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  • ||||||||||  Rituxan (rituximab) / Roche
    Journal, IO biomarker:  Autoimmune Neurobeachin Cerebellar Ataxia. (Pubmed Central) -  Aug 21, 2024   
    Trial completion date: Aug 2025 --> Aug 2026 | Trial primary completion date: Aug 2024 --> Aug 2025 Neurobeachin-IgG is a new neural antibody biomarker of cerebellar ataxia among a growing antibody repertoire, collectively common but often individually rare.
  • ||||||||||  Tyvyt (sintilimab) / Eli Lilly
    Trial completion date, Trial termination, Trial primary completion date, Metastases:  Sintilimab for the Treatment of Locally Advanced, Metastatic, Recurrent, or Unresectable Undifferentiated Pleomorphic Sarcoma, SiARa Cancer Study (clinicaltrials.gov) -  Aug 21, 2024   
    P2,  N=6, Terminated, 
    Neurobeachin-IgG is a new neural antibody biomarker of cerebellar ataxia among a growing antibody repertoire, collectively common but often individually rare. Trial completion date: Jul 2026 --> Feb 2024 | Active, not recruiting --> Terminated | Trial primary completion date: Jul 2026 --> Feb 2024; All subjects have finished their final visits and follow-up,
  • ||||||||||  Aliqopa (copanlisib) / Bayer, Rituxan (rituximab) / Roche
    Trial completion date, Trial primary completion date, Combination therapy:  FIL_Copa-RB: Copanlisib With Rituximab-Bendamustine in Patients With Relapsed-Refractory Diffuse Large B-cell Lymphoma (clinicaltrials.gov) -  Aug 21, 2024   
    P2,  N=37, Active, not recruiting, 
    Trial completion date: Jul 2026 --> Feb 2024 | Active, not recruiting --> Terminated | Trial primary completion date: Jul 2026 --> Feb 2024; All subjects have finished their final visits and follow-up, Trial completion date: Aug 2024 --> Dec 2024 | Trial primary completion date: Aug 2024 --> Dec 2024
  • ||||||||||  zalifrelimab (UGN-301) / Agenus, UroGen, balstilimab (AGEN2034) / Agenus
    Trial completion date, Trial primary completion date, Combination therapy, Checkpoint inhibition, Checkpoint block:  rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG (clinicaltrials.gov) -  Aug 21, 2024   
    P1,  N=36, Recruiting, 
    Trial completion date: Sep 2025 --> Apr 2026 | Trial primary completion date: May 2024 --> Apr 2026 Trial completion date: Mar 2025 --> Dec 2025 | Trial primary completion date: Dec 2024 --> Jun 2025
  • ||||||||||  Ocrevus (ocrelizumab) / Roche
    Journal, Real-world evidence, Real-world:  Ocrelizumab in people with primary progressive multiple sclerosis: A real-world multicentric study. (Pubmed Central) -  Aug 20, 2024   
    Our study demonstrates that ctDNA mirrors radiological responses and may serve as an ideal companion for diagnosis and disease monitoring in MCC. Our real-world data support the use of ocrelizumab in a much broader pwPPMS population than in the original randomized controlled trial.
  • ||||||||||  Rituxan (rituximab) / Roche
    Retrospective data, Journal:  Rituximab as Treatment for Lupus Nephritis: Data From the Peruvian ALMENARA Lupus Cohort. (Pubmed Central) -  Aug 20, 2024   
    CR and responder status were reached in less than one third of LN patients treated with RTX, regardless of the criteria used to define them. However, serum creatinine levels did not increase, and there was a decrease in proteinuria levels during the follow-up.
  • ||||||||||  Rituxan (rituximab) / Roche
    Journal:  Sialadenitis in Antineutrophil Cytoplasmic Antibodies Vasculitis. (Pubmed Central) -  Aug 20, 2024   
    Easy accessibility of salivary glands allows early biopsy and timely treatment. In our case with GPA, salivary gland involvement was unresponsive to cyclophosphamide but remitted with rituximab.
  • ||||||||||  M1069 / EMD Serono, Domain Therap
    Preclinical, Journal:  Dual A2A/ A2B adenosine receptor antagonist M1069 counteracts immuno-suppressive mechanisms of adenosine and reduces tumor growth in vivo. (Pubmed Central) -  Aug 20, 2024   
    In vivo, M1069 decreased tumor growth as a monotherapy and enhanced anti-tumor activity of bintrafusp alfa (BA) or cisplatin in syngeneic adenosinehi/CD73hi 4T1 breast tumor model, but not in the CD73 knockout (KO) 4T1 tumor model or in adenosinelow/CD73low MC38 murine colon carcinoma model. In summary, our dual A2A/A2B AR antagonist M1069 may counteract immune-suppressive mechanisms of high concentrations of adenosine in vitro and in vivo and enhance the anti-tumor activity of other agents, including BA and cisplatin.
