levetiracetam / Generic mfg. |
| Not yet recruiting | 4 | 20 | | | Prof. David C. Reutens, UCB Pharma | acute seizures | | | | |
ACTRN12606000102572: Neuropsychiatric, Neurocognitive And Quality Of Life Outcomes In Patients With Epilepsy Treated With Levetiracetam (Keppra) Verses Older AEDs As First Substitution Monotherapy. |
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| Recruiting | 4 | 200 | | | Associate Prof. Terence O'Brien and RMH Neurosciences Foundation, UCB Pharma Belgium | Epilepsy | | | | |
ACTRN12615000643572: EpiNet-First Trial 1: Comparison of efficacy of levetiracetam, lamotrigine and carbamazepine in people with previously untreated epilepsy who have focal seizures. |
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| Recruiting | 4 | 1467 | | | EpiNet Study Group, Health Research Council of New Zealand, Neurological Foundation of New Zealand, Julius Brendel Trust | Epilepsy | | | | |
ChiCTR-TRC-13003743: Anti-epilepsy drugs prophylaxis in cranioplasty for patients with skull defection: A prospective randomized controlled study |
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| Completed | 4 | 200 | | levetiracetam prophylaxis vs without levetiracetam prophylaxis | The First Affiliated Hospital of PLA General Hospital; Level of the institution:, Research funds | Epilepsy | | | | |
2012-001884-64: A study of Standard and New Antiepileptic Drugs – SANAD-II. |
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| Ongoing | 4 | 1510 | Europe | Sodium Valproate, Lamotrigine, Levetiracetam, Zonisamide, Tablet, Capsule, hard, Lamictal, Keppra, Zonegran | University of Liverpool, The Walton Centre NHS Foundation Trust, National Institute for Health Research (NIHR) Health Technology Assessment Program (HTA) | Epilepsy, Brain disorder, Diseases [C] - Nervous System Diseases [C10] | | | | |
ChiCTR-OCC-11001874: Evaluate the efficacy and safety of Levetiracetam for prophylaxis and treatment of febrile seizure in children |
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| Completed | 4 | 67 | | NA ;starting dose with LEV 30mg/kg | PLA General Hospital; PLA General Hospital, NA | febrile seizure | | | | |
2014-002188-13: Emergency treatment with levetiracetam or phenytoin in status epilepticus in children (EcLiPSE) - a randomsied unblinded controlled trial |
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| Ongoing | 4 | 308 | Europe | Levetiracetam, Phenytoin, Concentrate for solution for infusion, Keppra, Epanutin | University of Liverpool, Alder Hey Children's NHS Foundation Trust, National Institute Health Research Health Technology Assessment (NETSCC), ational Institute Health Research Health Technology Assessment (NETSCC) | Convulsive Status Epilepticus, A convulsive seizure which continues for a prolonged period (longer than five minutes), or when convulsive seizures occur one after the other with no recovery between., Diseases [C] - Nervous System Diseases [C10] | | | | |
2004-002114-11: A double blind, randomized, placebo-controlled, cross-over study to evaluate the effects of Levetiracetam on membrane excitability properties of afferent myelinated and unmyelinated fibers and change in neuropathic pain in patients with painful traumatic nerve injury. |
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| Ongoing | 4 | 20 | Europe | Levetiracetam, - Keppra 250mg, - Keppra 500mg, - Keppra 250mg, - Keppra 500mg | Infociencia Clinical Research | Neuropathic pain due to a traumatic nerve lesion | | | | |
2005-001516-41: Efficacy and safety of Levetiracetam treatment in patients suffering from Restless Legs SyndromeEficacia y seguridad de un tratamiento con levetiracetam en pacientes con síndrome idiopático de piernas inquietas |
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| Ongoing | 4 | 12 | Europe | Levetiracetam, Keppra 250, Keppra 500, Keppra 250, Keppra 500 | Clínica Plató Fundació Privada | Restless legs syndrome (RLS) | | | | |
2005-002041-40: Double-blind, placebo controlled cross-over study to assess efficacy of Levetiracetam in paediatric and childhood Tourette syndrome. Estudio cruzado, aleatorizado, doble ciego controlado con placebo, para evaluar la eficacia del Levetiracetam en el control de los tics de pacientes pediátricos y adolescentes con síndrome de Gilles de la Tourette |
