| simvastatin / Generic mfg. |
ACTRN12608000423314: Effect of statin ingestion on muscle function at rest and following acute exercise in humans |
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| Not yet recruiting | 4 | 24 | | | The University of Melbourne, The University of Melbourne | Statin-induced myopathy | | | | |
ACTRN12615000491561: Simvastatin treatment for patients with Chronic obstructive pulmonary disease (COPD) and elevated C-reactive protein (CRP). |
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| Not yet recruiting | 4 | 48 | | | Associate Professor Robert Young, Health Research Council (HRC) | Chronic Obstructive Pulmonary Disease (COPD), Elevated CRP | | | | |
ChiCTR-TTRCC-12002801: Assessment of a pharmacokinetic and pharmacodynamics interaction between simvastatin and Ginkgo biloba extracts in health subjects |
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| Completed | 4 | 36 | | administrated with simvastatin and Ginkgo biloba extract ;administrated with simvastatin | Institute of Clinical Pharmacology, Central South University; Level of the institution：, The National Scientific Foundation of China (No. 81273595, 81001476, 30901834) | Healthy volunteers | | | | |
CHIEF, ChiCTR-TRC-08000087: Randomised trial of initial low-dose CCB and ARB combination in Chinese hypertension patients (updated in February 5 2009) |
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| Completed | 4 | 24000 | | (Total Cholesterol concentration of participants: <4.0 or >6.1mmol/L). Amlodipine 2.5mg and compound amiloride half of a tablet. ;(Total Cholesterol concentration of participants <4.0 or >6.1mmol/L). Amlodipine 2.5mg and telmisartan 40mg. ;(Total Cholesterol concentration of participants: 4.0-6.1mmol/L). Amlodipine 2.5mg, telmisartan 40mg and simvastatin 10mg. ;(Total Cholesterol concentration of participants: 4.0-6.1mmol/L). Amlodipine 2.5mg and telmisartan 40mg, regular remedy of serum lipid decided by the doctors. ;(Total Cholesterol concentration of participants 4.0-6.1mmol/L). Amlodipine 2.5mg and compound amiloride half of a tabella and regular remedy of serum lipid decided by the doctors. ;(Total Cholesterol concentration of participants: 4.0-6.1mmol/L). Amlodipine 2.5mg, compound amiloride 2.5mg and simvastatin 10mg ;(Includes group 1, group 2, and group 5). Amlodipine 2.5mg, compound amiloride half of a tablet. ;(Includes group 3, group 4 and group 6). Amlodipine 2.5mg, telmisartan 40mg. | Fu Wai Hospital for Cardiovascular Disease; The Ministry of Science and Technology of the People's Republic of China, The Ministry of Science and Technology of the People's Republic of China | Hypertension | | | | |
2011-002082-38: The effect of Simvastatin on the immune system of healthy older people |
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| Ongoing | 4 | 33 | Europe | Simvastatin, PL0025/0366, Tablet, Simastatin 80mg once daily | University of Birmingham, Queen Elizabeth Hospital Charities | We are investigating the effects of Simvastatin 80mg on neutrophil function (using in vitro studies of neutrophil function), in healthy elderly subjects as there is evidence to suggest that Simvastatin may improve neutrophil responses to inflammation in this population. Clinical and experimental data have suggested that response to infection is improved in patients receiving statins. Our own preliminary in vitro data suggest that this may be due to enhance neutrophil migration., Healthy older subjects. The usual indication for Simvastatin is to treat raised cholesterol levels in people at risk of heart disease, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
ChiCTR-TRC-12002361: Effect of Sodium Tanshinon IIA and Simvastatin on Serum Levels of Inflammatory Markers in Patients with Coronary Heart Disease：A Radomized Controlled Trial |
