| simvastatin / Generic mfg. |
ACTRN12614000133639: The STRICT pilot study - Simvastatin Therapy for Reducing Inflammation in Colorectal cancer Trial |
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| Not yet recruiting | 2 | 10 | | | University of Sydney, Northern Translational Cancer Research Unit Seed
Funding, Bosch Institute (University of Sydney) Translational Grant in Aid | Colorectal cancer, Systemic Inflammation | | | | |
ACTRN12615000357550: The effect of micro encapsulated highly bioavailable Simvastatin on plasma lipid profile and oxidative status in patients with high plasma cholesterol level
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| Recruiting | 2 | 120 | | | Lycotec Ltd, Cambridge, UK, Lycotec Ltd | atherosclerosis, hyperlipidemia, hypercholesterolemia, cardiovascular disease, atherosclerosis, coronary heart disease | | | | |
ACTRN12617001087347: A clinical trial comparing Simvastatin to placebo, in addition to standard chemotherapy and radiotherapy, in preoperative treatment for patients with rectal cancer. |
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| Recruiting | 2 | 222 | | | The Australasian Gastro-Intestinal Trials Group (AGITG), Cancer Council NSW, Cancer Australia | Rectal Cancer | | | | |
| Ongoing | 2 | 20 | Europe | Intravenous infusion, Tablet, Velbe, Zocord | Karolinska Institutet | Langerhans cell histiocytosis | | | | |
ChiCTR-TRC-12002971: A clinical study for the effecacy and safety of Cangpu decoction in the treatment of atherosclerosis |
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| Completed | 2 | 240 | | cangpu decoction ;simvastatin capsules | Tongji University; Tongji University, The government | Atherosclerosis | | | | |
ChiCTR-ONRC-12002929: Safety and efficacy study of umbilical cord mesenchymal stem cells transplantation for the treatment of cerebral infarction |
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| Completed | 2 | 200 | | Infusion of umbilical cord mesenchymal stem cells ;Using conventional drug therapy, including the application of cerebral protection agent (such as cell two choline and intravenous infusion of 10 d/course), improve microcirculation (Salvia miltiorrhiza injection and intravenous infusion of 10 d/course), antiplatelet drugs (aspirin 100 mg/d ), statins (simvastatin for 40 mg\d ). ;Infusion of umbilical cord mesenchymal stem cells | The 105th Hospital of PLA; Level of the institution：, Discipline supporting program funding from the 105th Hospital of PLA | cerebral infarction | | | | |
2006-004396-35: Investigation of the anti-inflammatory effects of simvastatin in a model of acute lung injury after inhalation of lipopolysaccharide by healthy volunteers |
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| Ongoing | 2 | 30 | Europe | simvastatin 40mg, simvastatin 40mg, simvastatin 40mg | Belfast City Hospital Trust | Acute lung injury (ALI) | | | | |
2007-002454-37: Prevention by HMGCoA reductase inhibition of ALI associated with one lung ventilation following oesophagectomy by a Reduction of Pulmonary vascular dysfunction and inflammation (Prevention-HARP) |
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| Ongoing | 2 | 40 | Europe | simvastatin 40mg, simvastatin 40mg, simvastatin 40mg | The Royal Group Hospitals Trust | Acute lung injury (ALI) | | | | |
2009-011736-35: Etude pilote de phase II, N=1 en crossover répétés, en double aveugle, randomiséeversus placebo, multicentrique, évaluant l’efficacité de la SIMVAstatine sur lesDYSkinésies induites par la L-Dopa chez des patients atteints de maladie de Parkinson |
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| Ongoing | 2 | 10 | Europe | simvastatine, LODALÈS®, LODALÈS® | CHU de Bordeaux | Maladie de Parkinson | | | | |
