- |||||||||| dexamethasone / Generic mfg.
Retrospective data, Journal: Adrenal incidentalomas, cortisol secretion and cancer: is there a real crosstalk? (Pubmed Central) - Jan 28, 2024
The study concludes that both intralesional 5-FU and TA are effective and safe for treating localized vitiligo, with 5-FU potentially being more efficacious in lesion size reduction and promoting repigmentation. Cortisol secretion was defined by a cortisol post-dexamethasone suppression test > 1.8
- |||||||||| Sarclisa (isatuximab-irfc) / Sanofi, iberdomide (CC-220) / BMS
Enrollment open: An immune-therapeutic salvage strategy for (EUDRACT) - Jan 27, 2024
P2, N=50, Recruiting,
However, the evaluation of its long-term efficacy is still needed. Not yet recruiting --> Recruiting
- |||||||||| dexamethasone / Generic mfg.
Journal: Highly Responsive Bioassay for Quantification of Glucocorticoids. (Pubmed Central) - Jan 26, 2024
Precision (CV < 20%) was validated down to 3-6 nM dexamethasone, and estimation of the total cortisol concentration was comparable to cortisol immunoassay and LC-MS/MS in most serum samples...The HEK293F-GRE assay holds the potential to be a complementary method for estimating cortisol in clinical practice. The ability to quantify bioavailable cortisol directly from serum samples is alluring and provides an opportunity for monitored and personal dose regimens of exogenous glucocorticoids.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Review, Journal: Hypereosinophilia-associated acute intradialytic hypotension: a report of three cases and literature review. (Pubmed Central) - Jan 26, 2024
Pretreatment with methylprednisolone given intravenously before the dialysis session was also ineffective...Hypereosinophilia-associated acute intradialytic hypotension is an under-recognized condition; therefore, clinicians need to be aware of this clinical entity and initiate effective treatment strategies. We also provide a brief summary of previously published cases.
- |||||||||| Sarclisa (isatuximab-irfc) / Sanofi
Journal: Onset of Testicular Plasmacytoma in a Patient with Refractory Multiple Myeloma (Pubmed Central) - Jan 26, 2024
The patient is currently under follow-up without recurrence. While testicular tumors are difficult to diagnose by imaging studies alone and extramedullary plasmacytomas rarely occur in the testis, pathological assessment is critical for treatment planning.
- |||||||||| pioglitazone / Generic mfg.
Review, Journal: Peroxisome proliferator-activated receptor?/? agonist pioglitazone for rescuing relapsed or refractory neoplasias by unlocking phenotypic plasticity. (Pubmed Central) - Jan 26, 2024
Pioglitazone, integrated in differentially designed editing schedules, facilitated induction of tumor cell death as indicated by complete remission (CR) in r/r non-PML AML, continuous CR in r/r RCCC, mLCH, and in HL by addition of everolimus, or long-term disease control in melanoma by efficaciously controlling metastasis, post-therapy cancer repopulation and acquired cell-resistance and genetic/molecular-genetic tumor cell heterogeneity (M-CRAC)...Low-dose MCT facilitates targeted reprogramming of cancer hallmarks with transcriptional modulators, induction of tumor cell death, M-CRAC control and editing of non-oncogene addiction. Thus, pioglitazone, integrated in tumor tissue editing protocols, is an important biomodulatory drug for addressing urgent therapeutic problems, such as M-CRAC in relapsed or refractory tumor disease.
- |||||||||| dexamethasone / Generic mfg.
Journal: ICAM-1 targeted and ROS-responsive nanoparticles for the treatment of acute lung injury. (Pubmed Central) - Jan 26, 2024
In response, we constructed a ?3 peptide-decorated and ROS-responsive nanoparticle system encapsulating therapeutic dexamethasone (Dex/PSB-?3 NPs)...This combined approach improves treatment accuracy, and drug bioavailability, and effectively inhibits inflammation progression. Our study could effectively reduce the risk of ALI progressing to ARDS and hold potential for the early treatment of ALI.