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| Completed | 4 | 72 | | Sodium Tanshinon IIA+STS-statin ;STS-statin | China Academy of Chinese Medical Sciences Xiyuan Hospital; China Academy of Chinese Medical Sciences Xiyuan Hospital, Jiangsu Ke Feiping Pharmaceutical Limited Company | Coronary Heart Disease | | | | |
2013-001715-76: Gastrointestinal behavior of simvastatin in healthy volunteers Gastrointestinaal gedrag van simvastatin in gezonde vrijwilligers |
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| Ongoing | 4 | 10 | Europe | Simvastatin, Tablet, Zocor 40mg tablets | KU Leuven-Drug Delivery and Disposition, KU Leuven | Healthy volunteers (administration of a hypolipidemic drug) Gezonde vrijwilligers (toediening van een cholesterolverlagend middel), Healthy volunteers (between 18-35 years) Gezonde vrijwilligers (tussen 18-35 jaar), Body processes [G] - Physiological processes [G07] | | | | |
2004-004802-26: ESTUDIO DE LA INFLUENCIA DE LAS ESTATINAS EN LA REPLICACIÓN PLASMÁTICA DEL VIH EN PACIENTES CON INFECCION POR EL VIH-1 QUE INTERRUMPEN EL TRATAMIENTO ANTIRRETROVIRAL |
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| Ongoing | 4 | 70 | Europe | Atorvastatina, Simvastatina, | Fundació Lluita contra la SIDA | Patients HIV infected | | | | |
2005-001466-14: A Proof of Concept Study to Investigate the use of Simvastatin as a Putative Anti-inflammatory Agent in Asthma |
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| Ongoing | 4 | 20 | Europe | Salmeterol xinafoate, Simvastatin, Serevent inhaler, Zocor, Serevent inhaler, Zocor | University of Dundee | Asthma | | | | |
2005-000989-39: A Single Centre, double blind, placebo controlled, randomised trial to evaluate the efficacy and safety of Simvastatin in the treatment of Psoriasis. |
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| Ongoing | 4 | 53 | Europe | Simvastatin, Simvador 40mg tablets, Simvador 40mg tablets | Guy\'s & St Thomas NHS foundation Trust | Psoriasis | | | | |
2005-004080-28: Efficacy and Safety of Niaspan in South Asian Stroke Survivors: NIASTAR TRIAL(Niaspan: Indo-Asian Stroke patienT Atherosclerotic Regression trial) |
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| Ongoing | 4 | 280 | Europe | Niaspan, Simvastatin, Niaspan, Simvastatin, Niaspan, Simvastatin | Sandwell Medical Research Unit | 1. Patients diagnosed as having a stroke based on the WHO CriteriaPatients with transient ischaemic attacks will be included if symptoms of motor or sensory loss were demonstrable with full recovery within 24 hours. Only strokes and TIA that are ischaemic in nature (thrombo-embolic) will be included in the study | | | | |
| Ongoing | 4 | 200 | Europe | Simvastatin, Simvastatin, | Oxford Radcliffe Hospitals NHS Trust | Severe sepsis | | | | |
2006-001414-33: The effect of hydroxyl-methyl coenzyme A reductase inhibition (statins) in patients with acute lung injury(ALI) and the acute respiratory distress syndrome(ARDS) |
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| Ongoing | 4 | 60 | Europe | simvastatin 40mg, | The Royal Group Hospitals Trust | Acute Lung Injury (ALI) and the Acute Respiratory Distress Syndrome (ARDS) | | | | |
2007-000197-24: EFFECTS OF NICOTINIC ACID PLUS SIMVASTATIN VS.SIMVASTATIN ALONE ON CAROTID AND FEMORAL INTIMA-MEDIA THICKNESS IN PATIENTS WITH PERIPHERAL ARTERY DISEASE (NASCIT) –A RANDOMIZED CONTROLLED TRIAL |
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| Ongoing | 4 | 200 | Europe | Simvastatin Merck 40mg, Niaspan 500mg, Simvastatin Merck 40mg 1-24892, Niaspan 500mg Merck 1-25383, Simvastatin Merck 40mg 1-24892, Niaspan 500mg Merck 1-25383 | MUW, Univ.Klinik f. Innere Medizin II, Abteilung f. Angiologie | 200 consecutive patients with PAD and low serum HDL cholesterol levels (<45mg/dL in men, <55 mg/dL in women) will be enrolled in this single-center prospective randomized controlled open-label trial. | | | | |
