simvastatin / Generic mfg.  >>  Phase 3
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17 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
simvastatin / Generic mfg.
2006-006328-20: A multicentre, randomised, double-blind, controlled with placebo clinical trial with parallel groups, for the evaluation of the efficacy and safety of combined treatment with L-carnitine and simvastatin in the reduction of serum lipoprotein (a) or/and triglycerides in patients with mixed hyperlipidemia

Ongoing
3
110
Europe
Oral solution, Coated tablet, Inestom, Antichol
HELP Pharmaceuticals S.A.
This study will evaluate the safety and efficacy of combined treatment with L- Carnitine and Simvastatin in reducing the Lipoprotein (a) and triglyceride level of patients with mixed hyperlipidemia. It can also include recently diagnosed patients wih diabetes mellitus type 2, who receive only dietary treatment.Lipoprotein (a) and hyperlipidemia are known risk factors for cardiovascular heart disease.
 
 
2014-003213-29: A randomized, multicenter, open-label, two-arm, parallel, phase III study to evaluate the efficacy and safety of nicotinic acid administered in combination with simvastatin for 6 months in comparison to simvastatin therapy alone in inhibiting the progression of atherosclerosis in patients with carotid arteries stenosis and dyslipidemia. Randomizowane, wieloośrodkowe, otwarte, dwuramienne w grupach równoległych, badanie III fazy oceniające skuteczność i bezpieczeństwo podawanego przez 6 miesięcy kwasu nikotynowego w leczeniu skojarzonym z simwastatyną, w porównaniu do terapii samą simwastatyną, w zahamowaniu progresji zmian miażdżycowych u pacjentów ze zwężeniem tętnic szyjnych i dyslipidemią.

Ongoing
3
110
Europe
Nicotinic acid, 500 mg, prolonged-release tablet, Nicotinic acid, 750 mg, prolonged-release tablet, Nicotinic acid, 1000 mg, prolonged-release tablet, Prolonged-release tablet, Film-coated tablet, Simvastatin Bluefish, 20 mg, film-coated tablets, Simvastatin Bluefish, 40 mg, film-coated tablets
SciencePharma spółka z ograniczoną odpowiedzialnością sp. j., SciencePharma spółka z ograniczoną odpowiedzialnością sp. j., Polska Agencja Rozwoju Przedsiębiorczości (PARP)
Inhibiting the progression of atherosclerosis in patients with carotid arteries stenosis and dyslipidemia., Inhibiting the progression of atherosclerosis in patients with carotid arteries stenosis and dyslipidemia., Diseases [C] - Cardiovascular Diseases [C14]
 
 
2006-000569-13: Influence on the coronary Microcirculation and on myocArdial perfusion Reserve of Niaspan given IN addition to simvastatin in diabEtic patients

Ongoing
3
40
Europe
Tablet
Cardioangiologisches Centrum Bethanien
Diabetic patients at high risk for CVD
 
 
2008-008900-42: The DIEP flap as a model of ischemia-reperfusion: an intervention study

Ongoing
3
30
Europe
Zocor, fluimucil, RVG 13195, RVG 29806, Zocor, fluimucil, Zocor, fluimucil
MUMC
ischemia reperfusion
 
 
2010-021593-11: Prevención de la progresión de la hipertensión portal en la cirrosis compensada mediante el uso de vasodilatadores hepáticos selectivos. Estudio multicéntrico, aleatorizado y doble-ciego

Ongoing
3
80
Europe
ZOCOR 20 mg comprimidos recubiertos con película, ZOCOR 20 mg comprimidos recubiertos con película
INSTITUT DE RESERCA.HSCSP
El objetivo de estudio es valorar el efecto de las estatinas, en su efecto vasodilatador selectivo hepático, en la prevención de la progresión de la hipertensión portal ( con un gradiente de presión entre 6 y 10 mmHg) en pacientes con cirrosis hepática compensada.
 
 
2016-000647-14: Treatment with simvastatin of growth and bone abnormalities in children with Noonan syndrome Traitement des anomalies osseuses et de croissance par la simvastatine chez les enfants atteints du syndrome de Noonan

Ongoing
3
62
Europe
Simvastatin, Film-coated tablet, Simvastatin
University Hospital Toulouse, Programme Hospitalier de Recherche Clinique, Enveloppe Nationale 2015
Noonan syndrome Syndrome de Noonan, Noonan syndrome Syndrome de Noonan, Body processes [G] - Genetic Phenomena [G05]
 
 
NCT03134157: The Effect of Simvastatin on Uterine Leiomyoma Development and Growth in Infertile Women

Recruiting
3
60
RoW
oral drug and vaginal placebo, oral drug and oral placebo, Vaginal placebo+ oral placebo
Royan Institute
Infertility
06/21
09/21
SIMBA-16, NCT04021498 / 2016-002445-31: Simvastatin in the Prevention of Recurrent Pancreatitis

Recruiting
3
144
Europe
Simvastatin 40mg, Brand name: Simvastatin Normon, 40 mg, Placebo, lactose (brand name: lactosa monohidrato Fagrón)
Enrique de-Madaria, Instituto de Salud Carlos III, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Generalitat Valenciana
Pancreatitis Relapsing
07/22
09/22
2022-002266-33: STATINS USE IN INTRACEREBRAL HEMORRHAGE PATIENTS (SATURN) USO DE ESTATINAS EN PACIENTES CON HEMORRAGIA INTRACEREBRAL

Not yet recruiting
3
1456
Europe
Simvastatina, Atorvastatina, Coated tablet, Simvastatina, Atorvastatina
BETH ISRAEL DEACONESS MEDICAL CENTER, NIH/NINDS
Intracerebral Hemorrhage (ICH) recurrence Recurrencia de hemorragia intracerebral (HIC), Intracerebral Hemorrhage (ICH) recurrence Recurrencia de hemorragia intracerebral (HIC), Diseases [C] - Nervous System Diseases [C10]
 
