Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Intermittent fasting reinforces rhythmic activation of intestinal circadian clock genes and the gut transcriptome during chronodisruption (Tiffany/Shah - Hilton Antwerp Old Town) -  Dec 19, 2023 - Abstract #BWG2024BWG_134;    
    Enteroid model: Mouse enteroids generated from the jejunal mucosa of Bmal1+/+ and Bmal1-/- mice were synchronized for 1h with 100 nM dexamethasone...Conclusions TRF during chronic jetlag can resynchronize the rhythms in jejunal clock genes and the gut transcriptome involved in the control of epithelial metabolic homeostasis. Mouse enteroids show rhythms in intestinal clock genes and can serve as a suitable model to study the role of clock genes in vitro.
  • ||||||||||  Entyvio (vedolizumab) / Takeda
    Limited long-term efficacy of corticosteroids in microscopic colitis emphasizing the need for advanced therapies (Lijn - Hilton Antwerp Old Town) -  Dec 19, 2023 - Abstract #BWG2024BWG_72;    
    More advanced therapies are being used, including anti-TNF agents (n=25), vedolizumab (n=9) and JAK inhibitors (n=8)...However, more than 50% of patients relapsed upon steroid tapering and/or withdrawal, resulting in a substantial need for advanced therapy in this patient population. The long-term efficacy and safety of these advanced IBD therapies in MC should therefore be further investigated.
  • ||||||||||  Darzalex (daratumumab) / J&J, Tecvayli (teclistamab-cqyv) / Genmab, J&J
    Enrollment open, Trial completion date, Trial primary completion date:  MASTER-2: Sequential Therapy in Multiple Myeloma Guided by MRD Assessments (clinicaltrials.gov) -  Dec 19, 2023   
    P2,  N=300, Recruiting, 
    The long-term efficacy and safety of these advanced IBD therapies in MC should therefore be further investigated. Not yet recruiting --> Recruiting
  • ||||||||||  Venclexta (venetoclax) / Roche, AbbVie, Walter and Eliza Hall Institute
    Review, Journal, IO biomarker:  Use of venetoclax in t(11;14) positive relapsed/refractory multiple myeloma: A systematic review. (Pubmed Central) -  Dec 19, 2023   
    When given with drugs like dexamethasone, daratumumab and carfilzomib, a synergistic effect is seen in treating translocation (11:14) positive relapsed/refractory MM. The use of venetoclax in clinical practice can potentially improve outcomes and quality of life in RRMM patients, and future research should continue to explore this promising treatment option.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Trial completion date, Trial primary completion date:  Triamcinolone Acetonide Injections in Primary Cutaneous Lymphoma Plaques With a Novel Needle-free Drug-delivery System. (clinicaltrials.gov) -  Dec 19, 2023   
    P=N/A,  N=22, Not yet recruiting, 
    A limited number of studies demonstrated a potential benefit of other medications such as Dexamethasone or Metformin, but more studies are needed. Trial completion date: Sep 2024 --> Feb 2025 | Trial primary completion date: Jun 2024 --> Dec 2024
  • ||||||||||  dexamethasone / Generic mfg., pomalidomide / Generic mfg.
    Journal:  Efficacy and safety of generic pomalidomide plus low-dose dexamethasone in relapsed or refractory multiple myeloma: a multicenter, open-label, single-arm trial. (Pubmed Central) -  Dec 19, 2023   
    P3
    Among the treatment-related adverse events (TRAEs), infective pneumonia (17.6%) was the most frequent non-hematologic adverse event, while a decrease in neutrophil count (52.9%) was the most common grade???3 TRAE. The study results indicated that the generic pomalidomide demonstrated consistent efficacy and a safety profile similar to the branded pomalidomide when combined with low-dose dexamethasone in Chinese RRMM patients.Registration number ClinicalTrials.gov NCT05236621, retrospectively registered on February 11, 2022.
  • ||||||||||  dexamethasone / Generic mfg., methotrexate IV / Generic mfg.
    Journal:  Primary central nervous system lymphoma. (Pubmed Central) -  Dec 19, 2023   
    Consolidation treatment consists of either whole brain radiotherapy (WBRT) or autologous stem cell transplantation (ASCT). Given the (cognitive) side effects of WBRT, ASCT is increasingly being used as the first choice of treatment.
  • ||||||||||  remdesivir / Generic mfg., dexamethasone / Generic mfg.
    Observational data, Journal:  Temporal trends in 90-day survival of hospitalised individuals during two years of the COVID-19 pandemic in Denmark. (Pubmed Central) -  Dec 19, 2023   
    Adjusting for vaccination, remdesivir treatment and dexamethasone treatment attenuated the association in patients requiring low-flow oxygen. Our study suggests lower hazard rates for mortality in patients hospitalised with COVID-19 from July 2020 compared to March-June 2020, mainly driven by lower mortality in patients with a need of oxygen at baseline.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Additional (Pubmed Central) -  Dec 18, 2023   
    For patients experiencing breakthrough nausea and vomiting, the available evidence suggests using a single dose of olanzapine daily for 3 Conventional induction protocol (CIP) of calving in buffaloes employs the intramuscular (IM) administration of dexamethasone (40
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Shifting the Focus from Dissolution to Permeation: Introducing the Meso-fluidic Chip for Permeability Assessment (MCPA). (Pubmed Central) -  Dec 18, 2023   
    The results were highly reproducible and clearly displayed the method's potential for evaluating the performance of enabling formulations, and possibly even predicting in vivo performance. We believe that, upon further development, the MCPA will serve as a useful in vitro tool that could push sustainability into pharmaceutics by refining, reducing and replacing animal testing in early-stage drug development.