2008-001579-32: Erectile dysfunction:a randomised controlled trial of lipid lowering with simvastatin (EDS trial) |
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| Ongoing | 4 | 170 | Europe | Simvastatin, Zocor, Zocor | University of Hertfordshire | Erectile dysfunction | | | | |
2008-002287-33: Effect of HMG-Co A reductase inhibition on endothelial dysfunction, bioavailability of tetrahydrobiopterin (BH4) and functional regulation of endothelial nitric oxide synthase (eNOS) in human heart failure. |
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| Ongoing | 4 | 60 | Europe | Simvastatin, Simvastatin Teva, Simvastatin Teva | Belfast Health and Social Care Trust, Queens University Belfast | Heart failure | | | | |
2008-004853-13: Effect of simvastatin on myocardial triglyceride accumulation, cardiac function and vessel wall thickness in patients with type 2 diabetes mellitus |
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| Ongoing | 4 | 20 | Europe | simvastatine, | LUMC | diabetes mellitus type 2 | | | | |
2008-005096-93: SIMVASTATINA EN LA NEUMONIA ADQUIRIDA EN LA COMUNIDAD QUE REQUIERE HOSPITALIZACION. ESTUDIO ALEATORIZADO, DOBLE-CIEGO, CONTROLADO CON PLACEBO (SIMVASTATIN IN COMMUNITY-ACQUIRED PNEUMONIA REQUIRING HOSPITALIZATION. A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL) |
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| Ongoing | 4 | 376 | Europe | SIMVASTATIN, | Jordi Carratalá | NEUMONIA ADQUIRIDA EN LA COMUNIDAD QUE REQUIERE HOSPITALIZACION(COMMUNITY-ACQUIRED PNEUMONIA REQUIRING HOSPITALIZATION) | | | | |
2009-017060-17: STIMULATE study: Statins influence on Minrin upregulation of von Willebrand factor and factor VIII |
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| Ongoing | 4 | 20 | Europe | simvastatin, Desmopressine, simvastatine, Minrin, simvastatine, Minrin | Academic Medical Center | Type 1 von Willebrand disease and mild hemophilia A | | | | |
2010-018491-24: Effect of aminobisphosphonates and statins on circulating Vy9Vd2-T cells |
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| Ongoing | 4 | 40 | Europe | simvastatin, simvastatin, simvastatin | Vrije Universiteit Medical Center | patients with malignant bone metastases | | | | |
2009-014913-28: RETRO-PRO: The effectiveness of simvastatin compared to atorvastatin: an e-clinical randomised trial within a research database in routine clinical practice - a feasibility study |
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| Ongoing | 4 | 300 | Europe | simvastatin, atorvastatin, simvastatin (non-proprietary), zogor, inegy, lipitor, simvastatin (non-proprietary), zogor, inegy, lipitor | London School of Hygiene & Tropical Medicine | subjects who in the opinion of the GP investigator would require a statin for primary prevention according to the 2008 NICE guideline on lipid modification: adults over 40 who have a 20% or greater 10-risk of developing cardiovascular disease. | | | | |
2010-023912-14: Evaluación de la eficacia de una herramienta de ayuda para la toma de decisiones (ELECCIÓN DE ESTATINAS) para personas con diabetes tipo 2Evaluation of the efficacy of a decision aid (STATIN CHOICE) for patients with type 2 diabetes mellitus |
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| Ongoing | 4 | 325 | Europe | SIMVASTATINA, PRAVASTATINA, | Fundación Canaria de Investigación y Salud | Diabetes mellitus tipo 2 | | | | |
2010-022516-39: Estudio aleatorizado sobre el efecto hemodinámico de la asociación de simvastatina con betabloqueantes no cardioselectivos en pacientes con cirrosis hepática e hipertensión portal clínicamente significativa. |