2010-022255-37: Etude de l’efficacité et de la tolérance, de l’injection intra prostatique de toxine botulique A, chez l’homme, dans le traitement de l’hyperplasie bénigne de prostate symptomatique. |
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| Ongoing | 2 | 226 | Europe | BOTOX 200 Unités ALLERGAN, poudre pour solution injectable, PERMIXON, TADENAN, CHIBRO-PROSCAR, AVODART, MECIR, XATRAL, ZOXAN, BOTOX 200 Unités ALLERGAN, poudre pour solution injectable, PERMIXON, TADENAN, CHIBRO-PROSCAR, AVODART, MECIR, XATRAL, ZOXAN | CHU de Bordeaux | HBP symptomatique modérée à sévère selon le score IPSS | | | | |
2011-001564-21: Towards Onset Prevention of COGnitive decline in adults with Down syndrome (the TOP-COG study) |
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| Ongoing | 2 | 70 | Europe | Simvastatin, | NHS Greater Glasgow and Clyde, University of Glasgow | Alzheimer\'s diseaseDown syndrome | | | | |
2012-005742-38: Early phase triple blind placebo controlled RCT of simvastatin treatment for autism in young children with Neurofibromatosis Type 1 |
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| Ongoing | 2 | 30 | Europe | Simvastatin, Simvastatin 20mg/5ml Oral Suspension, Simvastatin 20mg/5ml Oral Suspension | Central Manchester University Hospitals NHS Foundation Trust, Central Manchester University Hospitals NHS Foundation Trust | Neurofibromatosis Type 1 | | | | |
2015-004334-99: Treatment of Graves´ ophthalmopathy with diclofenak or simvastatin Behandling av Graves oftalmopati med diklofenak eller simvastatin |
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| Ongoing | 2 | 102 | Europe | Diclofenac T Ratiopharm, Simvastatin Teva, Tablet, Diclofenac T Ratiopharm, Simvastatin Teva | Department of Endocrinology, Department of Endocrinology | Graves´ophthalmopathy Graves oftalmopati, Graves´ophthalmopathy Graves oftalmopati, Diseases [C] - Hormonal diseases [C19] | | | | |
2015-004424-65: Prevention of heart and lung complications by using simvastatin in patients undergoing surgery for removal of food pipe |
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| Ongoing | 2 | 452 | Europe | Simvastatin, Tablet | Belfast Health and Social Care Trust, Public Health Agency | Post-operative complications - Post-operative Pulmonary complication, Acute Respiratory Distress Syndrome and Myocardial Infarction, Post surgical complications - Complications of lungs, severe lung injury (ARDS) and heart attack, Diseases [C] - Respiratory Tract Diseases [C08] | | | | |
NCT02096588: Detection and Prevention of Anthracycline-Related Cardiac Toxicity With Concurrent Simvastatin |
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| Terminated | 2 | 34 | US | Simvastatin, Zocor, Doxorubicin/cyclophosphamide, Adriamycin/Cytoxan | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Avon Foundation | Breast Cancer, Stage I Breast Cancer, Stage II Breast Cancer, Stage III Breast Cancer | 04/17 | 07/23 | | |
2017-001581-20: PREVENTION OF ISCHEMIA/REPERFUSION INJURIES IN LIVER TRANSPLANTATION RECIPIENTS BY ORAL ADMINISTRATION OF SIMVASTATIN INTO THE DECEASED BRAIN DONORS DURING THE HARVESTING PROCEDURES. PREVENZIONE DEL DANNO DA ISCHEMIA/RIPERFUSIONE AL PAZIENTE SOTTOPOSTO AL TRAPIANTO DI FEGATO MEDIANTE SOMMINISTRAZIONE DI SIMVASTATINA AL DONATORE CADAVERE NEL CORSO DELLE FASI DI PRELIEVO CHIRURGICO. |
