| simvastatin / Generic mfg. |
ChiCTR-TRC-12002138: Statins and White Matter Lesion Progression: A Randomised, Open-Label, Parellel Group Study |
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| Suspended | 1 | 100 | | Simvastatin : 40mg daily Atorvastatin : 40mg daily / 60 mg daily / 80 mg daily vs Simvastatin 10 mg for two years | NA; Chinese University of Hong Kong, CUHK Neurology Research Fund | Ischemic stroke | | | | |
| Completed | 1 | 40 | | oral ingestion of a single dose of simvastatin tablets ;oral ingestion of a single dose of simvastatin tablets | The Second Affiliated Hospital, School of Medicine, Zhejiang University; The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Xinchang Pharma Company | not disease-related | | | | |
ChiCTR-TTRCC-12002290: Investigations on relations between SNPs in statin-related transporters and metabolizing enzymes and pharmacokinetics of fluvastatin, simvastatin, rosuvastatin and pitavastatin |
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| Completed | 1 | 64 | | Retrospective analysis of pharmacokinetics data and collect 5ml blood for genotying ;Retrospective analysis of pharmacokinetics data and collect 5ml blood for genotying ;Retrospective analysis of pharmacokinetics data and collect 5ml blood for genotying ;Retrospective analysis of pharmacokinetics data and collect 5ml blood for genotying | The 2nd Affiliated Hospital, School of Medicine, Zhejiang University; The Second Affiliated Hospital， School of Medicine，Zhejiang University, Division of Clinical Pharmacology, The 2nd Affiliated Hospital, School of Medicine, Zhejiang University | not disease-related | | | | |
| Completed | 1 | 100 | | Simvastatin 40 mg qd; EECP treatment, one course (35-36 h) ;Simvastatin 40 mg qd | The First Affiliated Hospital of Sun Yat- sen University; Committee of The National Natural Scientific Fundation of China, National Natural Scientific Fundation of China | Atherosclerosis | | | | |
ChiCTR-ONC-13003007: Interactions of herbs with statin drugs and potential mediation by drug transporters |
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| Not yet recruiting | 1 | 36 | | Simvastatin 20mg/ Rosuvastatin 10mg for 3 days and Green Tea Extract 400mg for 15 days | Chinese University of Hong Kong; Level of the institution：, Chinese University of Hong Kong | Healthy Volunteers | | | | |
NCT02197234: Study to Assess the Effect of AZD9291 on the Blood Levels of Simvastatin in Patients With EGFRm+ NSCLC |
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| Completed | 1 | 52 | Europe, US, RoW | Pharmacokinetic sampling - AZD9291, Simvastatin, AZD9291 tablet dosing, Pharmacokinetic sampling - simvastatin, Pharmacokinetic sampling - AZ5140 and AZ7550 | AstraZeneca | Non Small Cell Lung Cancer | 04/15 | 06/24 | | |
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| Recruiting | 1 | 24 | | Phase 1: simvastatin tablets 20 mg (Europharm Lab Co Ltd., Hong Kong); Phase 2: simvastatin tablets 20 mg (Merck Sharp & Dohme Limited) ;Phase 1: simvastatin tablets 20 mg (Merck Sharp & Dohme Limited); Phase 2: simvastatin tablets 20 mg (Europharm Lab Co Ltd., Hong Kong) | Institute of Clinical Pharmacy, Central South University; Europharm Lab Co Ltd., Hong Kong, Europharm Lab Co Ltd., Hong Kong | Pharmacokinetics and Bioequivalence Study in Human | | | | |
NCT06207682: Effect of Repeated Oral Doses of Avacopan on the Pharmacokinetics (PK) of a Single Dose of Simvastatin |
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| Completed | 1 | 32 | US | Avacopan, CCX168, Simvastatin | Amgen | Healthy Volunteers | 08/22 | 08/22 | | |