- |||||||||| AZD8055 / AstraZeneca
Journal: Rhabdovirus encoded glycoprotein induces and harnesses host antiviral autophagy for maintaining its compatible infection. (Pubmed Central) - Jan 26, 2024
Together, our data support a model that SnRK1 senses rhabdovirus glycoprotein for autophagy initiation, while ATG6 mediates targeted degradation of viral glycoprotein. This conserved mechanism ensures compatible infection by limiting the toxicity of viral glycoprotein and restricting the infection of rhabdoviruses.Abbreviations: AMPK: adenosine 5'-monophosphate (AMP)-activated protein kinase; ANOVA: analysis of variance; ATG: autophagy related; AZD: AZD8055; BiFC: bimolecular fluorescence complementation; BYSMV: barley yellow striate mosaic virus; Co-IP: co-immunoprecipitation; ConA: concanamycin A; CTD: C-terminal domain; DEX: dexamethasone; DMSO: dimethyl sulfoxide; G: glycoprotein; GFP: green fluorescent protein; MD: middle domain; MDC: monodansylcadaverine; NTD: N-terminal domain; OE: over expression; Os: Oryza sativa; PBS: phosphate-buffered saline; PtdIns3K: class III phosphatidylinositol-3-kinase; qRT-PCR: quantitative real-time reverse-transcription PCR; RFP: red fluorescent protein; RSMV: rice stripe mosaic virus; RSV: rice stripe virus; SGS3: suppressor of gene silencing 3; SnRK1: sucrose nonfermenting1-related protein kinase1; SYNV: sonchus yellow net virus; TEM: transmission electron microscopy; TM: transmembrane region; TOR: target of rapamycin; TRV: tobacco rattle virus; TYMaV: tomato yellow mottle-associated virus; VSV: vesicular stomatitis virus; WT: wild type; Y2H: yeast two-hybrid; YFP: yellow fluorescent protein.
- |||||||||| opevesostat (ODM-208) / Merck (MSD)
Enrollment open, Metastases: A Study of Opevesostat (MK-5684) in China Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (MK-5684-001) (clinicaltrials.gov) - Jan 26, 2024
P1, N=14, Recruiting,
This conserved mechanism ensures compatible infection by limiting the toxicity of viral glycoprotein and restricting the infection of rhabdoviruses.Abbreviations: AMPK: adenosine 5'-monophosphate (AMP)-activated protein kinase; ANOVA: analysis of variance; ATG: autophagy related; AZD: AZD8055; BiFC: bimolecular fluorescence complementation; BYSMV: barley yellow striate mosaic virus; Co-IP: co-immunoprecipitation; ConA: concanamycin A; CTD: C-terminal domain; DEX: dexamethasone; DMSO: dimethyl sulfoxide; G: glycoprotein; GFP: green fluorescent protein; MD: middle domain; MDC: monodansylcadaverine; NTD: N-terminal domain; OE: over expression; Os: Oryza sativa; PBS: phosphate-buffered saline; PtdIns3K: class III phosphatidylinositol-3-kinase; qRT-PCR: quantitative real-time reverse-transcription PCR; RFP: red fluorescent protein; RSMV: rice stripe mosaic virus; RSV: rice stripe virus; SGS3: suppressor of gene silencing 3; SnRK1: sucrose nonfermenting1-related protein kinase1; SYNV: sonchus yellow net virus; TEM: transmission electron microscopy; TM: transmembrane region; TOR: target of rapamycin; TRV: tobacco rattle virus; TYMaV: tomato yellow mottle-associated virus; VSV: vesicular stomatitis virus; WT: wild type; Y2H: yeast two-hybrid; YFP: yellow fluorescent protein. Not yet recruiting --> Recruiting
- |||||||||| methimazole / Generic mfg., hydrocortisone / Generic mfg., propranolol / Generic mfg.
AN UNSUAL ACUTE ST SEGMENT MYOCARDIAL INFARCTION AS FIRST MANIFESTATION OF SEVERE HYPERTHYROIDISM (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_6777;
Hyperthyroidism, a potentially life-threatening condition, underscores the importance of routine thyroid function testing even in patients without risk factors who experience chest pain. A delay in diagnosis is linked to unfavorable outcomes and increased risk of cardiovascular complications.
- |||||||||| Integrilin (eptifibatide) / Takeda
CATASTROPHIC C'S - CULPRIT CORONARY OR COVID CARDITIS (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_6761;
Severe systemic inflammation with release of inflammatory cytokines and increased sympathetic stimulation due to COVID, can lead to increased thrombotic burden and present as multi-vessel thrombosis. Due to these factors, use of aspiration thrombectomy and GPIIB/IIIA inhibitors has been suggested in these COVID cases.
- |||||||||| Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi
REVERSIBLE COMPLETE HEART BLOCK IN A PATIENT AFTER ORTHOTOPIC HEART TRANSPLANTATION (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_6705;
CHB is a rare presentation of acute rejection but should be considered in the differential diagnosis. Treatment of rejection while ensuring the patient is stable using a TVP is a feasible option to allow the conduction system to recover.
- |||||||||| Opdivo (nivolumab) / Ono Pharma, BMS, Yervoy (ipilimumab) / Ono Pharma, BMS
DOUBLE TROUBLE: IMMUNOTHERAPY INDUCED MYOCARDITIS AND MYOSITIS (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_4947;
Timely intervention with high-dose steroids, IVIG, and mycophenolate may mitigate adverse outcomes. Additional research is needed for risk assessment and exploring the role of early mechanical circulatory support in managing such cases.
