
Mar 2014 - Mar 2014: In pts with mRCC & soft tissue sarcoma
Completed
1
24
US
bryostatin 1, B705008K112, BRYO, Bryostatin, temsirolimus, CCI-779, cell cycle inhibitor 779, Torisel
National Cancer Institute (NCI)
Recurrent Melanoma, Recurrent Renal Cell Cancer, Stage IV Melanoma, Stage IV Renal Cell Cancer, Unspecified Adult Solid Tumor, Protocol Specific
07/10
 
I-NET, NCT01079286: Study of Nelfinavir and Temsirolimus in Patients With Advanced Cancers

Completed
1
18
Europe
Nelfinavir and temsirolimus, nelfinavir: viracept
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Renal Cell Cancer, Cancer
05/11
08/11
NCT01155258: Temsirolimus and Vinorelbine Ditartrate in Treating Patients With Unresectable or Metastatic Solid Tumors

Completed
1
19
US
temsirolimus, CCI-779, cell cycle inhibitor 779, rapamycin analog CCI-779, Torisel, vinorelbine ditartrate, Biovelbin, Eunades, navelbine ditartrate, NVB, vinorelbine tartrate, VNB
University of Southern California, Wyeth is now a wholly owned subsidiary of Pfizer
Extensive Stage Small Cell Lung Cancer, Hereditary Paraganglioma, Male Breast Cancer, Malignant Paraganglioma, Metastatic Gastrointestinal Carcinoid Tumor, Metastatic Pheochromocytoma, Pancreatic Polypeptide Tumor, Recurrent Breast Cancer, Recurrent Cervical Cancer, Recurrent Endometrial Carcinoma, Recurrent Gastrointestinal Carcinoid Tumor, Recurrent Islet Cell Carcinoma, Recurrent Neuroendocrine Carcinoma of the Skin, Recurrent Non-small Cell Lung Cancer, Recurrent Ovarian Epithelial Cancer, Recurrent Ovarian Germ Cell Tumor, Recurrent Pheochromocytoma, Recurrent Prostate Cancer, Recurrent Renal Cell Cancer, Recurrent Small Cell Lung Cancer, Recurrent Uterine Sarcoma, Regional Gastrointestinal Carcinoid Tumor, Regional Pheochromocytoma, Stage III Cervical Cancer, Stage III Endometrial Carcinoma, Stage III Neuroendocrine Carcinoma of the Skin, Stage III Ovarian Epithelial Cancer, Stage III Ovarian Germ Cell Tumor, Stage III Prostate Cancer, Stage III Renal Cell Cancer, Stage III Uterine Sarcoma, Stage IIIA Breast Cancer, Stage IIIA Non-small Cell Lung Cancer, Stage IIIB Breast Cancer, Stage IIIB Non-small Cell Lung Cancer, Stage IIIC Breast Cancer, Stage IV Breast Cancer, Stage IV Endometrial Carcinoma, Stage IV Neuroendocrine Carcinoma of the Skin, Stage IV Non-small Cell Lung Cancer, Stage IV Ovarian Epithelial Cancer, Stage IV Ovarian Germ Cell Tumor, Stage IV Prostate Cancer, Stage IV Renal Cell Cancer, Stage IV Uterine Sarcoma, Stage IVA Cervical Cancer, Stage IVB Cervical Cancer, Thyroid Gland Medullary Carcinoma
01/13
05/14
NCT01198184: Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 and Temsirolimus in Treating Patients With Advanced Solid Tumors

Checkmark +temsirolimus
Jul 2013 - Jul 2013: +temsirolimus
Checkmark P1 data- ESMO 2012
Sep 2012 - Sep 2012: P1 data- ESMO 2012
Completed
1
18
Canada
temsirolimus, CCI-779, cell cycle inhibitor 779, Torisel, gamma-secretase/Notch signalling pathway inhibitor RO4929097, R4733, RO4929097, laboratory biomarker analysis, pharmacological study, pharmacological studies
National Cancer Institute (NCI)
Endometrial Papillary Serous Carcinoma, Recurrent Endometrial Carcinoma, Recurrent Renal Cell Cancer, Stage III Endometrial Carcinoma, Stage III Renal Cell Cancer, Stage IV Endometrial Carcinoma, Stage IV Renal Cell Cancer, Unspecified Adult Solid Tumor, Protocol Specific
07/13
10/13
NCT01548482: Trebananib And Temsirolimus in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

Checkmark ASCO 2013
May 2013 - May 2013: ASCO 2013
Completed
1
21
Canada
Laboratory Biomarker Analysis, Pharmacological Study, Temsirolimus, CCI-779, CCI-779 Rapamycin Analog, Cell Cycle Inhibitor 779, Rapamycin Analog, Rapamycin Analog CCI-779, Torisel, Trebananib, AMG 386, Angiopoietin 1/2-Neutralizing Peptibody AMG 386
National Cancer Institute (NCI)
Adult Solid Neoplasm, Lung Carcinoid Tumor, Recurrent Digestive System Neuroendocrine Tumor G1, Recurrent Renal Cell Carcinoma, Recurrent Uterine Corpus Sarcoma, Stage III Renal Cell Cancer, Stage IIIB Uterine Sarcoma, Stage IIIC Uterine Sarcoma, Stage IV Renal Cell Cancer, Stage IVA Uterine Sarcoma, Stage IVB Uterine Sarcoma
01/14
01/14
NCT01122615: Sunitinib Plus Temsirolimus in Patients With Renal Cell Cancer (RCC)

Checkmark ASCO-GU 2014
Jan 2014 - Jan 2014: ASCO-GU 2014
Completed
1
23
US
Sunitinib, Sunitinib Malate, Sutent, Temsirolimus, CCI-779, Torisel
M.D. Anderson Cancer Center, Pfizer
Renal Cell Cancer, Kidney Cancer
07/14
07/14
NCT01183663: Lenalidomide in Combination With Bevacizumab, Sorafenib, Temsirolimus, or 5-Fluorouracil, Leucovorin, Oxaliplatin (FOLFOX)

Checkmark Lenalidomide in combination with temsirolimus in pts with adv cancer
Aug 2013 - Aug 2013: Lenalidomide in combination with temsirolimus in pts with adv cancer
Checkmark ASCO 2013
May 2013 - May 2013: ASCO 2013
Checkmark Data-AACR
More
Completed
1
180
US
Lenalidomide, CC-5013, Revlimid, Bevacizumab, Avastin, Anti-VEGF monoclonal antibody, rhuMAB-VEGF, Sorafenib, Nexavar, BAY 43-90006, Temsirolimus, CC-779, Torisel, Oxaliplatin, Eloxatin, Leucovorin, Citrovorum, Wellcovorin, 5-fluorouracil, 5-FU, Adrucil, Efudex
M.D. Anderson Cancer Center, Celgene
Advanced Cancers
05/16
05/16

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