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| Ongoing | 4 | 70 | Europe | ZOCOR 20 mg comprimidos recubiertos con película, ZOCOR 20 mg comprimidos recubiertos con película | Institut de Recerca HSCSP | Se trata de un estudio hemodinámico, para el estudio del efecto en la progresión de hipertensión portal, de la asociación de simvastatina al tratamiento convencional de la profilaxis primaria en pacientes con cirrosis hepática compensada y varices esofágicas de riesgo. | | | | |
2011-001055-36: Randomized controlled clinical trial phase IV to validate a cost-effective tool to optimize statin treatment of diabetic dyslipidemia in primary care |
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| Ongoing | 4 | 28 | Europe | Simvastatina, Atorvastatina, Rosuvastatina, Ezetimiba, Fluvastatina sodica, Pravastatina, Simvastatina, Atorvastatina, Rosuvastatina, Ezetimiba, Fluvastatina sodica, Pravastatina, Simvastatina, Atorvastatina, Rosuvastatina, Ezetimiba, Fluvastatina sodica, Pravastatina | Eduardo García Díaz, Eduardo García Díaz | Diabetes and cardiovascular events Diabetes y eventos carrdiovasculares | | | | |
2011-004166-16: Does simvastatin treatment affect COPD exacerbations? - Evaluation in a randomized controlled trial Kann Simvastatin Exazerbationen bei COPD beeinflussen? - Evaluierung in einem randomisierten, doppelblinden Studienmodell |
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| Ongoing | 4 | 208 | Europe | Simvastatin 40mg-Filmtabletten, Simvastatin 40mg-Filmtabletten | Abteilung für Pulmologie, Landesklinikum Thermenregion Hochegg, Life Science Krems | patients with COPD in stage II-IV (according to the GOLD classification) COPD Patienten im GOLD Stadium II-IV | | | | |
2012-003343-29: Using Simvastatin to improve immune responses in older people with pneumonia |
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| Ongoing | 4 | 56 | Europe | Simvastatin, PL0025/0366, Simastatin (zocor) 80mg once daily, Simastatin (zocor) 80mg once daily | University of Birmingham, British Lung Foundation | Acute episodes of Pneumonia and sepsis in older adults | | | | |
2014-000348-14: Cholesterol-lowering treatment and neuropathy Kolesterolsænkende medicin og nervebetændelse |
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| Ongoing | 4 | 180 | Europe | Simvastatin, Simvastatin | Odense University Hospital, Department of Neurology, Region Syddanmark, Odense University Hospital - The Free Fonding, Odense University Hospital, Department og Neurology | Patients with cerebral infarction or transient ischemic attack. Patienter med cerebralt infarkt, eller transitorisk iskæmisk attak. | | | | |
2009-011291-29: RACE 3 study: Intensive vs. usual rhythm control for atrial fibrillation. |
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| Ongoing | 4 | 250 | Europe | eplerenone, Spironolactone, atorvastatin, Fluvastatin, Pravastatin, rosuvastatin, Simvastatin, eplerenone, spironolactone, atorvastatin, Fluvastatin, Pravastatin, rosuvastatin, Simvastatin, eplerenone, spironolactone, atorvastatin, Fluvastatin, Pravastatin, rosuvastatin, Simvastatin | Interuniversity Cardiology Institute of the Netherlands (ICIN), Interuniversity Cardiology Institute Netherlands, The Interuniversity Cardiology Institute of the Netherlands (ICIN), Netherlands Heart Foundation (NHS B 2008 035), Working group on Cardiovascular Research, the Netherlands, Sanofi Aventis, Boehringer Ingelheim, Medtronic, Biotronik, St Jude Medical, Boston Scientific, AstraZenenca, Interuniversity Cardiology Institute Netherlands, Working group on Cardiovascular Research, Astra Zeneca, Bayer | atrial fibrillation | | | | |
2015-001599-23: Imaging of brain inflammation in schizophrenic patients treated with simvastatin |
