| simvastatin / Generic mfg. |
ChiCTR-TRC-14005130: A random clinical trial study to assess the efficiency of fumigation with Lishi-jiangzhi Decoction in the treatment of hyperlipoidemia |
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| Completed | N/A | 90 | | Fumigation with Lishi Jiangzhi (reducing lipids) decoction ;Simvastatin ;Fumigation with placebo | Guanganmen Hospital of China Academy of Chinese Medical Sciences; Guanganmen Hospital of China Academy of Chinese Medical Sciences, Independent topics of China Academy of Chinese Medical Sciences | Hyperlipidemia | | | | |
ChiCTR-ROC-17010971: Impact of 1562C/T polymorphism of MMP-9 on lipid-lowering efficacy of simvastatin in Chinese patients with coronary heart disease |
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| Completed | N/A | 264 | | simvastatin,20 mg/day | The Fourth Affiliated Hospital of Harbin Medical University; The Fourth Affiliated Hospital of Harbin Medical University, Self-raised | coronary heart disease | | | | |
ChiCTR-ICR-15007290: Correlation between gut microbiota metabolite TMAO and sevrity of coronary artery disease and effects of ezetimibe on plasma TMAO levels |
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| Recruiting | N/A | 90 | | the patients were treated by simvastatin 20mg/d ;the patients were treated by ezetimibe 10mg/d ;the patients were treated by ezetimibe 10mg/d and simvastatin 20mg/d | Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 50,000 yuan raised | coronary heart atherosclerotic disease | | | | |
ChiCTR-TRC-14005164: Central Nerve System Protection Effect of Simvastatin Undergoing Cardiac Valve Replacement |
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| Recruiting | N/A | 140 | | simvastatin ;Placebo (starch tablets) | Sun yat-sen memorial hospital, Sun Yat-Sen University; Sun yat-sen memorial hospital, Sun Yat-Sen University, Supported by Science and Technology Planning Project of Guangdong Province, China | neurological complications after cardiac surgery | | | | |
ChiCTR1800016484: A bioequivalence study of Simvastatin Tablets 20 mg in healthy subjects under fasting and fed conditions |
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| Recruiting | N/A | 96 | | 1 tablet of IP taken per period, total 4 periods ;1 tablet of IP taken per period, total 2 periods | The First Hospital of Jilin University; The First Hospital of Jilin University, YiChang HEC ChangJiang Pharmaceutical Co., Ltd | Hyperlipidemia | | | | |
ChiCTR1900024410: Efficacy and safety of simvastatin ointment for the treatment of xanomatosis or juvenile xanthogranuloma |
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| Completed | N/A | 70 | | For xanomatosis, three different concentrations of the experimental drugs were topical given twice daily ;For juvenile xanthogranuloma, three different concentrations of the experimental drugs were topical given twice daily | Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine; Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, self -funded by department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine | xanomatosis and juvenile xanthogranuloma | | | | |
INTENSITY-HIGH, NCT03355027: Investigating the Lowest Threshold of Vascular Benefits From LDL Cholesterol Lowering in Patients With Stable CV Disease |
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| Active, not recruiting | N/A | 60 | Europe | Alirocumab 150 MG/ML, Praluent, Ezetimibe 10Mg Tablet, Ezetrol, Atorvastatin 40Mg Tablet, Atorvastatin 80Mg Tablet, Rosuvastatin 20Mg Tablet, Crestor, Rosuvastatin 40Mg Tablet, Simvastatin 80mg | Cambridge University Hospitals NHS Foundation Trust, University of Cambridge | Atherosclerosis, Cardiovascular Diseases | 09/19 | 11/23 | | |
ChiCTR1900025282: Clinical Study for Huazhuo Tongmai Decoction in the Treatment of Primary Hyperlipidemia Complicated with Carotid Atherosclerosis |
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| Recruiting | N/A | 156 | | Huazhuo Tongmaifang Granule ;Simvastatin Tablets | Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine; Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing Science and Technology Commission | Primary hyperlipidemia with carotid atherosclerosis | | | | |
ChiCTR1800014937: The effect of simvastatin on plasma amyloid-beta transport in patients with hypercholesterolemia |