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| Ongoing | 4 | 20 | Europe | Levetiracetam, Keppra 250 mg, Keppra 500 mg, Keppra 250 mg, Keppra 500 mg | Hospital Sant Joan de Déu | Tourette syndrome | | | | |
2005-002042-19: Double-blind, placebo controlled cross-over study to assess the efficacy of Levetiracetam in paediatric and childhood non-epileptic myoclonusEstudio cruzado, aleatorizado, doble ciego controlado con placebo, para evaluar la eficacia del Levetiracetam en el tratamiento del mioclonus no epiléctico en pacientes pediátricos y adolescentes |
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| Ongoing | 4 | 20 | Europe | Levetiracetam, Keppra 250 mg, Keppra 500 mg, Keppra 250 mg, Keppra 500 mg | Hospital Sant Joan de Déu | Non-epileptic myoclonus | | | | |
2005-002474-30: Influence of levetiracetam on gamma band activity in a group of epilepsy patientsEstudio sobre la influencia de levetiracetam en la actividad de las ondas gamma en pacientes con epilepsia |
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| Ongoing | 4 | 25 | Europe | Levetiracetam, Keppra 500mg, Keppra 1000mg, Keppra 500mg, Keppra 1000mg | Hospital Ruber Internacional | Epilepsy with partial and/or generalized seizures | | | | |
2005-003903-35: : The Role of Keppra in the Treatment of Tremor in Multiple Sclerosis |
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| Ongoing | 4 | 20 | Europe | Keppra ®, Keppra 250mg, Keppra 500mg | Newcastle-upon-Tyne Hospitals NHS Trust | Multiple Sclerosis | | | | |
2005-003411-75: Estudio sobre la utilización de levetiracetam en monoterapia en pacientes HIV-positivos con epilepsia |
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| Ongoing | 4 | 20 | Europe | levetiracetam, ucb-L059, Keppra 500 / 1000 mg comprimidos con cubierta pelicular, Keppra 500 / 1000 mg comprimidos con cubierta pelicular | Fundación para la Investigación Biomédica del Hospital Clínico de San Carlos | Pacientes HIV-positivos con epilepsia | | | | |
2008-000370-20: Evaluation of pharmacokinetic and pharmacodynamic interactions between escitalopram and drugs used for the treatment of bipolar disorders. |
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| Ongoing | 4 | 24 | Europe | Lamotrigine, Gabapentin, Carbamazepine, Oxcarbazepine, Levetiracetam, Valproic acid, CIPRALEX, LITIO CARBONATO, CIPRALEX, LITIO CARBONATO | AZIENDA OSPEDALIERA PISANA | bipolar disorders | | | | |
| Ongoing | 4 | 40 | Europe | carbamazepine, Levetiracetam, Lamotrigine, RVG 11401 (tabletten 100 mg), RVG 03899 (tabletten, RVG 29546, We won\'t be investigating a specific IMP but a group of antiepileptic drugs to be withdrawn earlier after epilepsy surgery. The earlier withdrawal is the research question. As discussed 3 IMPs wille be given; carbamazepine, Levetiracetam, Lamotrigine, We won\'t be investigating a specific IMP but a group of antiepileptic drugs to be withdrawn earlier after epilepsy surgery. The earlier withdrawal is the research question. As discussed 3 IMPs wille be given; carbamazepine, Levetiracetam, Lamotrigine | University Medical Center Utrecht, Dutch national epilepsy fund | We will investigate possible cognitive benifits of early antiepileptic drug withdrawal after pediatric epilepsy surgery. The concerning medical condition is refractory epilepsy | | | | |
2015-004827-30: Rapid versus slow withdrawal of antiepileptci monotherapy in two-year seizure free patients. Sospensione rapida contro sospensione lenta della monoterapia con un farmaco antiepilettico in pazienti senza crisi da almeno due anni |
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| Ongoing | 4 | 350 | Europe | Tablet, KEPPRA - 1000MG-COMPRESSA RIVESTITA CON FILM-USO ORALE BLISTER DIVISIBILE (ALLUMINIO/PVC)-100X1 (DOSE UNITARIA) | AZIENDA OSPEDALIERA "BIANCHI-MELACRINO-MORELLI", Ministero della Salute, REGIONE CALABRIA | Epilepsy Epilessia, Epilepsy Epilessia, Diseases [C] - Nervous System Diseases [C10] | | | | |
2018-000781-10: EFFICACY AND TOLERABILITY OF LOW versus STANDARD DAILY DOSES OF ANTIEPILEPTIC DRUGS IN NEWLY DIAGNOSED, PREVIOUSLY UNTREATED EPILEPSY Efficacia e tollerabilit¿ di basse dosi contro dosi standard dei farmaci antiepilettici in pazienti non trattati di nuova diagnosi. |