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| Ongoing | 4 | 75 | Europe | [11C]PK11195, [11C]PK11195, Injection | University Medical Center Groningen, NWO (Nederlandse Organisatie voor Wetenschappelijk Onderzoek) | Schizophrenia, Schizophrenia, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2016-003325-41: PREemptive Pharmacogenomic testing for Preventing Adverse drug REactions (PREPARE) |
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| Ongoing | 4 | 450 | Europe | Syrup, Tablet, Capsule, hard, Powder for injection, Capsule, Solution for injection, Concentrate for solution for infusion, Powder for solution for infusion, Codeine, Acenocoumarol, Amitriptyline, Aripiprazole, Atomoxetine, Atorvastatine, Azathioprine, Capecitabine, Carbamazepine, Citalopram, Clomipramine, Clopidogrel, Clozapine, Efavirenz, Escitalopram, Flecainide, Flucloxacillin, Fluorouracil, Haloperidol, Irinotecan, Mercaptopurine, Metoprolol, Oxycodone, Paroxetine, Phenprocoumon, Phenytoin, ORAP 1 mg Tabletten, Propafenone, Sertraline, Simvastatin, Tacrolimus, Tamoxifen, Tegafur, Tioguanine, Tramadol, Venlafaxine, Voriconazole, Zuclopenthixol, Ethinylestradiol, ORAP 4 mg Tabletten | Leiden University Medical Center, Leiden University Medical Center | Adverse drug reactions, Side-effects, Not possible to specify | | | | |
| Recruiting | 4 | 60 | | Simvastatin group ;Orlistat-Simvastatin group | Beijing Anzhen Hospital Capital Medical University; Beijing Anzhen Hospital, Capital Medical University, self-raised funds | Obesity complicated by hyperlipidemia | | | | |
| Not yet recruiting | 4 | 80 | | oral Minocycline ;oral Minocycline ;oral Simvastatin ;oral Placebo | Shanghai Dermatology Hospital; Shanghai Dermatology Hospital, Shanghai shen-kang hospital development center | vitiligo | | | | |
| Active, not recruiting | 4 | 30 | Europe | Training+Simvastatin+Q10-placebo, SP, Training+Simvastatin-placebo+Q10-placebo, PL, Training+Simvastatin+Q10, Simvastatin KRKA, SQ | University of Copenhagen | Cardiovascular Disease, Diabetes Mellitus | 07/21 | 12/21 | | |
NCT04049786: Impact of Bariatric Surgery on Pharmacokinetic Study of Simvastatin and Carvedilol |
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| Enrolling by invitation | 4 | 120 | US | Digestive biopsy, Carvedilol 25mg, Serial blood sampling for PK analysis, Metoprolol 100 mg for CYP2D6 phenotyping, Simvastatin 40mg, SVA, Midazolam 2 mg for CYP3A4 phenotyping, MDZ, Genotyping | Natalia Valadares de Moraes, Fundação de Amparo à Pesquisa do Estado de São Paulo, University of Sao Paulo | Obesity, Bariatric Surgery, Roux-en Y Gastric Bypass | 08/22 | 08/23 | | |
NCT05133310: Effect of Simvastatin on Sepsis and Febrile Neutropenia in Patients With Acute Lymphoblastic Leukemia |
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| Recruiting | 4 | 108 | RoW | Simvastatin, Intervention Group | Hospital General de Mexico | Strains, Acute Lymphoblastic Leukemia, Sepsis | 12/22 | 06/23 | | |
| Recruiting | 4 | 1000 | RoW | protective ventilation, prone position ventilation, glucocorticoid therapy, Dexamethasone, Hydrocortisone, restrictive fluid resuscitation, Thymosin Alpha, Muscle relaxant therapy, Vecuronium Bromide, Succinylcholine, Integrated Chinese and Western Medicine Treatment, statin therapy, Simvastatin, Rosuvastatin, anti-infective treatment, Extracorporeal Membrane Oxygenation（ECMO）, stem cell therapy, Sedative analgesia/muscle relaxant therapy, Propofol, midazolam, dexmedetomidine, inotropes therapy, Dopamine, Olprinone, Levosimendan, Vasoactive drug therapy, Norepinephrine, epinephrine, metaraminol, isoproterenol | Second Affiliated Hospital, School of Medicine, Zhejiang University, Renmin Hospital of Wuhan University, The Second Affiliated Hospital of Harbin Medical University, West China Hospital, The First Affiliated Hospital of Zhengzhou University, Peking Union Medical College Hospital, Wuhan Union Hospital, China, Fudan University, Guangdong Provincial People's Hospital, Ningbo No. 1 Hospital, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University | Acute Respiratory Distress Syndrome | 10/23 | 12/23 | | |