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| Not yet recruiting | 2 | 106 | Europe | SIMVASTATINA 40 mg capsule, SIMVA, Capsule, hard, SIMVASTATINA SANDOZ - 40 MG COMPRESSE RIVESTITE CON FILM 28 COMPRESSE IN BLISTER PVC/AL | ISTITUTO MEDITERRANEO PER I TRAPIANTI E TERAPIE AD ALTA SPECIALIZZAZIONE - ISMETT, MINISTERO DELLA SALUTE, RICERCA FINALIZZATA | ISCHEMIC REPERFUSION INJURY AFTER LIVER TRANSPLANTATION: HEPATIC ISCHEMIA AND REPERFUSION INJURY REPRESENTS THEMAIN UNDERLYING MECHANISM FOR GRAFT DYSFUNCTION, AND FAILURE, POST-TRANSPLANTATION. HYPOXIA AND REPERFUSIONACTIVATE INNATE MECHANISMS OF INFLAMMATION THAT CAUSES INJURY AND UNDERLINE DELAYED GRAFT FUNCTION. IT CAUSESALMOST 10% OF EARLY ORGAN FAILURE, AND CAN LEAD TO THE HIGHER INCIDENCE OF BOTH ACUTE AND CHRONIC REJECTION. DANNO DA ISCHEMIA RIPERFUSIONE DOPO TRAPIANTO DI FEGATO: LA SUA ESPRESSIONE CLINICA PU¿ ESSERE RAPPRESENTATADAL MANCATO FUNZIONAMENTO DELL¿ORGANO TRAPIANTATO, CHE PU¿ VERIFICARSI CON PICCHI DEL 10% DEI CASI. UNASINGOLA SOMMINISTRAZIONE DI SIMVASTATINA AL DONATORE CADAVERICO POTREBBE ESSERE PI¿ EFFICACE NEL MIGLIORARE ILMETABOLISMO DELL¿ORGANO TRAPIANTATO RISPETTO ALLA SOLA RIDUZIONE FISICA DI TEMPERATURA OTTENUTA CON LACONSERVAZIONE A FREDDO, HEPATIC ISCHEMIA & REPERFUSION INJURY AFFECTS HEPATIC CELLS THAT BECOME PROINFLAMMATORY INDUCING LIVER NECROSIS, INTRAHEPATIC CELLULAR INTERACTIONS & REPERFUSION INJURY CONTRIBUTE TO LIVER DYSFUNCTION I PRIMI 6 MESI DOPO IL TRAPIANTO DI FEGATO ¿CONSIDERATO IL PERIODO PI¿ VULNERABILE A CAUSA DI POTENZIALI ESITI DEL DANNO DA ISCHEMIA/RIPERFUSIONE (ES: LAMANCATA RIPRESA FUNZIONALE DOPO L¿INTERVENTO), Diseases [C] - Digestive System Diseases [C06] | | | | |
2012-002877-71: cGMP Enhancing Therapeutic Strategy for HFpEF: The cGETS Study An interventional, single blind, multicentre study. cGMP verhogende strategieën bij HFpEF: De cGETS Studie. Een interventionele, enkelblinde, multicentre studie. |
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| Ongoing | 2 | 25 | Europe | Tritace, Tablet, Film-coated tablet, Capsule, Januvia, Cialis, Lipitor, Zestril, Crestor, Zocor, Coversyl, Tritace, Atacand, Nebilet | European Commission FP7 Health 2010, European Commission FP7 Health 2010 | HFpEF patients over 18 years old and concomitant arterial hypertension, overweight or obesity and pulmonary hypertension. Patiënten met HFpEF die ouder zijn dan 18 jaar en tevens lijden aan arteriële hypertensie, overgewicht of obesitas en pulmonale hypertensie., Heart Failure with preserved Ejection Fraction in combination with a high blood pressure, high pulmonary blood pressure and overweight or obesity. Hartfalen met een bewaarde ejectiefractie met daarnaast een hoge bloeddruk, hoge longbloeddruk en overgewicht of zwaarlijvigheid., Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2018-002947-27: Simvastatin add-on to Escitalopram in patients with obesity and depression Simvastatin als Zusatztherapie zur antidepressiven Medikation mit Escitalopram bei Patienten mit Depression und Adipositas |
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| Not yet recruiting | 2 | 160 | Europe | SimvaHEXAL®, ESCITALOPRAM, Capsule, hard, Film-coated tablet, SimvaHEXAL® | Charité – Universitätsmedizin Berlin, Charité – Universitätsmedizin Berlin | Patients with comorbid obesity (body mass index ≥ 30) and major depression Patienten mit komorbider Adipositas (body mass index ≥ 30) und Major Depression, Patients with obesity and depression Patienten mit starkem Übergewicht und Depression, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2019-003127-38: Research on the effect of add-on high dosage simvastatin treatment on progression in MS patients treated with ocrelizumab and natalizumab. Onderzoek naar het effect van het toevoegen van hoge dosis simvastatine op progressie van MS patiënten die behandeld worden met ocrelizumab en natalizumab. |