  • ||||||||||  PT150 / The Pop Test & Palisades Therap
    Journal, IO biomarker:  Synergy between interleukin-1?, interferon-? and glucocorticoids to induce TLR2 expression involves NF-?B, STAT1 and GR. (Pubmed Central) -  Dec 18, 2023   
    plus dexamethasone (IL-1?+IFN-?+Dex)...Using the A549 cell model, TLR2 induction by IL-1?+IFN-?+Dex was antagonized by Org34517, a competitive GR antagonist...This effect involved positive combinatorial interactions between NF-?B/p65, GR and JAK-STAT1 signalling to synergistically upregulate TLR2 expression. Thus, synergies involving glucocorticoid-enhancement of TLR2 expression may occur in the immunopathology of glucocorticoid-resistant inflammatory diseases, including severe asthma.
  • ||||||||||  fluticasone / Generic mfg.
    Review, Journal:  Topical and oral steroids for otitis media with effusion (OME) in children. (Pubmed Central) -  Dec 17, 2023   
    The potential benefit of treatment may therefore be small and should be balanced with the risk of adverse effects. Future studies should aim to determine which children are most likely to benefit from treatment, rather than offering interventions to all children.
  • ||||||||||  Breztri Aerosphere (budesonide/formoterol fumarate/glycopyrronium) / AstraZeneca
    Retrospective data, Journal:  Benefit of Prompt Vs Delayed Initiation of Triple Therapy Following an Exacerbation in Patients with COPD in Japan: A Retrospective Cohort Study. (Pubmed Central) -  Dec 17, 2023   
    database initiating triple therapy as single-inhaler triple therapy (fluticasone furoate/umeclidinium/vilanterol or budesonide/glycopyrronium/formoterol) or multiple-inhaler triple therapy within 180 days of a moderate-to-severe exacerbation (index)...Weighted healthcare resource utilization rates were numerically lower in prompt vs delayed initiators, and weighted direct costs (all cause and COPD-related) were significantly lower in prompt initiators. This real-world study demonstrated that earlier initiation of triple therapy resulted in several benefits in clinical outcomes for COPD and may also reduce the economic burden of COPD management in Japan.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Penicimides A and B, two novel diels-alder [4 (Pubmed Central) -  Dec 17, 2023   
    This effect of GP may be attributed to the suppression of FoxO1 activity. Biological evaluations of Compounds 1-16 revealed that 3, 9-11, and 15 inhibited the production of NO in LPS-induced RAW264.7 cells with an IC value from 7.37
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  The functional and molecular impact of triamcinolone acetonide on primary human bone marrow mesenchymal stem cells. (Pubmed Central) -  Dec 17, 2023   
    RNA sequencing indicated that TA modulated the inflammatory response of MSCs, which may have an impact on the immunologic environment where the inflammatory phase is a physiological part of the natural healing process. These data indicate that triamcinolone acetonide should be used with consideration bearing the patient's outcome in mind, with the intention to optimize joint recovery and homeostasis.
  • ||||||||||  dexamethasone / Generic mfg., metformin / Generic mfg., doxazosin mesylate / Generic mfg.
    Journal:  Giant left pheochromocytoma with vascular anomalies and pelvic horseshoe kidney: a case report. (Pubmed Central) -  Dec 17, 2023   
    Our patient had a giant pheochromocytoma with anatomical variations complicating an already surgically challenging procedure. Nonetheless, with multiple provider collaboration, detailed pre-operative surgical planning, and meticulous perioperative monitoring, radical resection of the giant pheochromocytoma was safe and feasible with successful postoperative outcomes.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Lost in Space? Unmasking the T Cell Reaction to Simulated Space Stressors. (Pubmed Central) -  Dec 17, 2023   
    In our model, we showed a GBM outgrowth enhancing synergism between CXCR2-blocking and Dex-treatment in the native condition, which was levelled by PLX5622-pretreatment. We have exposed stimulated Jurkat cells to simulated space stressors (1 Gy, carbon ions/1 Gy photons, 1
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg., Rituxan (rituximab) / Biogen, Zenyaku Holdings, Roche
    Journal:  Systemic lupus erythematosus mimicking retinal migraine: a case report. (Pubmed Central) -  Dec 17, 2023   
    Future studies will explore the effects of vitamin C on these cells during inflammation and within the tendon niche in vivo. Given the clinical presentation, systemic lupus erythematosus should be considered as a cause of transient monocular blindness and should be distinguished from retinal migraine.
  • ||||||||||  Review, Journal:  Diclofenac for acute postoperative pain in children. (Pubmed Central) -  Dec 17, 2023   
    Healthcare providers should weigh the benefits and risks based on what is known of their respective pharmacological effects, rather than known efficacy. For surgical interventions in which bleeding or nausea and vomiting are a concern postoperatively, the risks of adverse events using opioids or diclofenac for managing pain should be considered.
  • ||||||||||  Journal, Real-world evidence, Real-world:  High-throughput target trial emulation for Alzheimer's disease drug repurposing with real-world data. (Pubmed Central) -  Dec 17, 2023   
    We also found that the deep learning-based propensity score model did not necessarily outperform logistic regression-based methods in covariate balancing. Finally, we highlighted five top-ranked drugs (pantoprazole, gabapentin, atorvastatin, fluticasone, and omeprazole) originally intended for other indications with potential benefits for Alzheimer's patients.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma, methylprednisolone sodium succinate / Generic mfg.
    Journal:  Defining the Clinicoradiologic Syndrome of SARS-CoV-2 Acute Necrotizing Encephalopathy. (Pubmed Central) -  Dec 17, 2023   
    Children and adults with SARS-CoV-2 ANE have similar clinical features and neuroimaging characteristics. Mortality is high, predominantly in patients not receiving immunotherapy and at the extremes of age.