Galibone, NCT06338241: Osteogenic Action of a Biphasic Bioceramic With Statin in a Third Molar Extraction Model |
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| Recruiting | 4 | 30 | Europe | Biphasic bioceramic of tricalcium phosphate and hydroxyapatite with simvastatin, Galibone, Bovine Hydroxyapatite, Bio-Oss | Mario Pérez Sayáns, Universidad de Murcia | Bone Loss, Regenerative Inflammation | 06/25 | 09/25 | | |
PREVESTATGx, NCT06262685: Efficacy, Safety and Cost-efficacy of a Pre-emptive Genotyping Strategy in Patients Receiving Statins |
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| Not yet recruiting | 4 | 216 | Europe | Preemptive pharmacogenetic atorvastatin dose based on CPIC guidelines, Preemptive pharmacogenetic simvastatin dose based on CPIC guidelines, Preemptive pharmacogenetic pitavastatin dose based on CPIC guidelines, Preemptive pharmacogenetic rosuvastatin dose based on CPIC guidelines, Preemptive pharmacogenetic pravastatin dose based on CPIC guidelines, Preemptive pharmacogenetic lovastatin dose based on CPIC guidelines, Preemptive pharmacogenetic fluvastatin dose based on CPIC guidelines, Standard of Care (SoC) dosing of atorvastatin, Standard of Care (SoC) dosing of simvastatin, Standard of Care (SoC) dosing of pitavastatin, Standard of Care (SoC) dosing of rosuvastatin, Standard of Care (SoC) dosing of prasavastatin, Standard of Care (SoC) dosing of lovastatin, Standard of Care (SoC) dosing of fluvastatin | Instituto de Investigación Hospital Universitario La Paz, Instituto de Salud Carlos III | Cardiovascular Diseases, Dyslipidemias, Statin Adverse Reaction, Pharmacogenic Myopathy | 02/25 | 03/25 | | |
NCT06399783: Topical Simvastatin Versus Topical Steroid in Treatment of Alopecia Areata |
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| Not yet recruiting | 4 | 54 | RoW | Simvastatin, Mometasone Furoate, Fractional CO2 laser | Assiut University | Alopecia Areata | 10/27 | 12/27 | | |
| Enrolling by invitation | 4 | 240 | RoW | Simvastatin 10mg, Ezetimibe 10mg | The University of Hong Kong | Diabetes Mellitus, Type 2 | 12/24 | 06/25 | | |
NCT03571802: Pharmacokinetics of Simvastatin Post Laparoscopic Sleeve Gastrectomy (LSG) |
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| Recruiting | 4 | 10 | RoW | Simvastatin, Study arm | National University Hospital, Singapore | Obesity, Hyperlipidemias | 06/25 | 06/25 | | |
ChiCTR2300074976: A single-arm clinical trial to evaluate the efficacy and safety of Simvastatin, Orlistat, and Trimetazidine in combination with second-line treatment drugs for advanced liver cancer |
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| Recruiting | 4 | 43 | | Patients with advanced liver cancer received Simvastatin 20mg po qn, Orlistat 120mg po tid, Trimetazidine 20mg po tid combined with second-line treatment drugs for advanced liver cancer | Affiliated Hospital of Qingdao University; Affiliated Hospital of Qingdao University, Self-funding for scientific research | Liver cancer | | | | |
| Recruiting | 4 | 28 | US | simvastatin 10mg, Bazedoxifene 20/Estrogens,Con 0.45Mg Tb | Penn State University, The John B. Pierce Laboratory | Endometriosis | 12/25 | 12/26 | | |
ChiCTR2000034035: Five-year prognosis of postmenopausal patients with hormone receptor-positive early breast cancer treated with different stains and aromatase inhibitors: a prospective, randomized controlled trial |
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| Not yet recruiting | 4 | 374 | | Simvastatin ;Pravastatin | The First Hospital of China Medical University; The First Hospital of China Medical University, self-raised | Breast Cancer | | | | |