  • ||||||||||  Keytruda (pembrolizumab) / Merck (MSD)
    Journal:  Pembrolizumab-induced hypertrophic lichenoid dermatitis with involvement of an old tattoo. (Pubmed Central) -  Aug 20, 2024   
    In summary, our dual A2A/A2B AR antagonist M1069 may counteract immune-suppressive mechanisms of high concentrations of adenosine in vitro and in vivo and enhance the anti-tumor activity of other agents, including BA and cisplatin. No abstract available
  • ||||||||||  Rituxan (rituximab) / Roche
    Journal:  Antineutrophil Cytoplasmic Antibody Vasculitis after Coronary Artery Bypass Grafting. (Pubmed Central) -  Aug 20, 2024   
    Renal biopsy ultimately showed focal necrotizing and crescentic glomerulonephritis, and the patient was successfully managed with corticosteroids and outpatient rituximab. This rare case highlights the importance of having an expanded differential for uncommon causes of cardiovascular disease and unexpected outcomes after coronary artery bypass grafting.
  • ||||||||||  Tyvyt (sintilimab) / Eli Lilly, Focus V (anlotinib) / Advenchen, Sino Biopharm
    Journal, PD(L)-1 Biomarker, IO biomarker, Metastases:  Combination of Sintilimab and Anlotinib for Metastatic Osteosarcoma: A Case Report. (Pubmed Central) -  Aug 20, 2024   
    The patient obtained an 11.7-month-sustained remission period, and he also enjoyed a better quality of life. This case demonstrates that sintilimab plus anlotinib may be a feasible treatment regimen for osteosarcoma patients.
  • ||||||||||  Keytruda (pembrolizumab) / Merck (MSD), Imfinzi (durvalumab) / AstraZeneca
    Journal, Tumor mutational burden, PD(L)-1 Biomarker, IO biomarker, Metastases:  Evolving approaches in advanced gallbladder cancer with complete pathological response using chemo?immunotherapy: A case report. (Pubmed Central) -  Aug 20, 2024   
    TOPAZ-1 and KEYNOTE-966 have demonstrated the efficacy of combining immunotherapy (durvalumab and pembrolizumab) with chemotherapy, even in gallbladder cancer (GBC), with a complete response rate of 2.7% in the TOPAZ-1 trial...The patient started chemo-immunotherapy with cisplatin-gemcitabine plus durvalumab in June 2022...Overall, chemo-immunotherapy has been effective in treating metastatic CCA, especially when tailored to specific molecular profiles. These treatments may lead to complete responses and novel strategies.
  • ||||||||||  Adcetris (brentuximab vedotin) / Takeda, Pfizer
    Trial completion date, Trial primary completion date, HEOR, Real-world evidence, Real-world:  A Study in Adults With Cutaneous T-cell Lymphoma (CTCL) Retreated With Brentuximab Vedotin (clinicaltrials.gov) -  Aug 20, 2024   
    P=N/A,  N=50, Recruiting, 
    PembroWM is the first study to evaluate the feasibility of PD-1 axis modulation in WM and has shown that in combination with Rituximab the combination is safe and deliverable. Trial completion date: Jun 2024 --> Sep 2024 | Trial primary completion date: Jun 2024 --> Sep 2024
  • ||||||||||  Orencia (abatacept) / BMS
    Enrollment open:  ABAGART: Abatacept for the Treatment of Giant Cell Arteritis (clinicaltrials.gov) -  Aug 20, 2024   
    P3,  N=78, Recruiting, 
    Trial completion date: Jun 2024 --> Sep 2024 | Trial primary completion date: Jun 2024 --> Sep 2024 Active, not recruiting --> Recruiting
  • ||||||||||  certepetide (LSTA1) / Lisata Therap
    Enrollment change, Trial completion date, Trial withdrawal, Trial primary completion date, Surgery:  Intraperitoneal LSTA1 in CRS-HIPEC (clinicaltrials.gov) -  Aug 20, 2024   
    P1,  N=0, Withdrawn, 
    Active, not recruiting --> Recruiting N=21 --> 0 | Trial completion date: Dec 2029 --> Jun 2024 | Recruiting --> Withdrawn | Trial primary completion date: Dec 2028 --> Jun 2024