NCT04824898: The Use of Injectable Plasma Versus the Use of Simvastatin Gel in Surgical Management of Bony Defect in Dentistry |
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| Active, not recruiting | 1 | 24 | RoW | Simvastatin, injectable plasma rich fibrin, i-prf | Ain Shams University | Intra-bony Pockets | 09/22 | 09/22 | | |
| Withdrawn | 1 | 24 | NA | Simvastatin, ZOCOR | Washington University School of Medicine, Duke University | Olfactory Disorder, COVID-19 | 05/23 | 05/23 | | |
NCT04514029: Neurotoxicity Prophylaxis With Intrathecal Dexamethasone and Simvastatin Post Axi-Cel |
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| Active, not recruiting | 1 | 37 | US | Simvastatin, Dexamethasone | Masonic Cancer Center, University of Minnesota | Lymphoma | 11/23 | 12/25 | | |
NCT04457089: Statin Therapy to Reduce Progression in Women With Platinum Sensitive Ovarian Cancer |
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| Recruiting | 1 | 20 | US | Simvastatin 40mg, Zocor | Bobbie Jo Rimel, MD | Recurrent Ovarian Cancer, Platinum-sensitive Ovarian Cancer | 01/25 | 01/26 | | |
NCT05878158: Simvastatin Versus MTA in Pulpotomy of Immature Permanent Molars |
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| Recruiting | 1 | 128 | RoW | Simvastatin, Mineral Trioxide Aggregate | Ahmad Elheeny | Pulp Exposure, Dental | 01/24 | 09/24 | | |
NCT06186622: A Drug-Drug Interaction Study of Orforglipron (LY3502970) in Healthy Overweight and Obese Participants |
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| Completed | 1 | 50 | US | Orforglipron, LY3502970, Simvastatin, Digoxin, Rosuvastatin, Acetaminophen, Midazolam, Sodium Bicarbonate | Eli Lilly and Company | Healthy, Obese, Overweight | 07/24 | 07/24 | | |
| Not yet recruiting | 1 | 12 | US | 5% simvastatin ointment | Joyce Teng, Stanford University | Hemangioma Skin | 07/25 | 12/25 | | |
NCT06379958: Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects |
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| Recruiting | 1 | 48 | Europe | leramistat 40mg, Itraconazole 200 mg, Phenytoin 100 Mg Oral Capsule, Simvastatin 40mg, Upadacitinib 15 MG | Modern Biosciences Ltd | Pharmacokinetics | 09/24 | 09/24 | | |
NCT06178640: Bioequivalence Study of Simvastatin 40 mg Film-coated Tablets in Healthy Thai Volunteers |
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| Not yet recruiting | 1 | 46 | NA | Simvastatin 40 mg film-coated tablet, Simvastatin, Zocor 40 mg film-coated tablet | International Bio service | Healthy Volunteer | 08/24 | 08/24 | | |
NCT03889795: Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors |
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| Recruiting | 1 | 15 | US | Metformin, Glucophage, Simvastatin, Zocor, Digoxin, Digitalis | Danae Hamouda, MD | Advanced Pancreatic Cancer, Advanced Solid Tumor | 12/25 | 12/26 | | |
NCT05464810: Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast Cancer |
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| Recruiting | 1 | 40 | US | Letrozole, CGS 20267, Femara, Simvastatin, MK 733, Synvinolin, Zocor | Emory University, National Cancer Institute (NCI) | Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, HER2-Negative Breast Carcinoma, Hormone Receptor-Positive Breast Carcinoma, Invasive Breast Carcinoma | 04/25 | 04/25 | | |
SMV in CP, NCT05771675: Simvastatin Treatment to Improve Patient-reported Outcomes in Patients With Chronic Pancreatitis |
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| Not yet recruiting | 1 | 90 | US | Simvastatin, Placebo | Cedars-Sinai Medical Center, United States Department of Defense | Recurrent Acute Pancreatitis, Chronic Pancreatitis | 12/25 | 06/26 | | |