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| Recruiting | N/A | 120 | | simvastatin 40mg po qn ;placebo 40mg po qn | The First Affiliated Hospital of Xi'an Jiaotong University; The First Affiliated Hospital of Xi'an Jiaotong University, Dyslipidemia and atherosclerosis research funding from China Heart House | Alzheimer's disease | | | | |
ChiCTR1800019285: Study for the intervention mechanism of shenqi maixintong capsule on atherosclerotic plaque |
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| Not yet recruiting | N/A | 90 | | Shenqi maixin tong capsule ;simvastatin | Guangzhou Integrated Traditional Chinese and Western Medicine Hospital; Guangzhou Integrated Traditional Chinese and Western Medicine Hospital, Traditional Chinese Medicine Bureau of Guangdong Province | Carotid atherosclerosis | | | | |
ChiCTR-IOR-17012195: The Effects of Carvedilol Combined with Simvastatin or Metformin on the Reduction of HVPG in Patients with Cirrhosis Portal Hypertention |
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| Not yet recruiting | N/A | 129 | | Carvedilol ;Carvedilol+Simvastatin ;Carvedilol+Metformin | Department of Gastroenterology, Eastern Hospital Shandong Provincial Hospital Affiliated to Shandong University; Shandong Provincial Hospital Affiliated to Shandong University, no funding | liver cirrhosis | | | | |
NCT05031923: Treatment of Intrabony Defects With Simvastatin and Antimicrobial Photodynamic Therapy |
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| Recruiting | N/A | 20 | RoW | SMV and antimicrobial photodynamic therapy, SMV application | Kafrelsheikh University | Simvastatin, Photodynamic Therapy, Periodontal Diseases | 08/24 | 08/24 | | |
ChiCTR2000037278: Effects and Safety of Simvastatin Ointment in the Treatment of Congenital Ichthyosis |
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| Recruiting | N/A | 55 | | Concentration of simvastatin cream ;Concentration of simvastatin cream | Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Pharmacy of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine | inherited ichthyosis | | | | |
| Completed | N/A | 101 | Europe | Simvastatin 20mg, Placebo | University of Oxford, Wellcome Trust | Depression, Inflammation | 02/23 | 02/23 | | |
NCT05187715: To Study the Safety and Efficacy of Simvastatin in Patients With Hepatopulmonary Syndrome in Cirrhosis. |
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| Recruiting | N/A | 45 | RoW | Simvastatin 40mg, Placebo, Standard medical Treatment | Institute of Liver and Biliary Sciences, India | Liver Cirrhosis | 10/23 | 10/23 | | |
NCT05525013: Effect of Simvastatin Versus Calcium Hydroxide Intracanal Medications on Post-operative Pain and Interleukin 6 and 8 |
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| Recruiting | N/A | 30 | RoW | Simvastatin Powder, Calcium Hydroxide | Cairo University | Periapical Periodontitis | 09/24 | 11/24 | | |
NCT05551871: Effects of Usage of Simvastatin in Mild to Moderate Traumatic Brain Injury (TBI) Patients. Could it Make a Difference? |
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| Not yet recruiting | N/A | 60 | NA | Simvastatin, Placebo drug | Assiut University | Traumatic Brain Injury | 12/23 | 12/23 | | |
ChiCTR2200064215: Evaluation of the effect of Natto Hongqu Capsules on blood lipid regulation |
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| Not yet recruiting | N/A | 400 | | Simvastatin Placebo + Natto Hongqu Placebo ;Simvastatin Placebo +Natto Hongqu Capsules ;Simvastatin Tablet + Natto Hongqu Placebo ;Simvastatin Tablet + Natto Hongqu Capsules | School of Public Health and Emergency Management, Southern University of Science and Technology; BYHEALTH Co., Ltd., ByHealth Co., Ltd. | Dyslipidemia | | | | |
ChiCTR2200064214: Evaluation of the effect of Natto Read Yeast Rice Capsules on blood lipid regulation |
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| Not yet recruiting | N/A | 488 | | Simvastatin placebo, Natto Read Yeast Rice placebo ;Simvastatin placebo, Natto Read Yeast Rice capsule ;Simvastatin tablet, Natto Read Yeast Rice placebo ;Simvastatin tablet, Natto Read Yeast Rice capsule | Fuwai Hospital, Chinese Academy of Medical Sciences; BYHEALTH Co., Ltd., BYHEALTH Co., Ltd. | Dyslipidemia | | | | |