 
SBSBC, NCT03971019: Survival Benefits of Statins in Breast Cancer Patients

Recruiting
3
314
RoW
statins, Simvastatin Shu Jiangzhi is manufactured by Merchant Company20mg*14 tablets Dose group: 20 mg once a day before bed, Atorvastatin Lipitor, commonly known as Atorvastatin Calcium Tablets, 20mg*7 tablets Dose group: 10 mg once a day before bed, Atorvastatin Ale Beijing Jialin Pharmaceutical Co., Ltd. Alatorvastatin Calcium Tablets Specification and packing: 10mg*7 tablets Dose group: 10 mg once a day before bed, Dietary intervention group (control group), Dietary and motor regulation
Peking Union Medical College Hospital
Breast Cancer Female
05/24
06/24
MS-STAT2, NCT03387670 / 2017-003328-56: Multiple Sclerosis-Simvastatin Trial 2

Completed
3
964
Europe
Simvastatin, Placebo
University College, London, University of Edinburgh, Queen Mary University of London, London School of Hygiene and Tropical Medicine, University of Leeds, The Leeds Teaching Hospitals NHS Trust, Imperial College Healthcare NHS Trust
Secondary Progressive Multiple Sclerosis (SPMS)
07/24
08/24
SACRED, NCT03654053: Multi-Center Study of the Effects of Simvastatin on Hepatic Decompensation and Death in Subjects Presenting With High-Risk Compensated Cirrhosis

Active, not recruiting
3
142
US
Placebo Oral Tablet, Placebo, Simvastatin 40mg, Simvastatin
VA Office of Research and Development
Cirrhosis
12/25
12/25
NCT03131726: Treatment of Graves´ophthalmopathy with Simvastatin (GO-S)

Recruiting
3
80
Europe
Simvastatin 40mg, ATC-code: C10AA01
Lund University, Region Skane
Graves Ophthalmopathy, Thyroid Associated Ophthalmopathy, Thyroid Associated Orbitopathy
01/27
03/28
REMAP-CAP, NCT02735707 / 2015-002340-14: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

Recruiting
3
20000
Europe, Canada, Japan, US, RoW
Ceftriaxone, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam, Ceftaroline, Amoxicillin-clavulanate, Standard course macrolide, Extended course macrolide, No systemic corticosteroid, Fixed-duration Hydrocortisone, Shock-dependent hydrocortisone, Fixed-duration higher dose Hydrocortisone, No antiviral agent for influenza, Five-days oseltamivir, Ten-days oseltamivir, No antiviral agent for COVID-19, Lopinavir / Ritonavir, Hydroxychloroquine, Hydroxychloroquine + lopinavir/ritonavir, Ivermectin, No immune modulation for COVID-19, Interferon beta-1a, IFN-β1a, Anakinra, Tocilizumab, Sarilumab, Local standard venous thromboprophylaxis, Therapeutic dose anticoagulation, Conventional low dose thromboprophylaxis, Intermediate dose thromboprophylaxis, Continuation of therapeutic dose anticoagulation, No immunoglobulin, Convalescent plasma, Delayed administration of convalescent plasma, No vitamin C, Vitamin C, No antiplatelet, Aspirin, acetylsalicylic acid, P2Y12 inhibitor, Clopidogrel, Prasugrel, Ticagrelor, No simvastatin, Simvastatin, Eritoran, Apremilast, Clinician-preferred mechanical ventilation strategy, Protocolised mechanical ventilation strategy, No renin-angiotensin system inhibitor, Angiotensin converting enzyme inhibitor, Ramipril, Lisinopril, Perindopril, Enalapril, Trandolapril, Captopril, Angiotensin Receptor Blockers, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, ARB + DMX-200, No cysteamine, Cysteamine, Fixed-duration dexamethasone, Baloxavir Marboxil, Five-days oseltamivir + baloxavir marboxil, Ten-days oseltamivir + baloxavir marboxil, No endothelial modulator, Imatinib, No Immune Modulator for Influenza, Baricitinib, Nirmatrelvir/ritonavir, Paxlovid, Remdesivir, Nirmatrelvir/ritonavir + remdesivir
UMC Utrecht, Australian and New Zealand Intensive Care Research Centre, Medical Research Institute of New Zealand, Unity Health, Berry Consultants, Global Coalition for Adaptive Research, University of Pittsburgh Medical Center, Intensive Care National Audit & Research Centre, St. Marianna University School of Medicine, Nat Intensive Care Surveillance - MORU, National University Hospital, Singapore
Community-acquired Pneumonia, Influenza, COVID-19
02/26
02/28
PiSCATIN, NCT04133792: Effect of Simvastatin on the Prognosis of Primary Primary Sclerosing Cholangitis (PSC)

Recruiting
3
700
Europe
Simvastatin 40mg, Placebo oral tablet
Annika Bergquist
Primary Sclerosing Cholangitis
05/27
05/27
NCT04705909: Efficacy of Statin Addition to Neoadjuvant Chemotherapy Protocols for Breast Cancer

Not yet recruiting
2/3
60
RoW
Pitavastatin, HMG CoA reductase inhibitor " Lipovastatin", placebo
Mansoura University
Breast Cancer
09/21
12/21
SIMFIB, NCT04971577: Efficacy of Simvastatin in Alcoholic Liver Fibrosis

Recruiting
2/3
90
Europe
Simvastatin 40mg
Anna Cruceta
Liver Fibrosis, Alcohol Abuse
03/24
01/25

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