- |||||||||| cyclophosphamide / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
ENIGMA (Moderated Poster Theater 10) - Jan 26, 2024 - Abstract #ACC2024ACC_4007;
HSS should be suspected in young patients with venous thrombosis and pulmonary artery aneurysms. The prognosis of this condition can be improved with early initiation of immunosuppression therapy.
- |||||||||| methimazole / Generic mfg., hydrocortisone / Generic mfg.
FLAIL MITRAL VALVE IN THYROTOXICOSIS - A RARE PRESENTATION OF GRAVES DISEASE (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_2207;
Our patient with untreated hyperthyroidism presented with thyrotoxicosis complicated by chordae tendineae rupture, which resulted in heart failure and cardiogenic shock. We stress the importance of early treatment of Grave's disease, and suggest early screening to visualize mitral valve abnormalities, which can avoid life-threatening long-term sequelae.
- |||||||||| hydralazine hydrochloride / Generic mfg.
ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY VASCULITIS: A RISING CONCERN WITH HYDRALAZINE USE (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_1669;
In the absence of typical signs and symptoms of hydralazine-induced lupus, consideration should be given to the possibility of hydralazine-induced vasculitis. Vigilance and early recognition of this adverse effect are essential for initiation of appropriate therapy and prevention of further complications.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD), Lenvima (lenvatinib) / Eisai, Merck (MSD)
FROM HEART TO MIND: IMMUNE CHECKPOINT INHIBITORS AND THE DUAL CHALLENGE (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_1351;
As ICIs usher in a new era in oncology, clinicians must remain vigilant. Their adverse effects can be severe, necessitating swift identification and intervention, especially when symptoms may mimic other conditions.
- |||||||||| Promacta (eltrombopag) / Novartis
NAVIGATING THE LABYRINTH: ACUTE CORONARY SYNDROME IN A PATIENT WITH AMEGAKARYOCYTIC THROMBOCYTOPENIA (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_839;
A critical factor that complicates the management of ACS in these patients is the elevated risk of bleeding due to thrombocytopenia. The balancing act between minimizing thrombotic risk, inherent in ACS, and mitigating the bleeding risk associated with thrombocytopenia can be a daunting task for clinicians.
- |||||||||| hydrocortisone / Generic mfg.
A CASE OF PROFOUND SINUS BRADYCARDIA AS AN UNUSUAL PRESENTATION OF ADRENAL INSUFFICIENCY (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_330;
The balancing act between minimizing thrombotic risk, inherent in ACS, and mitigating the bleeding risk associated with thrombocytopenia can be a daunting task for clinicians. Sinus bradycardia is a rare manifestation of AI, but timely recognition and management are essential to prevent potentially life-threatening complications associated with adrenal crisis.
- |||||||||| Sarclisa (isatuximab-irfc) / Sanofi
Enrollment open: Isa-Pom-Dex in Elderly/Frail Subjects With RRMM (clinicaltrials.gov) - Jan 25, 2024
P2, N=49, Recruiting,
Sinus bradycardia is a rare manifestation of AI, but timely recognition and management are essential to prevent potentially life-threatening complications associated with adrenal crisis. Not yet recruiting --> Recruiting
- |||||||||| budesonide / Generic mfg.
Lymphocytic Colitis: A large case series in the United Kingdom (Poster exhibition) - Jan 25, 2024 - Abstract #ECCOIBD2024ECCO_IBD_1992;
Treatment with either budesonide or loperamide generally lead to better symptom control, indicating patients should be referred to gastroenterology upon diagnosis. Clinicians should judiciously prescribe the above medications with clear indication and avoid prescribing indefinitely.
- |||||||||| Remicade (infliximab) / J&J, Humira (adalimumab) / AbbVie
High doses of methylprednisolone in inducing remission in acute severe ulcerative colitis (Poster exhibition) - Jan 25, 2024 - Abstract #ECCOIBD2024ECCO_IBD_1942;
For those inadequately responding to 5-aminosalicylic acid, remission may be induced via oral steroids or, in severe instances, intravenous methylprednisolone (1.5mg/kg per day)...For the 6/15 non-responders to methylprednisolone pulses, treatment was escalated (4 received infliximab, 1 adalimumab, and 1 initiated with cyclosporine followed by infliximab); notably, 3 required colectomy...Conclusion In conclusion, high-dose methylprednisolone appears to be a viable alternative for inducing remission in pediatric UC. However, due to limitations such as the small patient group and the retrospective nature of this analysis, further prospective studies are essential to validate these findings.
- |||||||||| prednisolone / Generic mfg.
First in human treatment of Crohn (Poster exhibition) - Jan 25, 2024 - Abstract #ECCOIBD2024ECCO_IBD_1908;
1 patient started oral prednisolone at wk 6 for active disease...Clinical and endoscopic changes should be interpreted with caution in such small numbers of patients. There is a rationale to proceed to Ph2.
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