- |||||||||| Puyouheng (pucotenlimab) / Taizhou Hanzhong Biopharma, Lepu Med, Inlyta (axitinib) / Pfizer
Axitinib in Combination With anti (1st Floor, 1D Meeting Room) - Oct 2, 2024 - Abstract #CSCO2024CSCO_594; Study group: [CSCO Malignant Melanoma Expert Committee]
- |||||||||| lerapolturev (PVS-RIPO) / Istari Oncology
Trial completion, Trial completion date, Trial primary completion date, Checkpoint inhibition, IO biomarker: LUMINOS-101: Lerapolturev (PVSRIPO) and Pembrolizumab in Patients with Recurrent Glioblastoma (clinicaltrials.gov) - Oct 1, 2024 P2, N=25, Completed, Trial completion date: Aug 2023 --> Dec 2024 | Recruiting --> Suspended | Trial primary completion date: Aug 2023 --> Dec 2024 Active, not recruiting --> Completed | Trial completion date: Mar 2024 --> Jun 2024 | Trial primary completion date: Mar 2024 --> Jun 2024
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date, Combination therapy, Checkpoint inhibition, Metastases: Quad Shot Radiotherapy in Combination With Immune Checkpoint Inhibition (clinicaltrials.gov) - Oct 1, 2024 P2, N=21, Active, not recruiting, Active, not recruiting --> Completed | Trial completion date: Mar 2024 --> Jun 2024 | Trial primary completion date: Mar 2024 --> Jun 2024 Suspended --> Active, not recruiting | N=15 --> 21 | Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2024 --> Oct 2023
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
Trial completion date, Trial primary completion date, Metastases: Docetaxel/Pembrolizumab in Head and Neck Squamous Cell Carcinoma (clinicaltrials.gov) - Oct 1, 2024 P2, N=27, Recruiting, Suspended --> Active, not recruiting | N=15 --> 21 | Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2024 --> Oct 2023 Trial completion date: May 2024 --> Nov 2025 | Trial primary completion date: Jan 2024 --> Nov 2024
- |||||||||| Ibrance (palbociclib) / Pfizer
Journal: A genome-wide CRISPR/Cas9 knockout screen identifies SEMA3F gene for resistance (Pubmed Central) - Oct 1, 2024 Our observation provided the first evidence of SEMA3F as a regulator of sensitivity to CDK4/6 inhibitors in breast cancer. The detailed mechanisms of resistance deserve further functional studies to develop the better strategy to overcome resistance in CDK4/6 inhibitors.
- |||||||||| Kimmtrak (tebentafusp-tebn) / Immunocore, Opdivo (nivolumab) / BMS, Yervoy (ipilimumab) / BMS
Retrospective data, Journal, PD(L)-1 Biomarker, IO biomarker, Metastases: Immunotherapy response and resistance in patients with advanced uveal melanoma: a retrospective cohort study. (Pubmed Central) - Oct 1, 2024 ImPERCIST5 and RECIST v1.1 are valuable tools in the radiological response assessment, but both methods display limitations. Accurate biomarkers to stratify patients at risk for disease progression and future translational studies to investigate mechanisms of response and resistance are required.
- |||||||||| Rituxan (rituximab) / Roche
Journal, Real-world evidence, Real-world: Outcome of patients with diffuse large B-cell lymphoma and testicular involvement - real world data. (Pubmed Central) - Oct 1, 2024 Majority (84.3%) received CNS prophylaxis with similar rates of prophylactic methotrexate (intravenous 19.1% vs. 16.6%, intrathecal 40.8% vs. 40.4%, or both 24.2% vs. 27.8%) between PTL and T-DLBCL (p?=?0.89)...Methotrexate prophylaxis did not alter CNS relapse risk. Prognosis of CNS relapse is particularly poor in T-DLBCL.
- |||||||||| Leukeran (chlorambucil) / GSK, Rituxan (rituximab) / Roche
Journal, Real-world evidence, Real-world: Real-world data for marginal zone lymphoma patients in the French REALYSA cohort: The REALMA study. (Pubmed Central) - Oct 1, 2024 At end of first line, overall response rate was 93% among treated patients with 75% of complete response. This French nationwide study provided for the first time prospective RWD on clinical characteristics, initial management and treatment response of MZL patients.
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