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| Not yet recruiting | 2 | 100 | Europe | Simvastatin, Tablet | VUmc Neurology Department, Stichting MS Research | Multiple sclerosis Multiple sclerose, Multiple sclerosis Multiple sclerose, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT03454529: The Effect of Simvastatin on Breast Cancer Cell Growth in Women With Stage I-II Breast Cancer |
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| Completed | 2 | 24 | US | Laboratory Biomarker Analysis, Simvastatin, MK 733, Synvinolin, Zocor | Michael Simon, National Cancer Institute (NCI) | Invasive Breast Carcinoma, Stage I Breast Cancer AJCC v7, Stage IA Breast Cancer AJCC v7, Stage IB Breast Cancer AJCC v7, Stage II Breast Cancer AJCC v6 and v7, Stage IIA Breast Cancer AJCC v6 and v7, Stage IIB Breast Cancer AJCC v6 and v7 | 10/21 | 10/21 | | |
2020-006023-33: Efficacy of simvastatin for the reduction of alcohol-induced liver fibrosis. Efficacy of simvastatin for the reduction of alcohol-induced liver fibrosis. |
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| Not yet recruiting | 2 | 90 | Europe | Simvastatin, Coated tablet | Institut d’Investigacions Biomèdiques August Pi i Sunyer, Instituto Carlos III-Beca FIS | reduction of liver fibrosis in patients with advanced fibrosis due to alcohol reducción de la fibrosis hepática en pacientes con fibrosis avanzada por alcohol, reduction of liver fibrosis in patients with advanced fibrosis due to alcohol reducción de la fibrosis hepática en pacientes con fibrosis avanzada por alcohol, Body processes [G] - Digestive System and Oral Physiological Phenomena [G10] | | | | |
NCT04698941: Combined Simvastatin and Albumin Paclitaxel in Treating ES-SCLC Patients Relapsed From 1st Chemotherapy |
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| Recruiting | 2 | 40 | RoW | Albumin Paclitaxel, Simvastatin, Simvastatin Tablets | Shanghai Pulmonary Hospital, Shanghai, China, Chinese Academy of Sciences | Small Cell Lung Cancer | 12/21 | 12/22 | | |
NCT01441349: Irinotecan/Cisplatin With or Without Simvastatin in Chemo-naive Patients With Extensive Disease-small Cell Lung Cancer |
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| Active, not recruiting | 2 | 192 | RoW | IP chemotherapy, IP, IP chemotherapy plus simvastatin, IPSimva | National Cancer Center, Korea | Small Cell Lung Carcinoma | 10/22 | 12/22 | | |
NCT04985201: Combined Simvastatin and Irinotecan in Treating ES-SCLC Patients Relapsed From 1st Chemotherapy |
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| Not yet recruiting | 2 | 40 | RoW | Irinotecan, Irinotecan injection, Simvastatin, Simvastatin 40mg | Shanghai Pulmonary Hospital, Shanghai, China, Chinese Academy of Sciences | Small Cell Lung Cancer | 12/22 | 08/23 | | |
2022-004154-63: Study of Valproic acid combinEd with Simvastatin and gemcitabine/nab-paclitaxel-based regimens in untreated metastatic Pancreatic Adenocarcinoma patients (The VESPA trial) Estudio del ácido valproico combinado con simvastatina y regímenes basados en gemcitabina/nab-paclitaxel en pacientes con adenocarcinoma pancreático metastásico no tratados (ensayo VESPA). |
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| Not yet recruiting | 2 | 240 | Europe | DEPAKIN CHRONO 300 mg, DEPAKIN CHRONO 500 mg, Simvastatina, [Acido valproico], [Simvastatina], Prolonged-release tablet, Film-coated tablet, DEPAKIN - CHRONO 300 MG COMPRESSE A RILASCIO PROLUNGATO BLISTER DA 30 COMPRESSE, DEPAKIN - CHRONO 500 MG COMPRESSE A RILASCIO PROLUNGATO BLISTER DA 30 COMPRESSE | ISTITUTO NAZIONALE TUMORI - IRCCS FONDAZIONE PASCALE, Ministero della Salute (progetto RF-2021-12371995), Remedi4All EU project (Project number: 101057442; HORIZON-HLTH-2021-DISEASE-04-02) | Metastatic Pancreatic Adenocarcinoma Adenocarcinoma pancreático metastásico, Metastatic pancreatic tumour Tumor pancreático metastásico, Diseases [C] - Cancer [C04] | | | | |