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| Not yet recruiting | 4 | 374 | Europe | CARBAMAZEPINA, OXCARBAZEPINA, LAMOTRIGINA, LEVETIRACETAM, TOPIRAMATO, ACIDO VALPROICO, GABAPENTIN, ZONISAMIDE, CARBAMAZEPINA BASSA DOSE, OXCARBAZEPINA BASSA DOSE, LAMOTRIGINA BASSA DOSE, LEVETIRACETAM BASSA DOSE, TOPIRAMATO BASSA DOSE, ACIDO VALPROICO BASSA DOSE, GABAPENTIN BASSA DOSE, ZONISAMIDE BASSA DOSE, CARBAMAZEPINA, OXCARBAZEPINA, LAMOTRIGINA, LEVETIRACETAM, TOPIRAMATO, ACIDO VALPROICO, GABAPENTIN, ZONISAMIDE, CARBAMAZEPINA BASSA DOSE, OXCARBAZEPINA BASSA DOSE, LAMOTRIGINA BASSA DOSE, LEVETIRACETAM BASSA DOSE, TOPIRAMATO BASSA DOSE, ACIDO VALPROICO BASSA DOSE, GABAPENTIN BASSA DOSE, ZONISAMIDE BASSA DOSE, Tablet, Capsule, hard, TEGRETOL - 200 MG COMPRESSE A RILASCIO MODIFICATO 30 COMPRESSE, TOLEP - 300 MG COMPRESSE 50 COMPRESSE DIVISIBILI, LAMOTRIGINA DOC - 100 MG COMPRESSE DISPERSIBILI 56 COMPRESSE IN BLISTER ACLAR/PVC/AL, LEVETIRACETAM DOC - 500 MG COMPRESSE RIVESTITE CON FILM 60 COMPRESSE, TOPIRAMATO DOC GENERICI - 100 MG COMPRESSE RIVESTITE CON FILM 60 COMPRESSE IN BLISTER AL/AL, ACIDO VALPROICO SANDOZ - 300 MG COMPRESSE A RILASCIO PROLUNGATO30 COMPRESSE, GABAPENTIN MYLAN GENERICS - 400 MG CAPSULE RIGIDE 500 (5X100) CAPSULE IN BLISTER PVC/ALU CONFEZIONE OSPEDALIERA, ZONEGRAN - 100 MG CAPSULA RIGIDA USO ORALE BLISTER (PVC/ALL) 196 CAPSULE | IRCCS- ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI, Ministero della Salute, Regione Lombardia | EPILEPSY EPILESSIA, EPILEPSY EPILESSIA, Diseases [C] - Nervous System Diseases [C10] | | | | |
ChiCTR-IPR-15007241: Intermittent oral levetiracetam preventing the recurrence of febrile seizure with epileptiform discharges under the monitoring of iThermonitor: a multicenter randomized controlled trail |
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| Not yet recruiting | 4 | 400 | | LEV 15-30mg/kg ;NA | Chinese PLA General Hospital; PLA General Hospital, NA | febrile seizure | | | | |
ACTRN12615000556549: EpiNet-First Trial 2: Comparison of efficacy of levetiracetam and sodium valproate in people with previously untreated epilepsy who have generalised seizures. |
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| Terminated | 4 | 506 | | | EpiNEt Study Group, Health Research Council of New Zealand;, Neurological Foundation of New Zealand, Julius Brendel Trust | Epilepsy | | | | |
ACTRN12615000641594: EpiNet-First Trial 5: Comparison of efficacy of levetiracetam and lamotrigine in people with previously untreated epilepsy who have unclassified seizures, and for whom sodium valporate is not deemed an acceptable anti-epileptic drug. |
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| Terminated | 4 | 664 | | | EpiNet Study Group, Health Research Council of New Zealand, Neurological Foundation of New Zealand, Julius Brendel Trust | Epilepsy | | | | |
ACTRN12615000640505: EpiNet-First Trial 4: Comparison of efficacy of levetiracetam, lamotrigine and sodium valproate in people with previously untreated epilepsy who have unclassified seizures. |
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| Terminated | 4 | 1176 | | | EpiNet Study Group, Health Research Council of New Zealand, Neurological Foundation of New Zealand, Julius Brendel Trust | Epilepsy | | | | |
ACTRN12615000639527: EpiNet-First Trial 3: Comparison of efficacy of levetiracetam and lamotrigine in people with previously untreated epilepsy who have generalised seizures, and for whom sodium valporate is not deemed an acceptable anti-epileptic drug. |
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| Terminated | 4 | 664 | | | EpiNet Study Group, Health Research Council of New Zealand, Neurological Foundation of New Zealand, Julius Brendel Trust | Epilepsy | | | | |
NCT04829838: Comparison of Efficacy of Phenytoin With Levetireacetam for the Management of Children With Status Epilepticus |
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| Recruiting | 4 | 244 | RoW | intravenous levetireacetam | ayesha tariq, King Edward Medical University | Status Epilepticus | 07/21 | 07/21 | | |
ChiCTR2200057041: Cost-effectiveness analysis of domestic and imported levetiracetam tablets in the treatment of children with focal epilepsy (real world study) |
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| Not yet recruiting | 4 | 80 | | Domestic levetiracetam treatment ;Imported levetiracetam treatment | Beijing Children's Hospital, Capital Medical University; Beijing Children's Hospital, Capital Medical University, none | Focal epilepsy in children | | | | |