LSTR, NCT05677945: 3Mixtatin Versus Modified 3Mix-MP in Lesion Sterilization and Tissue Repair for Treatment of Necrotic Primary Molars |
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| Not yet recruiting | N/A | 24 | NA | 3Mixtatin paste: Simvastatin mixed with modified triple antibiotic, 3Mix: Modified triple antibiotic mix in propylene glycol | Cairo University | Necrotic Primary Molars | 03/24 | 08/24 | | |
ChiCTR2300068268: The efficacy and safety of topical simvastatin cream for porokeratosis ptychotropica: a single-center, randomized, single-blind, placebo-controlled clinical trial |
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| Completed | N/A | 24 | | 2% simvastatin cream for external use on the skin lesions of the test side, and placebo for external use on the other side, twice a day ;2% simvastatin/2% cholesterol cream for external use on the skin lesions of the test side, and placebo for external use on the other side | Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 2021 Jiangsu mass entrepreneurship and innovation talents project (JSSCRC2021564) | porokeratosis ptychotropica | | | | |
CER-4-T2D, NCT05220917: Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study |
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| Active, not recruiting | N/A | 781430 | US | SGLT2 inhibitor, CANAGLIFLOZIN, CANAGLIFLOZIN/METFORMIN HCL, DAPAGLIFLOZIN PROPANEDIOL/METFORMIN HCL, DAPAGLIFLOZIN PROPANEDIOL, EMPAGLIFLOZIN, EMPAGLIFLOZIN/METFORMIN HCL, ERTUGLIFLOZIN PIDOLATE/METFORMIN HCL, ERTUGLIFLOZIN PIDOLATE, EMPAGLIFLOZIN/LINAGLIPTIN, EMPAGLIFLOZIN/LINAGLIPTIN/METFORMIN HCL, DAPAGLIFLOZIN PROPANEDIOL/SAXAGLIPTIN HCL, ERTUGLIFLOZIN PIDOLATE/SITAGLIPTIN PHOSPHATE, DPP-4 inhibitor, ALOGLIPTIN BENZOATE/METFORMIN HCL, ALOGLIPTIN BENZOATE, ALOGLIPTIN BENZOATE/PIOGLITAZONE HCL, SAXAGLIPTIN HCL, SAXAGLIPTIN HCL/METFORMIN HCL, LINAGLIPTIN, LINAGLIPTIN/METFORMIN HCL, SITAGLIPTIN PHOSPHATE/METFORMIN HCL, SITAGLIPTIN PHOSPHATE, SITAGLIPTIN PHOSPHATE/SIMVASTATIN, GLP-1RA, INSULIN DEGLUDEC/LIRAGLUTIDE*, INSULIN GLARGINE, HUMAN RECOMBINANT ANALOG/LIXISENATIDE*, LIXISENATIDE, LIRAGLUTIDE, DULAGLUTIDE, SEMAGLUTIDE, ALBIGLUTIDE, EXENATIDE MICROSPHERES, EXENATIDE, 2nd generation SU, PIOGLITAZONE HCL/GLIMEPIRIDE, ROSIGLITAZONE MALEATE/GLIMEPIRIDE, GLIPIZIDE/METFORMIN HCL, GLYBURIDE,MICRONIZED, GLYBURIDE/METFORMIN HCL, GLIMEPIRIDE, GLYBURIDE, GLIPIZIDE | Brigham and Women's Hospital, Patient-Centered Outcomes Research Institute, VA Boston Healthcare System, McGill University | Cardiovascular Events, Type2 Diabetes, Renal Disease | 07/24 | 07/24 | | |
CIRROSTAT, NCT06431919: Carvedilol + Simvastatin vs. Carvedilol Alone for Chronic Liver Disease and Cirrhotic Cardiomyopathy and Its Impact on Hepatic Decompensation and Survival; a Double-blind Randomized Controlled Trial |
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| Not yet recruiting | N/A | 260 | NA | Simvastatin 20mg, Carvedilol 3.125 mg | Post Graduate Institute of Medical Education and Research, Chandigarh, Indian Council of Medical Research | Decompensated Cirrhosis, Cirrhotic Cardiomyopathy, Cirrhosis, Liver, Left Ventricular Diastolic Dysfunction, Acute Kidney Injury | 08/25 | 08/27 | | |
| Recruiting | N/A | 300 | Europe | Simvastatin, Hyperlipidaemia, Losartan, Hypertension, Diabetes, Microalbuminuria, Metformin, Hyperglycaemia, Outpatient rheumatology department, Intervention, Refered to general practice, Control | MD, PhD, Annemarie Lyng Svensson | Rheumatoid Arthritis, Cardiovascular Diseases | 09/24 | 09/24 | | |
NCT01653223: Myocardial Protection Effect of Simvastatin Undergoing Cardiac Surgery |
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| Recruiting | N/A | 369 | RoW | simvastatin, simcor | Sun Yat-sen University | Congenital Heart Disease, Heart Valve Disease | 12/24 | 12/26 | | |
RADICALPC, NCT03127631: A RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients |
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| Recruiting | N/A | 6000 | Canada, US, RoW | Nutrition, Exercise, Smoking cessation, Statin (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin), ACE inhibitor | McMaster University, Prostate Cancer Canada, Canadian Cancer Society (CCS) | Prostate Cancer, Cardiovascular Disease | 12/25 | 12/25 | | |