| Active, not recruiting | 2 | 76 | US | Placebo Oral Capsule, Simvastatin, Zocor | Craig Hospital | Spinal Cord Injuries, Osteoporosis | 09/23 | 09/23 | | |
NCT02968810: Simvastatin in Preventing Liver Cancer in Patients With Liver Cirrhosis |
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| Active, not recruiting | 2 | 59 | US | Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Placebo Administration, Questionnaire Administration, Simvastatin, MK 733, Synvinolin, Zocor | National Cancer Institute (NCI) | Cirrhosis, Hepatocellular Carcinoma | 05/23 | 12/24 | | |
NCT03400826: Effects of Simvastatin on Uterine Leiomyoma Size |
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| Recruiting | 2 | 60 | US | Simvastatin 40mg, Simvastatin, Placebo 40 mg, Starch 1500 encapsulated | Johns Hopkins University, National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Fibroid Uterus, Fibroid Tumor, Leiomyoma, Fibromyoma, Leiomyoma, Uterine | 07/25 | 07/25 | | |
NCT05550415: The Role of Simvastatin in The Epithelial-Mesenchymal Transition Process of Breast Cancer |
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| Recruiting | 2 | 26 | RoW | Simvastatin 40mg, Simvastatin, Placebo, Placebo oral capsule 40 mg | Indonesia University | Triple Negative Breast Cancer, Chemotherapy Effect, Simvastatin Adverse Reaction | 08/24 | 02/25 | | |
NCT05586360: T-reg Function Changes: a Novel Immune Regulatory Effect Underlying Benefit of Statin Use on Lethal Prostate Cancer |
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| Recruiting | 2 | 36 | US | Simvastatin 40mg | Medical University of South Carolina | Prostate Cancer | 02/26 | 08/26 | | |
SIMCODE, NCT04301271: Simvastatin add-on Treatment to Standard Antidepressant Therapy in Patients With Comorbid Obesity and Major Depression |
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| Active, not recruiting | 2 | 161 | Europe | Simvastatin 40mg, Zocor, C10AA01, Placebo oral tablet | Charite University, Berlin, Germany, NeuroCure Clinical Research Center, Charite, Berlin, University Medical Center Goettingen | Depressive Disorder, Major, Obesity | 02/25 | 02/25 | | |
| Recruiting | 2 | 240 | Europe | Valproic acid, Simvastatin 20mg, Gemcitabine 1000 mg, Nab paclitaxel, Cisplatin, Capecitabine | National Cancer Institute, Naples, Ministero della Salute (progetto RF-2021-12371995), Remedi4All EU project (Project number: 101057442; HORIZON-HLTH-2021-DISEASE-04-02) | Adenocarcinoma of the Pancreas | 08/25 | 06/26 | | |
| Active, not recruiting | 2 | 5 | US | Simvastatin 80mg, Zocor | Baylor Breast Care Center | Breast Cancer Stage IV | 12/28 | 12/30 | | |
NCT03599609: Central Nervous System Vascular Changes in Adult Sickle Cell Disease and the Effect of Treatment With Simvastatin |
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| Active, not recruiting | 1/2 | 28 | RoW | Simvastatin 40mg | University of Campinas, Brazil | Sickle Cell Disease, Stroke | 01/20 | 07/21 | | |
NCT06016218: Effect of Local Application of Simvastatin Versus Bone Powder on Implant Bone Changes |
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| Completed | 1/2 | 24 | RoW | Simvastatin | British University In Egypt | Dental Caries Extending to Pulp, Dental Implant Failed | 01/22 | 02/23 | | |
C3, NCT06030622: Phase 2A Pilot Trial of Recurrent/Refractory Metastatic Advanced Pancreatic Cancer |
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| Recruiting | 1/2 | 25 | US | Gemcitabine and C3 (Metformin, Simvastatin, and Digoxin), Glucophage, Zocor, Digitalis, Gemzar, C3 (Metformin, Simvastatin, and Digoxin) only, Glucophage, Zocor, Digitalis | State University of New York - Downstate Medical Center | Pancreatic Cancer Metastatic | 12/24 | 12/24 | | |