ChiCTR2000030052: A single prospective randomized controlled clinical trial of antiepileptic drug regimen for glioma patients with non-preoperative epilepsy |
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| Not yet recruiting | 4 | 100 | | take levetiracetam for 1 week ;take levetiracetam for 4 weeks | Beijing Tiantan Hospital, Capital Medical University; Beijing Tiantan Hospital, Capital Medical University, Beijing Natural Science Foundation | Glioma related epilepsy | | | | |
ChiCTR2000030228: A single prospective randomized controlled clinical trial for antiepileptic drug regimen in the treatment of patients with glioma-related epilepsy |
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| Not yet recruiting | 4 | 100 | | levetiracetam for 6 months ;levetiracetam for 12 months | Beijing Tiantan Hospital, Capital Medical University; Beijing Tiantan Hospital, Capital Medical University, Beijing Natural Science Foundation | Glioma-related epilepsy | | | | |
NCT06403150: The Efficacy and Safety of Levetiracetam Versus Fosphenytoin in Convulsive Status Epilepticus |
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| Enrolling by invitation | 4 | 62 | RoW | Levetiracetam Injection, Iracet Injection, Neurocet Injection, Fosphenytoin Injection, Fosfen Injection | Dhaka Medical College | Status Epilepticus | 08/24 | 10/24 | | |
2020-004878-22: Pharmacokinetic and Placental Transfer of Levetiracetam Etude de la pharmacocinétique maternelle et du passage transplacentaire du Lévétiracétam |
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| Not yet recruiting | 4 | 50 | Europe | Film-coated tablet | ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, DGOS | Epilepsy in pregnancy l'épilepsie pendant la grossesse, Epilepsy in pregnancy l'épilepsie pendant la grossesse, Diseases [C] - Nervous System Diseases [C10] | | | | |
| Completed | 4 | 79 | US | Levetiracetam, Keppra | University of Michigan | Intracranial Aneurysms, Seizure | 10/23 | 10/23 | | |
GENESIS, NCT04759196: Generating Evidence on NonEpileptic, Stereotypical and Intermittent Symptoms (NESIS) in Chronic Subdural Hematomas |
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| Recruiting | 4 | 56 | Canada | Topamax, Topiramate, TPM, Levetiracetam, LEV, Keppra | Université de Sherbrooke | Chronic Subdural Hematoma, Epilepsy; Seizure, Cortical Depression; Cortical Depolarization, Nonepileptic, Stereotypical and Intermittent Symptoms, NESIS | 09/24 | 12/24 | | |
NCT06081283: Antiseizure Medication in Seizure Networks at Early Acute Brain Injury |
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| Recruiting | 4 | 54 | US | Phenobarbital Sodium Injection, phenobarbital, Levetiracetam, Lacosamide Injectable Product, Valproate Sodium, Valproate, Phosphenytoin | University of North Carolina, Chapel Hill | Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia, Hypoxia-Ischemia, Brain, Heart Arrest, Stroke, Intracranial Hemorrhages, Coma, Persistent Vegetative State | 11/24 | 02/25 | | |
NCT05969054: Improvement Effect of Lacosamide and Levetiracetam on Cognitive in Alzheimer's Disease Patients With Epilepsy |
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| Recruiting | 4 | 140 | RoW | Lacosamide 100 mg, Levetiracetam 250mg | Xiangya Hospital of Central South University | Alzheimer Disease 3, Epilepsy | 12/25 | 12/25 | | |
| Recruiting | 4 | 120 | Europe | Levetiracetam, Keppra, Valproic Acid, Depakine | Leiden University Medical Center, Medical Center Haaglanden, Erasmus Medical Center, Amsterdam UMC, location VUmc | Glioma | 01/26 | 01/28 | | |
NCT05737511: Efficacy of Hydroxyzine for Patients With Panic Disorder |
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| Not yet recruiting | 4 | 80 | NA | Hydroxyzine, Atarax, Vistaril, Escitalopram Oxalate, citalopram, fluoxetine, fluvoxamine, paroxetine, paroxetine CR, sertraline, venlafaxine XR,, Alprazolam, clomipramine, clonazepam, diazepam, imipramine, lorazepam, mirtazapine, reboxetine, Bupropion SR, divalproex, duloxetine, gabapentin, levetiracetam, milnacipran, moclobemide, olanzapine, phenelzine, quetiapine, risperidone, tranylcypromine | Sultan Qaboos University | Panic Disorder | 12/26 | 12/26 | | |